메뉴 건너뛰기




Volumn 12, Issue 10, 2012, Pages 2815-2824

Cholesterol metabolism altered and FGF21 levels high after pediatric liver transplantation despite normal serum lipids

Author keywords

Cholesterol; immunosuppression; lipids; long term outcomes; pediatric liver transplantation

Indexed keywords

AZATHIOPRINE; CAMPESTEROL; FIBROBLAST GROWTH FACTOR 21; LATHOSTEROL; LIPID; LIPOPROTEIN; METHYLPREDNISOLONE; SITOSTEROL; STEROL;

EID: 84867097076     PISSN: 16006135     EISSN: 16006143     Source Type: Journal    
DOI: 10.1111/j.1600-6143.2012.04147.x     Document Type: Article
Times cited : (13)

References (46)
  • 2
    • 0026575087 scopus 로고
    • Serum lipid abnormalities in pediatric liver transplant patients
    • McDiarmid SV, Gornbein JA, Fortunat M, et al,. Serum lipid abnormalities in pediatric liver transplant patients. Transplantation 1992; 53: 109-115.
    • (1992) Transplantation , vol.53 , pp. 109-115
    • McDiarmid, S.V.1    Gornbein, J.A.2    Fortunat, M.3
  • 3
    • 33745797963 scopus 로고    scopus 로고
    • Prevalence and risk factors for diabetes mellitus in moderate term survivors of liver transplantation
    • Saab S, Shpaner A, Zhao Y, et al,. Prevalence and risk factors for diabetes mellitus in moderate term survivors of liver transplantation. Am J Transplant 2006; 6: 1890-1895.
    • (2006) Am J Transplant , vol.6 , pp. 1890-1895
    • Saab, S.1    Shpaner, A.2    Zhao, Y.3
  • 4
    • 54849416140 scopus 로고    scopus 로고
    • Short- and long-time effects of pediatric liver transplantation on serum cholesterol and triglyceride levels-the Vienna cohort
    • Becker J, Huber WD, Aufricht C,. Short- and long-time effects of pediatric liver transplantation on serum cholesterol and triglyceride levels-the Vienna cohort. Pediatr Transplant 2008; 12: 883-888.
    • (2008) Pediatr Transplant , vol.12 , pp. 883-888
    • Becker, J.1    Huber, W.D.2    Aufricht, C.3
  • 5
    • 0033824223 scopus 로고    scopus 로고
    • The metabolic effects of cyclosporin and tacrolimus
    • Marchetti P, Navalesi R,. The metabolic effects of cyclosporin and tacrolimus. J Endocrinol Invest 2000; 23: 482-490.
    • (2000) J Endocrinol Invest , vol.23 , pp. 482-490
    • Marchetti, P.1    Navalesi, R.2
  • 6
    • 0027420074 scopus 로고
    • Steroid withdrawal from long-term immunosuppression in liver allograft recipients
    • Padbury RT, Gunson BK, Dousset B, et al,. Steroid withdrawal from long-term immunosuppression in liver allograft recipients. Transplantation 1993; 55: 789-794.
    • (1993) Transplantation , vol.55 , pp. 789-794
    • Padbury, R.T.1    Gunson, B.K.2    Dousset, B.3
  • 7
  • 8
    • 0038350657 scopus 로고    scopus 로고
    • Steroid withdrawal after pediatric liver transplantation: A long-term follow-up study in 109 recipients
    • Diem HV, Sokal EM, Janssen M, Otte JB, Reding R,. Steroid withdrawal after pediatric liver transplantation: A long-term follow-up study in 109 recipients. Transplantation 2003; 75: 1664-1670.
    • (2003) Transplantation , vol.75 , pp. 1664-1670
    • Diem, H.V.1    Sokal, E.M.2    Janssen, M.3    Otte, J.B.4    Reding, R.5
  • 9
    • 80053053350 scopus 로고    scopus 로고
    • The role of serum non-cholesterol sterols as surrogate markers of absolute cholesterol synthesis and absorption
    • Miettinen TA, Gylling H, Nissinen MJ,. The role of serum non-cholesterol sterols as surrogate markers of absolute cholesterol synthesis and absorption. Nutr Metab Cardiovasc Dis 2011; 21: 765-769.
