Cyclooxygenase-2 inhibitors modulate skin aging in a catalytic activity-independent manner

Experimental and Molecular Medicine

Volumn 44, Issue 9, 2012, Pages 536-544

  Lee, Mi Eun ^a   Kim, So Ra ^a   Lee, Seungkoo ^b   Jung, Yu Jin ^c   Choi, Sun Shim ^b   Kim, Woo Jin ^b   Han, Jeong A ^a  

^a Institute of Medical Sciences   (South Korea)

^b Kangwon National University   (South Korea)

^c Division of Life Sciences   (South Korea)

Author keywords

Caveolin 1; Cyclooxygenase inhibitors; Procollagen; Skin aging

Indexed keywords

ACETYLSALICYLIC ACID; CAVEOLIN 1; CELECOXIB; CYCLOOXYGENASE 2 INHIBITOR; N (2 CYCLOHEXYLOXY 4 NITROPHENYL)METHANESULFONAMIDE; PROCOLLAGEN; PROCOLLAGEN 1; PROTEIN P16; PROTEIN P53; UNCLASSIFIED DRUG;

AGING; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CATALYSIS; CONTROLLED STUDY; CUTANEOUS PARAMETERS; DRUG ACTIVITY; FEMALE; FIBROBLAST; GENE EXPRESSION REGULATION; IC 50; IN VIVO STUDY; MOUSE; NONHUMAN; PROTEIN BINDING; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; SKINFOLD THICKNESS; WRINKLE;

MUS;

EID: 84867117228     PISSN: 12263613     EISSN: 20926413     Source Type: Journal    
DOI: 10.3858/emm.2012.44.9.061     Document Type: Article

References (44)

