메뉴 건너뛰기




Volumn 32, Issue 10, 2012, Pages 1585-1595

Downregulation of FGL2/prothrombinase delays HCCLM6 xenograft tumour growth and decreases tumour angiogenesis

Author keywords

C Jun N terminal kinase (JNK); Extracellular signal regulated kinase (ERK); FGL2; Hepatocellular carcinoma (HCC); Protease activated receptor (PAR)

Indexed keywords

BLOOD CLOTTING FACTOR 10A; FIBRIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; STRESS ACTIVATED PROTEIN KINASE;

EID: 84867100989     PISSN: 14783223     EISSN: 14783231     Source Type: Journal    
DOI: 10.1111/j.1478-3231.2012.02865.x     Document Type: Article
Times cited : (43)

References (41)
  • 1
    • 78649532564 scopus 로고    scopus 로고
    • Thrombin is a therapeutic target for metastatic osteopontin-positive hepatocellular carcinoma
    • Xue YH, Zhang XF, Dong QZ, et al. Thrombin is a therapeutic target for metastatic osteopontin-positive hepatocellular carcinoma. Hepatology 2010; 52: 2012-22.
    • (2010) Hepatology , vol.52 , pp. 2012-2022
    • Xue, Y.H.1    Zhang, X.F.2    Dong, Q.Z.3
  • 2
    • 34247593381 scopus 로고    scopus 로고
    • Thrombin-mediated hepatocellular carcinoma cell migration: Cooperative action via proteinase-activated receptors 1 and 4
    • Kaufmann R, Rahn S, Pollrich K, et al. Thrombin-mediated hepatocellular carcinoma cell migration: Cooperative action via proteinase-activated receptors 1 and 4. J Cell Physiol 2007; 211: 699-707.
    • (2007) J Cell Physiol , vol.211 , pp. 699-707
    • Kaufmann, R.1    Rahn, S.2    Pollrich, K.3
  • 3
    • 60549101080 scopus 로고    scopus 로고
    • The pivotal role of thrombin in cancer biology and tumorigenesis
    • Snyder KM, Kessler CM. The pivotal role of thrombin in cancer biology and tumorigenesis. Semin Thromb Hemost 2008; 34: 734-41.
    • (2008) Semin Thromb Hemost , vol.34 , pp. 734-741
    • Snyder, K.M.1    Kessler, C.M.2
  • 4
    • 80052668558 scopus 로고    scopus 로고
    • Thrombomodulin is a determinant of metastasis through a mechanism linked to the thrombin binding domain but not the lectin-like domain
    • Horowitz NA, Blevins EA, Miller WM. Thrombomodulin is a determinant of metastasis through a mechanism linked to the thrombin binding domain but not the lectin-like domain. Blood 2011; 118: 2889-95.
    • (2011) Blood , vol.118 , pp. 2889-2895
    • Horowitz, N.A.1    Blevins, E.A.2    Miller, W.M.3
  • 5
    • 0031803215 scopus 로고    scopus 로고
    • Characterization of human fibroleukin, a fibrinogen-like protein secreted by T lymphocytes
    • Marazzi S, Blum S, Hartmann R, et al. Characterization of human fibroleukin, a fibrinogen-like protein secreted by T lymphocytes. J Immunol. 1998; 161: 138-47.
    • (1998) J Immunol. , vol.161 , pp. 138-147
    • Marazzi, S.1    Blum, S.2    Hartmann, R.3
  • 6
    • 78649868501 scopus 로고    scopus 로고
    • Expression and significance of fgl2 prothrombinase in cardiac microvascular endothelial cells of rats with type 2 diabetes
    • Ding Y, Liu K, Wang Y, et al. Expression and significance of fgl2 prothrombinase in cardiac microvascular endothelial cells of rats with type 2 diabetes. J Huazhong Univ Sci Technolog Med Sci. 2010; 30: 575-81.
    • (2010) J Huazhong Univ Sci Technolog Med Sci. , vol.30 , pp. 575-581
    • Ding, Y.1    Liu, K.2    Wang, Y.3
  • 7
    • 0037094135 scopus 로고    scopus 로고
    • Kinetic analysis of a unique direct prothrombinase, fgl2, and identification of a serine residue critical for the prothrombinase activity
    • Chan CW, Chan MW, Liu M, et al. Kinetic analysis of a unique direct prothrombinase, fgl2, and identification of a serine residue critical for the prothrombinase activity. J Immunol. 2002; 168: 5170-7.
