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Volumn 109, Issue 39, 2012, Pages 15871-15876

Single-cell analysis of early B-lymphocyte development suggests independent regulation of lineage specification and commitment in vivo

Author keywords

Deltex; Notch 1; Transcription

Indexed keywords

TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR EBF1; TRANSCRIPTION FACTOR PAX5; UNCLASSIFIED DRUG;

EID: 84866839947     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1210144109     Document Type: Article
Times cited : (33)

References (44)
  • 1
    • 70349728484 scopus 로고    scopus 로고
    • A recurrent network involving the transcription factors PU.1 and Gfi1 orchestrates innate and adaptive immune cell fates
    • Spooner CJ, Cheng JX, Pujadas E, Laslo P, Singh H (2009) A recurrent network involving the transcription factors PU.1 and Gfi1 orchestrates innate and adaptive immune cell fates. Immunity 31:576-586.
    • (2009) Immunity , vol.31 , pp. 576-586
    • Spooner, C.J.1    Cheng, J.X.2    Pujadas, E.3    Laslo, P.4    Singh, H.5
  • 2
    • 64049102658 scopus 로고    scopus 로고
    • Genome-wide lineage-specific transcriptional networks underscore Ikaros-dependent lymphoid priming in hematopoietic stem cells
    • Ng SY, Yoshida T, Zhang J, Georgopoulos K (2009) Genome-wide lineage-specific transcriptional networks underscore Ikaros-dependent lymphoid priming in hematopoietic stem cells. Immunity 30:493-507.
    • (2009) Immunity , vol.30 , pp. 493-507
    • Ng, S.Y.1    Yoshida, T.2    Zhang, J.3    Georgopoulos, K.4
  • 4
    • 48749094942 scopus 로고    scopus 로고
    • E2A proteins promote development of lymphoid-primed multipotent progenitors
    • Dias S, Månsson R, Gurbuxani S, Sigvardsson M, Kee BL (2008) E2A proteins promote development of lymphoid-primed multipotent progenitors. Immunity 29:217-227.
    • (2008) Immunity , vol.29 , pp. 217-227
    • Dias, S.1    Månsson, R.2    Gurbuxani, S.3    Sigvardsson, M.4    Kee, B.L.5
  • 5
    • 60549106831 scopus 로고    scopus 로고
    • E2A proteins maintain the hematopoietic stem cell pool and promote the maturation of myelolymphoid and myeloerythroid progenitors
    • Semerad CL, Mercer EM, Inlay MA, Weissman IL, Murre C (2009) E2A proteins maintain the hematopoietic stem cell pool and promote the maturation of myelolymphoid and myeloerythroid progenitors. Proc Natl Acad Sci USA 106:1930-1935.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 1930-1935
    • Semerad, C.L.1    Mercer, E.M.2    Inlay, M.A.3    Weissman, I.L.4    Murre, C.5
  • 6
    • 38449102306 scopus 로고    scopus 로고
    • Transcription factor EBF restricts alternative lineage options and promotes B cell fate commitment independently of Pax5
    • Pongubala JM, et al. (2008) Transcription factor EBF restricts alternative lineage options and promotes B cell fate commitment independently of Pax5. Nat Immunol 9:203-215.
    • (2008) Nat Immunol , vol.9 , pp. 203-215
    • Pongubala, J.M.1
  • 7
    • 0029045161 scopus 로고
    • Failure of B-cell differentiation in mice lacking the transcription factor EBF
    • Lin H, Grosschedl R (1995) Failure of B-cell differentiation in mice lacking the transcription factor EBF. Nature 376:263-267.
    • (1995) Nature , vol.376 , pp. 263-267
    • Lin, H.1    Grosschedl, R.2
  • 8
    • 51549083884 scopus 로고    scopus 로고
    • EBF1 is essential for B-lineage priming and establishment of a transcription factor network in common lymphoid progenitors
    • Zandi S, et al. (2008) EBF1 is essential for B-lineage priming and establishment of a transcription factor network in common lymphoid progenitors. J Immunol 181: 3364-3372.
    • (2008) J Immunol , vol.181 , pp. 3364-3372
    • Zandi, S.1
  • 9
    • 0027997502 scopus 로고
    • Complete block of early B cell differentiation and altered patterning of the posterior midbrain in mice lacking Pax5/BSAP
    • Urbánek P, Wang ZQ, Fetka I, Wagner EF, Busslinger M (1994) Complete block of early B cell differentiation and altered patterning of the posterior midbrain in mice lacking Pax5/BSAP. Cell 79:901- 912.
