CD18 is required for optimal lymphopenia-induced proliferation of mouse T cells

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 303, Issue 7, 2012, Pages

  Sarin, Ritu ^a   Abraham, Clara ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Adhesion molecules; Cell trafficking; Costimulation; T lymphocytes

Indexed keywords

AMPICILLIN; ANTIBIOTIC AGENT; CD18 ANTIGEN; METRONIDAZOLE; NEOMYCIN; RAG1 PROTEIN; VANCOMYCIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIBIOTIC THERAPY; ARTICLE; CD4 LYMPHOCYTE COUNT; CD4+ T LYMPHOCYTE; CELL FUNCTION; CELL TRANSFER; CONTROLLED STUDY; FLOW CYTOMETRY; HOMEOSTASIS; IRRADIATION; LYMPHOCYTE PROLIFERATION; LYMPHOCYTOPENIA; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SPLEEN; T LYMPHOCYTE ACTIVATION; TRANSGENIC ANIMAL;

ANIMALS; ANTIGENS, CD18; BLOOD CELL COUNT; CD4-POSITIVE T-LYMPHOCYTES; CELL ADHESION MOLECULES; CELL PROLIFERATION; COSTIMULATORY AND INHIBITORY T-CELL RECEPTORS; HOMEODOMAIN PROTEINS; IMMUNITY; INTESTINAL MUCOSA; LYMPHOPENIA; MAJOR HISTOCOMPATIBILITY COMPLEX; MICE; MICE, INBRED BALB C;

EID: 84867178600     PISSN: 01931857     EISSN: 15221547     Source Type: Journal    
DOI: 10.1152/ajpgi.00520.2011     Document Type: Article

References (40)

