Novel formulation of glycerin 1% artificial tears extends tear film break-up time compared with systane lubricant eye drops

Journal of Ocular Pharmacology and Therapeutics

Volumn 28, Issue 5, 2012, Pages 473-478

  Gensheimer, William G ^a   Kleinman, David M ^a,b   Gonzalez, Mithra O ^c   Sobti, Deepak ^d   Cooper, Eugene R ^b   Smits, Gerard ^e   Loxley, Andrew ^f   Mitchnick, Mark ^f   Aquavella, James V ^a  

^a UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

^b Eyeon Therapeutics Inc   (United States)

^c UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF ROCHESTER SCHOOL OF MEDICINE AND DENTISTRY   (United States)

^e Computer and Statistical Consultants Inc ^*  (United States)

^f Particle Sciences Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTIFICIAL TEAR; EMOLLIENT AGENT; EXCIPIENT; EYE DROPS; EYEON PROTECT; FLUORESCEIN; GLYCEROL; LUBRICATING AGENT; MACROGOL; POLYLYSINE; POLYMER; PROPYLENE GLYCOL; SYSTANE; UNCLASSIFIED DRUG;

ADULT; ARTICLE; ASYMPTOMATIC DISEASE; BREAK UP TIME; CLINICAL ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; DISEASE SEVERITY; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG FORMULATION; DRUG SAFETY; DRY EYE; EXPLORATORY RESEARCH; FEMALE; FLOW MEASUREMENT; HUMAN; MALE; OUTCOME ASSESSMENT; PARAMETERS; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; SHEAR STRESS; TEAR FILM; VISCOSITY;

ADULT; DOUBLE-BLIND METHOD; DRY EYE SYNDROMES; EXCIPIENTS; FEMALE; GLYCEROL; HUMANS; LUBRICATION; MALE; OPHTHALMIC SOLUTIONS; POLYETHYLENE GLYCOLS; POLYLYSINE; PROSPECTIVE STUDIES; SEVERITY OF ILLNESS INDEX; TEARS; TIME FACTORS; TREATMENT OUTCOME;

EID: 84866991393     PISSN: 10807683     EISSN: 15577732     Source Type: Journal    
DOI: 10.1089/jop.2011.0053     Document Type: Article

References (30)

