The added diagnostic value of 64-row multidetector CT combined with contrast-enhanced US in the evaluation of hepatocellular nodule vascularity: Implications in the diagnosis of malignancy in patients with liver cirrhosis

European Radiology

Volumn 19, Issue 3, 2009, Pages 651-663

  Quaia, Emilio ^a   Alaimo, Valerio ^b   Baratella, Elisa ^a   Medeot, Alessandro ^a   Midiri, Massimo ^b   Cova, Maria Assunta ^a  

^a UNIVERSITY OF TRIESTE   (Italy)

^b UNIVERSITY OF PALERMO   (Italy)

Author keywords

Hepatocellular carcinoma; Livercirrhosis; Microbubble contrast agents; Ultrasound

Indexed keywords

ADULT; AGED; ARTICLE; CLINICAL ASSESSMENT; CONTRAST ENHANCEMENT; DIAGNOSTIC ACCURACY; DIAGNOSTIC VALUE; ECHOGRAPHY; FEMALE; HUMAN; IMAGE ANALYSIS; IMAGE QUALITY; LIVER CELL CARCINOMA; LIVER CIRRHOSIS; LIVER HEMANGIOMA; LIVER NODULE; MAJOR CLINICAL STUDY; MALE; MULTIDETECTOR COMPUTED TOMOGRAPHY; PRIORITY JOURNAL; PSEUDOTUMOR; SENSITIVITY AND SPECIFICITY; TUMOR VASCULARIZATION;

ADULT; AGED; AGED, 80 AND OVER; BIOPSY; CARCINOMA, HEPATOCELLULAR; CONTRAST MEDIA; FEMALE; HUMANS; LIVER CIRRHOSIS; LIVER NEOPLASMS; MALE; MICROBUBBLES; MIDDLE AGED; PROSPECTIVE STUDIES; ULTRASONOGRAPHY;

EID: 59949101993     PISSN: 09387994     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00330-008-1179-3     Document Type: Article

References (31)

