Anti-inflammatory and anti-angiogenic effects of flavonoids isolated from Lycium barbarum Linnaeus on human umbilical vein endothelial cells

Food and Function

Volumn 3, Issue 10, 2012, Pages 1068-1081

  Wu, Wen Bin ^a   Hung, Dian Kun ^b   Chang, Fung Wei ^c   Ong, Eng Thaim ^d   Chen, Bing Huei ^a,b  

^a FU JEN CATHOLIC UNIVERSITY   (Taiwan)

^b FU JEN CATHOLIC UNIVERSITY   (Taiwan)

^c TRI SERVICE GENERAL HOSPITAL   (Taiwan)

^d CATHAY GENERAL HOSPITAL   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

CELL ADHESION; CELL PROLIFERATION; DEIONIZED WATER; ENDOTHELIAL CELLS; ETHANOL; FATTY ACIDS; METHANOL; PHENOLS; PHOSPHORYLATION;

ACIDIC FRACTION; ANGIOGENESIS; ANTI-INFLAMMATORIES; CAFFEIC ACIDS; CHLOROGENIC ACIDS; CYTOSOLS; EXTRACELLULAR MATRICES; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; INTERCELLULAR ADHESION MOLECULE-1; LYCIUM BARBARUM; NEUTRAL FRACTIONS; P-COUMARIC ACID; QUINIC ACIDS; REACTIVE OXYGEN SPECIES; RT-PCR ANALYSIS; TRADITIONAL CHINESE MEDICINE; VASCULAR CELL ADHESION; VASCULAR ENDOTHELIAL GROWTH FACTOR;

FLAVONOIDS;

LYCIUM BARBARUM;

ANGIOGENESIS INHIBITOR; ANTIINFLAMMATORY AGENT; FLAVONOID; I KAPPA B KINASE; ICAM1 PROTEIN, HUMAN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERCELLULAR ADHESION MOLECULE 1; MESSENGER RNA; PLANT EXTRACT; REACTIVE OXYGEN METABOLITE; TUMOR NECROSIS FACTOR ALPHA; VASCULAR CELL ADHESION MOLECULE 1;

ARTICLE; CELL ADHESION; CELL MOTION; CELL PROLIFERATION; CHEMISTRY; DRUG EFFECT; GENETICS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; LYCIUM; METABOLISM; METHODOLOGY; PHOSPHORYLATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; UMBILICAL VEIN ENDOTHELIAL CELL; WESTERN BLOTTING;

ANGIOGENESIS INHIBITORS; ANTI-INFLAMMATORY AGENTS; BLOTTING, WESTERN; CELL ADHESION; CELL MOVEMENT; CELL PROLIFERATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; FLAVONOIDS; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; I-KAPPA B KINASE; INTERCELLULAR ADHESION MOLECULE-1; LYCIUM; NF-KAPPA B; PHOSPHORYLATION; PLANT EXTRACTS; REACTIVE OXYGEN SPECIES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SIGNAL TRANSDUCTION; TUMOR NECROSIS FACTOR-ALPHA; VASCULAR CELL ADHESION MOLECULE-1;

EID: 84867013363     PISSN: 20426496     EISSN: 2042650X     Source Type: Journal    
DOI: 10.1039/c2fo30051f     Document Type: Article

References (34)

