Coexpression of p53 and Ki 67 and lack of c-erbB2 expression in oral leukoplakias in India

Brazilian Oral Research

Volumn 26, Issue 3, 2012, Pages 228-234

  Kumar, Priya ^a   Kane, Shubhada ^b   Rathod, Govind Pomaji ^c  

^a MAULANA AZAD INSTITUTE OF DENTAL SCIENCES   (India)

^b TATA MEMORIAL HOSPITAL   (India)

^c Rama Dental College   (India)

Author keywords

Immunohistochemistry; Leukoplakia; Mouth neoplasms; Oncogenes; Tumor suppressor protein p53

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR 2; KI 67 ANTIGEN; PROTEIN P53;

ADULT; AGED; ARTICLE; CHEMISTRY; EVALUATION; FEMALE; GENE EXPRESSION; GENETICS; HUMAN; IMMUNOHISTOCHEMISTRY; INDIA; LEUKOPLAKIA; MALE; MIDDLE AGED; MOUTH TUMOR; NONPARAMETRIC TEST; PATHOLOGY; PROGNOSIS; PROTO ONCOGENE; RISK FACTOR; TUMOR SUPPRESSOR GENE;

ADULT; AGED; FEMALE; GENE EXPRESSION; GENES, ERBB-2; GENES, P53; HUMANS; IMMUNOHISTOCHEMISTRY; INDIA; KI-67 ANTIGEN; LEUKOPLAKIA, ORAL; MALE; MIDDLE AGED; MOUTH NEOPLASMS; PROGNOSIS; RECEPTOR, ERBB-2; RISK FACTORS; STATISTICS, NONPARAMETRIC; TUMOR SUPPRESSOR PROTEIN P53; YOUNG ADULT;

EID: 84866944063     PISSN: 18068324     EISSN: 18073107     Source Type: Journal    
DOI: 10.1590/S1806-83242012000300008     Document Type: Article

References (30)