    • (2011) Nutr Metab Cardiovasc Dis , vol.21 , pp. 765-769
    • Miettinen, T.A.1    Gylling, H.2    Nissinen, M.J.3
  • 10
    • 0025156823 scopus 로고
    • Serum plant sterols and cholesterol precursors reflect cholesterol absorption and synthesis in volunteers of a randomly selected male population
    • Miettinen TA, Tilvis RS, Kesaniemi YA,. Serum plant sterols and cholesterol precursors reflect cholesterol absorption and synthesis in volunteers of a randomly selected male population. Am J Epidemiol 1990; 131: 20-31.
    • (1990) Am J Epidemiol , vol.131 , pp. 20-31
    • Miettinen, T.A.1    Tilvis, R.S.2    Kesaniemi, Y.A.3
  • 11
    • 42149107383 scopus 로고    scopus 로고
    • Adolescent cholesterol metabolism predicts coronary risk factors at middle age: The Cardiovascular Risk in Young Finns Study
    • Miettinen TA, Gylling H, Raitakari OT, Hallikainen M, Viikari J,. Adolescent cholesterol metabolism predicts coronary risk factors at middle age: The Cardiovascular Risk in Young Finns Study. Transl Res 2008; 151: 260-266.
    • (2008) Transl Res , vol.151 , pp. 260-266
    • Miettinen, T.A.1    Gylling, H.2    Raitakari, O.T.3    Hallikainen, M.4    Viikari, J.5
  • 12
    • 52949084731 scopus 로고    scopus 로고
    • Effects of dietary cholesterol and fat on serum non-cholesterol sterols according to different apolipoprotein e subgroups among healthy men
    • Nissinen MJ, Gylling H, Miettinen TA,. Effects of dietary cholesterol and fat on serum non-cholesterol sterols according to different apolipoprotein E subgroups among healthy men. Br J Nutr 2008; 100: 373-379.
    • (2008) Br J Nutr , vol.100 , pp. 373-379
    • Nissinen, M.J.1    Gylling, H.2    Miettinen, T.A.3
  • 13
    • 77950019488 scopus 로고    scopus 로고
    • Relation of non-cholesterol sterols to coronary risk factors and carotid intima-media thickness: The Cardiovascular Risk in Young Finns Study
    • Miettinen TA, Gylling H, Hallikainen M, et al,. Relation of non-cholesterol sterols to coronary risk factors and carotid intima-media thickness: The Cardiovascular Risk in Young Finns Study. Atherosclerosis 2010; 209: 592-597.
    • (2010) Atherosclerosis , vol.209 , pp. 592-597
    • Miettinen, T.A.1    Gylling, H.2    Hallikainen, M.3
  • 14
    • 34748832391 scopus 로고    scopus 로고
    • The distribution of squalene and non-cholesterol sterols in lipoproteins in type 2 diabetes
    • Simonen PP, Gylling H, Miettinen TA,. The distribution of squalene and non-cholesterol sterols in lipoproteins in type 2 diabetes. Atherosclerosis 2007; 194: 222-229.
    • (2007) Atherosclerosis , vol.194 , pp. 222-229
    • Simonen, P.P.1    Gylling, H.2    Miettinen, T.A.3
  • 15
    • 78649632998 scopus 로고    scopus 로고
    • Cholesterol synthesis is increased and absorption decreased in non-alcoholic fatty liver disease independent of obesity
    • Simonen P, Kotronen A, Hallikainen M, et al,. Cholesterol synthesis is increased and absorption decreased in non-alcoholic fatty liver disease independent of obesity. J Hepatol 2011; 54: 153-159.
    • (2011) J Hepatol , vol.54 , pp. 153-159
    • Simonen, P.1    Kotronen, A.2    Hallikainen, M.3
  • 16
    • 42149170104 scopus 로고    scopus 로고
    • Synthesis and absorption of cholesterol in Finnish boys by serum non-cholesterol sterols: The cardiovascular risk in Young Finns Study
    • Miettinen TA, Gylling H, Viikari J, Lehtimaki T, Raitakari OT,. Synthesis and absorption of cholesterol in Finnish boys by serum non-cholesterol sterols: The cardiovascular risk in Young Finns Study. Atherosclerosis 2008; 200: 177-183.
