Alterations in dynamic heart rate control in the β1-adrenergic receptor knockout mouse

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 274, Issue 4 43-4, 1998, Pages

  Rohrer, Daniel K ^a   Schauble, Eric H ^a   Desai, Kavin H ^a   Kobilka, Brian K ^a   Bernstein, Daniel ^a,b  

^a STANFORD UNIVERSITY   (United States)

^b NONE   (United States)

Author keywords

Autonomic; Baroreflex; Chronotropic; Exercise; Gene disruption

Indexed keywords

ATROPINE; BETA 1 ADRENERGIC RECEPTOR; ISOPRENALINE; PHENYLEPHRINE;

ADRENERGIC SYSTEM; ANIMAL EXPERIMENT; ARTICLE; CARDIOVASCULAR PERFORMANCE; CHRONOTROPISM; EXERCISE; FEMALE; HEART RATE VARIABILITY; HEMODYNAMICS; INOTROPISM; KNOCKOUT MOUSE; MALE; MOUSE; NONHUMAN; PRESSORECEPTOR REFLEX; PRIORITY JOURNAL;

EID: 33750872731     PISSN: 03636135     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpheart.1998.274.4.h1184     Document Type: Article

References (51)

1. Andersen, S. D., P. T. Bye, C. P. Perry, G. P. Hamor, G. Theobald, and G. Nyberg. Limitation of work performance in normal adult males in the presence of beta-adrenergic blockade. Aust. NZ J. Med. 9: 515-520, 1979.
2. Arner, P. Impact of exercise on adipose tissue metabolism in humans (Review). Int. J. Obesity Related Metab. Disorders 19, Suppl. 4: S18-S21, 1995.
3. Berkowitz, W. D., B. J. Scherlag, E. Stein, and A. N. Damato. Relative roles of sympathetic and parasympathetic nervous systems in the carotid sinus reflex in dogs. Circ. Res. 24: 447-455, 1969.
4. Berlan, M., J. Galitzky, and J. L. Montastruc. Beta 3-adrenoceptors in the cardiovascular system. Fundam. Clin. Pharmacol. 9: 234-239, 1995.
5. Bevilacqua, M., S. Savonitto, E. Bosisio, E. Chebat, P. L. Bertora, M. Sardina, and G. Norbiato. Role of the Frank-Starling mechanism in maintaining cardiac output during increasing levels of treadmill exercise in beta-blocked normal men. Am. J. Cardiol. 63: 853-857, 1989.
6. Brodde, O. E. Beta 1- and beta 2-adrenoceptors in the human heart: properties, function, and alterations in chronic heart failure [published erratum appears in Pharmacol. Rev. 43: 350, 1991]. Pharmacol. Rev. 43: 203-242, 1991.
7. Desai, K. H., D. K. Rohrer, B. K. Kobilka, and D. Bernstein. Diminished contractile response to isoproterenol in beta-1 adrenergic receptor deficient mice (Abstract). Circulation 94, Suppl.: I-288, 1996.
8. Desai, K. H., R. Sato, E. Schauble, G. S. Barsh, B. K. Kobilka, and D. Bernstein. Cardiovascular indexes in the mouse at rest and with exercise: new tools to study models of cardiac disease. Am. J. Physiol. 272 (Heart Circ. Physiol. 41): H1053-H1061, 1997.
9. Epstein, S., B. F. Robinson, R. L. Kahler, and E. Braunwald. Effects of beta-adrenergic blockade on the cardiac response to maximal and submaximal exercise in man. J. Clin. Invest. 44: 1745-1753, 1965.
10. Erikssen, J., E. Thaulow, R. Mundal, P. Opstad, and H. S. Nitter. Comparison of beta-adrenoceptor blockers under maximal exercise (pindolol v metoprolol v atenolol). Br. J. Clin. Pharmacol. 13, Suppl 2: 201S-209S, 1982.
11. Franco-Cereceda, A., J. M. Lundberg, and C. Dahlof. Neuropeptide Y and sympathetic control of heart contractility and coronary vascular tone. Acta Physiol. Scand. 124: 361-369, 1985.
12. Gilbert, E. M., W. T. Abraham, S. Olsen, B. Hattler, M. White, P. Mealy, P. Larrabee, and M. R. Bristow. Comparative hemodynamic, left ventricular functional, and antiadrenergic effects of chronic treatment with metoprolol vs. carvedilol in the failing heart. Circulation 94: 2817-2825, 1996.
13. Glick, G., and E. Braunwald. Relative roles of the sympathetic and parasympathetic nervous systems in the reflex control of heart rate. Circ. Res. 14: 363-375, 1965.
14. Heidenreich, P. A., T. T. Lee, and B. M. Massie. Effect of beta-blockade on mortality in patients with heart failure: a meta-analysis of randomized clinical trials. J. Am. Coll. Cardiol. 30: 27-34, 1997.