    • (1994) Cell , vol.79 , pp. 901-912
    • Urbánek, P.1    Wang, Z.Q.2    Fetka, I.3    Wagner, E.F.4    Busslinger, M.5
  • 10
    • 0033533822 scopus 로고    scopus 로고
    • Long-term in vivo reconstitution of T-cell development by Pax5-deficient B-cell progenitors
    • Rolink AG, Nutt SL, Melchers F, Busslinger M (1999) Long-term in vivo reconstitution of T-cell development by Pax5-deficient B-cell progenitors. Nature 401:603-606.
    • (1999) Nature , vol.401 , pp. 603-606
    • Rolink, A.G.1    Nutt, S.L.2    Melchers, F.3    Busslinger, M.4
  • 11
    • 0033533891 scopus 로고    scopus 로고
    • Commitment to the B-lymphoid lineage depends on the transcription factor Pax5
    • Nutt SL, Heavey B, Rolink AG, Busslinger M (1999) Commitment to the B-lymphoid lineage depends on the transcription factor Pax5. Nature 401:556-562.
    • (1999) Nature , vol.401 , pp. 556-562
    • Nutt, S.L.1    Heavey, B.2    Rolink, A.G.3    Busslinger, M.4
  • 12
    • 77952567987 scopus 로고    scopus 로고
    • Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities
    • Heinz S, et al. (2010) Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities. Mol Cell 38:576-589.
    • (2010) Mol Cell , vol.38 , pp. 576-589
    • Heinz, S.1
  • 13
    • 80053131310 scopus 로고    scopus 로고
    • Multilineage priming of enhancer repertoires precedes commitment to the B and myeloid cell lineages in hematopoietic progenitors
    • Mercer EM, et al. (2011) Multilineage priming of enhancer repertoires precedes commitment to the B and myeloid cell lineages in hematopoietic progenitors. Immunity 35:413-425.
    • (2011) Immunity , vol.35 , pp. 413-425
    • Mercer, E.M.1
  • 14
    • 34848853915 scopus 로고    scopus 로고
    • Conversion of mature B cells into T cells by dedifferentiation to uncommitted progenitors
    • DOI 10.1038/nature06159, PII NATURE06159
    • Cobaleda C, Jochum W, Busslinger M (2007) Conversion of mature B cells into T cells by dedifferentiation to uncommitted progenitors. Nature 449:473-477. (Pubitemid 47509547)
    • (2007) Nature , vol.449 , Issue.7161 , pp. 473-477
    • Cobaleda, C.1    Jochum, W.2    Busslinger, M.3
  • 16
    • 0033166301 scopus 로고    scopus 로고
    • Coordinate regulation of B cell differentiation by the transcription factors EBF and E2A
    • DOI 10.1016/S1074-7613(00)80078-3
    • O'Riordan M, Grosschedl R (1999) Coordinate regulation of B cell differentiation by the transcription factors EBF and E2A. Immunity 11:21-31. (Pubitemid 29359954)
    • (1999) Immunity , vol.11 , Issue.1 , pp. 21-31
    • O'Riordan, M.1    Grosschedl, R.2
  • 17
    • 64449088814 scopus 로고    scopus 로고
    • Stepwise activation of enhancer and promoter regions of the B cell commitment gene Pax5 in early lymphopoiesis
    • Decker T, et al. (2009) Stepwise activation of enhancer and promoter regions of the B cell commitment gene Pax5 in early lymphopoiesis. Immunity 30:508-520.
    • (2009) Immunity , vol.30 , pp. 508-520
    • Decker, T.1
  • 18
    • 70350093398 scopus 로고    scopus 로고
    • Ly6d marks the earliest stage of B-cell specification and identifies the branchpoint between B-cell and T-cell development
    • InlayMA, et al. (2009) Ly6d marks the earliest stage of B-cell specification and identifies the branchpoint between B-cell and T-cell development. Genes Dev 23:2376-2381.
    • (2009) Genes Dev , vol.23 , pp. 2376-2381
    • Inlay, M.A.1
  • 19
    • 50849143861 scopus 로고    scopus 로고
    • B-lineage commitment prior to surface expression of B220 and CD19 on hematopoietic progenitor cells
    • Mansson R, et al. (2008) B-lineage commitment prior to surface expression of B220 and CD19 on hematopoietic progenitor cells. Blood 112:1048-1055.
    • (2008) Blood , vol.112 , pp. 1048-1055
    • Mansson, R.1
  • 20
    • 77951002652 scopus 로고    scopus 로고
    • Single-cell analysis of the common lymphoid progenitor compartment reveals functional and molecular heterogeneity
