Clinical evaluation of the efficacy of PEG/PG lubricant eye drops with gelling agent (HP-Guar) for the relief of the signs and symptoms of dry eye disease: A review

Drugs of Today

Volumn 43, Issue 12, 2007, Pages 887-896

  Foulks, Gary N ^a,b  

^a UNIVERSITY OF KENTUCKY   (United States)

^b UNIVERSITY OF LOUISVILLE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADVANCED EYE RELIEF; ARTIFICIAL TEAR; BENZALKONIUM CHLORIDE; BION; BION TEARS; CARBOXYMETHYLCELLULOSE; CEVIMELINE; CYCLOSPORIN; CYCLOSPORIN A; DEXTRAN; EYE DROPS; GELLING AGENT; GENTEAL; GENTEAL PF; GLYCEROL; HYDROXYPROPYLENE GUAR; HYDROXYPROPYLMETHYLCELLULOSE; MACROGOL 400; MURINE TEARS; OPTIVE; PILOCARPINE; POLYVINYL ALCOHOL; POVIDONE; PROPYLENE GLYCOL; REFRESH CELLUVISC; REFRESH ENDURA; REFRESH LIQUIGEL; REFRESH TEARS; SOOTHE; SYSTANE; TEARS NATURALE; TEARS NATURALE FORTE; TEARS NATURALE FREE; TETRYZOLINE; THERATEARS; UNCLASSIFIED DRUG; VISINE TEARS;

BLURRED VISION; CLINICAL EVALUATION; CLINICAL FEATURE; CLINICAL TRIAL; COMBINATION CHEMOTHERAPY; CORNEA EPITHELIUM; COST EFFECTIVENESS ANALYSIS; DRUG COST; DRUG EFFICACY; DRUG FORMULATION; DRY EYE; EYE EXAMINATION; EYE SURGERY; GEL; HUMAN; NONHUMAN; PUNCTAL OCCLUSION; REVIEW; SCHIRMER TEST; TEAR FILM;

CONJUNCTIVA; CORNEA; DRY EYE SYNDROMES; GALACTANS; GELS; HUMANS; LUBRICANTS; MANNANS; OPHTHALMIC SOLUTIONS; PLANT GUMS; POLYETHYLENE GLYCOLS; PROPYLENE GLYCOLS;

EID: 38549107876     PISSN: 16993993     EISSN: 16994019     Source Type: Journal    
DOI: 10.1358/dot.2007.43.12.1162080     Document Type: Review

References (43)