1. Mehta FS, Gupta PC, Daftary DK, Pindborg JJ, Choksi SK. An epidemiologic study of oral cancer and precancerous conditions among 101,761 villagers in Maharashtra, India. Int J Cancer. 1972 Jul;10(1):134-41.
2. Reibel J. Prognosis of oral premalignant lesions: Significance of clinical, histopathological, and molecular biological characteristics. Crit Rev Oral Biol Med. 2003 Jan;14(1):47-62.
3. Lane DP. p53, guardian of the genome. Nature. 1992 Jul;358(6381):15-6.
4. Sarnath D, Tandle AT, Teni TR, Dedhia PM, Borges AM, Parikh D, et al. p53 inactivation in chewing tobacco-induced oral cancers and leukoplakias from India. Oral Oncol. 1999 May;35(3):242-50.
5. Iamaroon A, Khemaleelakul U, Pongsiriwet S, Pintong J. Coexpression of p53 and Ki 67 and lack of EBV expression in oral squamous cell carcinoma. J Oral Pathol Med. 2004 Jan;33(1):30-6.
6. Hynes NE. Amplification and overexpression of the erbB-2 gene in human tumors: its involvement in tumor development, significance as a prognostic factor, and potential as a target for cancer therapy. Semin Cancer Biol. 1993 Feb;4(1):19-26.
7. Chimenos-Kustner E, Font-Costa I, Lopez-Lopez J. Oral cancer risk and molecular markers. Med Oral Patol Oral Cir Bucal. 2004 Nov-Dec;9(5):377-84.
8. Schliephake H. Prognostic relevance of molecular markers of oral cancer - a review. Int J Oral Maxillofac Surg. 2003 Jun;32(3):233-45.
9. Levine AJ. p53, the cellular gate keeper for growth and division. Cell. 1997 Feb;88(3): 323-31.
10. Agarwal S, Mathur M, Srivastava A, Ranju R. MDM2/p53 coexpression in oral premalignant and malignant lesions: potential prognostic implications. Oral Oncol. 1999 Mar;35(2):209-16.
11. Kerdpon D, Rich AM, Reade PC. Expression of p53 in oral mucosal hyperplasia, dysplasia and squamous cell carcinoma. Oral Dis. 1997 Mar;3(2):86-92.
12. Murti PR, Warnakulasuriya KAAS, Johnson NW, Bhonsle RB, Gupta PC, Daftary DK, et al. p53 expression in oral precancer: a marker for malignant potential. J Oral Pathol Med. 1998 May;27(5):191-6.
13. van Oijen MGCT, van de Craats JG, Slootweg PJ. p53 overex-pression in oral mucosa in relation to smoking. J Pathol. 1999 Mar;187(4):469-74.
14. Warnakulasuriya KAAS, Ralhan R. Clinical, pathological and molecular lesions caused by oral smokeless tobacco - a review. J Oral Pathol Med. 2007 Feb;36(2):63-77.
15. Vered M, Allon I, Dayan D. Maspin, p53, and Ki- 67 in epithelial lesions of the tongue: from hyperplasia to dysplasia to carcinoma. J Oral Pathol Med. 2009 Mar;38(3):314-20.
16. Girod SC, Pfeiffer P, Ries J, Pape HD. Proliferative activity and loss of function of tumour suppressor genes as biomarkers in diagnosis and prognosis of benign and preneoplastic oral lesions and oral squamous cell carcinoma. Br J Oral Maxillofac Surg. 1998 Aug;36(4):252-60.
17. Yamamoto T, Ikawa S, Akiyama T, Semba K, Nomura N, Miyajima N, et al. Similarity of protein encoded by the human c-erb-B-2 gene to epidermal growth factor receptor. Nature. 1986 Jan;319(6050):230-4.
18. Del Sordo R, Angiero F, Bellezza G, Cavaliere A, Mameli M-G, Stefani M, et al. HER family receptors expression in squamous cell carcinoma of the tongue: study of the possible prognostic and biologic significance. J Oral Pathol Med. 2010 Jan;39(1):79-86.
19. Ibrahim SO, Lillehaug JR, Johannessen AC, Liavaag PG, Nilsen R, Vasstrand EN, et al. Expression of biomarkers (p53, transforming growth factor alpha, epidermal growth factor receptor, c-erbB-2/neu and the proliferative cell nuclear antigen) in oropharyngeal squamous cell carcinoma. Oral Oncol. 1999 May;35(3):302-13.
20. Liu X, Han Z, Wang Y. Xing jiao yuan he c-erbb-2 zai kou qiang nian zhu jun bai ban zhong de biao da gao yan. Zhonghua Kou Qiang Yi Xue Za Zhi. 1999 Nov.;34(6):325-7.
21. Hou L, Shi D, Tu SM, Zhang HZ, Hung MC, Ling D. Oral cancer progression and c-erb-B2/neu proto-oncogene expression. Cancer Lett. 1992 Aug;65(3):215-20. Complement.
22. Wilkman TSE, Hietanen JPH, Malmstrom MJ, Konttinen YT. Immunohistochemical analysis of the oncoprotein c-erb-B2 expression in oral benign and malignant lesions. Int J Oral Maxillofac Surg. 1998 Jun;27(3):209-12.
23. Cruz I, Napier SS, van der Waal I, Snijders PJF, Walboomers JMM, Lamey PJ, et al. Suprabasal p53 immunoexpression is strongly associated with high grade dysplasia and risk for malignant transformation in potentially malignant oral lesions from Northern Ireland. J Clin Pathol. 2002 Feb;55(2):98-104.
24. Cruz IB, Snijders PF, Meijer CJ, Braakhuis BJ, Snow BG, Walbloomers JM, et al. p53 expression above the basal cell layer in oral mucosa is an early event of malignant transformation and has predictive value for developing oral squamous cell carcinoma. J Pathol. 1998 Apr;184(4):360-8.
25. INK4a and Ki-67 as basic biomarker for malignant progression of oral leukoplakias. J Oral Pathol Med. 2011 Sep;40(8):629-35.
26. Kurokawa H, Matsumoto S, Murata T, Yamashita Y, Tomoyose T, Zhang M et al. Immunohistochemical study of syndecan-1 downregulation and expression of p53 protein or Ki-67 antigen in oral leukoplakia with or without epithelial dysplasia. J Oral Pathol Med. 2003 Oct;32(9):513-21.
27. Girod SC, Krueger G, Pape HD. p53 and Ki-67 expression in preneoplastic and neoplastic lesions of the oral mucosa. Int J Oral Maxillofac Surg. 1993 Oct;22(5):285-8.
28. Takeda T, Sugihara K, Hirayama Y, Hirano M, Tanuma JT. Immunohistological evaluation of Ki67, p63, CK 19 and p53 expression in oral epithelial dysplasias. J Oral Pathol Med. 2006 Jul;35(6):369-75.
29. Gouvea AF, Vargas PA, Coletta RD, Jorge J, Lopes MA. Clinicopathological features and immunohistochemical expression of p53, Ki-67, Mcm-2 and Mcm-5 in proliferative verrucous leukoplakia. J Oral Pathol Med. 2010 Jul;39(6):447-52.
30. Chang F, Syrjanen S, Syrjanen K. Implications of the p53 tumor suppressor gene in clinical oncology. J Clin Oncol. 1995 Apr;13(4):1009-22.