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7
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0033055316
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Kuhn W., Schmalfeldt B., Reuning U., Pache L., Berger U., Ulm K., Harbeck N., Spathe K., Dettmar P., Hofler H., Janicke F., Schmitt M., and Graeff H. Br. J. Cancer 79 (1999) 1746
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Harbeck, N.7
Spathe, K.8
Dettmar, P.9
Hofler, H.10
Janicke, F.11
Schmitt, M.12
Graeff, H.13
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10
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33645984262
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Kratz F., Warnecke A., Schmid B., Chung D.E., and Gitzel M. Curr. Med. Chem. 13 (2006) 477
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Gitzel, M.5
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11
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0037028050
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Kratz F., Warnecke A., Scheuermann K., Stockmar C., Schwab J., Lazar P., Drückes P., Esser N., Drevs J., Rognan D., Bissantz C., Hinderling C., Folkers G., Fichtner I., and Unger C. J. Med. Chem. 45 (2002) 5523
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Esser, N.8
Drevs, J.9
Rognan, D.10
Bissantz, C.11
Hinderling, C.12
Folkers, G.13
Fichtner, I.14
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12
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0035817258
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Unger, C.7
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13
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0042173127
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Fichtner, I.7
Kratz, F.8
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14
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27644436770
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Kratz F., Mansour A., Soltau J., Warnecke A., Fichtner I., Unger C., and Drevs J. Arch. Pharm. 338 (2005) 462
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Drevs, J.7
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16
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33747368307
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Unger C., Medinger M., Steinbild S., Drevs J., and Häring B. German Cancer Congress, Berlin (2006)
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(2006)
German Cancer Congress, Berlin
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Unger, C.1
Medinger, M.2
Steinbild, S.3
Drevs, J.4
Häring, B.5
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19
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33747352090
-
-
note
-
+, HPLC (495 nm): >95%.
-
-
-
-
20
-
-
33747329418
-
-
note
-
2, pH 5.0, containing 0.1% Brij 35). Homogenization was carried out with a micro-dismemberator at 3000 rpm for 3 min with the aid of glass balls, and the samples were then centrifuged at 5000 rpm for 10 min and kept frozen at -78 °C prior to use.
-
-
-
-
21
-
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33747361080
-
-
note
-
HPLC was performed with a BioLogic Duo Flow System from Bio-Rad (Munich, Germany), which was connected with a Merck F-1050 Fluorescence Spectrophotometer (EX. 490 nm, EM. 540 nm) and a Lambda 1000 visible detector from Bischoff (at λ = 495 nm); UV-detection at 280 nm; column: Waters, 300 Å, Symmetry C18 (4.6 × 250 mm) with precolumn; injection volume: 50 μL.
-
-
-
-
22
-
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33747348525
-
-
note
-
3CN, 30% 4 mM sodium phosphate buffer (pH 3.0); gradient: 0-25 min 100% mobile phase A; 25-40 min increase to mobile phase B; 40-50 min 100% mobile phase B; 50-60 min decrease to initial mobile phase.
-
-
-
-
24
-
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0029073861
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Duffy M.J., Blaser J., Duggan C., McDermott E., O'Higgins N., Fennelly J.J., and Tschesche H. Br. J. Cancer 71 (1995) 1025
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Br. J. Cancer
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Duffy, M.J.1
Blaser, J.2
Duggan, C.3
McDermott, E.4
O'Higgins, N.5
Fennelly, J.J.6
Tschesche, H.7
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27
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0017873119
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-
Zimmerman M., Quigley J.P., Ashe B., Dorn C., Goldfarb R., and Troll W. Proc. Natl. Acad. Sci. U.S.A. 75 (1978) 750
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Proc. Natl. Acad. Sci. U.S.A.
, vol.75
, pp. 750
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Zimmerman, M.1
Quigley, J.P.2
Ashe, B.3
Dorn, C.4
Goldfarb, R.5
Troll, W.6
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28
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0024381362
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Kurtzhals P., Larsen C., Hansen S., Aasmul-Olsen S., and Widmer F. Acta. Pharm. Nord. 1 (1989) 269
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(1989)
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, vol.1
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Kurtzhals, P.1
Larsen, C.2
Hansen, S.3
Aasmul-Olsen, S.4
Widmer, F.5
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29
-
-
33747349817
-
-
note
-
+.
-
-
-
-
30
-
-
33747347636
-
-
note
-
3CN, 30% 20 mM potassium phosphate (pH 7.0); gradient: 0-25 min 100% mobile phase A; 25-40 min increase to mobile phase B; 40-50 min 100% mobile phase B; 50-60 min decrease to initial mobile phase.
-
-
-
-
31
-
-
33747332108
-
-
note
-
-1]. The concentration of 1 in the conjugate was adjusted to 500 ± 50 μM by concentrating the sample with CENTRIPREP-10-concentrators from Amicon, FRG (4 °C and 4500 rpm). Samples were kept frozen at -20 °C and thawed prior to use.
-
-
-
-
32
-
-
33747345731
-
-
note
-
In vivo experiment. For the orientating toxicity study of 1 two female NMRI: nude mice were used. Compound 1 was dissolved in 10 mM sodium phosphate/5% d-glucose buffer, pH 7.0, and was administered at a dose of 3 × 59.95 mg/kg (3 × 24 mg/kg doxorubicin equivalents) by intravenous application to two animals with an interval of 7 days (1th, 8th, and 15th day).
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