1. International Working Party (1995) Terminology of nodular hepatocellular lesions. Hepatology 22:983-993
2. Bruix J, Sherman M, Llovet JM et al (2001) Clinical management of hepatocellular carcinoma. Conclusions of the Barcelona-2000 EASL conference. European Association for the Study of the Liver. J Hepatol 35:421-430
3. Bruix J, Sherman M (2005) Management of hepatocellular carcinoma. Hepatology 42:1208-1236
4. Iannacone R, Laghi A, Catalano C et al (2004) Focal liver lesions in the cirrhotic patient: Multislice spiral CT evaluation. Radiol Med 107:304-316
5. Laghi A, Iannacone R, Rossi P et al (2003) Hepatocellular carcinoma: detection with triple-phase multi-detector row helical CT in patients with chronic hepatitis. Radiology 226:543-549
6. Ichikawa T, Kakajima H, Nanbu A, Hori M, Araki T (2006) Effect of injection rate of contrast material on CT of hepatocellular carcinoma. AJR Am J Roentgenol 186:1413-1418
7. Monzawa S, Ichikawa T, Nakajima H, Kitanaka Y, Omata K, Araki T (2007) Dynamic CT for detecting small hepatocellular carcinoma: Usefulness of delayed phase imaging. AJR Am J Roentgenol 188:147-153
8. Claudon M, Cosgrove D, Albrecht T et al (2008) Guidelines and good clinical practice recommendations for contrast enhanced ultrasound (CEUS)-Update 2008. Ultraschall Med 29:28-44
9. Quaia E, Calliada F, Bertolotto M, Rossi S, Garioni L, Rosa L, Pozzi-Mucelli R (2004) Characterization of focal liver lesions by contrast-specific US modes and a sulfur hexafluoride-filled microbubble contrast agent: Diagnostic performance and confidence. Radiology 232:420-430
10. Nicolau C, Catalá V, Vilana R, Gilabert R, Bianchi L, Sole M, Pages M, Bru C (2004) Evaluation of hepatocellular carcinoma using SonoVue, a second generation ultrasound contrast agent: Correlation with cellular differentiation. Eur Radiol 14:1092-1099
11. Giorgio A, Ferraioli G, Tarantino L et al (2004) Contrast-enhanced sonographic appearance of hepatocellular carcinoma in patients with cirrhosis: Comparison with contrast-enhanced CT appearance. AJR Am J Roentgenol 183:1319-1326
12. Quaia E, D'Onofrio M, Cabassa P et al (2007) Diagnostic value of hepatocellular nodule vascularity after sulfur hexafluoride-filled microbubble injection in patients with liver cirrhosis: Analysis of diagnostic performance and confidence in malignancy characterization. AJR Am J Roentgenology 189:1474-1483
13. Gaiani S, Celli N, Piscaglia F et al (2004) Usefulness of contrast-enhanced perfusional sonography in the assessment of hepatocellular carcinoma hypervascular at spiral computed tomography. J Hepatol 41:421-426
14. Bolondi L, Gaiani S, Celli N et al (2005) Characterization of hepatocellular nodules in 40 cirrhosis by assessment of vascularity: The problem of hypovascular hepatocellular carcinoma. Hepatology 42:27-34
15. Pompili M, Riccardi L, Semeraro S et al (2008) Contrast-enhanced ultrasound assessment of arterial vascularization of small nodules arising in the cirrhotic liver. Dig Liver Dis 40(3):206-215
16. Burns P, Wilson SR (2007) Focal liver lesions: Enhancement patterns on contrast-enhanced images - Concordance of US scans with CT scans and MR images. Radiology 242(1):162-174
17. Forner A, Villana R, Ayuso C et al (2008) Diagnosis of hepatic nodules 20 mm or smaller in cirrhosis: Prospective validation of the noninvasive diagnostic criteria for hepatocellular carcinoma. Hepatology 47:97-104
18. Bismuth H (1982) Surgical anatomy and anatomical surgery of the liver. World J Surg 6:3-8
19. Couinaud C (1957) Le foie: Études anatomiques et chirurgicales. Masson, Paris, pp 9-12
20. Sultana S, Awai K, Nakayama Y et al (2007) Hypervascular hepatocellular carcinomas: Bolus tracking with a 40-detector CT scanner to time arterial phase imaging. Radiology 243:140-147
21. Beck JR, Shultz EK (1986) The use of relative operating characteristic (ROC) curves in test performance evaluation. Arch Pathol Lab Med 110:13-20
22. Hanley JA, McNeil BJ (1983) A method of comparing the areas under receiver operating characteristic curves derived from the same cases. Radiology 148:839-843
23. Tanaka S, Ioka T, Oshikawa O, Hamada Y, Yoshioka F (2001) Dynamic sonography of hepatic tumours. AJR Am J Roentgenol 177:799-805
24. Lee HM, Lu DS, Krasny RM, Busuttil R, Kadell B, Lucas J (1997) Hepatic lesion characterization in cirrhosis: Significance of arterial hypervascularity on dual-phase helical CT. AJR Am J Roentgenol 169:125-130
25. Baron RL, Peterson MS (2001) Screening the cirrhotic liver for hepatocellular carcinoma with CT and MR imaging: Opportunities and pitfalls. Radiographics 21:S117-S132
26. Lim JH, Kim CK, Lee WJ et al (2000) Detection of hepatocellular carcinomas and dysplastic nodules in cirrhotic livers: Accuracy of helical CT in transplant patients. AJR Am J Roentgenol 175:693-698
27. Rode A, Bancel B, Douek P et al (2001) Small nodule detection in cirrhotic livers: Evaluation with US, spiral CT, and MRI and correlation with pathologic examination of explanted liver. J Comput Assist Tomogr 25(3):327-336
28. Valls C, Cos M, Figueras J et al (2004) Pretransplantation diagnosis and staging of hepatocellular carcinoma in patients with cirrhosis: Value of dual phase helical CT. AJR Am J Roentgenol 182:1011-1017
29. Forner A, Vilana R, Ayuso C et al (2007) Diagnosis of hepatic nodules 20 mm or smaller in cirrhosis: Prospective validation of the noninvasive diagnostic criteria for hepatocellular carcinoma. Hepatology 47:1-7
30. Krinsky GA, Lee VS, Theise ND et al (2001) Hepatocellular carcinoma and dysplastic nodules in patients with cirrhosis: Prospective diagnosis with MR imaging and explantation correlation. Radiology 219:445-454
31. Bhartia B, Ward J, Guthrie JA, Robinson PJ (2003) Hepatocellular carcinoma in cirrhotic livers: Double-contrast thin-section MR imaging with pathologic correlation of explanted tissue. AJR Am J Roentgenol 180:577-584