메뉴 건너뛰기




Volumn 59, Issue 5, 2012, Pages 508-515

Epidermal growth factor receptor (EGFR) expression and mutations in the EGFR signaling pathway in correlation with anti-EGFR therapy in head and neck squamous cell carcinomas

Author keywords

EGFR; EGFR gene expression; HNSCC; KRAS

Indexed keywords

CETUXIMAB; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE INHIBITOR; ANTINEOPLASTIC AGENT; EGFR PROTEIN, HUMAN; EPIDERMAL GROWTH FACTOR RECEPTOR VIII; KRAS PROTEIN, HUMAN; MONOCLONAL ANTIBODY; ONCOPROTEIN; RAS PROTEIN;

EID: 84866770542     PISSN: 00282685     EISSN: 13384317     Source Type: Journal    
DOI: 10.4149/neo_2012_065     Document Type: Article
Times cited : (42)

References (36)
  • 1
    • 32144433159 scopus 로고    scopus 로고
    • Radiotherapy plus cetuximab for squamous-cell carcinoma of the head and neck
    • BONNER JA, HARARI PM, GIRALT J, AZARNIA N, SHIN DM et al. Radiotherapy plus cetuximab for squamous-cell carcinoma of the head and neck. N Engl J Med 2006; 354: 567-678. http://dx.doi.org/10.1056/NEJMoa053422
    • (2006) N Engl J Med , vol.354 , pp. 567-678
    • Bonner, J.A.1    Harari, P.M.2    Giralt, J.3    Azarnia, N.4    Shin, D.M.5
  • 2
    • 34250155320 scopus 로고    scopus 로고
    • Epidermal growth factor receptor copy number alterations correlate with poor clinical outcome in patients with head and neck squamous cancer
    • TEMAM S, KAWAGUCHI H, EL-NAGGAR AK, JELINEK J, TANG H et al. Epidermal growth factor receptor copy number alterations correlate with poor clinical outcome in patients with head and neck squamous cancer. J Clin Oncol 2007; 25: 2164-2170. http://dx.doi.org/10.1200/JCO.2006.06.6605
    • (2007) J Clin Oncol , vol.25 , pp. 2164-2170
    • Temam, S.1    Kawaguchi, H.2    El-Naggar, A.K.3    Jelinek, J.4    Tang, H.5
  • 3
    • 44649115694 scopus 로고    scopus 로고
    • Targeting epidermal growth factor receptor and SRC pathways in head and neck cancer
    • EGLOFF AM, GRANDIS JR. Targeting epidermal growth factor receptor and SRC pathways in head and neck cancer. Semin Oncol 2008; 35: 286-297. http://dx.doi.org/10.1053/j.seminoncol.2008.03.008
    • (2008) Semin Oncol , vol.35 , pp. 286-297
    • Egloff, A.M.1    Grandis, J.R.2
  • 4
    • 84859243184 scopus 로고    scopus 로고
    • The Nuclear Epidermal Growth Factor Receptor Signaling Network and Its Role in Cancer
    • BRAND TM, IIDA M, CHUNRONG L, WHEELER DL. The Nuclear Epidermal Growth Factor Receptor Signaling Network and Its Role in Cancer. Discov Med 2011; 12: 419-432.
    • (2011) Discov Med , vol.12 , pp. 419-432
    • Brand, T.M.1    Iida, M.2    Chunrong, L.3    Wheeler, D.L.4
  • 5
    • 79958053606 scopus 로고    scopus 로고
    • Clinical significance of genetic alterations and expression of epidermal growth factor receptor (EGFR) in head and neck squamous cell carcinomas
    • SZABO B, NELHUBEL GA, KARPATI A, KENESSEY I, JORI B et al. Clinical significance of genetic alterations and expression of epidermal growth factor receptor (EGFR) in head and neck squamous cell carcinomas. Oral Oncology 2011; 47: 487-496. http://dx.doi.org/10.1016/j.oraloncology.2011.03.020
    • (2011) Oral Oncology , vol.47 , pp. 487-496
    • Szabo, B.1    Nelhubel, G.A.2    Karpati, A.3    Kenessey, I.4    Jori, B.5
  • 6
    • 68949201629 scopus 로고    scopus 로고
    • Activating and resistance mutations of EGFR in non-small-cell lung cancer: Role in clinical response to EGFR tyrosine kinase inhibitors
