Liver X receptor signaling is a determinant of stellate cell activation and susceptibility to fibrotic liver disease

Gastroenterology

Volumn 140, Issue 3, 2011, Pages 1052-1062

  Beaven, Simon W ^a,b   Wroblewski, Kevin ^a   Wang, Jiaohong ^c,d   Hong, Cynthia ^a   Bensinger, Steven ^a   Tsukamoto, Hide ^c,d   Tontonoz, Peter ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b Division of Digestive Diseases   (United States)

^c UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^d VA GREATER LOS ANGELES HEALTHCARE SYSTEM   (United States)

Author keywords

Hepatic Stellate Cells; Liver Fibrosis; LXRs; Nuclear Receptors

Indexed keywords

ABC TRANSPORTER A1; ALPHA SMOOTH MUSCLE ACTIN; AUTACOID; CARBON TETRACHLORIDE; CHOLINE; COLLAGEN TYPE 1; LIPID; LIVER X RECEPTOR ALPHA; LIVER X RECEPTOR BETA; METHIONINE; STEROL REGULATORY ELEMENT BINDING PROTEIN 1C;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BONE MARROW TRANSPLANTATION; CELL ACTIVATION; CELL FUNCTION; CELL IMMORTALIZATION; CONTROLLED STUDY; DISEASE MODEL; DISEASE PREDISPOSITION; IN VIVO STUDY; LIPID METABOLISM; LIVER FIBROSIS; MALE; MOUSE; NONHUMAN; PATHOGENESIS; PHENOTYPE; PRIORITY JOURNAL; PROTEIN SYNTHESIS; SIGNAL TRANSDUCTION; STELLATE CELL; WILD TYPE;

EID: 79952301247     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.gastro.2010.11.053     Document Type: Article

References (37)