    • (2002) J Immunol. , vol.168 , pp. 5170-5177
    • Chan, C.W.1    Chan, M.W.2    Liu, M.3
  • 8
    • 0035251795 scopus 로고    scopus 로고
    • Genomic characterization, localization, and functional expression of FGL2, the human gene encoding fibroleukin: A novel human procoagulant
    • Yuwaraj S, Ding J, Liu M, Marsden PA, Levy GA. Genomic characterization, localization, and functional expression of FGL2, the human gene encoding fibroleukin: A novel human procoagulant. Genomics 2001; 71: 330-8.
    • (2001) Genomics , vol.71 , pp. 330-338
    • Yuwaraj, S.1    Ding, J.2    Liu, M.3    Marsden, P.A.4    Levy, G.A.5
  • 9
    • 0033839077 scopus 로고    scopus 로고
    • Molecular and functional analysis of the human prothrombinase gene (HFGL2) and its role in viral hepatitis
    • Levy GA, Liu M, Ding J, et al. Molecular and functional analysis of the human prothrombinase gene (HFGL2) and its role in viral hepatitis. Am J Pathol 2000; 156: 1217-25.
    • (2000) Am J Pathol , vol.156 , pp. 1217-1225
    • Levy, G.A.1    Liu, M.2    Ding, J.3
  • 10
    • 0031721786 scopus 로고    scopus 로고
    • Expression of the fgl2 and its protein product in tissues during murine hepatitis virus strain-3 infection
    • Ding JW, Ning Q, Liu MF, et al. Expression of the fgl2 and its protein product in tissues during murine hepatitis virus strain-3 infection. Adv Exp Med Biol 1998; 440: 609-618.
    • (1998) Adv Exp Med Biol , vol.440 , pp. 609-618
    • Ding, J.W.1    Ning, Q.2    Liu, M.F.3
  • 11
    • 21044447902 scopus 로고    scopus 로고
    • Role of fibrinogen-like protein 2 prothrombinase/fibroleukin in experimental and human allograft rejection
    • Ning Q, Sun Y, Han M, et al. Role of fibrinogen-like protein 2 prothrombinase/fibroleukin in experimental and human allograft rejection. J Immunol. 2005; 174: 7403-11.
    • (2005) J Immunol. , vol.174 , pp. 7403-7411
    • Ning, Q.1    Sun, Y.2    Han, M.3
  • 12
    • 31144479157 scopus 로고    scopus 로고
    • Fibrinogen-like protein 2 fibroleukin expression and its correlation with disease progression in murine hepatitis virus type 3-induced fulminant hepatitis and in patients with severe viral hepatitis B
    • Zhu CL, Yan WM, Zhu F, et al. Fibrinogen-like protein 2 fibroleukin expression and its correlation with disease progression in murine hepatitis virus type 3-induced fulminant hepatitis and in patients with severe viral hepatitis B. World J Gastroenterol 2005; 11: 6936-40.
    • (2005) World J Gastroenterol , vol.11 , pp. 6936-6940
    • Zhu, C.L.1    Yan, W.M.2    Zhu, F.3
  • 13
    • 2142820093 scopus 로고    scopus 로고
    • Endothelial induction of fgl2 contributes to thrombosis during acute vascular xenograft rejection
    • Ghanekar A, Mendicino M, Liu H, et al. Endothelial induction of fgl2 contributes to thrombosis during acute vascular xenograft rejection. J Immunol. 2004; 172: 5693-701.
    • (2004) J Immunol. , vol.172 , pp. 5693-5701
    • Ghanekar, A.1    Mendicino, M.2    Liu, H.3
  • 14
    • 1042303514 scopus 로고    scopus 로고
    • The fgl2 prothrombinase/fibroleukin gene is required for lipopolysaccharide-triggered abortions and for normal mouse reproduction
    • Clark DA, Foerster K, Fung L, et al. The fgl2 prothrombinase/fibroleukin gene is required for lipopolysaccharide-triggered abortions and for normal mouse reproduction. Mol Hum Reprod 2004; 10: 99-108.
    • (2004) Mol Hum Reprod , vol.10 , pp. 99-108
    • Clark, D.A.1    Foerster, K.2    Fung, L.3
  • 15
    • 33646888039 scopus 로고    scopus 로고
    • Cytokine-induced hepatic apoptosis is dependent on FGL2/fibroleukin: The role of Sp1/Sp3 and STAT1/PU.1 composite cis elements
    • Liu M, Mendicino M, Ning Q, et al. Cytokine-induced hepatic apoptosis is dependent on FGL2/fibroleukin: The role of Sp1/Sp3 and STAT1/PU.1 composite cis elements. J Immunol. 2006; 176: 7028-38.