1. T. Finkel N. J. Holbrook Oxidants, oxidative stress and the biology of aging Nature 2000 408 239 247
2. C. K. Glass J. L. Witztum Atherosclerosis, the road ahead Cell 2001 104 503 516
3. R. Stocker J. F. Keaney Jr. Role of oxidative modifications in atherosclerosis Physiol. Rev. 2004 84 1381 1478 (Pubitemid 39302636)
4. M. H. Pan C. S. Lai C. T. Ho Anti-inflammatory activity of natural dietary flavonoids Food Funct. 2010 1 15 31
5. I. Kronzon P. A. Tunick Aortic atherosclerotic disease and stroke Circulation 2006 114 63 75 (Pubitemid 44305276)
6. G. Rajashekhar A. Willuweit C. E. Patterson P. Sun A. Hilbig G. Breier A. Helisch M. Clauss Continuous endothelial cell activation increases angiogenesis: evidence for the direct role of endothelium linking angiogenesis and inflammation J. Vasc. Res. 2006 43 193 204 (Pubitemid 43248001)
7. S. Kobayashi N. Inoue H. Azumi T. Seno K. Hirata S. Kawashima Y. Hayashi H. Itoh H. Yokozaki M. Yokoyama Expressional changes of the vescular antioxidant system in atherosclerotic coronary arteries J. Atheroscler. Thromb. 2002 9 184 190
8. T. Kondo M. Hirose K. Kageyama Roles of oxidative stress and redox regulation in atherosclerosis J. Atheroscler. Thromb. 2009 16 532 538
9. S. H. Ganji S. Qin L. Zhang V. S. Kamanna M. L. Kashyap Niacin inhibits vascular oxidative stress, redox-sensitive genes, and monocyte adhesion to human aortic endothelial cells Atherosclerosis 2009 202 68 75
10. R. C. Chang K. F. So Use of anti-aging herbal medicine, Lycium barbarum, against aging-associated diseases. What do we know so far? Cell. Mol. Neurobiol. 2008 28 643 652 (Pubitemid 351905068)
11. K. T. Ha S. J. Yoon D. Y. Choi D. W. Kim J. K. Kim C. H. Kim Protective effect of Lycium Chinese fruit on carbon tetrachloride-induced hepatotoxicity J. Ethnopharmacol. 2005 96 529 535
12. B. S. Inbaraj H. Lu T. H. Kao B. H. Chen Simultaneous determination of phenolic acids and flavonoids in Lycium barbarum Linnaeus by HPLC-DAD-ESI-MS J. Pharm. Biomed. Anal. 2010 51 549 556
13. C. C. Wang S. C. Chang B. S. Inbaraj B. H. Chen Isolation of carotenoids, flavonoids and polysaccharides from Lycium barbarum L. and evaluation of antioxidant activity Food Chem. 2010 120 184 192
14. J. Y. Qian D. Liu A. G. Huang The efficiency of flavonoids in polar extracts of Lycium Chinese Mill fruit as free radical scavenger Food Chem. 2004 87 283 288 (Pubitemid 38581906)
15. H. J. Chen B. S. Inbaraj B. H. Chen Determination of phenolic acids and flavonoids in Taraxacum formosanum Kitam by liquid chromatography-tandem mass spectrometry coupled with a post-column derivatization technique Int. J. Mol. Sci. 2012 13 260 285
16. T. S. Chi S. F. Lee C. P. Wu R. Chu Y. F. Yang L. J. Chang H. P. Yang Chemical composition in Lycium barbarum fruit and Lycium barbarum juice Chinese Medicinal Herb Bulletin (in Chinese) 1986 3 41 43
17. Z. Zhou M. C. Connell D. J. MacEwan TNFR1-induced NF-kappaB, 107 but not ERK, p38MAPK or JNK activation, mediates TNF-induced ICAM-1 and VCAM-1 expression on endothelial cells Cell. Signalling 2007 19 1238 1248 (Pubitemid 46561561)
18. C. C. Chen M. P. Chow W. C. Huang Y. C. Lin Y. J. Chang Flavonoids inhibit tumor necrosis factor-alpha-induced up-regulation of intercellular adhesion molecule-1 (ICAM-1) in respiratory epithelial cells through activator protein-1 and nuclear factor-kappaB: structure-activity relationships Mol. Pharmacol. 2004 66 683 693
