Evaluation of the cytotoxic activity of new jadomycin derivatives reveals the potential to improve its selectivity against tumor cells

Journal of Antibiotics

Volumn 65, Issue 9, 2012, Pages 449-452

  Fan, Keqiang ^a   Zhang, Xia ^a   Liu, Hongchun ^b   Han, Hui ^a   Luo, Yuanming ^a   Wang, Qian ^a   Geng, Meiyu ^b   Yang, Keqian ^a  

^a INSTITUTE OF MICROBIOLOGY   (China)

^b SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ANGUCYCLINE DERIVATIVE; ANTIBIOTIC AGENT; JADOMYCIN B; JADOMYCIN DERIVATIVE; JANDOMYCIN ABU; JANDOMYCIN HSE; JANDOMYCIN L; JANDOMYCIN NLE; JANDOMYCIN ORN; JANDOMYCIN S; JANDOMYCIN T; JANDOMYCIN V; UNCLASSIFIED DRUG;

ARTICLE; CYTOTOXICITY; DRUG IDENTIFICATION; DRUG PURIFICATION; FERMENTATION; HUMAN; HUMAN CELL; IC 50; MASS SPECTROMETRY; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION; TUMOR CELL LINE;

AMINO ACIDS; ANTIBIOTICS, ANTINEOPLASTIC; CELL SURVIVAL; DRUG SCREENING ASSAYS, ANTITUMOR; HCT116 CELLS; HUMANS; ISOQUINOLINES; MCF-7 CELLS; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; SPECTROPHOTOMETRY, ULTRAVIOLET; STREPTOMYCES; TANDEM MASS SPECTROMETRY;

EID: 84866919120     PISSN: 00218820     EISSN: 18811469     Source Type: Journal    
DOI: 10.1038/ja.2012.48     Document Type: Article

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