    • (2006) J Immunol. , vol.176 , pp. 7028-7038
    • Liu, M.1    Mendicino, M.2    Ning, Q.3
  • 16
    • 59849115004 scopus 로고    scopus 로고
    • Fibrinogen-like protein 2/fibroleukin prothrombinase contributes to tumor hypercoagulability via IL-2 and IFN-gamma
    • Su K, Chen F, Yan WM, et al. Fibrinogen-like protein 2/fibroleukin prothrombinase contributes to tumor hypercoagulability via IL-2 and IFN-gamma. World J Gastroenterol 2008; 14: 5980-5989.
    • (2008) World J Gastroenterol , vol.14 , pp. 5980-5989
    • Su, K.1    Chen, F.2    Yan, W.M.3
  • 17
    • 85047694360 scopus 로고    scopus 로고
    • The Fgl2/fibroleukin prothrombinase contributes to immunologically mediated thrombosis in experimental and human viral hepatitis
    • Marsden PA, Ning Q, Fung LS, et al. The Fgl2/fibroleukin prothrombinase contributes to immunologically mediated thrombosis in experimental and human viral hepatitis. J Clin Invest. 2003; 112: 58-66.
    • (2003) J Clin Invest. , vol.112 , pp. 58-66
    • Marsden, P.A.1    Ning, Q.2    Fung, L.S.3
  • 18
    • 70350056427 scopus 로고    scopus 로고
    • siRNA and miRNA for the treatment of cancer
    • Jankovic R, Radulovic S, Brankovic-Magic M. siRNA and miRNA for the treatment of cancer. J BUON. 2009; 14(Suppl 1): S43-9.
    • (2009) J BUON. , vol.14 , Issue.SUPPL. 1
    • Jankovic, R.1    Radulovic, S.2    Brankovic-Magic, M.3
  • 19
    • 76749088358 scopus 로고    scopus 로고
    • Pathological roles of MAPK signaling pathways in human diseases
    • Kim EK, Choi EJ. Pathological roles of MAPK signaling pathways in human diseases. Biochim Biophys Acta 2010; 1802: 396-405.
    • (2010) Biochim Biophys Acta , vol.1802 , pp. 396-405
    • Kim, E.K.1    Choi, E.J.2
  • 20
    • 54049141728 scopus 로고    scopus 로고
    • Mitogen-activated protein (MAP) kinase/MAP kinase phosphatase regulation: Roles in cell growth, death, and cancer
    • Boutros T, Chevet E, Metrakos P. Mitogen-activated protein (MAP) kinase/MAP kinase phosphatase regulation: Roles in cell growth, death, and cancer. Pharmacol Rev 2008; 60: 261-310.
    • (2008) Pharmacol Rev , vol.60 , pp. 261-310
    • Boutros, T.1    Chevet, E.2    Metrakos, P.3
  • 21
    • 29144435996 scopus 로고    scopus 로고
    • Computational modelling of the receptor-tyrosine-kinase-activated MAPK pathway
    • Orton RJ, Sturm OE, Vyshemirsky V, et al. Computational modelling of the receptor-tyrosine-kinase-activated MAPK pathway. Biochem J 2005; 392: 249-61.
    • (2005) Biochem J , vol.392 , pp. 249-261
    • Orton, R.J.1    Sturm, O.E.2    Vyshemirsky, V.3
  • 22
    • 79955402374 scopus 로고    scopus 로고
    • Proline-rich tyrosine kinase 2 (Pyk2) promotes cell motility of hepatocellular carcinoma through induction of epithelial to mesenchymal transition
    • Sun CK, Ng KT, Lim ZX, et al. Proline-rich tyrosine kinase 2 (Pyk2) promotes cell motility of hepatocellular carcinoma through induction of epithelial to mesenchymal transition. PLoS ONE 2011; 6: e18878.
    • (2011) PLoS ONE , vol.6
    • Sun, C.K.1    Ng, K.T.2    Lim, Z.X.3
  • 23
    • 33645152608 scopus 로고    scopus 로고
    • Induction of stable RNA interference in mammalian cells
    • Cullen BR. Induction of stable RNA interference in mammalian cells. Gene Ther 2006; 13: 503-8.
    • (2006) Gene Ther , vol.13 , pp. 503-508
    • Cullen, B.R.1
  • 24
    • 66549114936 scopus 로고    scopus 로고
    • Infarction of tumor vessels by NGR-peptide-directed targeting of tissue factor: Experimental results and first-in-man experience
    • Bieker R, Kessler T, Schwoppe C, et al. Infarction of tumor vessels by NGR-peptide-directed targeting of tissue factor: Experimental results and first-in-man experience. Blood 2009; 113: 5019-27.
