Ubiquitination and Degradation of the Hominoid-Specific Oncoprotein TBC1D3 Is Mediated by CUL7 E3 Ligase

PLoS ONE

Volumn 7, Issue 9, 2012, Pages

  Kong, Chen ^a   Samovski, Dmitri ^a   Srikanth, Priya ^a,c   Wainszelbaum, Marisa J ^a,d   Charron, Audra J ^a,e   Liu, Jialiu ^a   Lange, Jeffrey J ^a,f   Chen, Pin I ^a,g   Pan, Zhen Qiang ^b   Su, Xiong ^a   Stahl, Philip D ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^c BRIGHAM AND WOMEN S HOSPITAL   (United States)

^d MERRIMACK PHARMACEUTICALS   (United States)

^e DARTMOUTH MEDICAL SCHOOL   (United States)

^f STOWERS INSTITUTE FOR MEDICAL RESEARCH   (United States)

^g STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALKALINE PHOSPHATASE; F BOX PROTEIN; F BOX PROTEIN 8; ONCOPROTEIN; PROTEIN CUL7; PROTEIN TBC1D3; SCAFFOLD PROTEIN; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG;

ARTICLE; COMPLEX FORMATION; CONTROLLED STUDY; ENZYME SUBSTRATE; FETUS; HUMAN; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; PROTEIN DEGRADATION; PROTEIN DETERMINATION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN METABOLISM; PROTEIN PHOSPHORYLATION; PROTEIN PROCESSING; PROTEIN PROTEIN INTERACTION; REGULATORY MECHANISM; TWO HYBRID SYSTEM; UBIQUITINATION;

CULLIN PROTEINS; F-BOX PROTEINS; GTPASE-ACTIVATING PROTEINS; HELA CELLS; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; LEUPEPTINS; PHOSPHORYLATION; PROTEASOME INHIBITORS; PROTEIN BINDING; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEOLYSIS; PROTO-ONCOGENE PROTEINS; TWO-HYBRID SYSTEM TECHNIQUES; UBIQUITIN-PROTEIN LIGASES; UBIQUITINATION;

HOMINOIDEA;

EID: 84866948390     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0046485     Document Type: Article

References (25)

