Discrimination between neoplastic and non-neoplastic lesions in cirrhotic liver using contrast-enhanced ultrasound

British Journal of Radiology

Volumn 85, Issue 1018, 2012, Pages 1376-1384

  Xu, Hui Xiong ^a,b   Lu, M D ^b   Liu, L N ^a,b   Zhang, Y F ^a   Guo, L H ^a   Xu, J M ^a   Liu, C ^a  

^a TENTH PEOPLE S HOSPITAL OF TONGJI UNIVERSITY   (China)

^b SUN YAT SEN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

SULFUR HEXAFLUORIDE;

ADULT; AGED; ARTICLE; CANCER DIAGNOSIS; CANCER GRADING; CONTRAST ENHANCED ULTRASOUND; CONTRAST ENHANCEMENT; DIAGNOSTIC ACCURACY; DIAGNOSTIC VALUE; DIFFERENTIAL DIAGNOSIS; DOPPLER FLOWMETRY; FEMALE; HUMAN; IMAGE ANALYSIS; IMAGE QUALITY; LIVER CELL CARCINOMA; LIVER CIRRHOSIS; LIVER NODULE; MAJOR CLINICAL STUDY; MALE; MICROBUBBLE; PREDICTIVE VALUE; PROSPECTIVE STUDY; SENSITIVITY AND SPECIFICITY; TUMOR VASCULARIZATION; TUMOR VOLUME; ULTRASOUND;

ADULT; AGED; AGED, 80 AND OVER; CARCINOMA, HEPATOCELLULAR; CONTRAST MEDIA; DIAGNOSIS, DIFFERENTIAL; EARLY DETECTION OF CANCER; FEMALE; HUMANS; LIVER CIRRHOSIS; LIVER NEOPLASMS; MALE; MICROBUBBLES; MIDDLE AGED; PHOSPHOLIPIDS; PROSPECTIVE STUDIES; SULFUR HEXAFLUORIDE; ULTRASONOGRAPHY, DOPPLER; YOUNG ADULT;

EID: 84866883853     PISSN: 00071285     EISSN: None     Source Type: Journal    
DOI: 10.1259/bjr/19932596     Document Type: Article

References (46)