    • (2009) Blood , vol.113 , pp. 5019-5027
    • Bieker, R.1    Kessler, T.2    Schwoppe, C.3
  • 25
    • 0001298849 scopus 로고    scopus 로고
    • Study of angiogenesis induced by metastatic and non-metastatic liver cancer by corneal micropocket model in nude mice
    • Sun HC, Li XM, Xue Q, et al. Study of angiogenesis induced by metastatic and non-metastatic liver cancer by corneal micropocket model in nude mice. World J Gastroenterol 1999; 5: 116-118.
    • (1999) World J Gastroenterol , vol.5 , pp. 116-118
    • Sun, H.C.1    Li, X.M.2    Xue, Q.3
  • 27
    • 77949524521 scopus 로고    scopus 로고
    • Lymphoma endothelium preferentially expresses Tim-3 and facilitates the progression of lymphoma by mediating immune evasion
    • Huang X, Bai X, Cao Y, et al. Lymphoma endothelium preferentially expresses Tim-3 and facilitates the progression of lymphoma by mediating immune evasion. J Exp Med 2010; 207: 505-20.
    • (2010) J Exp Med , vol.207 , pp. 505-520
    • Huang, X.1    Bai, X.2    Cao, Y.3
  • 28
    • 0036856355 scopus 로고    scopus 로고
    • MethPrimer: designing primers for methylation PCRs
    • Li LC, Dahiya R. MethPrimer: designing primers for methylation PCRs. Bioinformatics 2002; 18: 1427-1431
    • (2002) Bioinformatics , vol.18 , pp. 1427-1431
    • Li, L.C.1    Dahiya, R.2
  • 29
    • 70349728786 scopus 로고    scopus 로고
    • Simultaneous detection of ERK-, p38-, and JNK-MAPK phosphorylation in human adipose-derived stem cells using the Cytometric Bead Array technology
    • Schubert R, Geiger H, Zielen S, Baer PC. Simultaneous detection of ERK-, p38-, and JNK-MAPK phosphorylation in human adipose-derived stem cells using the Cytometric Bead Array technology. J Immunol Methods 2009; 350: 200-4.
    • (2009) J Immunol Methods , vol.350 , pp. 200-204
    • Schubert, R.1    Geiger, H.2    Zielen, S.3    Baer, P.C.4
  • 30
    • 77955925169 scopus 로고    scopus 로고
    • Expression of proteinase-activated receptor 1-4 (PAR 1-4) in human cancer
    • Elste AP, Petersen I. Expression of proteinase-activated receptor 1-4 (PAR 1-4) in human cancer. J Mol Histol 2010; 41: 89-99.
    • (2010) J Mol Histol , vol.41 , pp. 89-99
    • Elste, A.P.1    Petersen, I.2
  • 31
    • 79953155300 scopus 로고    scopus 로고
    • The Endothelial Protein C Receptor Supports Tissue Factor Ternary Coagulation Initiation Complex Signaling through Protease-activated Receptors
    • Disse J, Petersen HH, Larsen KS, et al. The Endothelial Protein C Receptor Supports Tissue Factor Ternary Coagulation Initiation Complex Signaling through Protease-activated Receptors. J Biol Chem 2011; 286: 5756-67.
    • (2011) J Biol Chem , vol.286 , pp. 5756-5767
    • Disse, J.1    Petersen, H.H.2    Larsen, K.S.3
  • 32
    • 38949215535 scopus 로고    scopus 로고
    • Thrombin and protease-activated receptors (PARs) in atherothrombosis
    • Martorell L, Martínez-González J, Rodríguez C, et al. Thrombin and protease-activated receptors (PARs) in atherothrombosis. Thromb Haemost 2008; 99: 305-15.
    • (2008) Thromb Haemost , vol.99 , pp. 305-315
    • Martorell, L.1    Martínez-González, J.2    Rodríguez, C.3
  • 33
    • 0030979972 scopus 로고    scopus 로고
    • Protease-activated receptor 3 is a second thrombin receptor in humans
    • Ishihara H, Connolly AJ, Zeng D, et al. Protease-activated receptor 3 is a second thrombin receptor in humans. Nature 1997; 386: 502-506.
    • (1997) Nature , vol.386 , pp. 502-506
    • Ishihara, H.1    Connolly, A.J.2    Zeng, D.3
  • 34
    • 0036838021 scopus 로고    scopus 로고
    • Thrombin (PAR-1)-induced proliferation in astrocytes via MAPK involves multiple signaling pathways
    • Wang H, Ubl JJ, Stricker R, Reiser G. Thrombin (PAR-1)-induced proliferation in astrocytes via MAPK involves multiple signaling pathways. Am J Physiol Cell Physiol 2002; 283: C1351-64.
