Glucose-dependent enhancement of diabetic bladder contraction is associated with a rho kinase-regulated protein kinase C pathway

Journal of Pharmacology and Experimental Therapeutics

Volumn 328, Issue 3, 2009, Pages 940-950

  Nobe, Koji ^a   Yamazaki, Taigi ^a   Tsumita, Naoki ^a   Hashimoto, Terumasa ^a   Honda, Kazuo ^a  

^a SHOWA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

12 (2 CYANOETHYL) 6,7,12,13 TETRAHYDRO 13 METHYL 5 OXOINDOLO[2,3 A]PYRROLO[3,4 C]CARBAZOLE; 4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; CALCIUM; CARBACHOL; FASUDIL; GLUCOSE; PROTEIN KINASE C; RHO KINASE; ROTTLERIN;

ADOLESCENT; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLADDER CAPACITY; BLADDER CONTRACTION; BLADDER DYSFUNCTION; C57BL MOUSE; DIABETES MELLITUS; ENZYME ACTIVATION; ENZYME ACTIVITY; GLUCOSE BLOOD LEVEL; HYPERGLYCEMIA; MALE; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OVERACTIVE BLADDER; PRIORITY JOURNAL;

ANIMALS; BLOOD GLUCOSE; CARBACHOL; CHOLESTEROL; DIABETES MELLITUS, TYPE 2; FATTY ACIDS, NONESTERIFIED; GLUCOSE; MALE; MICE; MICE, INBRED C57BL; MICE, OBESE; MUSCLE CONTRACTION; MUSCLE, SMOOTH; PHOSPHOLIPIDS; PROTEIN KINASE C; RHO-ASSOCIATED KINASES; TRIGLYCERIDES; URINARY BLADDER;

EID: 62449112022     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.108.144907     Document Type: Article

References (4)

1. Akiyama N, Naruse K, Kobayashi Y, Nakamura N, Hamada Y, Nakashima E, Matsubara T, Oiso Y, and Nakamura J (2008) High glucose-induced upregulation of rho/rho-kinase via platelet-derived growth factor receptor-beta increases migration of aortic smooth muscle cells. JMol Cell Cardiol 45:326-332.
2. Andersson KE and Arner A (2004) Urinary bladder contraction and relaxation: physiology and pathophysiology. Physiol Rev 84:935-986.
3. Arun KH, Kaul CL, and Ramarao P (2005) ATI receptors and L-type calcium channels: functional coupling in supersensitivity to angiotensin II in diabetic rats. Cardiovasc Res 65:374-386.
4. Brown JS, Wessells H, Chancellor MB, Howards SS, Stamm WE, Stapleton AE, Steers WD, Van Den Eeden SK, and McVary KT (2005) Urologic complications of diabetes. Diabetes Care 28:177-185.