An evaluation of tear film breakup time extension and ocular protection index scores among three marketed lubricant eye drops

Cornea

Volumn 26, Issue 8, 2007, Pages 949-952

  Ousler, George W ^a   Michaelson, Clifford ^b   Christensen, Mike T ^c  

^a ORA Clinical Research and Development   (United States)

^b Andover Eye Associates   (United States)

^c ALCON RESEARCH LTD   (United States)

Author keywords

Artificial tears; Clinical study; Dry eye; Ocular protection index; Tear film breakup time

Indexed keywords

ARTIFICIAL TEAR; CARBOXYMETHYLCELLULOSE; EYE DROPS; MACROGOL; PROPYLENE GLYCOL; REFRESH; SYSTANE; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DISEASE SEVERITY; DOUBLE BLIND PROCEDURE; DRUG EFFECT; DRUG EFFICACY; DRUG SAFETY; DRY EYE; EYE EXAMINATION; EYE PROTECTION; HUMAN; LUBRICATION; OUTCOME ASSESSMENT; PRIORITY JOURNAL; TEAR FILM; TEAR FLOW; UNSPECIFIED SIDE EFFECT; VISUAL ACUITY;

ADULT; AGED; AGED, 80 AND OVER; BLINKING; CARBOXYMETHYLCELLULOSE; CROSS-OVER STUDIES; DOUBLE-BLIND METHOD; DRUG EVALUATION; DRY EYE SYNDROMES; FEMALE; HUMANS; LUBRICANTS; MALE; MIDDLE AGED; OPHTHALMIC SOLUTIONS; POLYETHYLENE GLYCOLS; POLYSACCHARIDES; PROPYLENE GLYCOL; TEARS; TIME FACTORS;

EID: 34548247321     PISSN: 02773740     EISSN: None     Source Type: Journal    
DOI: 10.1097/ICO.0b013e3180de1c38     Document Type: Article

References (24)

1. Stern ME, Beuerman RW, Fox RI, et al. A unified theory of the role of the ocular surface in dry eye. In: Sullivan DA, Dartt DA, Meneray MA, eds. Lacrimal Gland, Tear Film and Dry Eye Syndromes 2. New York: Plenum Press; 1998:643-651.
2. Bron AJ. Diagnosis of dry eye. Surv Ophthalmol. 2001;45(suppl 2):S221-S226.
3. Abelson MB, Lamberts DW, eds. Dry Eye Update. Princeton, NJ: Excerpta Medica; 1983.
4. Abelson MB, Ousler GW III, Nally LA, et al. Alternative reference values for tear film break up time in normal and dry eye populations. Adv Exp Med Biol. 2002;506:1121-1125.
5. Lemp MA, Dohlman CH, Holley FJ. Corneal desiccation despite normal tear volume. Ann Ophthalmol. 1970;284:258-261.
6. Doughty MJ, Fonn D, Richter D, et al. A patient questionnaire approach to estimating the prevalence of dry eye symptoms in subjects presenting to optometric practices across Canada. Optom Vis Sci. 1997;74:624-631.
7. Begley CG, Caffrey B, Chalmers RL, et al. Use of a dry eye questionnaire to measure symptoms of ocular irritation in subjects with aqueous tear deficient dry eye. Cornea. 2002;21:664-670.
8. Donshik PC, Nelson JD, Abelson M, et al. Effectiveness of Bion Tears, Cellufresh, Aquasite, and Refresh Plus for moderate to severe dry eye. In: Sullivan DA, Dartt DA, Meneray MA, eds. Lacrimal Gland, Tear Film and Dry Eye Syndromes 2. New York: Plenum Press; 1998:753-760.
9. Schaumberg DA, Sullivan DA, Dana MR. Epidemiology of dry eye syndrome. In: Sullivan DA, Stern ME, Tsubota K, et al, eds. Lacrimal Gland, Tear Film, and Dry Eye Syndromes 3, Part B. New York: Plenum Press; 2002:989-998.
10. Lemp MA. Epidemiology and classification of dry eye. In: Sullivan DA, Dartt DA, Meneray MA, eds. Lacrimal Gland, Tear Film and Dry Eye Syndromes 2. New York: Plenum Press; 1998:791-803.
11. Caffery BE, Richter D, Simpson T, et al. The Canadian dry eye epidemiology study. In: Sullivan DA, Dartt DA, Meneray MA, eds. Lacrimal Gland, Tear Film and Dry Eye Syndromes 2. New York: Plenum Press; 1998:805-806.
12. O'Brien PD, Collum LM. Dry eye: diagnosis and current treatment strategies. Curr Allergy Asthma Rep. 2004;4:314-319.
13. Kaswan R. Cyclosporine drops: a potential breakthrough for dry eyes. In: Research to Prevent Blindness Science Writers Seminar. New York: Research to Prevent Blindness; 1989:18-20.
14. Lemp MA. Report of the National Eye Institute/Industry workshop on Clinical Trials in Dry Eyes. CLAO J. 1995;21:221-232.
15. Cho P, Brown B. Review of the tear break-up time and a closer look at the tear break-up time of Hong Kong Chinese. Optom Vis Sci. 1993;70:30-38.
16. Scherz W, Doane MG, Dohlman CH. Tear volume in normal eyes and keratoconjunctivitis sicca. Albrecht Von Graefes Arch Klin Exp Ophthalmol. 1974;192:141-150.
17. Dogru M, Tsubota K. New insights into the diagnosis and treatment of dry eye. Ocul Surf. 2004;2:59-75.
18. Ousler GW, Emory TB, Welch D, et al. Factors that influence the interblink interval (IBI) as measured by the ocular protection index (OPI). [e-abstract #56]. Presented at the Association of Research in Vision and Ophthalmology Annual Meeting, May 5-10, 2002, Fort Lauderdale, FL.
19. Abelson MB. Tear substitutes. In: Albert DM, Jakobiec FA, Azar DT, et al, eds. Principles and Practice of Ophthalmology. 2nd ed. Philadelphia: WB Saunders; 1994:1055-1059.
20. Yamada M, Mochizuki H, Kawai M, et al. Fluorophotometric measurement of pH of human tears in vivo. Curr Eye Res. 1997;16:482-486.
21. Maurice D. The Charles Prentice Award lecture 1989: the physiology of tears. Optom Vis Sci. 1990;67:391-399.
22. Gifford P, Evans BJ, Mosrris J. A clinical evaluation of Systane. Cont Lens Anterior Eye. 2006;29:31-40.
23. Christensen MT, Cohen S, Rinehart J, et al. Clinical evaluation of an HP-guar gellable lubricant eye drop for the relief of dryness of the eye. Curr Eye Res. 2004;28:55-62.
24. Korb DR. The Tear Film: Structure, Function and Clinical Examination. Oxford, England: BH/BCLA; 2002.