15. Higginbotham, M. B., K. G. Morris, R. S. Williams, P. A. McHale, R. E. Coleman, and F. R. Cobb. Regulation of stroke volume during submaximal and maximal upright exercise in normal man. Circ. Res. 58: 281-291, 1986.
16. Hoffman, B. B., and R. J. Lefkowitz. The Pharmacological Basis of Therapeutics, edited by A. G. Gilman. New York: Pergamon, 1990, chapt. 11, p. 221-243.
17. Ishii, K., M. Kuwahara, H. Tsubone, and S. Sugano. Autonomic nervous function in mice and voles (Microtus arvalis): investigation by power spectral analysis of heart rate variability. Lab. Anim. 30: 359-364, 1996.
18. Janssen, B. J., Z. J. Van, G. G. Essed, and J. F. Smits. Role of the baroreflex in beta 2-sympathomimetic induced tachycardia in male rats. Eur. J. Obstet. Gynecol. Reprod. Biol. 51: 47-53, 1993.
19. Joyner, M. J., B. J. Freund, S. M. Jilka, G. A. Hetrick, E. Martinez, G. A. Ewy, and J. H. Wilmore. Effects of beta-blockade on exercise capacity of trained and untrained men: a hemodynamic comparison. J. Appl. Physiol. 60: 1429-1434, 1986.
20. Kaiser, P. Running performance as a function of the dose-response relationship to beta-adrenoceptor blockade. Int. J. Sports Med. 3: 29-32, 1982.
21. Kaiser, P. Physical performance and muscle metabolism during beta-adrenergic blockade in man. Acta Physiol. Scand. Suppl. 536: 1-53, 1984.
22. Kendall, M. J., and I. Rajman. A risk-benefit assessment of celiprolol in the treatment of cardiovascular disease. Drug Saf. 10: 220-232, 1994.
23. Klug, S., R. Thiel, R. Schwabe, H. J. Merker, and D. Neubert. Toxicity of beta-blockers in a rat whole embryo culture: concentration-response relationships and tissue concentrations. Arch. Toxicol. 68: 375-384, 1994.
24. Lafontan, M. Differential recruitment and differential regulation by physiological amines of fat cell beta-1, beta-2 and beta-3 adrenergic receptors expressed in native fat cells and in transfected cell lines. Cell. Signal. 6: 363-392, 1994.
25. Leenen, F. H., C. H. Coenen, M. Zonderland, and A. H. Maas. Effects of cardioselective and nonselective beta-blockade on dynamic exercise performance in mildly hypertensive men. Clin. Pharmacol. Ther. 28: 12-21, 1980.
26. Lefkowitz, R. J., B. B. Hoffman, and P. Taylor. The Pharmacological Basis of Therapeutics, edited by A. G. Gilman. New York: Pergamon, 1990, chapts. 5, 10-11, p. 84-121, 187-243.
27. Li, Q., J. Zhang, M. Pfaffendorf, and V. Pa. Direct positive chronotropic effects of angiotensin II and angiotensin III in pithed rats and in rat isolated atria. Br. J. Pharmacol. 118: 1653-1658, 1996.
28. Lundborg, P., H. Astrom, C. Bengtsson, E. Fellenius, S. H. Von, L. Svensson, and U. Smith. Effect of beta-adrenoceptor blockade on exercise performance and metabolism. Clin. Sci. 61: 299-305, 1981.
29. Maksud, M. G., F. E. Tristani, K. D. Coutts, J. J. Barboriak, and L. H. Hamilton. Effects of propranolol on several physiological responses during orthostatic and exercise stress in healthy male subjects. Can. J. Physiol. Pharmacol. 49: 867-872, 1971.
30. Milano, C. A., L. F. Allen, H. A. Rockman, P. C. Dolber, T. R. McMinn, K. R. Chien, T. D. Johnson, R. A. Bond, and R. J. Lefkowitz. Enhanced myocardial function in transgenic mice overexpressing the beta 2-adrenergic receptor. Science 264: 582-586, 1994.
31. Nishio, H., A. Fujii, and Y. Nakata. Re-examination for pharmacological properties of serotonin-induced tachycardia in isolated guinea-pig atrium. Behav. Brain Res. 73: 301-304, 1996.
32. O'Donnell, S. R., and J. C. Wanstall. Beta-1 and beta-2 adrenoceptor-mediated responses in preparations of pulmonary artery and aorta from young and aged rats. J. Pharmacol. Exp. Ther. 228: 733-738, 1984.
