Effect of viscosity on tear drainage and ocular residence time

Optometry and Vision Science

Volumn 85, Issue 8, 2008, Pages

  Zhu, Heng ^a   Chauhan, Anuj ^a  

^a J Crayton Pruitt Family Department of Biomedical Engineering   (United States)

Author keywords

Canaliculi; Model; Shear thinning; Tear balance; Tear drainage; Viscosity

Indexed keywords

ARTIFICIAL TEARS; CANALICULI; CRITICAL VALUE; DRAINAGE RATE; DRY EYE; EXPERIMENTAL DATA; EXPERIMENTAL OBSERVATION; EXPERIMENTAL STUDIES; EYE DROPS; MASS BALANCE; NEWTONIAN FLUIDS; NON-NEWTONIAN FLUIDS; POWER LAW FLUID; POWER-LAW; RESIDENCE TIME; RHEOLOGICAL PARAMETER; SHEAR-THINNING; TEAR BALANCE; TEAR DRAINAGE; THERAPEUTIC BENEFITS;

BIOCHEMISTRY; COMPUTER SIMULATION; FLOW MEASUREMENT; FLUID DYNAMICS; FLUIDS; HYDRAULIC MODELS; MACHINE DESIGN; NEWTONIAN LIQUIDS; NON NEWTONIAN FLOW; RHEOLOGY; TRANSIENTS; VISCOSITY; VISCOUS FLOW;

MATHEMATICAL MODELS;

AQUEOUS HUMOR; ARTICLE; BIOAVAILABILITY; EXPERIMENTAL STUDY; EYE; FLOW KINETICS; LACRIMAL DUCT; LACRIMAL FLUID; MATHEMATICAL MODEL; MEDICAL LITERATURE; PRIORITY JOURNAL; VISCOSITY; BIOLOGICAL MODEL; CORNEA; DRY EYE; HUMAN; MATHEMATICS; METABOLISM; OSMOLARITY; TIME;

EYE DROPS;

BIOLOGICAL AVAILABILITY; CORNEA; DRY EYE SYNDROMES; HUMANS; MATHEMATICS; MODELS, BIOLOGICAL; OPHTHALMIC SOLUTIONS; OSMOLAR CONCENTRATION; TEARS; TIME FACTORS; VISCOSITY;

EID: 52049090878     PISSN: 10405488     EISSN: None     Source Type: Journal    
DOI: 10.1097/OPX.0b013e3181824dc4     Document Type: Article

References (26)

1. Maurice DM. The dynamics and drainage of tears. Int Ophthalmol Clin 1973;13:103-16.
2. Snibson GR, Greaves JL, Soper ND, Prydal JI, Wilson CG, Bron AJ. Precorneal residence times of sodium hyaluronate solutions studied by quantitative gamma scintigraphy. Eye 1990;4(Pt 4):594-602.
3. Yokoi N, Komuro A. Non-invasive methods of assessing the tear film. Exp Eye Res 2004;78:399-407.
4. Meadows DL, Paugh JR, Joshi A, Mordaunt J. A novel method to evaluate residence time in humans using a nonpenetrating fluorescent tracer. Invest Ophthalmol Vis Sci 2002;43:1032-9.
5. Zaki I, Fitzgerald P, Hardy JG, Wilson CG. A comparison of the effect of viscosity on the precorneal residence of solutions in rabbit and man. J Pharm Pharmacol 1986;38:463-6.
6. Doane MG. Blinking and the mechanics of the lacrimal drainage system. Ophthalmology 1981;88:844-51.
7. Zhu H, Chauhan A. A mathematical model for tear drainage through the canaliculi. Curr Eye Res 2005;30:621-30.
8. Snibson GR, Greaves JL, Soper ND, Tiffany JM, Wilson CG, Bron AJ. Ocular surface residence times of artificial tear solutions. Cornea 1992;11:288-93.
9. Greaves JL, Wilson CG, Birmingham AT. Assessment of the precor-neal residence of an ophthalmic ointment in healthy subjects. Br J Clin Pharmacol 1993;35:188-92.
10. Paugh JR, Chatelier RC, Huff JW. Ocular residence time of car-boxymethylcellulose solutions. Adv Exp Med Biol 1998;438:761-7.
11. Zhu H, Chauhan A. A mathematical model for ocular tear and solute balance. Curr Eye Res 2005;30:841-54.
12. Wong H, Fatt II, Radke CJ. Deposition and Thinning of the Human Tear Film. J Colloid Interface Sci 1996;184:44-51.
13. Yokoi N, Bron AJ, Tiffany JM, Maruyama K, Komuro A, Kinoshita S. Relationship between tear volume and tear meniscus curvature. Arch Ophthalmol 2004;122:1265-9.
14. Yokoi N, Bron A, Tiffany J, Brown N, Hsuan J, Fowler C. Reflective meniscometry: a non-invasive method to measure tear meniscus curvature. Br J Ophthalmol 1999;83:92-7.
15. Jones LT. Epiphora. II. Its relation to the anatomic structures and surgery of the medial canthal region. Am J Ophthalmol 1957;43: 203-12.
16. Jones LT. Anatomy of the tear system. Int Ophthalmol Clin 1973; 13:3-22.
17. Pandit JC, Nagyova B, Bron AJ, Tiffany JM. Physical properties of stimulated and unstimulated tears. Exp Eye Res 1999;68:247-53.
18. Wilson G, Merrill R. The lacrimal drainage system: pressure changes in the canaliculus. Am J Optom Physiol Opt 1976;53:55-9.
19. Tiffany JM. The viscosity of human tears. Int Ophthalmol 1991;15: 371-6.
20. Mishima S, Gasset A, Klyce SD Jr, Baum JL. Determination of tear volume and tear flow. Invest Ophthalmol 1966;5:264-76.
21. Prausnitz MR, Noonan JS. Permeability of cornea, sclera, and conjunctiva: a literature analysis for drug delivery to the eye. J Pharm Sci 1998;87:1479-88.
22. Watsky MA, Jablonski MM, Edelhauser HF. Comparison of conjunctival and corneal surface areas in rabbit and human. Curr Eye Res 1988;7:483-6.
23. Madsen K, Schenholm M, JahnkeG,Tengblad A.Hyaluronate binding to intact corneas and cultured endothelial cells. Invest Ophthal-mol Vis Sci 1989;30:2132-7.
24. Zhu H, Bhatia S, Chauhan A. Dynamic mechanical properties of porcine lacrimal canaliculus. Curr Eye Res 2007;32:829-35.
25. Podder SK, Moy KC, Lee VH. Improving the safety of topically applied timolol in the pigmented rabbit through manipulation of formulation composition. Exp Eye Res 1992;54:747-57.
26. Keister JC, Cooper ER, Missel PJ, Lang JC, Hager DF. Limits on optimizing ocular drug delivery. J Pharm Sci 1991;80:50-3.