    • Mansson R, et al. (2010) Single-cell analysis of the common lymphoid progenitor compartment reveals functional and molecular heterogeneity. Blood 115:2601-2609.
    • (2010) Blood , vol.115 , pp. 2601-2609
    • Mansson, R.1
  • 21
    • 80051573966 scopus 로고    scopus 로고
    • IL-7 mediates Ebf-1-dependent lineage restriction in early lymphoid progenitors
    • Tsapogas P, et al. (2011) IL-7 mediates Ebf-1-dependent lineage restriction in early lymphoid progenitors. Blood 118:1283- 1290.
    • (2011) Blood , vol.118 , pp. 1283-1290
    • Tsapogas, P.1
  • 22
    • 0032522538 scopus 로고    scopus 로고
    • Identification of BSAP (Pax-5) target genes in early B-cell development by loss- and gain-of-function experiments
    • DOI 10.1093/emboj/17.8.2319
    • Nutt SL, Morrison AM, Dörfler P, Rolink A, Busslinger M (1998) Identification of BSAP (Pax-5) target genes in early B-cell development by loss- and gain-of-function experiments. EMBO J 17:2319-2333. (Pubitemid 28171916)
    • (1998) EMBO Journal , vol.17 , Issue.8 , pp. 2319-2333
    • Nutt, S.L.1    Morrison, A.M.2    Dorfler, P.3    Rolink, A.4    Busslinger, M.5
  • 23
    • 0031038031 scopus 로고    scopus 로고
    • Essential functions of Pax5 (BSAP) in pro-B cell development: Difference between fetal and adult B lymphopoiesis and reduced V-to-DJ recombination at the IgH locus
    • Nutt SL, Urbánek P, Rolink A, Busslinger M (1997) Essential functions of Pax5 (BSAP) in pro-B cell development: difference between fetal and adult B lymphopoiesis and reduced V-to-DJ recombination at the IgH locus. Genes Dev 11:476-491. (Pubitemid 27097646)
    • (1997) Genes and Development , vol.11 , Issue.4 , pp. 476-491
    • Nutt, S.L.1    Urbanek, P.2    Relink, A.3    Busslinger, M.4
  • 24
    • 40349107459 scopus 로고    scopus 로고
    • Identification of Pax5 target genes in early B cell differentiation
    • Pridans C, et al. (2008) Identification of Pax5 target genes in early B cell differentiation. J Immunol 180:1719-1728.
    • (2008) J Immunol , vol.180 , pp. 1719-1728
    • Pridans, C.1
  • 25
    • 0037025198 scopus 로고    scopus 로고
    • Reversion of B cell commitment upon loss of Pax5 expression
    • DOI 10.1126/science.1067518
    • Mikkola I, Heavey B, Horcher M, Busslinger M (2002) Reversion of B cell commitment upon loss of Pax5 expression. Science 297:110-113. (Pubitemid 34743105)
    • (2002) Science , vol.297 , Issue.5578 , pp. 110-113
    • Mikkola, I.1    Heavey, B.2    Horcher, M.3    Busslinger, M.4
  • 27
    • 0030831130 scopus 로고    scopus 로고
    • Identification of clonogenic common lymphoid progenitors in mouse bone marrow
    • Kondo M, Weissman IL, Akashi K (1997) Identification of clonogenic common lymphoid progenitors in mouse bone marrow. Cell 91:661-672. (Pubitemid 27513657)
    • (1997) Cell , vol.91 , Issue.5 , pp. 661-672
    • Kondo, M.1    Weissman, I.L.2    Akashi, K.3
  • 28
    • 59649094661 scopus 로고    scopus 로고
    • Reductive isolation from bone marrow and blood implicates common lymphoid progenitors as the major source of thymopoiesis
    • Serwold T, Ehrlich LI, Weissman IL (2009) Reductive isolation from bone marrow and blood implicates common lymphoid progenitors as the major source of thymopoiesis. Blood 113:807-815.
    • (2009) Blood , vol.113 , pp. 807-815
    • Serwold, T.1    Ehrlich, L.I.2    Weissman, I.L.3
  • 29
    • 34547126466 scopus 로고    scopus 로고
    • Transcription factor Pax5 activates the chromatin of key genes involved in B cell signaling, adhesion, migration, and immune function
    • Schebesta A, et al. (2007) Transcription factor Pax5 activates the chromatin of key genes involved in B cell signaling, adhesion, migration, and immune function. Immunity 27:49- 63.
    • (2007) Immunity , vol.27 , pp. 49-63
    • Schebesta, A.1
  • 30
    • 0042025062 scopus 로고    scopus 로고
    • Myeloid lineage switch of Pax5 mutant but not wild-type B cell progenitors by C/EBPα and GATA factors
    • DOI 10.1093/emboj/cdg380