    • (2008) Atherosclerosis , vol.200 , pp. 177-183
    • Miettinen, T.A.1    Gylling, H.2    Viikari, J.3    Lehtimaki, T.4    Raitakari, O.T.5
  • 17
    • 32844463024 scopus 로고    scopus 로고
    • Cholesterol absorption and synthesis in pediatric kidney, liver, and heart transplant recipients
    • Siirtola A, Ketomaki A, Miettinen TA, et al,. Cholesterol absorption and synthesis in pediatric kidney, liver, and heart transplant recipients. Transplantation 2006; 81: 327-334.
    • (2006) Transplantation , vol.81 , pp. 327-334
    • Siirtola, A.1    Ketomaki, A.2    Miettinen, T.A.3
  • 19
    • 61649127208 scopus 로고    scopus 로고
    • Fibroblast growth factor 21 reverses hepatic steatosis, increases energy expenditure, and improves insulin sensitivity in diet-induced obese mice
    • Xu J, Lloyd DJ, Hale C, et al,. Fibroblast growth factor 21 reverses hepatic steatosis, increases energy expenditure, and improves insulin sensitivity in diet-induced obese mice. Diabetes 2009; 58: 250-259.
    • (2009) Diabetes , vol.58 , pp. 250-259
    • Xu, J.1    Lloyd, D.J.2    Hale, C.3
  • 20
    • 77955474305 scopus 로고    scopus 로고
    • Increased fibroblast growth factor 21 in obesity and nonalcoholic fatty liver disease
    • Dushay J, Chui PC, Gopalakrishnan GS, et al,. Increased fibroblast growth factor 21 in obesity and nonalcoholic fatty liver disease. Gastroenterology 2010; 139: 456-463.
    • (2010) Gastroenterology , vol.139 , pp. 456-463
    • Dushay, J.1    Chui, P.C.2    Gopalakrishnan, G.S.3
  • 21
    • 68149091653 scopus 로고    scopus 로고
    • Circulating fibroblast growth factor-21 is elevated in impaired glucose tolerance and type 2 diabetes and correlates with muscle and hepatic insulin resistance
    • Chavez AO, Molina-Carrion M, Abdul-Ghani MA, Folli F, Defronzo RA, Tripathy D,. Circulating fibroblast growth factor-21 is elevated in impaired glucose tolerance and type 2 diabetes and correlates with muscle and hepatic insulin resistance. Diabetes Care 2009; 32: 1542-1546.
    • (2009) Diabetes Care , vol.32 , pp. 1542-1546
    • Chavez, A.O.1    Molina-Carrion, M.2    Abdul-Ghani, M.A.3    Folli, F.4    Defronzo, R.A.5    Tripathy, D.6
  • 22
    • 77957359658 scopus 로고    scopus 로고
    • Fibroblast growth factor 21 levels are increased in nonalcoholic fatty liver disease patients and are correlated with hepatic triglyceride
    • Li H, Fang Q, Gao F, et al,. Fibroblast growth factor 21 levels are increased in nonalcoholic fatty liver disease patients and are correlated with hepatic triglyceride. J Hepatol 2010; 53: 934-940.
    • (2010) J Hepatol , vol.53 , pp. 934-940
    • Li, H.1    Fang, Q.2    Gao, F.3
  • 23
    • 79954525448 scopus 로고    scopus 로고
    • Circulating FGF21 levels are progressively increased from the early to end stages of chronic kidney diseases and are associated with renal function in Chinese
    • Lin Z, Zhou Z, Liu Y, et al,. Circulating FGF21 levels are progressively increased from the early to end stages of chronic kidney diseases and are associated with renal function in Chinese. PLoS One 2011; 6: e18398.
