Real-time imaging with the sonographic contrast agent SonoVue: Differentiation between benign and malignant hepatic lesions

Journal of Ultrasound in Medicine

Volumn 23, Issue 12, 2004, Pages 1557-1568

  Von Herbay, Alexandra ^a,b   Vogt, Christoph ^b   Willers, Reinhard ^b   Häussinger, Dieter ^b  

^a UNIVERSITY OF TÜBINGEN   (Germany)

^b HEINRICH HEINE UNIVERSITY   (Germany)

Author keywords

Contrast media; Hemangioma; Hepatocellular carcinoma; Liver; Metastasis; Sonography; SonoVue

Indexed keywords

AGENTS; BIOLOGICAL ORGANS; BUBBLES (IN FLUIDS); MEDICAL IMAGING; PATIENT TREATMENT; REAL TIME SYSTEMS; SULFUR COMPOUNDS;

CONTRAST-ENHANCED SONOGRAPHY; HEPATIC LESIONS; REAL-TIME IMAGING; SONOGRAPHIC CONTRAST AGENT;

ULTRASONIC IMAGING;

ECHO CONTRAST MEDIUM; SONOVUE; SULFUR HEXAFLUORIDE;

ADULT; AGED; ARTICLE; B SCAN; BENIGN TUMOR; BILE DUCT CARCINOMA; CONTRAST ENHANCEMENT; CONTROLLED STUDY; DIAGNOSTIC ACCURACY; FATTY LIVER; FEMALE; HUMAN; IMAGING SYSTEM; LIVER ADENOMA; LIVER CELL CARCINOMA; LIVER CIRRHOSIS; LIVER HEMANGIOMA; LIVER METASTASIS; LYMPHOMA; MAJOR CLINICAL STUDY; MALE; MALIGNANT NEOPLASTIC DISEASE; NODULAR HYPERPLASIA; PROSPECTIVE STUDY; REAL TIME ECHOGRAPHY; SENSITIVITY AND SPECIFICITY;

EID: 9744250184     PISSN: 02784297     EISSN: None     Source Type: Journal    
DOI: 10.7863/jum.2004.23.12.1557     Document Type: Article

References (35)

