Angiotensin II: Tapping the cell cycle machinery to kill endothelial cells

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 303, Issue 7, 2012, Pages

  O'Reilly, Michael A ^a  

^a UNIVERSITY OF ROCHESTER SCHOOL OF MEDICINE AND DENTISTRY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOTENSIN 1 RECEPTOR; ANGIOTENSIN 2 RECEPTOR; BLEOMYCIN; CAPTOPRIL; DIPEPTIDYL CARBOXYPEPTIDASE; LOSARTAN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38;

APOPTOSIS; ARTICLE; CELL CYCLE; CELL GROWTH; CELL PROLIFERATION; DISEASE COURSE; ENDOTHELIUM CELL; FIBROSING ALVEOLITIS; HOMEOSTASIS; HUMAN; LUNG ALVEOLUS EPITHELIUM; LUNG FIBROSIS; LUNG PARENCHYMA; NONHUMAN; PRIORITY JOURNAL; RETROSPECTIVE STUDY; SCLERODERMA; WOUND HEALING;

ANGIOTENSIN II; ANIMALS; APOPTOSIS; CELL CYCLE; ENDOTHELIAL CELLS; HUMANS; IDIOPATHIC PULMONARY FIBROSIS; MICE;

EID: 84867152352     PISSN: 10400605     EISSN: 15221504     Source Type: Journal    
DOI: 10.1152/ajplung.00260.2012     Document Type: Article

References (22)

1. Adamson IY, Young L, Bowden DH. Relationship of alveolar epithelial injury and repair to the induction of pulmonary fibrosis. Am J Pathol 130: 377-383, 1988.
2. Ambrosini V, Cancellieri A, Chilosi M, Zompatori M, Trisolini R, Saragoni L, Poletti V. Acute exacerbation of idiopathic pulmonary fibrosis: report of a series. Eur Respir J 22: 821-826, 2003.
3. Budinger GR. Angiotensin II and pulmonary fibrosis, a new twist on an old story. Am J Physiol Lung Cell Mol Physiol 301: L267-L268, 2011.
4. Coward WR, Saini G, Jenkins G. The pathogenesis of idiopathic pulmonary fibrosis. Ther Adv Respir Dis 4: 367-388, 2010.
5. Day RM, Lee YH, Han L, Kim YC, Feng YH. Angiotensin II activates AMPKβfor execution of apoptosis through energy-dependent and -independent mechanisms. Am J Physiol Lung Cell Mol Physiol 301: L772-L781, 2011.
6. Hallstrom TC, Nevins JR. Balancing the decision of cell proliferation and cell fate. Cell Cycle 8: 532-535, 2009.
7. Keogh KA, Standing J, Kane GC, Terzic A, Limper AH. Angiotensin II antagonism fails to ameliorate bleomycin-induced pulmonary fibrosis in mice. Eur Respir J 25: 708-714, 2005.
8. Kim YC, Day RM. Ang II regulates activation of Bim via Rb/E2F1 during apoptosis: involvement of interaction between AMPKβ1/2 and Cdk4. Am J Physiol Lung Cell Mol Physiol 303: L228-L238, 2012.
9. Konigshoff M, Wilhelm A, Jahn A, Sedding D, Amarie OV, Eul B, Seeger W, Fink L, Gunther A, Eickelberg O, Rose F. The angiotensin II receptor 2 is expressed and mediates angiotensin II signaling in lung fibrosis. Am J Respir Cell Mol Biol 37: 640-650, 2007.
10. Lee YH, Mungunsukh O, Tutino RL, Marquez AP, Day RM. Angiotensin-II-induced apoptosis requires regulation of nucleolin and Bcl-xL by HP-2 in primary lung endothelial cells. J Cell Sci 123: 1634-1643, 2010.
11. Li X, Molina-Molina M, Abdul-Hafez A, Ramirez J, Serrano-Mollar A, Xaubet A, Uhal BD. Extravascular sources of lung angiotensin peptide synthesis in idiopathic pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol 291: L887-L895, 2006.
12. Li X, Rayford H, Uhal BD. Essential roles for angiotensin receptor AT1a in bleomycin-induced apoptosis and lung fibrosis in mice. Am J Pathol 163: 2523-2530, 2003.
13. Marshall RP, Gohlke P, Chambers RC, Howell DC, Bottoms SE, Unger T, McAnulty RJ, Laurent GJ. Angiotensin II and the fibroproliferative response to acute lung injury. Am J Physiol Lung Cell Mol Physiol 286: L156-L164, 2004.
14. Moore BB, Hogaboam CM. Murine models of pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol 294: L152-L160, 2008.
15. Nadrous HF, Ryu JH, Douglas WW, Decker PA, Olson EJ. Impact of angiotensin-converting enzyme inhibitors and statins on survival in idiopathic pulmonary fibrosis. Chest 126: 438-446, 2004.
16. Papp M, Li X, Zhuang J, Wang R, Uhal BD. Angiotensin receptor subtype AT1 mediates alveolar epithelial cell apoptosis in response to ANG II. Am J Physiol Lung Cell Mol Physiol 282: L713-L718, 2002.
17. Shan B, Lee WH. Deregulated expression of E2F-1 induces S-phase entry and leads to apoptosis. Mol Cell Biol 14: 8166-8173, 1994.
18. Shenoy V, Qi Y, Katovich MJ, Raizada MK. ACE2, a promising therapeutic target for pulmonary hypertension. Curr Opin Pharmacol 11: 150-155, 2011.
19. Uhal BD, Li X, Piasecki CC, Molina-Molina M. Angiotensin signaling in pulmonary fibrosis. Int J Biochem Cell Biol 44: 465-468, 2012.
20. Uhal BD, Li X, Xue A, Gao X, Abdul-Hafez A. Regulation of alveolar epithelial cell survival by the ACE-2/angiotensin 1-7/Mas axis. Am J Physiol Lung Cell Mol Physiol 301: L269-L274, 2011.
21. Wang R, Ibarra-Sunga O, Verlinski L, Pick R, Uhal BD. Abrogation of bleomycin-induced epithelial apoptosis and lung fibrosis by captopril or by a caspase inhibitor. Am J Physiol Lung Cell Mol Physiol 279: L143-L151, 2000.
22. Zoz DF, Lawson WE, Blackwell TS. Idiopathic pulmonary fibrosis: a disorder of epithelial cell dysfunction. Am J Med Sci 341: 435-438, 2011.