    • (2011) PLoS One , vol.6
    • Lin, Z.1    Zhou, Z.2    Liu, Y.3
  • 24
    • 67649923737 scopus 로고    scopus 로고
    • Fibroblast growth factor 21: An overview from a clinical perspective
    • Ryden M,. Fibroblast growth factor 21: An overview from a clinical perspective. Cell Mol Life Sci 2009; 66: 2067-2073.
    • (2009) Cell Mol Life Sci , vol.66 , pp. 2067-2073
    • Ryden, M.1
  • 25
    • 79958810325 scopus 로고    scopus 로고
    • Serum FGF21 in boys with idiopathic short stature: Relationship to lipid profile, onset of puberty and growth
    • doi: 10.1111/j.1365-2265.2011.03999.x. [Epub ahead of print]
    • Hero M, Dunkel L, Vaaralahti K, Raivio T,. Serum FGF21 in boys with idiopathic short stature: Relationship to lipid profile, onset of puberty and growth. Clin Endocrinol (Oxf) 2011. doi: 10.1111/j.1365-2265.2011.03999.x. [Epub ahead of print]
    • (2011) Clin Endocrinol (Oxf)
    • Hero, M.1    Dunkel, L.2    Vaaralahti, K.3    Raivio, T.4
  • 26
    • 79953848724 scopus 로고    scopus 로고
    • New Finnish growth references for children and adolescents aged 0 to 20 years: Length/height-for-age, weight-for-length/height, and body mass index-for-age
    • Saari A, Sankilampi U, Hannila ML, Kiviniemi V, Kesseli K, Dunkel L,. New Finnish growth references for children and adolescents aged 0 to 20 years: Length/height-for-age, weight-for-length/height, and body mass index-for-age. Ann.Med 2011; 43: 235-248.
    • (2011) Ann.Med , vol.43 , pp. 235-248
    • Saari, A.1    Sankilampi, U.2    Hannila, M.L.3    Kiviniemi, V.4    Kesseli, K.5    Dunkel, L.6
  • 27
    • 0021813187 scopus 로고
    • Homeostasis model assessment: Insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man
    • Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC,. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 1985; 28: 412-419.
    • (1985) Diabetologia , vol.28 , pp. 412-419
    • Matthews, D.R.1    Hosker, J.P.2    Rudenski, A.S.3    Naylor, B.A.4    Treacher, D.F.5    Turner, R.C.6
  • 28
    • 79251488789 scopus 로고    scopus 로고
    • Metabolic syndrome in liver transplant recipients: Prevalence, risk factors, and association with cardiovascular events
    • Laish I, Braun M, Mor E, Sulkes J, Harif Y, Ari ZB,. Metabolic syndrome in liver transplant recipients: Prevalence, risk factors, and association with cardiovascular events. Liver Transpl 2011; 17: 15-22.
    • (2011) Liver Transpl , vol.17 , pp. 15-22
    • Laish, I.1    Braun, M.2    Mor, E.3    Sulkes, J.4    Harif, Y.5    Ari, Z.B.6
  • 29
    • 0015348189 scopus 로고
    • Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge
    • Friedewald WT, Levy RI, Fredrickson DS,. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem 1972; 18: 499-502.
    • (1972) Clin Chem , vol.18 , pp. 499-502
    • Friedewald, W.T.1    Levy, R.I.2    Fredrickson, D.S.3
  • 30
    • 0023865658 scopus 로고
    • Cholesterol metabolism during ketoconazole treatment in man
    • Miettinen TA,. Cholesterol metabolism during ketoconazole treatment in man. J Lipid Res 1988; 29: 43-51.
    • (1988) J Lipid Res , vol.29 , pp. 43-51
    • Miettinen, T.A.1
  • 31
    • 0028234491 scopus 로고
    • Intraobserver and interobserver variations in liver biopsy interpretation in patients with chronic hepatitis C. The French METAVIR Cooperative Study Group
    • Intraobserver and interobserver variations in liver biopsy interpretation in patients with chronic hepatitis C. The French METAVIR Cooperative Study Group. Hepatology 1994; 20 (1 Pt 1): 15-20.