19. S. Shankar Q. Chen R. K. Srivastava Inhibition of PI3K/AKT and MEK/ERK pathways act synergistically to enhance antiangiogenic effects of EGCG through activation of FOXO transcription factor Journal of Molecular Signaling 2008 3 1 7
20. J. Mojzis L. Varinska G. Mojzisova I. Kostova L. Mirossay Antiangiogenic effects of flavonoids and chalcones Pharmacol. Res. 2008 57 259 265
21. D. A. Calderwood S. J. Shattil M. H. Ginsberg Integrins and Actin Filaments: Reciprocal Regulation of Cell Adhesion and Signaling J. Biol. Chem. 2000 275 22607 22610 (Pubitemid 30646138)
22. W. T. Gerthoffer Mechanisms of vascular smooth muscle cell migration Circ. Res. 2007 100 607 621 (Pubitemid 46594875)
23. M. Vandermeeren S. Janssens M. Borgers J. Geysen Dimethylfumarate is an inhibitor of cytokine-induced E-selectin, VCAM-1, and ICAM-1 expression in human endothelial cells Biochem. Biophys. Res. Commun. 1997 234 19 23 (Pubitemid 27267523)
24. A. Ludwig M. Lorenz N. Grimbo F. Steinle S. Meiners C. Bartsch K. Stangl G. Baumann V. Stangl The tea flavonoid epigallocatechin-3-gallate reduces cytokine-induced VCAM-1 expression and monocyte adhesion to endothelial cells Biochem. Biophys. Res. Commun. 2004 316 659 665 (Pubitemid 38368003)
25. J. S. Choi Y. J. Choi S. H. Park J. S. Kang Y. H. Kang Flavones migrate 90 tumor necrosis factor-alpha-induced adhesion molecule upregulation in cultured human endothelial cells: role of nuclear factor-kappa B J. Nutr. 2004 134 1013 1019
26. A. S. Baldwin Jr. The NF-kappa B and I Kappa B proteins: new discoveries and insights Ann. Rev. Immunol. 1996 14 649 683 (Pubitemid 26130197)
27. R. Khurana M. Simons J. F. Martin I. C. Zachary Role of angiogenesis in cardiovascular disease: a critical appraisal Circulation 2005 112 1813 1824 (Pubitemid 41368158)
28. F. L. Celletti J. M. Waugh P. G. Amabile A. Brendolan P. R. Hilfiker M. D. Dale Vascular endothelial growth factor enhances atherosclerotic plaque progression Nat. Med. 2001 7 425 429 (Pubitemid 32298544)
29. M. J. Karkkainen T. V. Petrova Vascular endothelial growth factor receptors in the regulation of angiogenesis and lymphangiogenesis Oncogene 2000 19 5598 5605
30. I. Zachary G. Gliki Signaling transduction mechanisms mediating biological actions of the vascular endothelial growth factor family Cardiovasc. Res. 2001 49 568 581 (Pubitemid 32146420)
31. R. I. Kirk M. R. Sanderson K. M. Lerea Threonine phosphorylation of the beta 3 integrin cytoplasmic tail, at a site recognized by PDK1 and Akt/PKB in vitro, regulates Shc binding J. Biol. Chem. 2000 275 30901 30906
32. M. Morales-Ruiz D. Fulton G. Sowa L. R. Languino Y. Fujio K. Walsh W. C. Sessa Vascular endothelial growth factor-stimulated actin reorganization and migration of endothelial cells is regulated via the serine/threonine kinase Akt Circ. Res. 2000 86 892 896 (Pubitemid 30246987)
33. H. Amagase N. Farnsworth A review of botanical characteristics, phytochemistry, clinical relevance in efficacy and safety of Lycium barbarum fruit (Goji) Food Res. Int. 2011 44 1702 1717
34. W. Zhang, Receipe of wolfberry fruit and shredded meat and specially prepared black soybean (Fazhi Heidou). In Chinese Medicated Diet, E. Zhang (Ed.), Publishing House of Shanghai College of Traditional Chinese Medicine, Shanghai, China, 1988, p.634-636