-
1
-
-
70349728484
-
A recurrent network involving the transcription factors PU.1 and Gfi1 orchestrates innate and adaptive immune cell fates
-
Spooner CJ, Cheng JX, Pujadas E, Laslo P, Singh H (2009) A recurrent network involving the transcription factors PU.1 and Gfi1 orchestrates innate and adaptive immune cell fates. Immunity 31:576-586.
-
(2009)
Immunity
, vol.31
, pp. 576-586
-
-
Spooner, C.J.1
Cheng, J.X.2
Pujadas, E.3
Laslo, P.4
Singh, H.5
-
2
-
-
64049102658
-
Genome-wide lineage-specific transcriptional networks underscore Ikaros-dependent lymphoid priming in hematopoietic stem cells
-
Ng SY, Yoshida T, Zhang J, Georgopoulos K (2009) Genome-wide lineage-specific transcriptional networks underscore Ikaros-dependent lymphoid priming in hematopoietic stem cells. Immunity 30:493-507.
-
(2009)
Immunity
, vol.30
, pp. 493-507
-
-
Ng, S.Y.1
Yoshida, T.2
Zhang, J.3
Georgopoulos, K.4
-
4
-
-
48749094942
-
E2A proteins promote development of lymphoid-primed multipotent progenitors
-
Dias S, Månsson R, Gurbuxani S, Sigvardsson M, Kee BL (2008) E2A proteins promote development of lymphoid-primed multipotent progenitors. Immunity 29:217-227.
-
(2008)
Immunity
, vol.29
, pp. 217-227
-
-
Dias, S.1
Månsson, R.2
Gurbuxani, S.3
Sigvardsson, M.4
Kee, B.L.5
-
5
-
-
60549106831
-
E2A proteins maintain the hematopoietic stem cell pool and promote the maturation of myelolymphoid and myeloerythroid progenitors
-
Semerad CL, Mercer EM, Inlay MA, Weissman IL, Murre C (2009) E2A proteins maintain the hematopoietic stem cell pool and promote the maturation of myelolymphoid and myeloerythroid progenitors. Proc Natl Acad Sci USA 106:1930-1935.
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, pp. 1930-1935
-
-
Semerad, C.L.1
Mercer, E.M.2
Inlay, M.A.3
Weissman, I.L.4
Murre, C.5
-
6
-
-
38449102306
-
Transcription factor EBF restricts alternative lineage options and promotes B cell fate commitment independently of Pax5
-
Pongubala JM, et al. (2008) Transcription factor EBF restricts alternative lineage options and promotes B cell fate commitment independently of Pax5. Nat Immunol 9:203-215.
-
(2008)
Nat Immunol
, vol.9
, pp. 203-215
-
-
Pongubala, J.M.1
-
7
-
-
0029045161
-
Failure of B-cell differentiation in mice lacking the transcription factor EBF
-
Lin H, Grosschedl R (1995) Failure of B-cell differentiation in mice lacking the transcription factor EBF. Nature 376:263-267.
-
(1995)
Nature
, vol.376
, pp. 263-267
-
-
Lin, H.1
Grosschedl, R.2
-
8
-
-
51549083884
-
EBF1 is essential for B-lineage priming and establishment of a transcription factor network in common lymphoid progenitors
-
Zandi S, et al. (2008) EBF1 is essential for B-lineage priming and establishment of a transcription factor network in common lymphoid progenitors. J Immunol 181: 3364-3372.
-
(2008)
J Immunol
, vol.181
, pp. 3364-3372
-
-
Zandi, S.1
-
9
-
-
0027997502
-
Complete block of early B cell differentiation and altered patterning of the posterior midbrain in mice lacking Pax5/BSAP
-
Urbánek P, Wang ZQ, Fetka I, Wagner EF, Busslinger M (1994) Complete block of early B cell differentiation and altered patterning of the posterior midbrain in mice lacking Pax5/BSAP. Cell 79:901- 912.
-
(1994)
Cell
, vol.79
, pp. 901-912
-
-
Urbánek, P.1
Wang, Z.Q.2
Fetka, I.3
Wagner, E.F.4
Busslinger, M.5
-
10
-
-
0033533822
-
Long-term in vivo reconstitution of T-cell development by Pax5-deficient B-cell progenitors
-
Rolink AG, Nutt SL, Melchers F, Busslinger M (1999) Long-term in vivo reconstitution of T-cell development by Pax5-deficient B-cell progenitors. Nature 401:603-606.