1. Fouiks, G.N. What is dry eye and what does it mean to contact lens wearer? Eye Contact Lens 2003, 29(1S): S96-S100.
2. Behrens, A., Doyle, J.J., Stern, L., et al. Dysfunctional tear syndrome a delphi approach to treatment recommendations. Cornea 2006, 25(8): 900-7.
3. International Dry Eye Workshop (DEWS). Ocul Surface 2007, 5(2): 75-92.
4. Schaumberg, D.A., Sullivan, D. A., Buring, J.E., Dana, M.R. Prevalence of dry eye syndrome among US women. Am J Ophthalmol 2003, 136(2): 318-26.
5. Fox, R.I., Howell, H.V., Bone, R.C., et al. Primary Sjögren's syndrome: clinical and immunopathologic features. Semin Arthritis Rheumatol 1984, 14: 77-105.
6. Lin, P.I., Tsai, S.Y., Cheng, C.Y., et al. Prevalence of dry eye among an elderly Chinese population in Taiwan: The Shihpai eye study. Ophthalmology 2003, 110: 1096-101.
7. Schein, O.D., Munoz, B., Tielsvh, J.M., Bandeen-Roche, K., West, S. Prevalence of dry eye among the elderly. Am J Ophthalmol 1997, 124(6): 723-8.
8. Moss, S. E., Klein, R., Klein, B.E.K. Incidence of dry eye in an older population. Arch Ophthalmol 2004, 122: 369-73.
9. Moss, S.E., Klein, R., Klein, B.E. Prevalence of and risk factors for dry eye syndrome. Arch Ophthalmol 2000, 118: 1264-8.
10. th ed. Blackstone Co.: New York 1954, 20-34.
11. Dilly, P.N. Structure and function of the tear film. Adv Exp Med Biol 1994, 350: 239-47.
12. Foulks, G.N. Determinants of Tearfilm Stability American Academy of Ophthalmology Annual Meeting (October 15-18, Chicago) 2005, The Castroviejo Lecture.
13. Sires, B.S., Lemke, B.N., Kincaid, M.C. Orbital and ocular anatomy. In: K. S. Wright (Ed.). Textbook of ophthalmology. Williams & Wilkins: Baltimore 1997, 3-54.
14. Terry, M.A. Dry eye in the elderly. Drugs Aging 2001, 18(2): 101-7.
15. Stern, M.E., Beuerman, R.W., Fox, R.I. The pathology of dry eye: the interaction between the ocular surface and the ocular glands. Cornea 1998, 17: 584-9.
16. Wilson, M.W., Dailey, R.A. Eyelid malposition. In: G.A. Cioffi (Ed.). The Devers manual: ophthalmology for the health care professional. Williams & Wilkins: Baltimor 1997, 27-35.
17. Murillo-Lopez, F., Pflugfelder, S.C. Dry eye. In: J.H. Krachmer, M.J. Mannis, Holland (Eds.). Cornea. Mosby Year Book: St. Louis 1997, 663-86.
18. Hartstein, I., Khwarg, S., Przydryga, J. An open-label evaluation of HP-Guar gellable lubricant eye drops for the improvement of dry eye signs and symptoms in a moderate dry eye adult population. Curr Med Res Opinion 2005, 21(2): 255-60.
19. Christensen, M.T., Cohen, S., Rinehart, J., et al. Clinical evaluation of an HP-Guar gellable lubricant eye drop for the relief of dryness of the eye. Curr Eye Res 2004, 28(1): 55-62.
20. Begley, C.G., Caffery, B., Chalmers, R.L., Mitchell, G.L. Use of dry eye questionnaire to measure symptoms of ocular irritationin subjects withwith aqueous tear deficient dry eye. Cornea 2002, 21(7): 664-70.
21. Perry, H.D., Donnenfeld, E.D. Dry eye diagnosis and management in 2004. Curr Opin Ophthalmol 2004, 15: 299-304.
22. Barabino, S., Chen, W., Dana, M.R. Tear film and ocular surface tests in animal models of dry eye: uses and limitations. Exp Eye Res 79: 613-21.
23. Macri, A. Pflugfelder, S. Correlation of the Schirmer 1 and fluorescein clearance test with the severity of corneal epithelial and eyelid disease. Arch Ophthalmol 2000, 118: 1632-8.
24. Fahim, M.M., Haji, S., Koonapareddy, C.V., Fan, V.C., Asbell, P.A. Fluorophotometry as a diagnostic tool for the evaluation of dry eye disease. BMC Ophthalmol 2006, 6: 20.
25. Turner, A.W., Layton, C.J., Bron, A.J. Survey of eye practitioners' attitudes towards diagnostic tests and therapies for dry eye disease. Clin Exper Ophthalmolo 2005, 33: 351-5.
26. Restasis® Package Insert.
27. Göbbels, M., Spitznas, M. influence of artificial tears on corneal epithelium in dry-eye syndrome. Graefe's Arch Clin Exp Ophthalmol 1989, 227: 139-41.
28. Bernal, D.L., Ubels, J.L. Quantitative evaluation of the corneal epithelial barrier: effect of artificial tears and preservatives. Curr Eye Res 1991, 10(7): 645-56.
29. Berdy, G.J. Abelson, M.B., Smith, L.M., George, M.A. Preservative-free artificial tear preparations. Arch Ophthalmol 1992, 110: 528-32.
30. Yamada, M., Mochizuki, H., Kawai, M., Yoshino, M., Mashima, Y. Fluorophotometric measurement of pH of human tears in vivo. Curr Eye Res 1997, 16: 482-486.
31. Meyer, A.E. Tissue-on-tissue testing of dry eye formulations for reduction of bioadhesion. J Adhe 2006, 82: 607-27.
32. Gifford, P. Evans, B.J.W., Morris, J. Evaluation of Systane. Contact Lens Ant Eye 2006, 29: 31-40.
33. Asgharian, b. Nolen, L., Meadows, D., et al. Novel gel-forming ophthalmic polymer system for artificial tear solution. Ass Res Vis Ophthalmol (May 4-9, Ft. Lauderdale) 2003, Abst 2472.
34. Korb, D.R., Herman, J.P., Greiner, J.V. et al. Lid wiper epitheliopathy and dry eye symptoms. Eye & Contact Lens 2005, 31(1): 2-8.
35. Korb, D.R., Greiner, J.V., Herman, J.P., Herbert, E., Finnemore, V.M., Exford, J.M., Glonel, T., Olson, M.C. Lid-wiper epitheliopathy and dry-eye symptoms in contact lens wearer. CLAO J 2002, 28(4): 211-6.
36. Ubels, J.L., Clousing, D.P., van Haitsma, T.A., Hong, B.S., Stauffer, P., Asgharian, B., Meadows, D. Pre-clinical investigation of the efficacy of an artificial tear solution containing hudroxypropyl-guar as a gelling agent. Curr Eye Res 2004, 28(6): 437-44.
37. Ousler, G.W., Michaelson, C., Christensen, M.T. An Evaluation of Tear Film Break-up Time Extension and Ocular Protection Index Scores between Three Marketed Lubricant Eye Drops. Cornea 2007, 26(8): 949-52.
38. Guillon, M., Chamberlain, P., Marks, M.G., Stein, J.M. Effect of eye drop composition characteristics on tear film. Invest Ophthalmol Vis Sci 2004, 45 E-Abstr. 3878.
39. D'Aienzo, P., Ousler III, G.W., Schindelar, M.R. A comparison of two marketed artificial tears in improvement of tear film stability as measured by tear film break-up time (TFBUT) and ocular protection and ocular protection index (OPI). Tear Film and Ocular Surface Society. (September 5-8, Taormina) 2007, Poster.
40. Sall, K.N., Cohen, S.M. An evaluation of the efficacy of cyclosporine-based dry eye therapy when used with marketed artificial tears as supportive therapy in dry eye. Eye & Contact Lens 2006, 32(1): 21-6.
41. Lemp, M. A. Report of the National Eye Institute/Industry Workshop on Clinical Trials in Dry Eyes. CLAO J 1995, 21(4): 221-32.
42. Reddy, P., Grad, O., Rajagopalan, K. The economic burden of dry eye: A conceptual framework and preliminary assessment. Cornea 2004, 23(8): 751-61.
43. Wlodarczyk, J., Fairchild, C. The cost-effectiveness of Systane® in the treatment of Dry Eye. In preparation. Submitted to Value in Health, October 2007.