    • Heavey B, Charalambous C, Cobaleda C, Busslinger M (2003) Myeloid lineage switch of Pax5 mutant but not wild-type B cell progenitors by C/EBPalpha and GATA factors. EMBO J 22:3887-3897. (Pubitemid 36975715)
    • (2003) EMBO Journal , vol.22 , Issue.15 , pp. 3887-3897
    • Heavey, B.1    Charalambous, C.2    Cobaleda, C.3    Busslinger, M.4
  • 32
    • 0036906546 scopus 로고    scopus 로고
    • Pax5 promotes B lymphopoiesis and blocks T cell development by repressing Notch1
    • DOI 10.1016/S1074-7613(02)00472-7
    • Souabni A, Cobaleda C, Schebesta M, Busslinger M (2002) Pax5 promotes B lymphopoiesis and blocks T cell development by repressing Notch1. Immunity 17:781-793. (Pubitemid 35477797)
    • (2002) Immunity , vol.17 , Issue.6 , pp. 781-793
    • Souabni, A.1    Cobaleda, C.2    Schebesta, M.3    Busslinger, M.4
  • 36
    • 33847359485 scopus 로고    scopus 로고
    • Reporter gene insertions reveal a strictly B lymphoid-specific expression pattern of Pax5 in support of its B cell identity function
    • Fuxa M, Busslinger M (2007) Reporter gene insertions reveal a strictly B lymphoidspecific expression pattern of Pax5 in support of its B cell identity function. J Immunol 178:3031-3037. (Pubitemid 46333183)
    • (2007) Journal of Immunology , vol.178 , Issue.5 , pp. 3031-3037
    • Fuxa, M.1    Busslinger, M.2
  • 37
    • 0036916440 scopus 로고    scopus 로고
    • Induction of T cell development from hematopoietic progenitor cells by delta-like-1 in vitro
    • Schmitt TM, Zúñiga-Pflücker JC (2002) Induction of T cell development from hematopoietic progenitor cells by delta-like-1 in vitro. Immunity 17:749- 756.
    • (2002) Immunity , vol.17 , pp. 749-756
    • Schmitt, T.M.1    Zúñiga-Pflücker, J.C.2
  • 38
    • 24744442149 scopus 로고    scopus 로고
    • Inhibition of EBF function by active Notch signaling reveals a novel regulatory pathway in early B-cell development
    • DOI 10.1182/blood-2004-12-4744
    • Smith EM, Akerblad P, Kadesch T, Axelson H, Sigvardsson M (2005) Inhibition of EBF function by active Notch signaling reveals a novel regulatory pathway in early B-cell development. Blood 106:1995-2001. (Pubitemid 41291712)
    • (2005) Blood , vol.106 , Issue.6 , pp. 1995-2001
    • Smith, E.M.K.1    Akerblad, P.2    Kadesch, T.3    Axelson, H.4    Sigvardsson, M.5
  • 39
    • 0242556813 scopus 로고    scopus 로고
    • Notch-induced E2A ubiquitination and degradation are controlled by MAP kinase activities
    • DOI 10.1093/emboj/cdg567
    • Nie L, Xu M, Vladimirova A, Sun XH (2003) Notch-induced E2A ubiquitination and degradation are controlled by MAP kinase activities. EMBO J 22:5780-5792. (Pubitemid 37408817)
    • (2003) EMBO Journal , vol.22 , Issue.21 , pp. 5780-5792
    • Nie, L.1    Xu, M.2    Vladimirova, A.3    Sun, X.-H.4
  • 40
    • 77953289247 scopus 로고    scopus 로고
    • Early B cell factor 1 regulates B cell gene networks by activation, repression, and transcription-independent poising of chromatin
    • Treiber T, et al. (2010) Early B cell factor 1 regulates B cell gene networks by activation, repression, and transcription-independent poising of chromatin. Immunity 32:714-725.
    • (2010) Immunity , vol.32 , pp. 714-725
    • Treiber, T.1
  • 41
    • 77953763449 scopus 로고    scopus 로고
    • A global network of transcription factors, involving E2A, EBF1 and Foxo1, that orchestrates B cell fate
    • Lin YC, et al. (2010) A global network of transcription factors, involving E2A, EBF1 and Foxo1, that orchestrates B cell fate. Nat Immunol 11:635-643.
    • (2010) Nat Immunol , vol.11 , pp. 635-643
    • Lin, Y.C.1
  • 43
    • 0142121516 scopus 로고    scopus 로고
    • Exploration, normalization, and summaries of high density oligonucleotide array probe level data
    • Irizarry RA, et al. (2003) Exploration, normalization, and summaries of high density oligonucleotide array probe level data. Biostatistics 4:249-264.
    • (2003) Biostatistics , vol.4 , pp. 249-264
    • Irizarry, R.A.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.