Synthesis and antiviral activity of 4,6-disubstituted pyrimido[4,5-b]indole ribonucleosides

Bioorganic and Medicinal Chemistry

Volumn 20, Issue 20, 2012, Pages 6123-6133

  Tichý, Michal ^a   Pohl, Radek ^a   Xu, Hao Ying ^b   Chen, Yen Liang ^b   Yokokawa, Fumiaki ^b   Shi, Pei Yong ^b   Hocek, Michal ^a,c  

^a INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY   (Czech Republic)

^b NOVARTIS INSTITUTE FOR TROPICAL DISEASES   (Singapore)

^c CHARLES UNIVERSITY   (Czech Republic)

Author keywords

Anti dengue virus activity; Nucleosides; Pyrimido 4,5 b indoles; Suzuki and Stille cross coupling

Indexed keywords

3H PYRIMIDO[4,5 B]INDOL 4(9H) ONE; 4 (BENZOFURAN 2 YL) 6 CHLORO 9 (2,3,5 TRI O BENZOYL BETA DEXTRO RIBOFURANOSYL) 9H PYRIMIDO[4,5 B]INDOLE; 4 (BENZOFURAN 2 YL) 6 CHLORO 9 BETA DEXTRO RIBOFURANOSYL 9H PYRIMIDO[4,5 B]INDOLE; 4 (FURAN 2 YL) 6 (FURAN 3 YL) 9 (2,3,5 TRI O BENZOYL BETA DEXTRO RIBOFURANOSYL) 9H PYRIMIDO[4,5 B]INDOLE; 4 (FURAN 2 YL) 6 PHENYL 9 (2,3,5 TRI O BENZOYL BETA DEXTRO RIBOFURANOSYL) 9H PYRIMIDO[4,5 B]INDOLE; 4 (FURAN 2 YL) 9 (2,3,5 TRI O BENZOYL BETA DEXTRO RIBOFURANOSYL) 9H PYRIMIDO[4,5 B]INDOLE; 4 (FURAN 2 YL) 9 BETA DEXTRO RIBOFURANOSYL 9H PYRIMIDO[4,5 B]INDOLE; 4 CHLORO 9 (2,3,5 TRI O BENZOYL BETA DEXTRO RIBOFURANOSYL)PYRIMIDO[4,5 B]INDOLE; 4 CHLORO 9H PYRIMIDO[4,5 B]INDOLE; 4,6 BIS(FURAN 2 YL) 9 (2,3,5 TRI O BENZOYL BETA DEXTRO RIBOFURANOSYL) 9H PYRIMIDO[4,5 B]INDOLE; 4,6 DICHLORO 9 (2,3,5 TRI O BENZOYL BETA DEXTRO RIBOFURANOSYL)PYRIMIDO[4,5 B]INDOLE; 4,6 DICHLORO 9H PYRIMIDO[4,5 B]INDOLE; 4,6 DICHLOROPYRIMIDO[4,5 B]INDOLE RIBONUCLEOSIDE; 4,6 DISUBSTITUTED PYRIMIDO[4,5 B]INDOLE RIBONUCLEOSIDE DERIVATIVE; 6 CHLORO 3H PYRIMIDO[4,5 B]INDOL 4(9H) ONE; 6 CHLORO 4 (FURAN 2 YL) 9 (2,3,5 TRI O BENZOYL BETA DEXTRO RIBOFURANOSYL) 9H PYRIMIDO[4,5 B]INDOLE; 6 CHLORO 4 (FURAN 2 YL) 9 BETA DEXTRO RIBOFURANOSYL 9H PYRIMIDO[4,5 B]INDOLE; 6 CHLORO 4 (FURAN 3 YL) 9 (2,3,5 TRI O BENZOYL BETA DEXTRO RIBOFURANOSYL) 9H PYRIMIDO[4,5 B]INDOLE; 6 CHLORO 4 (FURAN 3 YL) 9 BETA DEXTRO RIBOFURANOSYL 9H PYRIMIDO[4,5 B]INDOLE; 6 CHLORO 4 (THIOPHEN 2 YL) 9 (2,3,5 TRI O BENZOYL BETA DEXTRO RIBOFURANOSYL) 9H PYRIMIDO[4,5 B]INDOLE; 6 CHLORO 4 (THIOPHEN 2 YL) 9 BETA DEXTRO RIBOFURANOSYL 9H PYRIMIDO[4,5 B]INDOLE; 6 CHLORO 4 (THIOPHEN 3 YL) 9 (2,3,5 TRI O BENZOYL BETA DEXTRO RIBOFURANOSYL) 9H PYRIMIDO[4,5 B]INDOLE; 6 CHLORO 4 (THIOPHEN 3 YL) 9 BETA DEXTRO RIBOFURANOSYL 9H PYRIMIDO[4,5 B]INDOLE; 6 CHLORO 4 PHENYL 9 (2,3,5 TRI O BENZOYL BETA DEXTRO RIBOFURANOSYL) 9H PYRIMIDO[4,5 B]INDOLE; ETHYL 2 (2 NITROPHENYL) 2 CYANOACETIC ACID; ETHYL 2 (5 CHLORO 2 NITROPHENYL) 2 CYANOACETIC ACID; ETHYL 2 AMINO 1H INDOLE 3 CARBOXYLIC ACID; ETHYL 2 AMINO 5 CHLORO 1H INDOLE 3 CARBOXYLIC ACID; RIBONUCLEOSIDE DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANTIPROLIFERATIVE ACTIVITY; ANTIVIRAL ACTIVITY; ARTICLE; CONCENTRATION RESPONSE; CROSS COUPLING REACTION; DENGUE VIRUS; DEPROTECTION REACTION; DRUG CYTOTOXICITY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IN VITRO STUDY; PROMYELOCYTIC LEUKEMIA; REPLICON; UTERINE CERVIX CARCINOMA;

ANTIVIRAL AGENTS; CATALYSIS; CELL LINE, TUMOR; CELL PROLIFERATION; DENGUE VIRUS; HEP G2 CELLS; HEPACIVIRUS; HUMANS; INDOLES; PALLADIUM; PYRIMIDINES; RIBONUCLEOSIDES; VIRUS REPLICATION;

DENGUE VIRUS; PHOS;

EID: 84866950720     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2012.08.021     Document Type: Article

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