Gene deletion of P2Y 4 receptor lowers exercise capacity and reduces myocardial hypertrophy with swimming exercise

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 303, Issue 7, 2012, Pages

  Horckmans, Michael ^a   Léon Gómez, Elvira ^a   Robaye, Bernard ^a   Balligand, Jean Luc ^b   Boeynaems, Jean Marie ^a,c   Dessy, Chantal ^a   Communi, Didier ^a  

^a UNIVERSITÉ LIBRE DE BRUXELLES   (Belgium)

^b UNIVERSITÉ CATHOLIQUE DE LOUVAIN   (Belgium)

^c ERASME HOSPITAL   (Belgium)

Author keywords

Cardiac hypertrophy; Exercise capacity; Extracellular nucleotides; P2Y receptors

Indexed keywords

BETA ADRENERGIC RECEPTOR; CATECHOLAMINE; NORADRENALIN; PURINERGIC P2Y4 RECEPTOR; BETA ADRENERGIC RECEPTOR STIMULATING AGENT; DOBUTAMINE; PURINERGIC P2 RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD PRESSURE; CATECHOLAMINE BLOOD LEVEL; CELL SIZE; CONTROLLED STUDY; EXERCISE RECOVERY; EXERCISE TEST; GENE DELETION; GENE EXPRESSION; GENE FUNCTION; HEART MUSCLE CELL; HEART RATE; HEART STRESS; HEART VENTRICLE HYPERTROPHY; HEART VENTRICLE PRESSURE; HISTOPATHOLOGY; LOCOMOTION; MALE; MOTIVATION; MOUSE; NONHUMAN; NORADRENALIN BLOOD LEVEL; OPEN FIELD BEHAVIOR; PHYSICAL CAPACITY; PHYSICAL STRESS; PRIORITY JOURNAL; REGULATOR GENE; RUNNING; SWIMMING; SYMPATHETIC INNERVATION; TAIL FLICK TEST; TREADMILL EXERCISE; WILD TYPE; ADRENERGIC NERVE; ANIMAL; ANIMAL BEHAVIOR; BLOOD PRESSURE MONITORING; C57BL MOUSE; CARDIOMEGALY; CONVALESCENCE; DISEASE MODEL; DRUG EFFECT; EXERCISE INDUCED CARDIOMEGALY; EXERCISE TOLERANCE; GENETICS; GENOTYPE; HEART; HEART MUSCLE; HYPOTHERMIA; INNERVATION; METABOLISM; MOUSE MUTANT; PATHOLOGY; PATHOPHYSIOLOGY; PHENOTYPE; TELEMETRY; TIME;

ADRENERGIC BETA-AGONISTS; ADRENERGIC FIBERS; ANIMALS; BEHAVIOR, ANIMAL; BLOOD PRESSURE; BLOOD PRESSURE MONITORING, AMBULATORY; CARDIOMEGALY; CARDIOMEGALY, EXERCISE-INDUCED; CATECHOLAMINES; DISEASE MODELS, ANIMAL; DOBUTAMINE; EXERCISE TEST; EXERCISE TOLERANCE; GENE DELETION; GENOTYPE; HEART; HEART RATE; HYPOTHERMIA; LOCOMOTION; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MYOCARDIUM; PHENOTYPE; RECEPTORS, ADRENERGIC, BETA; RECEPTORS, PURINERGIC P2; RECOVERY OF FUNCTION; SWIMMING; TELEMETRY; TIME FACTORS;

EID: 84867155012     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00256.2012     Document Type: Article

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