High glucose-induced upregulation of Rho / Rho-kinase via platelet-derived growth factor receptor-β increases migration of aortic smooth muscle cells

Journal of Molecular and Cellular Cardiology

Volumn 45, Issue 2, 2008, Pages 326-332

  Akiyama, Noboru ^a   Naruse, Keiko ^a,b   Kobayashi, Yasuko ^b   Nakamura, Nobuhisa ^a   Hamada, Yoji ^c   Nakashima, Eitaro ^a   Matsubara, Tatsuaki ^b   Oiso, Yutaka ^a   Nakamura, Jiro ^a  

^a NAGOYA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b AICHI GAKUIN UNIVERSITY   (Japan)

^c NAGOYA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Diabetes; Platelet derived growth factor; Rho; Rho kinase; Vascular smooth muscle cells

Indexed keywords

4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; GLUCOSE; IMATINIB; NEUTRALIZING ANTIBODY; PLATELET DERIVED GROWTH FACTOR BETA RECEPTOR; RHO KINASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; AORTA MEDIA; ARTICLE; CELL CULTURE; CELL MIGRATION; CONTROLLED STUDY; ENZYME ACTIVITY; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SMOOTH MUSCLE FIBER; STREPTOZOCIN DIABETES; VASCULAR DISEASE; WESTERN BLOTTING;

AMIDES; ANIMALS; AORTA; CELL MOVEMENT; CELLS, CULTURED; GLUCOSE; HUMANS; MALE; MYOCYTES, SMOOTH MUSCLE; PYRIDINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, PLATELET-DERIVED GROWTH FACTOR BETA; RHO GTP-BINDING PROTEINS; RHO-ASSOCIATED KINASES; UP-REGULATION;

RATTUS;

EID: 48849099229     PISSN: 00222828     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.yjmcc.2008.04.006     Document Type: Article

References (27)