33. Perlini, S., F. Giangregorio, M. Coco, A. Radaelli, P. L. Solda, L. Bernardi, and A. U. Ferrari. Autonomic and ventilatory components of heart rate and blood pressure variability in freely behaving rats. Am. J. Physiol. 269 (Heart Circ. Physiol. 38): H1729-H1734, 1995.
34. Rand, M. J., L. H. Tung, W. J. Louis, and D. F. Story. Cardiac alpha-adrenoceptors: postjunctional and prejunctional. J. Mol. Cell. Cardiol. 5: 17-32, 1986.
35. Reid, J. J., A. T. Lieu, and M. J. Rand. Interactions between endothelin-1 and other chronotropic agents in rat isolated atria. Eur. J. Pharmacol. 194: 173-181, 1991.
36. Reybrouck, T., A. Amery, and L. Billiet. Hemodynamic response to graded exercise after chronic beta-adrenergic blockade. J. Appl. Physiol. 42: 133-138, 1977.
37. Robinson, B. F., S. E. Epstein, G. D. Beiser, and E. Braunwald. Control of heart rate by the autonomic nervous system. Studies in man on the interrelation between baroreceptor mechanisms and exercise. Circ. Res. 19: 400-411, 1966.
38. Rohrer, D. K., K. H. Desai, J. R. Jasper, M. E. Stevens, D. J. Regula, G. S. Barsh, D. Bernstein, and B. K. Kobilka. Targeted disruption of the mouse betal-adrenergic receptor gene: developmental and cardiovascular effects. Proc. Natl. Acad. Sci. USA 93: 7375-7380, 1996.
39. Rowell, L. B. Human Circulation: Regulation During Physical Stress. New York: Oxford Univ. Press, 1986.
40. Saito, K., M. Kurihara, R. Cruciani, W. Z. Potter, and J. M. Saavedra. Characterization of beta 1- and beta 2-adrenoceptor subtypes in the rat atrioventricular node by quantitative autoradiography. Circ. Res. 62: 173-177, 1988.
41. Scher, A. M., and A. C. Young. Reflex control of heart rate in the unanesthetized dog. Am. J. Physiol. 218: 780-789, 1970.
42. Shen, Y. T., P. Cervoni, T. Claus, and S. F. Vatner. Differences in beta 3-adrenergic receptor cardiovascular regulation in conscious primates, rats and dogs. J. Pharmacol. Exp. Ther. 278: 1435-1443, 1996.
43. Shipley, J. B., and M. L. Hess. Inotropic therapy for the failing myocardium. Clin. Cardiol. 18: 615-619, 1995.
44. Sklar, J., G. D. Johnston, P. Overlie, J. G. Gerber, H. L. Brammell, J. Gal, and A. S. Nies. The effects of a cardioselective (metoprolol) and a nonselective (propranolol) beta-adrenergic blocker on the response to dynamic exercise in normal men. Circulation 65: 894-899, 1982.
45. Stimpfel, T. M., and E. L. Gershey. Selecting anesthetic agents for human safety and animal recovery surgery. FASEB J. 5: 2099-2104, 1991.
46. Ungerer, M., M. Bohm, J. S. Elce, E. Erdmann, and M. J. Lohse. Altered expression of beta-adrenergic receptor kinase and beta 1-adrenergic receptors in the failing human heart. Circulation 87: 454-463, 1993.
47. VanBaak, M. Hypertension, beta-adrenoceptor blocking agents and exercise. Int. J. Sports Med. 15: 112-115, 1994.
48. VanWaarde, A., J. G. Meeder, P. K. Blanksma, O. E. Brodde, G. M. Visser, P. H. Eisinga, A. M. Paans, W. Vaalburg, and K. I. Lie. Uptake of radioligands by rat heart and lung in vivo: CGP 12177 does and CGP 26505 does not reflect binding to beta-adrenoceptors. Eur. J. Pharmacol. 222: 107-112, 1992.
49. Vatner, S. F., C. B. Higgins, and E. Braunwald. Sympathetic and parasympathetic components of reflex tachycardia induced by hypotension in conscious dogs with and without heart failure. Cardiovasc. Res. 8: 153-161, 1974.
50. Wilmore, J. H., B. J. Freund, M. J. Joyner, G. A. Hetrick, A. A. Hartzell, R. T. Strother, G. A. Ewy, and W. E. Faris. Acute response to submaximal and maximal exercise consequent to beta-adrenergic blockade: implications for the prescription of exercise. Am. J. Cardiol. 55: 135D-141D, 1985.
51. Yonga, G. O., H. W. Oyuga, and E. K. Njeru. Influence of beta-blockade with beta-1-selectivity or intrinsic sympathomimetic activity on some cardiorespiratory responses to exercise. East Afr. Med. J. 70: 405-408, 1993.