-
(1999)
Nature
, vol.401
, pp. 603-606
-
-
Rolink, A.G.1
Nutt, S.L.2
Melchers, F.3
Busslinger, M.4
-
11
-
-
0033533891
-
Commitment to the B-lymphoid lineage depends on the transcription factor Pax5
-
Nutt SL, Heavey B, Rolink AG, Busslinger M (1999) Commitment to the B-lymphoid lineage depends on the transcription factor Pax5. Nature 401:556-562.
-
(1999)
Nature
, vol.401
, pp. 556-562
-
-
Nutt, S.L.1
Heavey, B.2
Rolink, A.G.3
Busslinger, M.4
-
12
-
-
77952567987
-
Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities
-
Heinz S, et al. (2010) Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities. Mol Cell 38:576-589.
-
(2010)
Mol Cell
, vol.38
, pp. 576-589
-
-
Heinz, S.1
-
13
-
-
80053131310
-
Multilineage priming of enhancer repertoires precedes commitment to the B and myeloid cell lineages in hematopoietic progenitors
-
Mercer EM, et al. (2011) Multilineage priming of enhancer repertoires precedes commitment to the B and myeloid cell lineages in hematopoietic progenitors. Immunity 35:413-425.
-
(2011)
Immunity
, vol.35
, pp. 413-425
-
-
Mercer, E.M.1
-
14
-
-
34848853915
-
Conversion of mature B cells into T cells by dedifferentiation to uncommitted progenitors
-
DOI 10.1038/nature06159, PII NATURE06159
-
Cobaleda C, Jochum W, Busslinger M (2007) Conversion of mature B cells into T cells by dedifferentiation to uncommitted progenitors. Nature 449:473-477. (Pubitemid 47509547)
-
(2007)
Nature
, vol.449
, Issue.7161
, pp. 473-477
-
-
Cobaleda, C.1
Jochum, W.2
Busslinger, M.3
-
15
-
-
33846141460
-
Distinct promoters mediate the regulation of Ebf1 gene expression by interleukin-7 and Pax5
-
DOI 10.1128/MCB.01192-06
-
Roessler S, et al. (2007) Distinct promoters mediate the regulation of Ebf1 gene expression by interleukin-7 and Pax5. Mol Cell Biol 27:579-594. (Pubitemid 46080126)
-
(2007)
Molecular and Cellular Biology
, vol.27
, Issue.2
, pp. 579-594
-
-
Roessler, S.1
Gyory, I.2
Imhof, S.3
Spivakov, M.4
Williams, R.R.5
Busslinger, M.6
Fisher, A.G.7
Grosschedl, R.8
-
16
-
-
0033166301
-
Coordinate regulation of B cell differentiation by the transcription factors EBF and E2A
-
DOI 10.1016/S1074-7613(00)80078-3
-
O'Riordan M, Grosschedl R (1999) Coordinate regulation of B cell differentiation by the transcription factors EBF and E2A. Immunity 11:21-31. (Pubitemid 29359954)
-
(1999)
Immunity
, vol.11
, Issue.1
, pp. 21-31
-
-
O'Riordan, M.1
Grosschedl, R.2
-
17
-
-
64449088814
-
Stepwise activation of enhancer and promoter regions of the B cell commitment gene Pax5 in early lymphopoiesis
-
Decker T, et al. (2009) Stepwise activation of enhancer and promoter regions of the B cell commitment gene Pax5 in early lymphopoiesis. Immunity 30:508-520.
-
(2009)
Immunity
, vol.30
, pp. 508-520
-
-
Decker, T.1
-
18
-
-
70350093398
-
Ly6d marks the earliest stage of B-cell specification and identifies the branchpoint between B-cell and T-cell development
-
InlayMA, et al. (2009) Ly6d marks the earliest stage of B-cell specification and identifies the branchpoint between B-cell and T-cell development. Genes Dev 23:2376-2381.
-
(2009)
Genes Dev
, vol.23
, pp. 2376-2381
-
-
Inlay, M.A.1
-
19
-
-
50849143861
-
B-lineage commitment prior to surface expression of B220 and CD19 on hematopoietic progenitor cells
-
Mansson R, et al. (2008) B-lineage commitment prior to surface expression of B220 and CD19 on hematopoietic progenitor cells. Blood 112:1048-1055.