1. Horton KM, Bluemke DA, Hruban RH, Soyer P, Fishman EK. CT and MR imaging of benign hepatic and biliary tumors. Radiographics 1999; 19:431-451.
2. Bauer A, Hauff P, Lazenby J, et al. Wideband harmonic imaging: a novel contrast ultrasound imaging technique. Eur Radiol 1999; 9(suppl 3):S364-S367.
3. Albrecht T, Hoffmann CW, Schettler S, et al. B-mode enhancement at phase-inversion US with air-based microbubble contrast agent: initial experience in humans. Radiology 2000; 216:273-278.
4. Dill-Macky MJ, Burns PN, Khalili K, Wilson SR. Focal hepatic masses: enhancement patterns with SH U 508 A and pulse-inversion US. Radiology 2002; 222:95-102.
5. Shi WT, Forsberg F. Ultrasonic characterization of the nonlinear properties of contrast microbubbles. Ultrasound Med Biol 2000; 26:93-104.
6. von Herbay A, Vogt C, Häussinger D. Late-phase pulse-inversion sonography using the contrast agent Levovist: differentiation between benign and malignant focal lesions of the liver. AJR Am J Roentgenol 2002; 179:1273-1279.
7. von Herbay A, Vogt C, Häussinger D. Differentiation between benign and malignant hepatic lesions by stimulated acoustic emission with the microbubble contrast agent Levovist. J Ultrasound Med 2004; 23:207-215.
8. Harvey CJ, Albrecht T. Ultrasound of focal liver lesions. Eur Radiol 2001; 11:1578-1593.
9. Strobel D, Raeker S, Martus P, Hahn EG, Becker D. Phase inversion harmonic imaging versus contrast-enhanced power Doppler sonography for the characterization of focal liver lesions. Int J Colorectal Dis 2003; 18:63-72.
10. Wilson SR, Burns PN. Liver mass evaluation with ultrasound: the impact of microbubble contrast agents and pulse inversion imaging. Semin Liver Dis 2001; 21:147-159.
11. Kim TK, Choi BL, Han JK, Hong HS, Park SH, Moon SG. Hepatic tumors: contrast agent-enhancement patterns with pulse-inversion harmonic US. Radiology 2000; 216:411-417.
12. Quaia E, Bertolotto M, Calderan L, Mosconi E, Pozzi Mucelli R. US characterization of focal hepatic lesions with intermittent high-acoustic-power mode and contrast material. Acad Radiol 2003; 10:739-750.
13. Bertolotto M, Dalla Palma L, Quaia E, Locatelli M. Characterization of unifocal liver lesions with pulse inversion harmonic imaging after Levovist injection: preliminary results. Eur Radiol 2000; 10:1369-1376.
14. Blomley M, Sidhu PS, Cosgrove D. Do different types of liver lesions differ in their uptake of the microbubble contrast agent SH U 508 A in the liver late phase? Early experience. Radiology 2001; 220:661-667.
15. von Herbay A, Vogt C, Häussinger D. Pulse inversion sonography in the early phase of the ultrasound contrast agent Levovist: differentiation between benign and malignant focal liver lesions. J Ultrasound Med 2002; 21:1191-1200.
16. Schneider M, Arditi M, Barrau MB, et al. BR1: a new ultrasonographic contrast agent based on sulphur hexafluoride-filled microbubbles. Invest Radiol 1995; 30:451-457.
17. Schneider M. SonoVue, a new ultrasound contrast agent. Eur Radiol 1999; 9(suppl 3):S347-S348.
18. Campani R, Calliada F, Bottinelli O, et al. Contrast media in ultrasonography: hepatic focal lesions. Radiol Med (Torino) 1998; 95(5 suppl 1):47-52.
19. Morel DR, Schwieger I, Hohn L, et al. Human pharmacokinetics and safety evaluation of SonoVue, a new contrast agent for ultrasound imaging. Invest Radiol 2000; 35:80-85.
20. Correas JM, Burns PN, Lai X, Qi X. Infusion versus bolus of an ultrasound contrast agent: in vivo dose-response measurements of BRI. Invest Radiol 2000; 35:72-79.
21. Hohmann J, Skok J, Puls R, Albrecht T. Characterization of focal liver lesions with contrast-enhanced low MI real time ultrasound and SonoVue. Rofo 2003; 175:835-843.
22. Nisenbaum H, Rowling S. Ultrasound of focal hepatic lesions. Semin Roentgenol 1995; 30:324-346.
23. Swensson RG, King JL, Gur D. A constrained formulation for the receiver operating characteristic (ROC) curve based on probability summation. Med Phys 2001; 28:1597-1609
24. Dorfman DD, Berbaum KS, Metz CE. Receiver operating characteristics rating analysis: generalization of the population of readers and patients with the jack-knife method. Invest Radiol 1992; 27:723-731.
25. Schade T, Wermke W, Wermke W. Kontrastverhalten von Leberhämangiomen unter Echosignalverstärkung-Ergebnisse einer prospektiven Untersuchung von 110 Patienten [abstract]. Ultraschall Med 2002; 23(suppl):S36.
26. Lencioni R, Cloni D, Crocetti L, et al. Ultrasound imaging of focal liver lesions with a second-generation contrast agent. Acad Radiol 2002; 9(suppl 2):S371-S374.
27. Tanaka S, Ioka T, Oshikawa O, Hamada Y, Yoshioka F. Dynamic sonography of hepatic tumors. AJR Am J Roentgenol 2001; 177:799-805.
28. Lim AK, Patel N, Gedroyc WM. Hepatocellular adenoma: diagnostic difficulties and novel imaging techniques. Br J Radiol 2002; 75:695-699.
29. Strobel D, Hoefer A, Martus P, Hahn EG, Becker D. Dynamic contrast-enhanced power Doppler sonography improves the differential diagnosis of liver lesions. Int J Colorectal Dis 2001; 16:247-256.
30. Solbiati L, Cova L, Ierace T. The importance of arterial phase imaging for wideband harmonic sonography for the characterization of focal lesions in liver cirrhosis using a second generation contrast agent [abstract]. Radiology 2000; 217:305.
31. Schade T, Wermke W, Wermke T. Kontrastverhalten der fokalen nodulären Hyperplasie unter Echosignalverstärkung: Ergebnisse einer prospektiven Untersuchung von 112 Patienten [abstract]. Ultraschall Med 2002; 23(suppl):S36.
32. Albrecht T, Hoffmann CW, Schettler S, et al. Improved detection of liver metastases with phase inversion ultrasound during the late phase of Levovist. Acad Radiol 2002; 9(suppl.1):S236-S239.
33. Albrecht T, Hoffmann CW, Schmitz SA, et al. Phase-inversion sonography during the liver-specific late phase of contrast-enhancement: improved detection of liver metastases. AJR Am J Roentgenol 2001; 176:1191-1198.
34. Giovagnoni A, Martegani A, Aiani L, Ligabue G, Romagnoli R, Del Favero C. Pulse inversion ultrasonography with ultrasonography contrast media (levovist) in the evaluation of hepatic metastasis. Radiol Med (Torino) 2001; 101:111-117.
35. Albrecht T, Hoffmann CW, Schmitz SA, et al. Stimulated acoustic emission with the ultrasound contrast agent Levovist: a clinically useful contrast effect with liver-specific properties. Rofo 2000; 172:61-67.