1. S.L. Friedman Hepatic stellate cells: protean, multifunctional, and enigmatic cells of the liver Physiol Rev 88 2008 125 172
2. R. Bataller, and D.A. Brenner Liver fibrosis J Clin Invest 115 2005 209 218 (Pubitemid 40385459)
3. S. Bronfenmajer, F. Schaffner, and H. Popper Fat-storing cells (lipocytes) in human liver Arch Pathol 82 1966 447 453
4. W.S. Blaner, S.M. O'Byrne, and N. Wongsiriroj Hepatic stellate cell lipid droplets: a specialized lipid droplet for retinoid storage Biochim Biophys Acta 1791 2009 467 473
5. K. Wake "Sternzellen" in the liver: perisinusoidal cells with special reference to storage of vitamin A Am J Anat 132 1971 429 462
6. S.L. Friedman, F.J. Roll, and J. Boyles Hepatic lipocytes: the principal collagen-producing cells of normal rat liver Proc Natl Acad Sci U S A 82 1985 8681 8685 (Pubitemid 16101107)
7. A.M. Gressner, and M.G. Bachem Cellular sources of noncollagenous matrix proteins: role of fat-storing cells in fibrogenesis Semin Liver Dis 10 1990 30 46 (Pubitemid 20163704)
8. M. Matsuoka, and H. Tsukamoto Stimulation of hepatic lipocyte collagen production by Kupffer cell-derived transforming growth factor beta: implication for a pathogenetic role in alcoholic liver fibrogenesis Hepatology 11 1990 599 605 (Pubitemid 20151737)
9. D.C. Rockey, J.K. Boyles, and G. Gabbiani Rat hepatic lipocytes express smooth muscle actin upon activation in vivo and in culture J Submicrosc Cytol Pathol 24 1992 193 203
10. T.I. Novobrantseva, G.R. Majeau, and A. Amatucci Attenuated liver fibrosis in the absence of B cells J Clin Invest 115 2005 3072 3082 (Pubitemid 41567572)
11. J.S. Duffield, S.J. Forbes, and C.M. Constandinou Selective depletion of macrophages reveals distinct, opposing roles during liver injury and repair J Clin Invest 115 2005 56 65 (Pubitemid 40385505)
12. S. Radaeva, R. Sun, and B. Jaruga Natural killer cells ameliorate liver fibrosis by killing activated stellate cells in NKG2D-dependent and tumor necrosis factor-related apoptosis-inducing ligand-dependent manners Gastroenterology 130 2006 435 452 (Pubitemid 43202042)
13. N. Muhanna, S. Doron, and O. Wald Activation of hepatic stellate cells after phagocytosis of lymphocytes: a novel pathway of fibrogenesis Hepatology 48 2008 963 977
14. P. Tontonoz, and D.J. Mangelsdorf Liver X receptor signaling pathways in cardiovascular disease Mol Endocrinol 17 2003 985 993 (Pubitemid 36683707)
15. J.R. Schultz, H. Tu, and A. Luk Role of LXRs in control of lipogenesis Genes Dev 14 2000 2831 2838
16. S.W. Beaven, and P. Tontonoz Nuclear receptors in lipid metabolism: targeting the heart of dyslipidemia Annu Rev Med 57 2006 313 329 (Pubitemid 43261994)
17. A. Castrillo, and P. Tontonoz Nuclear receptors in macrophage biology: at the crossroads of lipid metabolism and inflammation Annu Rev Cell Dev Biol 20 2004 455 480 (Pubitemid 39488646)
18. S.B. Joseph, A. Castrillo, and B.A. Laffitte Reciprocal regulation of inflammation and lipid metabolism by liver X receptors Nat Med 9 2003 213 219 (Pubitemid 36227724)
19. A.J. Fowler, M.Y. Sheu, and M. Schmuth Liver X receptor activators display anti-inflammatory activity in irritant and allergic contact dermatitis models: liver-X-receptor-specific inhibition of inflammation and primary cytokine production J Invest Dermatol 120 2003 246 255 (Pubitemid 36513075)
20. S.J. Bensinger, M.N. Bradley, and S.B. Joseph LXR signaling couples sterol metabolism to proliferation in the acquired immune response Cell 134 2008 97 111 (Pubitemid 351905740)
21. H. Uppal, S.P. Saini, and A. Moschetta Activation of LXRs prevents bile acid toxicity and cholestasis in female mice Hepatology 45 2007 422 432 (Pubitemid 46374599)
22. H. Tsukamoto, H. She, and S. Hazra Anti-adipogenic regulation underlies hepatic stellate cell transdifferentiation J Gastroenterol Hepatol 21 Suppl 3 2006 S102 S105
23. T. Miyahara, L. Schrum, and R. Rippe Peroxisome proliferator-activated receptors and hepatic stellate cell activation J Biol Chem 275 2000 35715 35722
24. S. Fiorucci, E. Antonelli, and G. Rizzo The nuclear receptor SHP mediates inhibition of hepatic stellate cells by FXR and protects against liver fibrosis Gastroenterology 127 2004 1497 1512 (Pubitemid 39457775)
25. Y.P. Han, C. Yan, and L. Zhou A matrix metalloproteinase-9 activation cascade by hepatic stellate cells in trans-differentiation in the three-dimensional extracellular matrix J Biol Chem 282 2007 12928 12939 (Pubitemid 47100583)
26. E. Seki, S. De Minicis, and C.H. Osterreicher TLR4 enhances TGF-beta signaling and hepatic fibrosis Nat Med 13 2007 1324 1332 (Pubitemid 350073596)
27. L. Xu, A.Y. Hui, and E. Albanis Human hepatic stellate cell lines, LX-1 and LX-2: new tools for analysis of hepatic fibrosis Gut 54 2005 142 151 (Pubitemid 40007234)
28. J.J. Repa, S.D. Turley, and J.A. Lobaccaro Regulation of absorption and ABC1-mediated efflux of cholesterol by RXR heterodimers Science 289 2000 1524 1529
29. B.L. Wagner, A.F. Valledor, and G. Shao Promoter-specific roles for liver X receptor/corepressor complexes in the regulation of ABCA1 and SREBP1 gene expression Mol Cell Biol 23 2003 5780 5789 (Pubitemid 36951340)
30. G.F. Kalf, G.B. Post, and R. Snyder Solvent toxicology: recent advances in the toxicology of benzene, the glycol ethers, and carbon tetrachloride Annu Rev Pharmacol Toxicol 27 1987 399 427 (Pubitemid 17067242)
31. R.K. Tangirala, E.D. Bischoff, and S.B. Joseph Identification of macrophage liver X receptors as inhibitors of atherosclerosis Proc Natl Acad Sci U S A 99 2002 11896 11901 (Pubitemid 34994495)
32. S. Vogel, R. Piantedosi, and J. Frank An immortalized rat liver stellate cell line (HSC-T6): a new cell model for the study of retinid metabolism in vitro J Lipid Res 41 2000 882 893 (Pubitemid 30434319)
33. K. Hellemans, P. Verbuyst, and E. Quartier Differential modulation of rat hepatic stellate phenotype by natural and synthetic retinoids Hepatology 39 2004 97 108 (Pubitemid 38461472)
34. M. Okuno, H. Moriwaki, and S. Imai Retinoids exacerbate rat liver fibrosis by inducing the activation of latent TGF-beta in liver stellate cells Hepatology 26 1997 913 921 (Pubitemid 27413657)
35. H. Senoo, and K. Wake Suppression of experimental hepatic fibrosis by administration of vitamin A Lab Invest 52 1985 182 194 (Pubitemid 15125494)
36. E. Wandzioch, A. Kolterud, and M. Jacobsson Lhx2-/- mice develop liver fibrosis Proc Natl Acad Sci U S A 101 2004 16549 16554 (Pubitemid 39557750)
37. S. Ghisletti, W. Huang, and S. Ogawa Parallel SUMOylation-dependent pathways mediate gene- and signal-specific transrepression by LXRs and PPARgamma Mol Cell 25 2007 57 70 (Pubitemid 46049061)