Amino acid residue E543 in JAK2 C618R is a potential therapeutic target for myeloproliferative disorders caused by JAK2 C618R mutation

Archives of Biochemistry and Biophysics

Volumn 528, Issue 1, 2012, Pages 57-66

  Wu, Qing Yun ^a   Li, Feng ^a   Guo, Hua Yan ^a   Cao, Jiang ^a   Chen, Chong ^a   Chen, Wei ^a   Zhao, Kai ^a   Zeng, Ling Yu ^a   Han, Zheng Xiang ^a   Li, Zhen Yu ^a   Wang, Xiao Yun ^b   Xu, Kai Lin ^a  

^a XUZHOU MEDICAL UNIVERSITY   (China)

^b SHANDONG AGRICULTURAL UNIVERSITY   (China)

Author keywords

Conformational change; Constitutive activation; Inhibitor; Janus kinase 2; Myeloproliferative disorders; Target

Indexed keywords

ALANINE; ERYTHROPOIETIN RECEPTOR; GLUTAMIC ACID; JANUS KINASE 2; STAT5 PROTEIN;

AMINO ACID ANALYSIS; AMINO TERMINAL SEQUENCE; ARTICLE; CATALYSIS; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME SUBSTRATE; FIBROSARCOMA; FLUORESCENCE ACTIVATED CELL SORTING; HUMAN; HUMAN CELL; HYDROPHILICITY; MOLECULAR DYNAMICS; MUTATIONAL ANALYSIS; MYELOPROLIFERATIVE DISORDER; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN PURIFICATION; PROTEIN TARGETING; SITE DIRECTED MUTAGENESIS; SOMATIC MUTATION; STRUCTURE ACTIVITY RELATION; WESTERN BLOTTING;

AMINO ACID SUBSTITUTION; ANIMALS; CELL LINE; CELL LINE, TUMOR; CELL PROLIFERATION; CELL TRANSFORMATION, NEOPLASTIC; GLUTAMIC ACID; HUMANS; JANUS KINASE 2; MICE; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; MYELOPROLIFERATIVE DISORDERS; POINT MUTATION; PROTEIN CONFORMATION; PROTEIN REFOLDING; PROTEIN UNFOLDING;

EID: 84866777412     PISSN: 00039861     EISSN: 10960384     Source Type: Journal    
DOI: 10.1016/j.abb.2012.08.010     Document Type: Article

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