    • (1994) Hepatology , vol.20 , Issue.1 PART 1 , pp. 15-20
  • 32
    • 33747080802 scopus 로고    scopus 로고
    • Liver biopsy interpretation for causes of late liver allograft dysfunction
    • Banff Working Group
    • Banff Working Group, Demetris AJ, Adeyi O, et al,. Liver biopsy interpretation for causes of late liver allograft dysfunction. Hepatology 2006; 44: 489-501.
    • (2006) Hepatology , vol.44 , pp. 489-501
    • Demetris, A.J.1    Adeyi, O.2
  • 33
    • 48349127924 scopus 로고    scopus 로고
    • The circulating metabolic regulator FGF21 is induced by prolonged fasting and PPARalpha activation in man
    • Galman C, Lundasen T, Kharitonenkov A, et al,. The circulating metabolic regulator FGF21 is induced by prolonged fasting and PPARalpha activation in man. Cell Metab 2008; 8: 169-174.
    • (2008) Cell Metab , vol.8 , pp. 169-174
    • Galman, C.1    Lundasen, T.2    Kharitonenkov, A.3
  • 34
    • 63849189712 scopus 로고    scopus 로고
    • Serum concentrations and tissue expression of a novel endocrine regulator fibroblast growth factor-21 in patients with type 2 diabetes and obesity
    • Mraz M, Bartlova M, Lacinova Z, et al,. Serum concentrations and tissue expression of a novel endocrine regulator fibroblast growth factor-21 in patients with type 2 diabetes and obesity. Clin Endocrinol (Oxf) 2009; 71: 369-375.
    • (2009) Clin Endocrinol (Oxf) , vol.71 , pp. 369-375
    • Mraz, M.1    Bartlova, M.2    Lacinova, Z.3
  • 35
    • 1542723726 scopus 로고    scopus 로고
    • Insulin resistance is associated with increased cholesterol synthesis and decreased cholesterol absorption in normoglycemic men
    • Pihlajamaki J, Gylling H, Miettinen TA, Laakso M,. Insulin resistance is associated with increased cholesterol synthesis and decreased cholesterol absorption in normoglycemic men. J Lipid Res 2004; 45: 507-512.
    • (2004) J Lipid Res , vol.45 , pp. 507-512
    • Pihlajamaki, J.1    Gylling, H.2    Miettinen, T.A.3    Laakso, M.4
  • 36
    • 74549142381 scopus 로고    scopus 로고
    • Cardiovascular risk profile of patients with acute liver failure after liver transplantation when compared with the general population
    • Aberg F, Jula A, Hockerstedt K, Isoniemi H,. Cardiovascular risk profile of patients with acute liver failure after liver transplantation when compared with the general population. Transplantation 2010; 89: 61-68.
    • (2010) Transplantation , vol.89 , pp. 61-68
    • Aberg, F.1    Jula, A.2    Hockerstedt, K.3    Isoniemi, H.4
  • 37
    • 57849130369 scopus 로고    scopus 로고
    • Metabolic syndrome in liver transplantation: Relation to etiology and immunosuppression
    • Bianchi G, Marchesini G, Marzocchi R, Pinna AD, Zoli M,. Metabolic syndrome in liver transplantation: Relation to etiology and immunosuppression. Liver Transpl 2008; 14: 1648-1654.
    • (2008) Liver Transpl , vol.14 , pp. 1648-1654
    • Bianchi, G.1    Marchesini, G.2    Marzocchi, R.3    Pinna, A.D.4    Zoli, M.5
  • 38
    • 38549115640 scopus 로고    scopus 로고
    • Calcineurin inhibitor-sparing regimens in solid organ transplantation: Focus on improving renal function and nephrotoxicity
    • Flechner SM, Kobashigawa J, Klintmalm G,. Calcineurin inhibitor-sparing regimens in solid organ transplantation: Focus on improving renal function and nephrotoxicity. Clin Transplant 2008; 22: 1-15.
    • (2008) Clin Transplant , vol.22 , pp. 1-15
    • Flechner, S.M.1    Kobashigawa, J.2    Klintmalm, G.3
  • 39
    • 68849125258 scopus 로고    scopus 로고
    • Calcineurin inhibitor minimization in pediatric liver allograft recipients
    • Dell-Olio D, Kelly DA,. Calcineurin inhibitor minimization in pediatric liver allograft recipients. Pediatr Transplant 2009; 13: 670-681.