1. Hodzic D, Kong C, Wainszelbaum MJ, Charron AJ, Su X, et al. (2006) TBC1D3, a hominoid oncoprotein, is encoded by a cluster of paralogues located on chromosome 17q12. Genomics 88: 731-736.
2. Pei L, Peng Y, Yang Y, Ling XB, Van Eyndhoven WG, et al. (2002) PRC17, a novel oncogene encoding a Rab GTPase-activating protein, is amplified in prostate cancer. Cancer Res 62: 5420-5424.
3. Wu J, Jiao Y, Dal Molin M, Maitra A, de Wilde RF, et al. (2011) Whole-exome sequencing of neoplastic cysts of the pancreas reveals recurrent mutations in components of ubiquitin-dependent pathways. Proc Natl Acad Sci U S A 108: 21188-21193.
4. Hatanaka H, Tsukui M, Takada S, Kurashina K, Choi YL, et al. (2010) Identification of transforming activity of free fatty acid receptor 2 by retroviral expression screening. Cancer science 101: 54-59.
5. Starczynowski DT, Vercauteren S, Telenius A, Sung S, Tohyama K, et al. (2008) High-resolution whole genome tiling path array CGH analysis of CD34+ cells from patients with low-risk myelodysplastic syndromes reveals cryptic copy number alterations and predicts overall and leukemia-free survival. Blood 112: 3412-3424.
6. Nakamura T, Hillova J, Mariage-Samson R, Onno M, Huebner K, et al. (1992) A novel transcriptional unit of the tre oncogene widely expressed in human cancer cells. Oncogene 7: 733-741.
7. Huebner K, Cannizzaro LA, Nakamura T, Hillova J, Mariage-Samson R, et al. (1988) A rearranged transforming gene, tre, is made up of human sequences derived from chromosome regions 5q, 17q and 18q. Oncogene 3: 449-455.
8. Frittoli E, Palamidessi A, Pizzigoni A, Lanzetti L, Garre M, et al. (2008) The primate-specific protein TBC1D3 is required for optimal macropinocytosis in a novel ARF6-dependent pathway. Mol Biol Cell 19: 1304-1316.
9. Wainszelbaum MJ, Charron AJ, Kong C, Kirkpatrick DS, Srikanth P, et al. (2008) The hominoid-specific oncogene TBC1D3 activates Ras and modulates epidermal growth factor receptor signaling and trafficking. J Biol Chem 283: 13233-13242.
10. Wainszelbaum MJ, Liu J, Kong C, Srikanth P, Samovski D, et al. (2012) TBC1D3, a hominoid-specific gene, delays IRS-1 degradation and promotes insulin signaling by modulating p70 S6 kinase activity. PLoS One 7: e31225.
11. Sarikas A, Hartmann T, Pan ZQ, (2011) The cullin protein family. Genome Biol 12: 220.
12. Duda DM, Scott DC, Calabrese MF, Zimmerman ES, Zheng N, et al. (2011) Structural regulation of cullin-RING ubiquitin ligase complexes. Current opinion in structural biology 21: 257-264.
13. Laemmli UK, (1970) Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227: 680-685.
14. Kaustov L, Lukin J, Lemak A, Duan S, Ho M, et al. (2007) The conserved CPH domains of Cul7 and PARC are protein-protein interaction modules that bind the tetramerization domain of p53. J Biol Chem 282: 11300-11307.
15. Xu X, Sarikas A, Dias-Santagata DC, Dolios G, Lafontant PJ, et al. (2008) The CUL7 E3 ubiquitin ligase targets insulin receptor substrate 1 for ubiquitin-dependent degradation. Mol Cell 30: 403-414.
16. Paulding CA, Ruvolo M, Haber DA, (2003) The Tre2 (USP6) oncogene is a hominoid-specific gene. Proc Natl Acad Sci U S A 100: 2507-2511.
17. Sudmant PH, Kitzman JO, Antonacci F, Alkan C, Malig M, et al. (2010) Diversity of human copy number variation and multicopy genes. Science 330: 641-646.
18. Perry GH, Yang F, Marques-Bonet T, Murphy C, Fitzgerald T, et al. (2008) Copy number variation and evolution in humans and chimpanzees. Genome Res 18: 1698-1710.
19. Cheng J, DeCaprio JA, Fluck MM, Schaffhausen BS, (2009) Cellular transformation by Simian Virus 40 and Murine Polyoma Virus T antigens. Seminars in cancer biology 19: 218-228.
20. Zhao X, Madden-Fuentes RJ, Lou BX, Pipas JM, Gerhardt J, et al. (2008) Ataxia telangiectasia-mutated damage-signaling kinase- and proteasome-dependent destruction of Mre11-Rad50-Nbs1 subunits in Simian virus 40-infected primate cells. Journal of virology 82: 5316-5328.
21. Okabe H, Lee SH, Phuchareon J, Albertson DG, McCormick F, et al. (2006) A critical role for FBXW8 and MAPK in cyclin D1 degradation and cancer cell proliferation. PloS one 1: e128.
22. Litterman N, Ikeuchi Y, Gallardo G, O'Connell BC, Sowa ME, et al. (2011) An OBSL1-Cul7Fbxw8 ubiquitin ligase signaling mechanism regulates Golgi morphology and dendrite patterning. PLoS Biol 9: e1001060.
23. Hanson D, Murray PG, Black GC, Clayton PE, (2011) The genetics of 3-m syndrome: unravelling a potential new regulatory growth pathway. Hormone research in paediatrics 76: 369-378.
24. Hanson D, Murray PG, O'Sullivan J, Urquhart J, Daly S, et al. (2011) Exome sequencing identifies CCDC8 mutations in 3-M syndrome, suggesting that CCDC8 contributes in a pathway with CUL7 and OBSL1 to control human growth. American journal of human genetics 89: 148-153.
25. Hahn K, Miranda M, Francis VA, Vendrell J, Zorzano A, et al. (2010) PP2A regulatory subunit PP2A-B' counteracts S6K phosphorylation. Cell Metab 11: 438-444.