    • (2002) Am J Physiol Cell Physiol , vol.283
    • Wang, H.1    Ubl, J.J.2    Stricker, R.3    Reiser, G.4
  • 35
    • 80155171682 scopus 로고    scopus 로고
    • PAR-1 and Thrombin: The Ties That Bind the Microenvironment to Melanoma Metastasis
    • Zigler M, Kamiya T, Brantley EC, Villares GJ, Bar-Eli M. PAR-1 and Thrombin: The Ties That Bind the Microenvironment to Melanoma Metastasis. Cancer Res 2011; 71: 6561-6.
    • (2011) Cancer Res , vol.71 , pp. 6561-6566
    • Zigler, M.1    Kamiya, T.2    Brantley, E.C.3    Villares, G.J.4    Bar-Eli, M.5
  • 36
    • 84867101730 scopus 로고    scopus 로고
    • Gastrin signaling and Par-4 in pancreatic cancer
    • Kristin K. Fino, Rosalyn B. Irby, Jill P. Smith. Gastrin signaling and Par-4 in pancreatic cancer. Cancer Res, 2011; 71: 2891
    • (2011) Cancer Res , vol.71 , pp. 2891
    • Kristin, K.F.1    Rosalyn, B.I.2    Jill, P.S.3
  • 37
    • 0036842215 scopus 로고    scopus 로고
    • Vascular permeability factor/vascular endothelial growth factor: A critical cytokine in tumor angiogenesis and a potential target for diagnosis and therapy
    • Dvorak HF. Vascular permeability factor/vascular endothelial growth factor: A critical cytokine in tumor angiogenesis and a potential target for diagnosis and therapy. J Clin Oncol 2002; 20: 4368-80.
    • (2002) J Clin Oncol , vol.20 , pp. 4368-4380
    • Dvorak, H.F.1
  • 38
    • 0037443760 scopus 로고    scopus 로고
    • Singh RK.IL-8 directly enhanced endothelial cell survival, proliferation, and matrix metalloproteinases production and regulated angiogenesis
    • Li A, Dubey S, Varney ML, Dave BJ. Singh RK.IL-8 directly enhanced endothelial cell survival, proliferation, and matrix metalloproteinases production and regulated angiogenesis. J Immunol. 2003; 170: 3369-76.
    • (2003) J Immunol. , vol.170 , pp. 3369-3376
    • Li, A.1    Dubey, S.2    Varney, M.L.3    Dave, B.J.4
  • 39
    • 70350212686 scopus 로고    scopus 로고
    • Overactivation of the MEK/ERK pathway in liver tumor cells confers resistance to TGF-{beta}-induced cell death through impairing up-regulation of the NADPH oxidase NOX4
    • Caja L, Sancho P, Bertran E, et al. Overactivation of the MEK/ERK pathway in liver tumor cells confers resistance to TGF-{beta}-induced cell death through impairing up-regulation of the NADPH oxidase NOX4. Cancer Res 2009; 69: 7595-602.
    • (2009) Cancer Res , vol.69 , pp. 7595-7602
    • Caja, L.1    Sancho, P.2    Bertran, E.3
  • 40
    • 70049099306 scopus 로고    scopus 로고
    • Phosphorylated ERK is a potential predictor of sensitivity to sorafenib when treating hepatocellular carcinoma: Evidence from an in vitro study
    • Zhang Z, Zhou X, Shen H, Wang D, Wang Y. Phosphorylated ERK is a potential predictor of sensitivity to sorafenib when treating hepatocellular carcinoma: Evidence from an in vitro study. BMC Med. 2009; 7: 41.
    • (2009) BMC Med. , vol.7 , pp. 41
    • Zhang, Z.1    Zhou, X.2    Shen, H.3    Wang, D.4    Wang, Y.5
  • 41
    • 33846212284 scopus 로고    scopus 로고
    • Sorafenib blocks the RAF/MEK/ERK pathway, inhibits tumor angiogenesis, and induces tumor cell apoptosis in hepatocellular carcinoma model PLC/PRF/5
    • Liu L, Cao Y, Chen C, et al. Sorafenib blocks the RAF/MEK/ERK pathway, inhibits tumor angiogenesis, and induces tumor cell apoptosis in hepatocellular carcinoma model PLC/PRF/5. Cancer Res 2006; 66: 11851-8.
    • (2006) Cancer Res , vol.66 , pp. 11851-11858
    • Liu, L.1    Cao, Y.2    Chen, C.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.