Inverting the regioselectivity of the berberine bridge enzyme by employing customized fluorine-containing substrates

Chemistry - A European Journal

Volumn 18, Issue 41, 2012, Pages 13173-13179

  Resch, Verena ^a   Lechner, Horst ^a   Schrittwieser, Joerg H ^a   Wallner, Silvia ^b   Gruber, Karl ^a   MacHeroux, Peter ^b   Kroutil, Wolfgang ^a  

^a UNIVERSITY OF GRAZ   (Austria)

^b GRAZ UNIVERSITY OF TECHNOLOGY   (Austria)

Author keywords

alkaloids; biocatalysis; C H activation; enzyme catalysis; regioselectivity

Indexed keywords

ALKALOIDS; BIOACTIVE COMPOUNDS; BIOCATALYSIS; C-H ACTIVATION; ENZYME CATALYSIS; PROTEIN ENGINEERING; REACTION CENTER; REACTION PATHWAYS; REACTION SITES; REGIOISOMERS; RING CLOSURES; SPECIFIC SITES; WILD-TYPE ENZYMES;

ACTIVATION ANALYSIS; CATALYSIS; ENANTIOSELECTIVITY; ENZYMES; FLUORINE; GENETIC ENGINEERING; REGIOSELECTIVITY;

SUBSTRATES;

FLUORINE; ISOQUINOLINE DERIVATIVE; N DEMETHYLASE; RETICULINE OXIDASE;

ARTICLE; CHEMICAL STRUCTURE; CHEMISTRY; ENZYME SPECIFICITY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; STEREOISOMERISM;

FLUORINE; ISOQUINOLINES; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR STRUCTURE; OXIDOREDUCTASES, N-DEMETHYLATING; STEREOISOMERISM; SUBSTRATE SPECIFICITY;

EID: 84867074307     PISSN: 09476539     EISSN: 15213765     Source Type: Journal    
DOI: 10.1002/chem.201201895     Document Type: Article

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