    • (2009) Pediatr Transplant , vol.13 , pp. 670-681
    • Dell-Olio, D.1    Kelly, D.A.2
  • 40
    • 46249105200 scopus 로고    scopus 로고
    • Calcineurin inhibitor sparing in paediatric solid organ transplantation: Managing the efficacy/toxicity conundrum
    • Tredger JM, Brown NW, Dhawan A,. Calcineurin inhibitor sparing in paediatric solid organ transplantation: Managing the efficacy/toxicity conundrum. Drugs 2008; 68: 1385-1414.
    • (2008) Drugs , vol.68 , pp. 1385-1414
    • Tredger, J.M.1    Brown, N.W.2    Dhawan, A.3
  • 41
    • 84859906325 scopus 로고    scopus 로고
    • Health status of children alive 10 years after pediatric liver transplantation performed in the US and Canada: Report of the Studies of Pediatric Liver Transplantation Experience
    • Ng VL, Alonso EM, Bucuvalas JC, et al,. Health status of children alive 10 years after pediatric liver transplantation performed in the US and Canada: Report of the Studies of Pediatric Liver Transplantation Experience. J Pediatr 2012; 5: 820-826.
    • (2012) J Pediatr , vol.5 , pp. 820-826
    • Ng, V.L.1    Alonso, E.M.2    Bucuvalas, J.C.3
  • 42
    • 0026775034 scopus 로고
    • Low-dose steroid therapy in cyclosporine-treated renal transplant recipients with well-functioning grafts. The Canadian Multicentre Transplant Study Group
    • Sinclair NR,. Low-dose steroid therapy in cyclosporine-treated renal transplant recipients with well-functioning grafts. The Canadian Multicentre Transplant Study Group. CMAJ 1992; 147: 645-657.
    • (1992) CMAJ , vol.147 , pp. 645-657
    • Sinclair, N.R.1
  • 43
    • 79956344354 scopus 로고    scopus 로고
    • Steroids in kidney transplant patients
    • Steiner RW, Awdishu L,. Steroids in kidney transplant patients. Semin Immunopathol 2011; 33: 157-167.
    • (2011) Semin Immunopathol , vol.33 , pp. 157-167
    • Steiner, R.W.1    Awdishu, L.2
  • 44
    • 2442683974 scopus 로고    scopus 로고
    • Serum lipids in children 3 to 5 years after kidney, liver, and heart transplantation
    • Siirtola A, Antikainen M, Ala-Houhala M, et al,. Serum lipids in children 3 to 5 years after kidney, liver, and heart transplantation. Transpl Int 2004; 17: 109-119.
    • (2004) Transpl Int , vol.17 , pp. 109-119
    • Siirtola, A.1    Antikainen, M.2    Ala-Houhala, M.3
  • 45
    • 84862323517 scopus 로고    scopus 로고
    • Liver X receptor negatively regulates fibroblast growth factor 21 in the fatty liver induced by cholesterol-enriched diet
    • [Epub ahead of print]
    • Uebanso T, Taketani Y, Yamamoto H, et al,. Liver X receptor negatively regulates fibroblast growth factor 21 in the fatty liver induced by cholesterol-enriched diet. J Nutr Biochem 2011. Sep 1. [Epub ahead of print]
    • (2011) J Nutr Biochem , vol.1
    • Uebanso, T.1    Taketani, Y.2    Yamamoto, H.3
  • 46
    • 79952301247 scopus 로고    scopus 로고
    • Liver X receptor signaling is a determinant of stellate cell activation and susceptibility to fibrotic liver disease
    • Beaven SW, Wroblewski K, Wang J, et al,. Liver X receptor signaling is a determinant of stellate cell activation and susceptibility to fibrotic liver disease. Gastroenterology 2011; 140: 1052-1062.
    • (2011) Gastroenterology , vol.140 , pp. 1052-1062
    • Beaven, S.W.1    Wroblewski, K.2    Wang, J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.