Evaluation of novel acute urinary rat kidney toxicity biomarker for subacute toxicity studies in preclinical trials

Toxicologic Pathology

Volumn 40, Issue 7, 2012, Pages 1031-1048

  Fuchs, Tobias Christian ^a   Frick, Katharina ^b   Emde, Barbara ^a   Czasch, Stephanie ^a   Landenberg, Friedrich Von ^a   Hewitt, Philip ^a  

^a Merck Serono GmbH   (Germany)

^b MANNHEIM UNIVERSITY OF APPLIED SCIENCES   (Germany)

Author keywords

28 day toxicity study; cisplatin; multiplexed analyte profiling; nephrotoxicity; puromycin; urinary biomarkers; vancomycin

Indexed keywords

BETA 2 MICROGLOBULIN; BIOLOGICAL MARKER; CALBINDIN; CISPLATIN; CLUSTERIN; GLUTATHIONE TRANSFERASE ALPHA; KIDNEY INJURY MOLECULE 1; NEUTROPHIL GELATINASE ASSOCIATED LIPOCALIN; OSTEOPONTIN; PROTEIN GSTYB1; PROTEIN RPA 1; PUROMYCIN; TISSUE INHIBITOR OF METALLOPROTEINASE 1; UNCLASSIFIED DRUG; VANCOMYCIN; VASCULOTROPIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASSAY; BETA 2 MICROGLOBULIN URINE LEVEL; CONTROLLED STUDY; DIAGNOSTIC TEST ACCURACY STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HISTOPATHOLOGY; KIDNEY INJURY; MALE; NEPHRON; NEPHROTOXICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN URINE LEVEL; RAT; TOXICITY; WISTAR RAT;

ACUTE DISEASE; ANIMALS; ANTI-BACTERIAL AGENTS; ANTIMETABOLITES, ANTINEOPLASTIC; BIOLOGICAL MARKERS; CISPLATIN; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG EVALUATION, PRECLINICAL; FEMALE; KIDNEY DISEASES; MALE; PUROMYCIN; RATS; RATS, WISTAR; TOXICITY TESTS, SUBACUTE; VANCOMYCIN; XENOBIOTICS;

RATTUS; RATTUS NORVEGICUS;

EID: 84867064909     PISSN: 01926233     EISSN: 15331601     Source Type: Journal    
DOI: 10.1177/0192623312444618     Document Type: Article

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