Urea, but not guanidinium, destabilizes proteins by forming hydrogen bonds to the peptide group

Proceedings of the National Academy of Sciences of the United States of America

Volumn 106, Issue 8, 2009, Pages 2595-2600

  Lim, Woon Ki ^a,b   Rösgen, Jörg ^c   Englander, S Walter ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b Pusan National University   (South Korea)

^c University of Texas Medical Branch School of Medicine   (United States)

Author keywords

Denaturation; Hydrogen exchange; Osmolyte; Solvation

Indexed keywords

GUANIDINE; PEPTIDE; UREA;

ARTICLE; CONTROLLED STUDY; DENATURATION; HYDROGEN BOND; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DENATURATION; PROTEIN STABILITY; PROTEIN STRUCTURE; PROTEIN TRANSPORT; PROTON TRANSPORT; THERMODYNAMICS;

GUANIDINE; HYDROGEN BONDING; PEPTIDES; PROTEIN DENATURATION; PROTEINS; THERMODYNAMICS; UREA;

EID: 62449341938     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0812588106     Document Type: Article

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