-
(2008)
Blood
, vol.112
, pp. 1048-1055
-
-
Mansson, R.1
-
20
-
-
77951002652
-
Single-cell analysis of the common lymphoid progenitor compartment reveals functional and molecular heterogeneity
-
Mansson R, et al. (2010) Single-cell analysis of the common lymphoid progenitor compartment reveals functional and molecular heterogeneity. Blood 115:2601-2609.
-
(2010)
Blood
, vol.115
, pp. 2601-2609
-
-
Mansson, R.1
-
21
-
-
80051573966
-
IL-7 mediates Ebf-1-dependent lineage restriction in early lymphoid progenitors
-
Tsapogas P, et al. (2011) IL-7 mediates Ebf-1-dependent lineage restriction in early lymphoid progenitors. Blood 118:1283- 1290.
-
(2011)
Blood
, vol.118
, pp. 1283-1290
-
-
Tsapogas, P.1
-
22
-
-
0032522538
-
Identification of BSAP (Pax-5) target genes in early B-cell development by loss- and gain-of-function experiments
-
DOI 10.1093/emboj/17.8.2319
-
Nutt SL, Morrison AM, Dörfler P, Rolink A, Busslinger M (1998) Identification of BSAP (Pax-5) target genes in early B-cell development by loss- and gain-of-function experiments. EMBO J 17:2319-2333. (Pubitemid 28171916)
-
(1998)
EMBO Journal
, vol.17
, Issue.8
, pp. 2319-2333
-
-
Nutt, S.L.1
Morrison, A.M.2
Dorfler, P.3
Rolink, A.4
Busslinger, M.5
-
23
-
-
0031038031
-
Essential functions of Pax5 (BSAP) in pro-B cell development: Difference between fetal and adult B lymphopoiesis and reduced V-to-DJ recombination at the IgH locus
-
Nutt SL, Urbánek P, Rolink A, Busslinger M (1997) Essential functions of Pax5 (BSAP) in pro-B cell development: difference between fetal and adult B lymphopoiesis and reduced V-to-DJ recombination at the IgH locus. Genes Dev 11:476-491. (Pubitemid 27097646)
-
(1997)
Genes and Development
, vol.11
, Issue.4
, pp. 476-491
-
-
Nutt, S.L.1
Urbanek, P.2
Relink, A.3
Busslinger, M.4
-
24
-
-
40349107459
-
Identification of Pax5 target genes in early B cell differentiation
-
Pridans C, et al. (2008) Identification of Pax5 target genes in early B cell differentiation. J Immunol 180:1719-1728.
-
(2008)
J Immunol
, vol.180
, pp. 1719-1728
-
-
Pridans, C.1
-
25
-
-
0037025198
-
Reversion of B cell commitment upon loss of Pax5 expression
-
DOI 10.1126/science.1067518
-
Mikkola I, Heavey B, Horcher M, Busslinger M (2002) Reversion of B cell commitment upon loss of Pax5 expression. Science 297:110-113. (Pubitemid 34743105)
-
(2002)
Science
, vol.297
, Issue.5578
, pp. 110-113
-
-
Mikkola, I.1
Heavey, B.2
Horcher, M.3
Busslinger, M.4
-
27
-
-
0030831130
-
Identification of clonogenic common lymphoid progenitors in mouse bone marrow
-
Kondo M, Weissman IL, Akashi K (1997) Identification of clonogenic common lymphoid progenitors in mouse bone marrow. Cell 91:661-672. (Pubitemid 27513657)
-
(1997)
Cell
, vol.91
, Issue.5
, pp. 661-672
-
-
Kondo, M.1
Weissman, I.L.2
Akashi, K.3
-
28
-
-
59649094661
-
Reductive isolation from bone marrow and blood implicates common lymphoid progenitors as the major source of thymopoiesis
-
Serwold T, Ehrlich LI, Weissman IL (2009) Reductive isolation from bone marrow and blood implicates common lymphoid progenitors as the major source of thymopoiesis. Blood 113:807-815.
-
(2009)
Blood
, vol.113
, pp. 807-815
-
-
Serwold, T.1
Ehrlich, L.I.2
Weissman, I.L.3
-
29
-
-
34547126466
-
Transcription factor Pax5 activates the chromatin of key genes involved in B cell signaling, adhesion, migration, and immune function
-
Schebesta A, et al. (2007) Transcription factor Pax5 activates the chromatin of key genes involved in B cell signaling, adhesion, migration, and immune function. Immunity 27:49- 63.
