Poor Cerebral Inflammatory Response in eIF2B Knock-In Mice: Implications for the Aetiology of Vanishing White Matter Disease

PLoS ONE

Volumn 7, Issue 10, 2012, Pages

  Cabilly, Yuval ^a   Barbi, Mali ^a   Geva, Michal ^a   Marom, Liraz ^a   Chetrit, David ^a   Ehrlich, Marcelo ^a   Elroy Stein, Orna ^a  

^a TEL AVIV UNIVERSITY   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; GUANINE NUCLEOTIDE EXCHANGE FACTOR; LIPOPOLYSACCHARIDE; MESSENGER RNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; ASTROCYTOSIS; BRAIN METABOLISM; CELL INTERACTION; CELL ISOLATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DETERIORATION; GENE INDUCTION; INFLAMMATION; MICROGLIA; MOUSE; MOUSE STRAIN; NONHUMAN; PATHOPHYSIOLOGY; PHENOTYPIC VARIATION; PHYSIOLOGICAL STRESS; PROTEIN SYNTHESIS; RNA TRANSLATION; STRESS; VANISHING WHITE MATTER DISEASE; WHITE MATTER LESION;

ANIMALS; BRAIN DISEASES; CELLS, CULTURED; ENZYME-LINKED IMMUNOSORBENT ASSAY; EUKARYOTIC INITIATION FACTOR-2B; LEUKOENCEPHALOPATHIES; LIPOPOLYSACCHARIDES; MALE; MICE; MICE, MUTANT STRAINS; MICROGLIA;

EUKARYOTA; MUS;

EID: 84867126559     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0046715     Document Type: Article

References (43)