1. International Working Party. Terminology of nodular hepatocellular lesions. Hepatology 1995;22:983-9.
2. Gaiani S, Celli N, Piscaglia F, Cecilioni L, Losinno F, Giangregorio F, et al. Usefulness of contrast-enhanced perfusional sonography in the assessment of hepatocellular carcinoma hyper-vascular at spiral computed tomography. J Hepatol 2004;41:421-6. (Pubitemid 39158751)
3. Bolondi L, Gaiani S, Celli N, Golfieri R, Grigioni WF, Leoni S, et al. Characterization of small nodules in cirrhosis by assessment of vascularity: the problem of hypo-vascular hepatocellular carcinoma. Hepatology 2005;42:27-34. (Pubitemid 40911308)
4. Bruix J, Sherman M, Llovet JM, Beaugrand M, Lencioni R, Burroughs AK, et al. Clinical management of hepatocellular carcinoma: conclusions of the Barcelona-2000 EASL Conference. J Hepatol 2001;35:421-30. (Pubitemid 32844200)
5. Quaia E, Calliada F, Bertolotto M, Rossi S, Garioni L, Rosa L, et al. Characterization of focal liver lesions with contrast-specific US modes and a sulfur hexafluoride-filled microbubble contrast agent: diagnostic performance and confidence. Radiology 2004;232:420-30. (Pubitemid 38971282)
6. Brannigan M, Burns PN, Wilson SR. Blood flow patterns in focal liver lesions at microbubble-enhanced US. Radiographics 2004;24:921-35. (Pubitemid 38943326)
7. Nicolau C, Vilana R, Catalá V, Bianchi L, Gilabert R, García A, et al. Importance of evaluating all vascular phases on contrast-enhanced sonography in the differentiation of benign from malignant focal liver lesions. AJR Am J Roentgenol 2006;186:158-67. (Pubitemid 46100378)
8. Xu HX, Lu MD, Liu GJ, Xie XY, Xu ZF, Zheng YL, et al. Imaging of peripheral cholangiocarcinoma using low mechanical index contrast-enhanced sonography and SonoVue: initial experience. J Ultrasound Med 2006;25: 23-33.
9. Albrecht T, Blomley M, Bolondi L, Claudon M, Correas JM, Cosgrove D, et al. Guidelines for the use of contrast agents in ultrasound. January 2004. Ultraschall Med 2004;25: 249-56. (Pubitemid 39128145)
10. Nicolau C, Brú C. Focal liver lesions: evaluation with contrast-enhanced ultrasonography. Abdom Imaging 2004;29: 348-59. (Pubitemid 38590819)
11. Dietrich CF. Characterization of focal liver lesions with contrast enhanced ultrasonography. Eur J Radiol 2004;51 (Suppl.):S9-17.
12. Xu HX, Liu GJ, Lu MD, Xie XY, Xu ZF, Zheng YL, et al. Characterization of small focal liver lesions using real-time contrast-enhanced ultrasound: diagnostic performance analysis in 200 patients. J Ultrasound Med 2006;25:349-61.
13. Catalano O, Lobianco R, Cusati B, Siani A. Hepatocellular carcinoma: spectrum of contrast-enhanced gray-scale harmonic sonography findings. Abdom Imaging 2004;29:341-7. (Pubitemid 38590818)
14. Ding H, Wang WP, Huang BJ, Wei RX, He NA, Qi Q, et al. Imaging of focal liver lesions: low-mechanical-index realtime ultrasonography with SonoVue. J Ultrasound Med 2005;24:285-97. (Pubitemid 40315955)
15. Jang HJ, Kim TK, Wilson SR. Small nodules (1-2 cm) in liver cirrhosis: characterization with contrast-enhanced ultrasound. Eur J Radiol 2009;72:418-24.
16. Quaia E, D'Onofrio M, Cabassa P, Vecchiato F, Caffarri S, Pittiani F, et al. The diagnostic value of hepatocellular nodule vascularity after sulfur hexafluoride-filled microbubble injection in patients with liver cirrhosis: analysis of diagnostic performance and confidence in malignancy characterization. AJR Am Journal Roentgenology 2007;189: 1474-83. (Pubitemid 350174816)
17. Giorgio A, Ferraioli G, Tarantino L, de Stefano G, Scala V, Scarano F, et al. Contrast-enhanced sonographic appearance of hepatocellular carcinoma in patients with cirrhosis: comparison with contrast-enhanced CT appearance. AJR Am J Roentgenol 2004;183:1319-26. (Pubitemid 44210595)
18. von Herbay A, Vogt C, Willers R, Häussinger D. Real-time imaging with the sonographic contrast agent SonoVue: differentiation between benign and malignant hepatic lesions. J Ultrasound Med 2004;23:1557-68. (Pubitemid 39586861)
19. Celik H, Ozdemir H, Yucel C, Gultekin S, Oktar SO, Arac M. Characterization of hyper-echoic focal liver lesions: quantitative evaluation with pulse inversion harmonic imaging in the late phase of Levovist. J Ultrasound Med 2005;24:39-47. (Pubitemid 40039780)
20. Bruix J, Sherman M. Management of hepatocellular carcinoma. Hepatology 2005;42:1208-36. (Pubitemid 43112690)
21. Bruix J, Sherman M; American Association for the Study of Liver Diseases. Management of hepatocellular carcinoma: an update. Hepatology 2011;53:1020-2.
22. Chen LD, Xu HX, Xie XY, Xie XH, Xu ZF, Liu GJ, et al. Intrahepatic cholangiocarcinoma and hepatocellular carcinoma: differential diagnosis with contrast-enhanced ultrasound. Eur Radiol 2010;20:743-53.
23. Forner A, Vilana R, Ayuso C, Bianchi L, Solé M, Ayuso JR, et al. Diagnosis of hepatic nodules 20mm or smaller in cirrhosis: Prospective validation of the noninvasive diagnostic criteria for hepatocellular carcinoma. Hepatology 2008;47:97-104. (Pubitemid 351171046)