-
(2007)
Immunity
, vol.27
, pp. 49-63
-
-
Schebesta, A.1
-
30
-
-
0042025062
-
Myeloid lineage switch of Pax5 mutant but not wild-type B cell progenitors by C/EBPα and GATA factors
-
DOI 10.1093/emboj/cdg380
-
Heavey B, Charalambous C, Cobaleda C, Busslinger M (2003) Myeloid lineage switch of Pax5 mutant but not wild-type B cell progenitors by C/EBPalpha and GATA factors. EMBO J 22:3887-3897. (Pubitemid 36975715)
-
(2003)
EMBO Journal
, vol.22
, Issue.15
, pp. 3887-3897
-
-
Heavey, B.1
Charalambous, C.2
Cobaleda, C.3
Busslinger, M.4
-
31
-
-
4644265888
-
Analysis of Notch1 function by in vitro T cell differentiation of Pax5 mutant lymphoid progenitors
-
Höflinger S, et al. (2004) Analysis of Notch1 function by in vitro T cell differentiation of Pax5 mutant lymphoid progenitors. J Immunol 173:3935-3944. (Pubitemid 39280757)
-
(2004)
Journal of Immunology
, vol.173
, Issue.6
, pp. 3935-3944
-
-
Hoflinger, S.1
Kesavan, K.2
Fuxa, M.3
Hutter, C.4
Heavey, B.5
Radtke, F.6
Busslinger, M.7
-
32
-
-
0036906546
-
Pax5 promotes B lymphopoiesis and blocks T cell development by repressing Notch1
-
DOI 10.1016/S1074-7613(02)00472-7
-
Souabni A, Cobaleda C, Schebesta M, Busslinger M (2002) Pax5 promotes B lymphopoiesis and blocks T cell development by repressing Notch1. Immunity 17:781-793. (Pubitemid 35477797)
-
(2002)
Immunity
, vol.17
, Issue.6
, pp. 781-793
-
-
Souabni, A.1
Cobaleda, C.2
Schebesta, M.3
Busslinger, M.4
-
33
-
-
34248580502
-
Immunology: Regulation of B versus T lymphoid lineage fate decision by the proto-oncogene LRF
-
DOI 10.1126/science.1140881
-
Maeda T, et al. (2007) Regulation of B versus T lymphoid lineage fate decision by the proto-oncogene LRF. Science 316:860-866. (Pubitemid 46764272)
-
(2007)
Science
, vol.316
, Issue.5826
, pp. 860-866
-
-
Maeda, T.1
Merghoyb, T.2
Hobbs, R.M.3
Dong, L.4
Maeda, M.5
Zakrzewski, J.6
Van Den, B.M.R.M.7
Zelent, A.8
Shigematsu, H.9
Akashi, K.10
Teruya-Feldstein, J.11
Cattoretti, G.12
Pandolfi, P.P.13
-
34
-
-
18344388633
-
Deltex1 redirects lymphoid progenitors to the B cell lineage by antagonizing Notch1
-
DOI 10.1016/S1074-7613(02)00271-6
-
Izon DJ, et al. (2002) Deltex1 redirects lymphoid progenitors to the B cell lineage by antagonizing Notch1. Immunity 16:231-243. (Pubitemid 34211963)
-
(2002)
Immunity
, vol.16
, Issue.2
, pp. 231-243
-
-
Izon, D.J.1
Aster, J.C.2
He, Y.3
Weng, A.4
Karnell, F.G.5
Patriub, V.6
Xu, L.7
Bakkour, S.8
Rodriguez, C.9
Allman, D.10
Pear, W.S.11
-
35
-
-
20244387299
-
+ lympho-myeloid stem cells lacking erythro-megakaryocytic potential: A revised road map for adult blood lineage commitment
-
DOI 10.1016/j.cell.2005.02.013
-
Adolfsson J, et al. (2005) Identification of Flt3+ lympho-myeloid stem cells lacking erythro-megakaryocytic potential a revised road map for adult blood lineage commitment. Cell 121:295-306. (Pubitemid 40546396)
-
(2005)
Cell
, vol.121
, Issue.2
, pp. 295-306
-
-
Adolfsson, J.1
Mansson, R.2
Buza-Vidas, N.3
Hultquist, A.4
Liuba, K.5
Jensen, C.T.6
Bryder, D.7
Yang, L.8
Borge, O.-J.9
Thoren, L.A.M.10
Anderson, K.11
Sitnicka, E.12
Sasaki, Y.13
Sigvardsson, M.14
Jacobsen, S.E.W.15
-
36
-
-
33847359485
-
Reporter gene insertions reveal a strictly B lymphoid-specific expression pattern of Pax5 in support of its B cell identity function
-
Fuxa M, Busslinger M (2007) Reporter gene insertions reveal a strictly B lymphoidspecific expression pattern of Pax5 in support of its B cell identity function. J Immunol 178:3031-3037. (Pubitemid 46333183)
-
(2007)
Journal of Immunology
, vol.178
, Issue.5
, pp. 3031-3037
-
-
Fuxa, M.1
Busslinger, M.2
-
37
-
-
0036916440
-
Induction of T cell development from hematopoietic progenitor cells by delta-like-1 in vitro
-
Schmitt TM, Zúñiga-Pflücker JC (2002) Induction of T cell development from hematopoietic progenitor cells by delta-like-1 in vitro. Immunity 17:749- 756.