1. Schiffmann R, Fogli A, Van der Knaap MS, Boespflug-Tanguy O (1993) Childhood Ataxia with Central Nervous System Hypomyelination/Vanishing White Matter.
2. Leegwater PA, Vermeulen G, Konst AA, Naidu S, Mulders J, et al. (2001) Subunits of the translation initiation factor eIF2B are mutant in leukoencephalopathy with vanishing white matter. Nat Genet 29: 383-388.
3. van der Knaap MS, Leegwater PA, Konst AA, Visser A, Naidu S, et al. (2002) Mutations in each of the five subunits of translation initiation factor eIF2B can cause leukoencephalopathy with vanishing white matter. Ann Neurol 51: 264-270.
4. Fogli A, Boespflug-Tanguy O, (2006) The large spectrum of eIF2B-related diseases. Biochem Soc Trans 34: 22-29.
5. van der Knaap MS, Pronk JC, Scheper GC, (2006) Vanishing white matter disease. Lancet Neurol 5: 413-423.
6. Pronk JC, van Kollenburg B, Scheper GC, van der Knaap MS, (2006) Vanishing white matter disease: a review with focus on its genetics. Ment Retard Dev Disabil Res Rev 12: 123-128.
7. Schiffmann R, Elroy-Stein O, (2006) Childhood ataxia with CNS hypomyelination/vanishing white matter disease-a common leukodystrophy caused by abnormal control of protein synthesis. Mol Genet Metab 88: 7-15.
8. Bugiani M, Boor I, Powers JM, Scheper GC, van der Knaap MS, (2010) Leukoencephalopathy with vanishing white matter: a review. J Neuropathol Exp Neurol 69: 987-996.
9. Wong K, Armstrong RC, Gyure KA, Morrison AL, Rodriguez D, et al. (2000) Foamy cells with oligodendroglial phenotype in childhood ataxia with diffuse central nervous system hypomyelination syndrome. Acta Neuropathol 100: 635-646.
10. Fogli A, Wong K, Eymard-Pierre E, Wenger J, Bouffard JP, et al. (2002) Cree leukoencephalopathy and CACH/VWM disease are allelic at the EIF2B5 locus. Ann Neurol 52: 506-510.
11. Dietrich J, Lacagnina M, Gass D, Richfield E, Mayer-Proschel M, et al. (2005) EIF2B5 mutations compromise GFAP+ astrocyte generation in vanishing white matter leukodystrophy. Nat Med 11: 277-283.
12. van Kollenburg B, van Dijk J, Garbern J, Thomas AA, Scheper GC, et al. (2006) Glia-specific activation of all pathways of the unfolded protein response in vanishing white matter disease. J Neuropathol Exp Neurol 65: 707-715.
13. Bugiani M, Boor I, van Kollenburg B, Postma N, Polder E, et al. (2011) Defective glial maturation in vanishing white matter disease. J Neuropathol Exp Neurol 70: 69-82.
14. Kimball SR, (1999) Eukaryotic initiation factor eIF2. Int J Biochem Cell Biol 31: 25-29.
15. Proud CG, (2001) Regulation of eukaryotic initiation factor eIF2B. Prog Mol Subcell Biol 26: 95-114.
16. Dever TE, (2002) Gene-specific regulation by general translation factors. Cell 108: 545-556.
17. Holcik M, Sonenberg N, (2005) Translational control in stress and apoptosis. Nat Rev Mol Cell Biol 6: 318-327.
18. Pavitt GD, (2005) eIF2B, a mediator of general and gene-specific translational control. Biochem Soc Trans 33: 1487-1492.
19. Wek RC, Cavener DR, (2007) Translational control and the unfolded protein response. Antioxid Redox Signal 9: 2357-2371.
20. Ishibashi T, Dakin KA, Stevens B, Lee PR, Kozlov SV, et al. (2006) Astrocytes promote myelination in response to electrical impulses. Neuron 49: 823-832.
21. Semmler A, Okulla T, Sastre M, Dumitrescu-Ozimek L, Heneka MT, (2005) Systemic inflammation induces apoptosis with variable vulnerability of different brain regions. J Chem Neuroanat 30: 144-157.
22. Sofroniew MV, Vinters HV, (2010) Astrocytes: biology and pathology. Acta Neuropathol 119: 7-35.
23. Zhang D, Hu X, Qian L, O'Callaghan JP, Hong JS, (2010) Astrogliosis in CNS pathologies: is there a role for microglia? Mol Neurobiol 41: 232-241.
24. Geva M, Cabilly Y, Assaf Y, Mindroul N, Marom L, et al. (2010) A mouse model for eukaryotic translation initiation factor 2B-leucodystrophy reveals abnormal development of brain white matter. Brain 133: 2448-2461.
25. Middeldorp J, Hol EM, (2011) GFAP in health and disease. Prog Neurobiol 93: 421-443.
26. Williams A, Piaton G, Lubetzki C, (2007) Astrocytes-friends or foes in multiple sclerosis? Glia 55: 1300-1312.
27. Takeda K, Kaisho T, Akira S, (2003) Toll-like receptors. Annu Rev Immunol 21: 335-376.
28. van Neerven S, Nemes A, Imholz P, Regen T, Denecke B, et al. (2010) Inflammatory cytokine release of astrocytes in vitro is reduced by all-trans retinoic acid. J Neuroimmunol 229: 169-179.
29. Belmadani A, Tran PB, Ren D, Miller RJ, (2006) Chemokines regulate the migration of neural progenitors to sites of neuroinflammation. J Neurosci 26: 3182-3191.
30. Rodriguez D, Gelot A, della Gaspera B, Robain O, Ponsot G, et al. (1999) Increased density of oligodendrocytes in childhood ataxia with diffuse central hypomyelination (CACH) syndrome: neuropathological and biochemical study of two cases. Acta Neuropathol 97: 469-480.
31. Francalanci P, Eymard-Pierre E, Dionisi-Vici C, Boldrini R, Piemonte F, et al. (2001) Fatal infantile leukodystrophy: a severe variant of CACH/VWM syndrome, allelic to chromosome 3q27. Neurology 57: 265-270.
32. Schwartz M, (2003) Macrophages and microglia in central nervous system injury: are they helpful or harmful? J Cereb Blood Flow Metab 23: 385-394.
33. Butovsky O, Ziv Y, Schwartz A, Landa G, Talpalar AE, et al. (2006) Microglia activated by IL-4 or IFN-gamma differentially induce neurogenesis and oligodendrogenesis from adult stem/progenitor cells. Mol Cell Neurosci 31: 149-160.
34. Farina C, Aloisi F, Meinl E, (2007) Astrocytes are active players in cerebral innate immunity. Trends Immunol 28: 138-145.
35. Liberto CM, Albrecht PJ, Herx LM, Yong VW, Levison SW, (2004) Pro-regenerative properties of cytokine-activated astrocytes. J Neurochem 89: 1092-1100.
36. Louis JC, Magal E, Takayama S, Varon S, (1993) CNTF protection of oligodendrocytes against natural and tumor necrosis factor-induced death. Science 259: 689-692.
37. Schonrock LM, Gawlowski G, Bruck W, (2000) Interleukin-6 expression in human multiple sclerosis lesions. Neurosci Lett 294: 45-48.
38. Arnett HA, Mason J, Marino M, Suzuki K, Matsushima GK, et al. (2001) TNF alpha promotes proliferation of oligodendrocyte progenitors and remyelination. Nat Neurosci 4: 1116-1122.
39. Mason JL, Suzuki K, Chaplin DD, Matsushima GK, (2001) Interleukin-1beta promotes repair of the CNS. J Neurosci 21: 7046-7052.
40. Hanisch UK, Kettenmann H, (2007) Microglia: active sensor and versatile effector cells in the normal and pathologic brain. Nat Neurosci 10: 1387-1394.
41. Liu AR, van der Lei HD, Wang X, Wortham NC, Tang H, et al. (2011) Severity of Vanishing White Matter disease does not correlate with deficits in eIF2B activity or the integrity of eIF2B complexes. Hum Mutat.
42. Mayo L, Stein R, (2007) Characterization of LPS and interferon-gamma triggered activation-induced cell death in N9 and primary microglial cells: induction of the mitochondrial gateway by nitric oxide. Cell Death Differ 14: 183-186.
43. Saura J, Tusell JM, Serratosa J, (2003) High-yield isolation of murine microglia by mild trypsinization. Glia 44: 183-189.