Chronic inflammation and elevated homocysteine levels are associated with increased body mass index in women with polycystic ovary syndrome

Gynecological Endocrinology

Volumn 23, Issue 9, 2007, Pages 505-510

  Guzelmeric, Kadir ^a,b   Alkan, Nevriye ^a   Pirimoglu, Meltem ^a   Unal, Orhan ^a   Turan, Cem ^a  

^a DR LUTFI KIRDAR KARTAL EDUCATION AND RESEARCH HOSPITAL   (Turkey)

^b NONE   (Turkey)

Author keywords

Body mass index; C reactive protein; Homocysteine; Insulin resistance; Polycystic ovary syndrome

Indexed keywords

BIOLOGICAL MARKER; C REACTIVE PROTEIN; CHOLESTEROL; FOLLITROPIN; HOMOCYSTEINE; LOW DENSITY LIPOPROTEIN; LUTEINIZING HORMONE; TESTOSTERONE;

ADULT; ARTICLE; BODY MASS; CHOLESTEROL BLOOD LEVEL; CHRONIC INFLAMMATION; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; FEMALE; FOLLITROPIN BLOOD LEVEL; HOMEOSTASIS; HUMAN; HYPERANDROGENISM; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; ISCHEMIC HEART DISEASE; LUTEINIZING HORMONE BLOOD LEVEL; MULTIPLE REGRESSION; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; OVARY POLYCYSTIC DISEASE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RISK FACTOR; TESTOSTERONE BLOOD LEVEL; TRIACYLGLYCEROL BLOOD LEVEL;

ADULT; BODY MASS INDEX; C-REACTIVE PROTEIN; CASE-CONTROL STUDIES; CHRONIC DISEASE; FEMALE; HOMOCYSTEINE; HUMANS; INFLAMMATION; INSULIN RESISTANCE; OBESITY; POLYCYSTIC OVARY SYNDROME; RISK FACTORS;

EID: 35448985807     PISSN: 09513590     EISSN: 14730766     Source Type: Journal    
DOI: 10.1080/09513590701554306     Document Type: Article

References (28)