-
(2002)
Immunity
, vol.17
, pp. 749-756
-
-
Schmitt, T.M.1
Zúñiga-Pflücker, J.C.2
-
38
-
-
24744442149
-
Inhibition of EBF function by active Notch signaling reveals a novel regulatory pathway in early B-cell development
-
DOI 10.1182/blood-2004-12-4744
-
Smith EM, Akerblad P, Kadesch T, Axelson H, Sigvardsson M (2005) Inhibition of EBF function by active Notch signaling reveals a novel regulatory pathway in early B-cell development. Blood 106:1995-2001. (Pubitemid 41291712)
-
(2005)
Blood
, vol.106
, Issue.6
, pp. 1995-2001
-
-
Smith, E.M.K.1
Akerblad, P.2
Kadesch, T.3
Axelson, H.4
Sigvardsson, M.5
-
39
-
-
0242556813
-
Notch-induced E2A ubiquitination and degradation are controlled by MAP kinase activities
-
DOI 10.1093/emboj/cdg567
-
Nie L, Xu M, Vladimirova A, Sun XH (2003) Notch-induced E2A ubiquitination and degradation are controlled by MAP kinase activities. EMBO J 22:5780-5792. (Pubitemid 37408817)
-
(2003)
EMBO Journal
, vol.22
, Issue.21
, pp. 5780-5792
-
-
Nie, L.1
Xu, M.2
Vladimirova, A.3
Sun, X.-H.4
-
40
-
-
77953289247
-
Early B cell factor 1 regulates B cell gene networks by activation, repression, and transcription-independent poising of chromatin
-
Treiber T, et al. (2010) Early B cell factor 1 regulates B cell gene networks by activation, repression, and transcription-independent poising of chromatin. Immunity 32:714-725.
-
(2010)
Immunity
, vol.32
, pp. 714-725
-
-
Treiber, T.1
-
41
-
-
77953763449
-
A global network of transcription factors, involving E2A, EBF1 and Foxo1, that orchestrates B cell fate
-
Lin YC, et al. (2010) A global network of transcription factors, involving E2A, EBF1 and Foxo1, that orchestrates B cell fate. Nat Immunol 11:635-643.
-
(2010)
Nat Immunol
, vol.11
, pp. 635-643
-
-
Lin, Y.C.1
-
42
-
-
34247092922
-
Molecular Evidence for Hierarchical Transcriptional Lineage Priming in Fetal and Adult Stem Cells and Multipotent Progenitors
-
DOI 10.1016/j.immuni.2007.02.013, PII S1074761307002130
-
Månsson R, et al. (2007) Molecular evidence for hierarchical transcriptional lineage priming in fetal and adult stem cells and multipotent progenitors. Immunity 26:407-419. (Pubitemid 46603001)
-
(2007)
Immunity
, vol.26
, Issue.4
, pp. 407-419
-
-
Mansson, R.1
Hultquist, A.2
Luc, S.3
Yang, L.4
Anderson, K.5
Kharazi, S.6
Al-Hashmi, S.7
Liuba, K.8
Thoren, L.9
Adolfsson, J.10
Buza-Vidas, N.11
Qian, H.12
Soneji, S.13
Enver, T.14
Sigvardsson, M.15
Jacobsen, S.E.W.16
-
43
-
-
0142121516
-
Exploration, normalization, and summaries of high density oligonucleotide array probe level data
-
Irizarry RA, et al. (2003) Exploration, normalization, and summaries of high density oligonucleotide array probe level data. Biostatistics 4:249-264.
-
(2003)
Biostatistics
, vol.4
, pp. 249-264
-
-
Irizarry, R.A.1
|