24. Vilana R, Forner A, Bianchi L, García-Criado A, Rimola J, de Lope CR, et al. Intrahepatic peripheral cholangiocarcinoma in cirrhosis patients may display a vascular pattern similar to hepatocellular carcinoma on contrast-enhanced ultrasound. Hepatology 2010;51:2020-9.
25. Shephard DA. The 1975 Declaration of Helsinki and consent. Can Med Assoc J 1976;115:1191-2.
26. Matsui O. Imaging of multistep human hepatocarcinogenesis by CT during intra-arterial contrast injection. Intervirology 2004;47:271-6. (Pubitemid 39279465)
27. Kondo F, Kondo Y, Nagato Y, Tomizawa M, Wada K. Interstitial tumour cell invasion in small hepatocellular carcinoma. Evaluation in microscopic and low magnification views. J Gastroenterol Hepatol 1994;9:604-12. (Pubitemid 24364612)
28. Borzio M, Fargion S, Borzio F, Fracanzani AL, Croce AM, Stroffolini T, et al. Impact of large regenerative, low grade and high grade dysplastic nodules in hepatocellular carcinoma development. J Hepatol 2003;39:208-14. (Pubitemid 36920556)
29. Arakawa M, Kage M, Sugihara S, Nakashima T, Suenaga M, Okuda K. Emergence of malignant lesions within an adenomatous hyperplastic nodule in a cirrhotic liver. Observations in five cases. Gastroenterology 1986;91:198-208. (Pubitemid 16086674)
30. Ueda K, Terada T, Nakanuma Y, Matsui O. Vascular supply in adenomatous hyperplasia of the liver and hepatocellular carcinoma: a morphometric study. Hum Pathol 1992;23: 619-26.
31. Roncalli M, Roz E, Coggi G, Di Rocco MG, Bossi P, Minola E. The vascular profile of regenerative and dysplastic nodules of the cirrhotic liver: implications for diagnosis and classification. Hepatology 1999;30:1174-8. (Pubitemid 29510855)
32. Hayashi M, Matsui O, Ueda K, Kawamori Y, Gabata T, Kadoya M. Progression to hyper-vascular hepatocellular carcinoma: correlation with intranodular blood supply evaluated with CT during intraarterial injection of contrast material. Radiology 2002;225:143-9.
33. Bhayana D, Kim TK, Jang HJ, Burns PN, Wilson SR. Hypervascular liver masses on contrast-enhanced ultrasound: the importance of washout. AJR Am J Roentgenol 2010;194:977-83.
34. Maruyama H, Takahashi M, Ishibashi H, Yoshikawa M, Yokosuka O. Contrast-enhanced ultrasound for characterisation of hepatic lesions appearing non-hypervascular on CT in chronic liver diseases. Br J Radiol 2012;85:351-7.
35. Quaia E, Alaimo V, Baratella E, Medeot A, Midiri M, Cova MA. The added diagnostic value of 64-row multidetector CT combined with contrast-enhanced US in the evaluation of hepatocellular nodule vascularity: implications in the diagnosis of malignancy in patients with liver cirrhosis. Eur Radiol 2009;19:651-63.
36. Ikeda K, Saitoh S, Koida I, Tsubota A, Arase Y, Chayama K, et al. Diagnosis and follow-up of small hepatocellular carcinoma with selective intraarterial digital subtraction angiography. Hepatology 1993;17:1003-7. (Pubitemid 23187403)
37. Chen RC, Wang CK, Wang CS, Chen WT, Shih LS, Chiang LC, et al. Depiction of vasculature in small hepatocellular carcinoma, and dysplastic nodules: evaluation with carbondioxide ultrasonography and angiography. Acta Radiol 2002;43:66-70.
38. Kojiro M. Focus on dysplastic nodules and early hepatocellular carcinoma: an Eastern point of view. Liver Transpl 2004;10(Suppl. 1):S3-8. (Pubitemid 38240092)
39. Takayama T, Makuuchi M, Hirohashi S, Sakamoto M, Okazaki N, Takayasu K, et al. Malignant transformation of adenomatous hyper-plasia to hepatocellular carcinoma. Lancet 1990;336:1150-3. (Pubitemid 20362906)
40. Lencioni R, Cioni D, Crocetti L, Bartolozzi C. Percutaneous ablatioin of hepatocellular carcinoma: state-of-the-art. Liver Transpl 2004;10:S91-7. (Pubitemid 38247742)
41. Lu MD, Yin XY, Xie XY, Xu HX, Xu ZF, Liu GJ, et al. Percutaneous thermal ablation for recurrent hepatocellular carcinoma after hepatectomy. Br J Surg 2005;92:1393-8.
42. Xu HX, Lu MD, Xie XY, Yin XY, Kuang M, Chen JW, et al. Prognostic factors for long term outcome after percutaneous thermal ablation for hepatocellular carcinoma: a survival analysis of 137 consecutive patients. Clin Radiol 2005;60: 1018-25. (Pubitemid 41194673)
43. Shiina S, Teratani T, Obi S, Sato S, Tateishi R, Fujishima T, et al. A randomized controlled trial of radiofrequency ablation with ethanol injection for small hepatocellular carcinoma. Gastroenterology 2005;129:122-30. (Pubitemid 41002049)
44. Liang P, Dong B, Yu X, Wang Y, Sheng L, Yu D, et al. Sonography-guided percutaneous microwave ablation of high-grade dysplastic nodules in cirrhotic liver. AJR Am J Roentgenol 2005;184:1657-60. (Pubitemid 43821854)
45. Nicolau C, Catalá V, Vilana R, Gilabert R, Bianchi L, Solé M, et al. Evaluation of hepatocellular carcinoma using SonoVue, a second generation ultrasound contrast agent: correlation with cellular differentiation. Eur Radiol 2004;14: 1092-9. (Pubitemid 38787254)
46. Jang HJ, Kim TK, Burns PN, Wilson SR. Enhancement patterns of hepatocellular carcinoma at contrast-enhanced US: comparison with histologic differentiation. Radiology 2007;244:898-906. (Pubitemid 47292103)