1. Alcorta DA, Xiong Y, Phelps D, Hannon G, Beach D, Barrett JC. Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblasts. Proc Natl Acad Sci USA 1996;93:13742-7
2. Atadja P, Wong H, Garkavtsev I, Veillette C, Riabowol K. Increased activity of p53 in senescing fibroblasts. Proc Natl Acad Sci USA 1995;92:8348-52
3. Baek BS, Kim JW, Lee JH, Kwon HJ, Kim ND, Kang HS, Yoo MA, Yu BP, Chung HY. Age-related increase of brain cyclooxygenase activity and dietary modulation of oxidative status. J Gerontol A Biol Sci Med Sci 2001;56:B426-31
4. Barnett J, Chow J, Ives D, Chiou M, Mackenzie R, Osen E, Nguyen B, Tsing S, Bach C, Freire J, et al. Purification, characterization and selective inhibition of human prostaglandin G/H synthase 1 and 2 expressed in the baculovirus system. Biochim Biophys Acta 1994;1209:130-9
5. Bartholomew JN, Volonte D, Galbiati F. Caveolin-1 regulates the antagonistic pleiotropic properties of cellular senescence through a novel Mdm2/p53-mediated pathway. Cancer Res 2009;69:2878-86
6. Braidy N, Guillemin GJ, Mansour H, Chan-Ling T, Poljak A, Grant R. Age related changes in NAD+ metabolism oxidative stress and Sirt1 activity in wistar rats. PLoS One 2011;6: e19194
7. Campisi J. Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors. Cell 2005; 120:513-22
8. Ching TT, Chiang WC, Chen CS, Hsu AL. Celecoxib extends C. elegans lifespan via inhibition of insulin-like signaling but not cyclooxygenase-2 activity. Aging Cell 2011;10:506-19
9. Cho KA, Ryu SJ, Park JS, Jang IS, Ahn JS, Kim KT, Park SC. Senescent phenotype can be reversed by reduction of caveolin status. J Biol Chem 2003;278:27789-95
10. Cho KA, Park SC. Caveolin-1 as a prime modulator of aging: a new modality for phenotypic restoration? Mech Ageing Dev 2005;126:105-10
11. Chung HY, Cesari M, Anton S, Marzetti E, Giovannini S, Seo AY, Carter C, Yu BP, Leeuwenburgh C. Molecular inflammation: underpinnings of aging and age-related diseases. Ageing Res Rev 2009;8:18-30
12. Chung JH, Seo JY, Choi HR, Lee MK, Youn CS, Rhie G, Cho KH, Kim KH, Park KC, Eun HC. Modulation of skin collagen metabolism in aged and photoaged human skin in vivo. J Invest Dermatol 2001;117:1218-24
13. Dimri GP, Lee X, Basile G, Acosta M, Scott G, Roskelley C, Medrano EE, Linskens M, Rubelj I, Pereira-Smith O, et al. A biomarker that identifies senescent human cells in culture and in aging skin in vivo. Proc Natl Acad Sci USA 1995;92: 9363-7
14. Donato AJ, Black AD, Jablonski KL, Gano LB, Seals DR. Aging is associated with greater nuclear NF kappa B, reduced I kappa B alpha, and increased expression of proinflammatory cytokines in vascular endothelial cells of healthy humans. Aging Cell 2008;7:805-12
15. Dorszewska J, Adamczewska-Goncerzewicz Z. Oxidative damage to DNA, p53 gene expression and p53 protein level in the process of aging in rat brain. Respir Physiol Neurobiol 2004;139:227-36
16. Flower RJ. The development of COX2 inhibitors. Nat Rev Drug Discov 2003;2:179-91
17. Funk CD. Prostaglandins and leukotrienes: advances in eicosanoid biology. Science 2001;294:1871-5
18. Han JH, Roh MS, Park CH, Park KC, Cho KH, Kim KH, Eun HC, Chung JH. Selective COX-2 inhibitor, NS-398, inhibits the replicative senescence of cultured dermal fibroblasts. Mech Ageing Dev 2004;125:359-66
19. Herbig U, Ferreira M, Condel L, Carey D, Sedivy JM. Cellular senescence in aging primates. Science 2006;311:1257
20. Johnson JL, Wimsatt J, Buckel SD, Dyer RD, Maddipati KR. Purification and characterization of prostaglandin H synthase-2 from sheep placental cotyledons. Arch Biochem Biophys 1995;324:26-34
21. Kim HH, Lee MJ, Lee SR, Kim KH, Cho KH, Eun HC, Chung JH. Augmentation of UV-induced skin wrinkling by infrared irradiation in hairless mice. Mech Ageing Dev 2005;126: 1170-7
22. Kim HJ, Kim KW, Yu BP, Chung HY. The effect of age on cyclooxygenase-2 gene expression: NF-kappaB activation and IkappaBalpha degradation. Free Radic Biol Med 2000; 28:683-92
23. Kim JW, Baek BS, Kim YK, Herlihy JT, Ikeno Y, Yu BP, Chung HY. Gene expression of cyclooxygenase in the aging heart. J Gerontol A Biol Sci Med Sci 2001;56:B350-5
24. Kim SR, Park JH, Lee ME, Park JS, Park SC, Han JA. Selective COX-2 inhibitors modulate cellular senescence in human dermal fibroblasts in a catalytic activity-independent manner. Mech Ageing Dev 2008;129:706-13
25. Krishnamurthy J, Torrice C, Ramsey MR, Kovalev GI, Al-Regaiey K, Su L, Sharpless NE. Ink4a/Arf expression is a biomarker of aging. J Clin Invest 2004;114:1299-307
26. Kulju KS, Lehman JM. Increased p53 protein associated with aging in human diploid fibroblasts. Exp Cell Res 1995;217: 336-45
27. Lyons TR, O'Brien J, Borges VF, Conklin MW, Keely PJ, Eliceiri KW, Marusyk A, Tan AC, Schedin P. Postpartum mammary gland involution drives progression of ductal carcinoma in situ through collagen and COX-2. Nat Med 2011;17:1109-15
28. Massie HR, Williams TR, Iodice AA. Influence of antiinflammatory agents on the survival of Drosophila. J Gerontol 1985;40:257-60
29. Paik YH, Kim JK, Lee JI, Kang SH, Kim DY, An SH, Lee SJ, Lee DK, Han KH, Chon CY, Lee SI, Lee KS, Brenner DA. Celecoxib induces hepatic stellate cell apoptosis through inhibition of Akt activation and suppresses hepatic fibrosis in rats. Gut 2009;58:1517-27
30. Park EJ, Kwon TK. Rottlerin enhances IL-1β-induced COX-2 expression through sustained p38 MAPK activation in MDA-MB-231 human breast cancer cells. Exp Mol Med 2011; 43:669-75
31. Park WY, Park JS, Cho KA, Kim DI, Ko YG, Seo JS, Park SC. Up-regulation of caveolin attenuates epidermal growth factor signaling in senescent cells. J Biol Chem 2000;275:20847-52
32. Rittie L, Fisher GJ. UV-light-induced signal cascades and skin aging. Ageing Res Rev 2002;1:705-20
33. Rouzer CA, Marnett LJ. Non-redundant functions of cyclooxygenases: oxygenation of endocannabinoids. J Biol Chem 2008;283:8065-9
34. Sanguino E, Roglans N, Alegret M, Sanchez RM, Vazquez- Carrera M, Laguna JC. Prevention of age-related changes in rat cortex transcription factor activator protein-1 by hypolipidemic drugs. Biochem Pharmacol 2004;68:1411-21
35. Shen W, Li Y, Tang Y, Cummins J, Huard J. NS-398, a cyclooxygenase-2-specific inhibitor, delays skeletal muscle healing by decreasing regeneration and promoting fibrosis. Am J Pathol 2005;167:1105-17
36. Shoulders MD, Raines RT. Collagen structure and stability. Annu Rev Biochem 2009;78:929-58
37. Smith WL, Garavito RM, DeWitt DL. Prostaglandin endoperoxide H synthases (cyclooxygenases)-1 and -2. J Biol Chem 1996;271:33157-60
38. Surazynski A, Palka J, Wolczynski S. Acetylsalicylic acid-dependent inhibition of collagen biosynthesis and beta1-integrin signaling in cultured fibroblasts. Med Sci Monit 2004;10:BR175-9
39. Varani J, Warner RL, Gharaee-Kermani M, Phan SH, Kang S, Chung JH, Wang ZQ, Datta SC, Fisher GJ, Voorhees JJ. Vitamin A antagonizes decreased cell growth and elevated collagen-degrading matrix metalloproteinases and stimulates collagen accumulation in naturally aged human skin. J Invest Dermatol 2000;114:480-6
40. Volonte D, Zhang K, Lisanti MP, Galbiati F. Expression of caveolin-1 induces premature cellular senescence in primary cultures of murine fibroblasts. Mol Biol Cell 2002;13: 2502-17
41. Volonte D, Galbiati F. Inhibition of thioredoxin reductase 1 by caveolin 1 promotes stress-induced premature senescence. EMBO Rep 2009;10:1334-40
42. Wang C, Jurk D, Maddick M, Nelson G, Martin-Ruiz C, von Zglinicki T. DNA damage response and cellular senescence in tissues of aging mice. Aging Cell 2009;8:311-23
43. Zdanov S, Bernard D, Debacq-Chainiaux F, Martien S, Gosselin K, Vercamer C, Chelli F, Toussaint O, Abbadie C. Normal or stress-induced fibroblast senescence involves COX-2 activity. Exp Cell Res 2007;313:3046-56
44. Zou H, Stoppani E, Volonte D, Galbiati F. Caveolin-1, cellular senescence and age-related diseases. Mech Ageing Dev 2011;132:533-42