1. Abraham C, Griffith J, Miller J. The dependence for leukocyte functionassociated antigen-1/ICAM-1 interactions in T cell activation cannot be overcome by expression of high density TCR ligand. J Immunol 162: 4399-4405, 1999.
2. Abraham C, Miller J. Molecular mechanisms of IL-2 gene regulation following costimulation through LFA-1. J Immunol 167: 5193-5201, 2001.
3. Bachmann MF, McKall-Faienza K, Schmits R, Bouchard D, Beach J, Speiser DE, Mak TW, Ohashi PS. Distinct roles for LFA-1 and CD28 during activation of naive T cells: adhesion versus costimulation. Immunity 7: 549-557, 1997.
4. Barthlott T, Kassiotis G, Stockinger B. T cell regulation as a side effect of homeostasis and competition. J Exp Med 197: 451-460, 2003.
5. Berlin-Rufenach C, Otto F, Mathies M, Westermann J, Owen MJ, Hamann A, Hogg N. Lymphocyte migration in lymphocyte functionassociated antigen (LFA)-1-deficient mice. J Exp Med 189: 1467-1478, 1999.
6. Cho JH. Immunochip-based analysis of a large IBD case-control cohort identifies 50 novel loci, refining definitions of disease pathways. International Inflammatory Bowel Disease Genetics Consortium. Gastroenterology 142: S149-S150, 2012.
7. Dummer W, Ernst B, LeRoy E, Lee D, Surh C. Autologous regulation of naive T cell homeostasis within the T cell compartment. J Immunol 166 2460-2468, 2001.
8. Durant L, Watford WT, Ramos HL, Laurence A, Vahedi G, Wei L, Takahashi H, Sun HW, Kanno Y, Powrie F, O'Shea JJ. Diverse targets of the transcription factor STAT3 contribute to T cell pathogenicity and homeostasis. Immunity 32: 605-615, 2010.
9. Elson CO, Cong Y, McCracken VJ, Dimmitt RA, Lorenz RG, Weaver CT. Experimental models of inflammatory bowel disease reveal innate, adaptive, and regulatory mechanisms of host dialogue with the microbiota. Immunol Rev 206: 260-276, 2005.
10. Ernst B, Lee DS, Chang JM, Sprent J, Surh CD. The peptide ligands mediating positive selection in the thymus control T cell survival and homeostatic proliferation in the periphery. Immunity 11: 173-181, 1999.
11. Ge Q, Rao VP, Cho BK, Eisen HN, Chen J. Dependence of lymphopenia-induced T cell proliferation on the abundance of peptide/MHC epitopes and strength of their interaction with T cell receptors. Proc Natl Acad Sci USA 98: 1728-1733, 2001.
12. + T cells in lymphopenic hosts. Immunity 11 183-190, 1999.
13. Grabbe S, Varga G, Beissert S, Steinert M, Pendl G, Seeliger S, Bloch W, Peters T, Schwarz T, Sunderkotter C, Scharffetter-Kochanek K. 2-Integrins are required for skin homing of primed T cells but not for priming naive T cells. J Clin Invest 109: 183-192, 2002.
14. + T cells: costimulatory requirements and role in memory formation. J Immunol 167: 3699-3707, 2001.
15. Hagen KA, Moses CT, Drasler EF, Podetz-Pedersen KM, Jameson SC, Khoruts A. A role for CD28 in lymphopenia-induced proliferation of CD4 T cells. J Immunol 173: 3909-3915, 2004.
16. + T cells is required for optimal antigen-dependent activation in vivo. J Immunol 173: 4443-4451, 2004.
17. Kieper WC, Burghardt JT, Surh CD. A role for TCR affinity in regulating naive T cell homeostasis. J Immunol 172: 40-44, 2004.
18. Kieper WC, Troy A, Burghardt JT, Ramsey C, Lee JY, Jiang HQ, Dummer W, Shen H, Cebra JJ, Surh CD. Recent immune status determines the source of antigens that drive homeostatic T cell expansion. J Immunol 174: 3158-3163, 2005.
19. King C, Ilic A, Koelsch K, Sarvetnick N. Homeostatic expansion of T cells during immune insufficiency generates autoimmunity. Cell 117: 265-277, 2004.
20. Li O, Zheng P, Liu Y. CD24 expression on T cells is required for optimal T cell proliferation in lymphopenic host. J Exp Med 200: 1083-1089, 2004.
21. Liu Z, Geboes K, Colpaert S, Overbergh L, Mathieu C, Heremans H, de Boer M, Boon L, D'Haens G, Rutgeerts P, Ceuppens JL. Prevention of experimental colitis in SCID mice reconstituted with CD45RBhigh CD4 T cells by blocking the CD40-CD154 interactions. J Immunol 164: 6005-6014, 2000.
22. Marski M, Ye A, Abraham C. CD18 is required for intestinal T cell responses at multiple immune checkpoints. J Immunol 178: 2104-2112, 2007.
23. Min B, Yamane H, Hu-Li J, Paul WE. Spontaneous and homeostatic proliferation of CD4 T cells are regulated by different mechanisms. J Immunol 174: 6039-6044, 2005.
24. Monti P, Scirpoli M, Maffi P, Ghidoli N, De Taddeo F, Bertuzzi F, Piemonti L, Falcone M, Secchi A, Bonifacio E. Islet transplantation in patients with autoimmune diabetes induces homeostatic cytokines that expand autoreactive memory T cells. J Clin Invest 118: 1806-1814, 2008.
25. Moses CT, Thorstenson KM, Jameson SC, Khoruts A. Competition for self ligands restrains homeostatic proliferation of naive CD4 T cells. Proc Natl Acad Sci USA 100: 1185-1190, 2003.
26. Pavlick KP, Ostanin DV, Furr KL, Laroux FS, Brown CM, Gray L, Kevil CG, Grisham MB. Role of T-cell-associated lymphocyte functionassociated antigen-1 in the pathogenesis of experimental colitis. Int Immunol 18: 389-398, 2006.
27. Prlic M, Blazar BR, Khoruts A, Zell T, Jameson SC. Homeostatic expansion occurs independently of costimulatory signals. J Immunol 167: 5664-5668, 2001.
28. Rakoff-Nahoum S, Paglino J, Eslami-Varzaneh F, Edberg S, Medzhitov R. Recognition of commensal microflora by Toll-like receptors is required for intestinal homeostasis. Cell 118: 229-241, 2004.
29. Sandau MM, Winstead CJ, Jameson SC. IL-15 is required for sustained lymphopenia-driven proliferation and accumulation of CD8 T cells. J Immunol 179: 120-125, 2007.
30. Scharffetter-Kochanek K, Lu H, Norman K, van Nood N, Munoz F, Grabbe S, McArthur M, Lorenzo I, Kaplan S, Ley K, Smith CW, Montgomery CA, Rich S, Beaudet AL. Spontaneous skin ulceration and defective T cell function in CD18 null mice. J Exp Med 188: 119-131, 1998.
31. Schluns KS, Kieper WC, Jameson SC, Lefrancois L. Interleukin-7 mediates the homeostasis of naive and memory CD8 T cells in vivo. Nat Immunol 1: 426-432, 2000.
32. Schmits R, Kundig TM, Baker DM, Shumaker G, Simard JJ, Duncan G, Wakeham A, Shahinian A, van der Heiden A, Bachmann MF, Ohashi PS, Mak TW, Hickstein DD. LFA-1-deficient mice show normal CTL responses to virus but fail to reject immunogenic tumor. J Exp Med 183: 1415-1426, 1996.
33. Seibel JL, Wilson N, Kozono H, Marrack P, Kappler JW. Influence of the NH2-terminal amino acid of the T cell receptor-chain on major histocompatibility complex (MHC) class II peptide recognition. J Exp Med 185: 1919-1927, 1997.
34. Shvets A, Chakrabarti R, Gonzalez-Quintial R, Baccala R, Theofilopoulos AN, Prud'homme GJ. Impaired negative regulation of homeostatically proliferating T cells. Blood 113: 622-625, 2009.
35. + T cells. J Exp Med 205: 1019-1027, 2008.
36. Troy AE, Shen H. Homeostatic proliferation of peripheral T lymphocytes is regulated by clonal competition. J Immunol 170: 672-676, 2003.
37. Uzel G, Kleiner DE, Kuhns DB, Holland SM. Dysfunctional LAD-1 neutrophils and colitis. Gastroenterology 121: 958-964, 2001.
38. Vu MD, Clarkson MR, Yagita H, Turka LA, Sayegh MH, Li XC. Critical, but conditional, role of OX40 in memory T cell-mediated rejection. J Immunol 176: 1394-1401, 2006.
39. Winstead CJ, Fraser JM, Khoruts A. Regulatory CD4 CD25 Foxp3 T cells selectively inhibit the spontaneous form of lymphopenia-induced proliferation of naive T cells. J Immunol 180: 7305-7317, 2008.
40. Wu Z, Bensinger SJ, Zhang J, Chen C, Yuan X, Huang X, Markmann JF, Kassaee A, Rosengard BR, Hancock WW, Sayegh MH, Turka LA. Homeostatic proliferation is a barrier to transplantation tolerance. Nat Med 10: 87-92, 2004.