1. Montés-Micó, R. Role of the tear film in the optical quality of the human eye. J. Cataract Refract. Surg. 33:1631-1635, 2007.
2. Wang, J., Aquavella, J., Palakuru, J., Chung, S., and Feng, C. Relationships between central tear film thickness and tear menisci of the upper and lower eyelids. Invest. Ophthalmol. Vis. Sci. 47:4349-4355, 2006.
3. Pflugfelder, S.C., Solomon, A., and Stern, M.E. The diagnosis and management of dry eye: a twenty-five-year review. Cornea. 19:644-649, 2000.
4. Argüeso, P., Herreras, J.M., Calonge, M., Citores, L., Pastor, J.C., and Girbés, T. Analysis of human ocular mucus: effects of neuraminidase and chitinase enzymes. Cornea. 17:200-207, 1998.
5. [No authors listed]. The definition and classification of dry eye disease: report of the Definition and Classification Subcommittee of the International Dry Eye Workshop (2007). Ocul. Surf. 5:75-92, 2007.
6. Bron AJ. Diagnosis of dry eye. Surv. Ophthalmol. 45 Suppl 2:S221-S226, 2001.
7. [No authors listed]. The epidemiology of dry eye disease: report of the Epidemiology Subcommittee of the International Dry Eye Workshop (2007). Ocul. Surf. 5:93-107, 2007.
8. Schaumberg, D.A., Sullivan, D.A., Buring, J.E., and Dana, M.R. Prevalence of dry eye syndrome among US women. Am. J. Ophthalmol. 136:318-326, 2003.
9. Gayton, J.L. Etiology, prevalence, and treatment of dry eye disease. Clin. Ophthalmol. 3:405-412.
10. O'Brien, P.D., and Collum, L.M. Dry eye: diagnosis and current treatment strategies. Curr. Allergy Asthma Rep. 4:314-319, 2004.
11. Nichols, K.K., Mitchell, G.L., and Zadnik, K. The repeatability of clinical measurements of dry eye. Cornea. 23:272-285, 2004.
12. Mengher, L.S., Bron A.J., Tonge, S.R., and Gilbert, D.J. Effect of fluorescein instillation on the pre-corneal tear film stability. Curr. Eye Res. 4:9-12, 1985.
13. Nichols, J.J., Nichols, K.K., Puent, B., Saracino, M., and Mitchell, G.L. Evaluation of tear film interference patterns and measures of tear break-up time. Optom. Vis. Sci. 79:363-369, 2002.
14. Ousler, G.W., Michaelson, C., and Christensen, M.T. An evaluation of tear film breakup time extension and ocular protection index scores among three marketed lubricant eye drops. Cornea. 26:949-952, 2007.
15. Simmons, P.A., and Vehige, J.G. Clinical performance of a mid-viscosity artificial tear for dry eye treatment. Cornea. 26:294-302, 2007.
16. Paugh, J.R., Nguyen, A.L., Huang, P., and Hwang, J.S. Retention and retention of effect of topical formulations in dry eye subjects. Optom. Vis. Sci. 85:873-879, 2008.
17. Prabhasawat, P., Tesavibul, N., and Kasetsuwan, N. Performance profile of sodium hyaluronate in patients with lipid tear deficiency: randomised, double-blind, controlled, exploratory study. Br. J. Ophthalmol. 91:47-50, 2007.
18. Snibson, G.R., Greaves, J.L., Soper, N.D., Tiffany, J.M., Wilson, C.G., and Bron A.J. Ocular surface residence times of artificial tear solutions. Cornea. 11:288-293, 1992.
19. Zhu, H., and Chauhan, A. Effect of viscosity on tear drainage and ocular residence time. Optom. Vis. Sci. 85:715-725, 2008.
20. Food and Drug Administration, HHS. Part 349-Ophthalmic Drug Products for Over-The-Counter Human Use. Available at www.accessdata.fda.gov/scripts/cdrh/ cfdocs/cfcfr/CFRSearch.cfm?CFRPart = 349&showFR = 1. Accessed February 20, 2012.
21. Pasche, S., De Paul, S.M., Vörös, J., Spencer, N.D., and Textor, M. Poly(l-lysine)-graft-poly(ethylene glycol) assembled monolayers on niobium oxide surfaces: a quantitative study of the influence of polymer interfacial architecture on resistance to protein absorption by ToF-SIMS and in situ OWLS. Langmuir. 19:9216-9225, 2003.
22. Huang, N.-P., Michel, R., Voros, J., Textor, M., Hofer, R., Rossi, A., Elbert, D.L., Hubbell, J.A., and Spencer, N.D. Poly(l-lysine)-g-poly(ethylene glycol) layers on metal oxide surfaces: surface-analytical characterization and resistance to serum and fibrinogen adsorption. Langmuir. 17:489-498, 2001.
23. VandeVondele, S., Voros, J., Hubell, J.A. RGD-grafted polyl-lysine-graft-(polyethylene glycol) copolymers block nonspecific protein adsorption while promoting cell adhesion. Biotechnol. Bioeng. 82:784-790, 2003.
24. Hansson, K.M., Tosatti, S., Isaksson, J., Wetterö, J., Textor, M., Lindahl, T.L., and Tengvall, P. Whole blood coagulation on protein adsorption-resistant PEG and peptide functionalised PEG-coated titanium surfaces. Biomaterials. 26:861-872, 2005.
25. Harris, L.G., Tosatti, S., Wieland, M., Textor, M., and Richards, R.G. Staphylococcus aureus adhesion to titanium oxide surfaces coated with non-functionalized and peptidefunctionalized poly(L-lysine)-grafted- poly(ethylene glycol) copolymers. Biomaterials. 25:4135-4148, 2004.
26. Billinger, M., Buddeberg, F., Hubbell, J.A., Elbert, D.L., Schaffner, T., Mettler, D., Windecker, S., Meier, B., Otto M. Hess, O.M. Polymer stent coating for prevention of neointimal hyperplasia. J. Invasive Cardiol. 18:423-426, 2006.
27. Wilson, J.T., Krishnamurthy, V.R., Cui, W., Qu, Z., and Chaikof, E.L. Noncovalent cell surface engineering with cationic graft copolymers. J. Am. Chem. Soc. 131:18228-18229, 2009.
28. Drobek, T., and Spencer, N.D. Nanotribology of surfacegrafted PEG layers in an aqueous environment. Langmuir. 24:1484-1488, 2008.
29. Nalam, P.C., Clasohm, J.N., Mashaghi,A, and Spencer, N.D. Macrotribological studies of poly(l-lysine)-graft-poly(ethylene glycol) in aqueous glyercol mixtures. Tribol. Lett. 37:541-552, 2010.
30. Foulks, G.N. Clinical evaluation of the efficacy of PEG/PG lubricant eye drops with gelling agent (HP-Guar) for the relief of the signs and symptoms of dry eye disease: a review. Drugs Today. 43:887-896, 2007.