1. Bell D.S. Heart failure: the frequent, forgotten, and often fatal complication of diabetes. Diabetes Care 26 (2003) 2433-2441
2. Buetow B.S., Tappan K.A., Crosby J.R., Seifert R.A., and Bowen-Pope D.F. Chimera analysis supports a predominant role of PDGFRbeta in promoting smooth-muscle cell chemotaxis after arterial injury. Am J Pathol 163 (2003) 979-984
3. Huang B., Dreyer T., Heidt M., Yu J.C., Philipp M., Hehrlein F.W., et al. Insulin and local growth factor PDGF induce intimal hyperplasia in bypass graft culture models of saphenous vein and internal mammary artery. Eur J Cardiothorac Surg 21 (2002) 1002-1008
4. Abedi H., and Zachary I. Signalling mechanisms in the regulation of vascular cell migration. Cardiovasc Res 30 (1995) 544-556
5. Kawano M., Koshikawa T., Kanzaki T., Morisaki N., Saito Y., and Yoshida S. Diabetes mellitus induces accelerated growth of aortic smooth muscle cells: association with overexpression of PDGF beta-receptors. Eur J Clin Invest 23 (1993) 84-90
6. Nakamura J., Kasuya Y., Hamada Y., Nakashima E., Naruse K., Yasuda Y., et al. Glucose-induced hyperproliferation of cultured rat aortic smooth muscle cells through polyol pathway hyperactivity. Diabetologia 44 (2001) 480-487
7. Campbell M., Allen W.E., Silversides J.A., and Trimble E.R. Glucose-induced phosphatidylinositol 3-kinase and mitogen-activated protein kinase-dependent upregulation of the platelet-derived growth factor-beta receptor potentiates vascular smooth muscle cell chemotaxis. Diabetes 52 (2003) 519-526
8. Ross R. Atherosclerosis-an inflammatory disease. N Engl J Med 340 (1999) 115-126
9. Aznar S., and Lacal J.C. Rho signals to cell growth and apoptosis. Cancer Lett 165 (2001) 1-10
10. Amano M., Chihara K., Kimura K., Fukata Y., Nakamura N., Matsuura Y., et al. Formation of actin stress fibers and focal adhesions enhanced by Rho-kinase. Science 275 (1997) 1308-1311
11. Chrissobolis S., and Sobey C.G. Recent evidence for an involvement of rho-kinase in cerebral vascular disease. Stroke 37 (2006) 2174-2180
12. Guilluy C., Sauzeau V., Rolli-Derkinderen M., Guerin P., Sagan C., Pacaud P., et al. Inhibition of RhoA/Rho kinase pathway is involved in the beneficial effect of sildenafil on pulmonary hypertension. Br J Pharmacol 146 (2005) 1010-1018
13. Morishige K., Shimokawa H., Eto Y., Hoshijima M., Kaibuchi K., and Takeshita A. In vivo gene transfer of dominant-negative rho-kinase induces regression of coronary arteriosclerosis in pigs. Ann N Y Acad Sci 947 (2001) 407-411
14. Wang Y.X., Martin-McNulty B., da Cunha V., Vincelette J., Lu X., Feng Q., et al. Fasudil, a Rho-kinase inhibitor, attenuates angiotensin II-induced abdominal aortic aneurysm in apolipoprotein E-deficient mice by inhibiting apoptosis and proteolysis. Circulation 111 (2005) 2219-2226
15. Sandu O.A., Ragolia L., and Begum N. Diabetes in the Goto-Kakizaki rat is accompanied by impaired insulin-mediated myosin-bound phosphatase activation and vascular smooth muscle cell relaxation. Diabetes 49 (2000) 2178-2189
16. Kobayashi Y., Naruse K., Hamada Y., Nakashima E., Kato K., Akiyama N., et al. Human proinsulin C-peptide prevents proliferation of rat aortic smooth muscle cells cultured in high-glucose conditions. Diabetologia 48 (2005) 2396-2401
17. Zondag G.C., Evers E.E., ten Klooster J.P., Janssen L., van der Kammen R.A., and Collard J.G. Oncogenic Ras downregulates Rac activity, which leads to increased Rho activity and epithelial-mesenchymal transition. J Cell Biol 149 (2000) 775-782
18. Ross R. The pathogenesis of atherosclerosis-an update. N Engl J Med 314 (1986) 488-500
19. Kanzaki T., Shinomiya M., Ueda S., Morisaki N., Saito Y., and Yoshida S. Enhanced arterial intimal thickening after balloon catheter injury in diabetic animals accompanied by PDGF beta-receptor overexpression of aortic media. Eur J Clin Invest 24 (1994) 377-381
20. Ai S., Kuzuya M., Koike T., Asai T., Kanda S., Maeda K., et al. Rho-Rho kinase is involved in smooth muscle cell migration through myosin light chain phosphorylation-dependent and independent pathways. Atherosclerosis 155 (2001) 321-327
21. Kamiyama M., Utsunomiya K., Taniguchi K., Yokota T., Kurata H., Tajima N., et al. Contribution of Rho A and Rho kinase to platelet-derived growth factor-BB-induced proliferation of vascular smooth muscle cells. J Atheroscler Thromb 10 (2003) 117-123
22. Weiss S., Frischknecht K., Greutert H., Payeli S., Steffel J., Luscher T.F., et al. Different migration of vascular smooth muscle cells from human coronary artery bypass vessels. Role of Rho/ROCK pathway. J Vasc Res 44 (2007) 149-156
23. Zubiaur M., Sancho J., Terhorst C., and Faller D.V. A small GTP-binding protein, Rho, associates with the platelet-derived growth factor type-beta receptor upon ligand binding. J Biol Chem 270 (1995) 17221-17228
24. Miao L., Calvert J.W., Tang J., and Zhang J.H. Upregulation of small GTPase RhoA in the basilar artery from diabetic (mellitus) rats. Life Sci 71 (2002) 1175-1185
25. Seasholtz T.M., Zhang T., Morissette M.R., Howes A.L., Yang A.H., and Brown J.H. Increased expression and activity of RhoA are associated with increased DNA synthesis and reduced p27(Kip1) expression in the vasculature of hypertensive rats. Circ Res 89 (2001) 488-495
26. Savage D.G., and Antman K.H. Imatinib mesylate-a new oral targeted therapy. N Engl J Med 346 (2002) 683-693
27. Schermuly R.T., Dony E., Ghofrani H.A., Pullamsetti S., Savai R., Roth M, et al. Reversal of experimental pulmonary hypertension by PDGF inhibition. J Clin Invest 115 (2005) 2811-2821