1. Slowey MJ. Polycystic ovary syndrome. New prospective on an old problem. South Med J 2001;94:190-196.
2. Cibul D, Cifkova R, Fanta M. Increased risk of non-insulin dependent diabetes mellitus, arterial hypertension and coronary heart disease in perimenopausal women with a history of the polycystic ovary syndrome. Hum Reprod 2000;15:785-789.
3. Solomon CG. The epidemiology of polycystic ovary syndrome. Endocrinol Metab Clin North Am 1999;28:247-263.
4. Clarke R, Lewington S, Donald A, Johnston C. Underestimation of the importance of homocysteine as a risk factor for cardiovascular disease in epidemiological studies. J Cardiovasc Risk 2001;8:363-369.
5. Welch GN, Loscalzo J. Homocysteine and atherothrombosis. N Engl J Med 1998;338:1042-1050.
6. Refsum H, Ueland PM, Nygard O, Vollset SE. Homocysteine and cardiovascular disease. Annu Rev Med 1998;49:31-62.
7. Giltay EJ, Hoogeveen EK, Elbers JMH, Gooren LJG, Asscheman H, Stehouwer CDA. Insulin resistance is associated with elevated plasma total homocysteine levels in healthy, non-obese subjects. Atherosclerosis 1998;139:197-198.
8. McCarty MF. Insulin secretion as a potential determinant of homocysteine levels. Med Hypotheses 2000;55:454-455.
9. Alexander RW. Inflammation and coronary heart disease. N Engl J Med 1998;331:468-469.
10. Ridker PM, Henekens CH, Buring JE, Rifai N. C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women. N Engl J Med 2000;342:836-843.
11. Kelly CCJ, Lyall J, Petrie JR, Gould WG, Connell JMC, Satter N. Low grade inflammation in women with polycystic ovarian syndrome. J Clin Endocrinol Metab 2001;86:2453-2455.
12. Tallova J, Tomandl J, Bicikova M, Hill M. Changes of plasma total homocysteine levels during the menstrual cycle. Eur J Clin Invest 1999;129:1041-1044.
13. Brattström L, Lindgren A, Israelsson B, Andersson A, Hultberg B. Homocysteine and cysteine: determinants of plasma levels in middle-aged and elderly subjects. J Intern Med 1994;236:633-641.
14. Guttormsen AB, Schneede J, Fiskerstrand T, Ueland PM, Refsum HM. Plasma concentrations of homocysteine and other aminothiol compounds are related to food intake in healthy human subjects. J Nutr 1994;124:889-891.
15. Wijeyaratne CN, Nirantharakumar K, Balen AH, Barth JH, Sheriff R, Belchetz PE. Plasma homocysteine in polycystic ovary syndrome: does it correlate with insulin resistance and ethnicity? Clin Endocrinol (Oxf) 2004;60:560-567.
16. Fonesca V, Guba SC, Fink LM. Hyperhomocysteinemia and endocrine system: implications for atherosclerosis and thrombosis. Endocr Rev 1999;20:738-759.
17. Pasceri V, Willerson JT, Yeh ET. Direct proinflammatory effect of C-reactive protein on human endothelial cells. Circulation 2000;102:2165-2168.
18. Blake GJ, Ridker PM. Inflammatory biomarkers and cardiovascular risk prediction. J Intern Med 2002;252:283-294.
19. Temelkova-Kurktschiev T, Henkel E, Koehler C, Karrie K, Hanefeld M. Subclinical inflammation in newly detected type II diabetes and impaired glucose tolerance. Diabetologia 2002;45:151.
20. Danesh J, Collins R, Appleby P, Peto R. Association of fibrinogen, C-reactive protein, albumin or leukocyte count with coronary heart disease: meta-analyses of prospective studies. J Am Med Assoc 1998;279:1477-1482.
21. Pirwani I, Fleming R, Greer IA, Packard CJ, Sattar N. Lipids and lipoprotein subfractions in women with women with PCOS. Clin Endocrinol (Oxf) 2001;54:447-454.
22. Gorgels WJ, Graaf Y, Blankenstein MA, Collette HJ, Erkelens DW, Banga JD. Urinary sex hormone excretions in premenopausal women and coronary heart disease risk: a nested case-referent study in the DOM-cohort. J Clin Epidemiol 1997;50:275-281.
23. Schachter M, Raziel A, Friedler S, Strassburger D, Bern O, Ron-El R. Insulin resistance in patients with polycystic ovary syndrome is associated with elevated homocysteine. Hum Reprod 2003;18:721-727.
24. Abbasi F, Facchini F, Humphreys MH, Reaven GM. Plasma homocysteine concentrations in healthy volunteers are not related to differences in insulin-mediated glucose disposal. Atherosclerosis 1999;146:175-178.
25. Kilic-Okman T, Guldiken S, Kucuk M. Relationship between homocysteine and insulin resistance in women with polycystic ovary syndrome. Endocr J 2004;5:505-508.
26. Festa A, D'Agostino RJ, Howard G, Mykkanen L, Tracy RP, Haffner SM. Chronic subclinical inflammation as part of the insulin resistance syndrome: The Insulin Resistance Atherosclerosis Study (IRAS). Circulation 2000;102:42-47.
27. Lemieux I, Pascot A, Prud'homme D, Almeras N, Bogaty P, Wadeau A, Bergeron J, Despres JP. Elevated C-reactive protein: another component of the atherothrombotic profile of abdominal obesity. Arteriscler Thromb Vasc Biol 2001;21(6):961-967.
28. Möhlig M, Spranger J, Osterhoff M, Ristow M, Pfeiffer AF, Schill T, Schlösser HW, Brabant G, Schöfl C. The polycystic ovary syndrome per se is not associated with increased chronic inflammation. Eur J Endocrinol 2004;150:525-532.