    • GAZDAR AF. Activating and resistance mutations of EGFR in non-small-cell lung cancer: role in clinical response to EGFR tyrosine kinase inhibitors. Oncogene 2009; 28(Suppl 1): 24-31. http://dx.doi.org/10.1038/onc.2009.198
    • (2009) Oncogene , vol.28 , Issue.SUPPL. 1 , pp. 24-31
    • Gazdar, A.F.1
  • 7
    • 77956268839 scopus 로고    scopus 로고
    • Understanding resistance to EGFR inhibitors-impact on future treatment strategies
    • WHEELER DL, DUNN EF HARARI PM. Understanding resistance to EGFR inhibitors-impact on future treatment strategies. Nature rewiewe Clin Oncol 2010; 7: 493-507.
    • (2010) Nature rewiewe Clin Oncol , vol.7 , pp. 493-507
    • Wheeler, D.L.1    Dunn Ef Harari, P.M.2
  • 8
    • 67650667527 scopus 로고    scopus 로고
    • Cigarettes smoking habit may reduce benefit from cetuximab-based treatment in advanced colorectal cancer patients
    • VINCENZI B, SANTINI D, LOUPAKIS F, ADDEO R, LLIMPE FLR et al. Cigarettes smoking habit may reduce benefit from cetuximab-based treatment in advanced colorectal cancer patients. Expert Opin Biol Ther 2009; 9: 945-949. http://dx.doi.org/10.1517/14712590903081694
    • (2009) Expert Opin Biol Ther , vol.9 , pp. 945-949
    • Vincenzi, B.1    Santini, D.2    Loupakis, F.3    Addeo, R.4    Llimpe, F.L.R.5
  • 9
    • 23844491524 scopus 로고    scopus 로고
    • Differential effects of gefitinib and cetuximab on non-small cell lung cancers bearing epidermal growth factor receptor mutations
    • MUKOHARA T, ENGELMAN JA, HANNA NH, YEAP BY, KOBAYASHI S et al. Differential effects of gefitinib and cetuximab on non-small cell lung cancers bearing epidermal growth factor receptor mutations. J Nat Cancer Inst 2005; 97: 1185-1194. http://dx.doi.org/10.1093/jnci/dji238
    • (2005) J Nat Cancer Inst , vol.97 , pp. 1185-1194
    • Mukohara, T.1    Engelman, J.A.2    Hanna, N.H.3    Yeap, B.Y.4    Kobayashi, S.5
  • 10
    • 33746896572 scopus 로고    scopus 로고
    • The evolving role of cetuximab in non-small cell lung cancer
    • LILENBAUM RC, JOHNSON B, LYNCH T, SANDLER A, BUNN P et al. The evolving role of cetuximab in non-small cell lung cancer. Clin Cancer Res 2006; 12: 4432-4435. http://dx.doi.org/10.1158/1078-0432.CCR-06-0097
    • (2006) Clin Cancer Res , vol.12 , pp. 4432-4435
    • Lilenbaum, R.C.1    Johnson, B.2    Lynch, T.3    Sandler, A.4    Bunn, P.5
  • 11
    • 33846244217 scopus 로고    scopus 로고
    • Epidermal Growtht Factor Receptor Activ ation: How Exon 19 and 21 Mutations Changed Our Understanding of the Pathway
    • ROSELL R, TARON M, REQUART N, ISLA D, MORAN T. Epidermal Growtht Factor Receptor Activ ation: How Exon 19 and 21 Mutations Changed Our Understanding of the Pathway. Clin Cancer Res 2006; 12: 7222-7230. http://dx.doi.org/10.1158/1078-0432.CCR-06-0627
    • (2006) Clin Cancer Res , vol.12 , pp. 7222-7230
    • Rosell, R.1    Taron, M.2    Requart, N.3    Isla, D.4    Moran, T.5
  • 12
    • 77951744287 scopus 로고    scopus 로고
    • New strategies in head and neck cancer: Understanding resistance to epidermal growth factor receptor inhibitors
    • CHEN L F, COHEN E E, GRANDIS J R. New strategies in head and neck cancer: understanding resistance to epidermal growth factor receptor inhibitors. Clinical Cancer Research 2010; 16: 2489-2495. http://dx.doi.org/10.1158/1078-0432.CCR-09-2318
    • (2010) Clinical Cancer Research , vol.16 , pp. 2489-2495
    • Chen, L.F.1    Cohen, E.E.2    Grandis, J.R.3
  • 13
    • 77950680537 scopus 로고    scopus 로고
    • Cetuximab-based immunotherapy and radioimmunotherapy of head and neck quamous cell carcinoma
    • NIU G, SUN X, CAO Q, COURTER D, KOONG A et al. Cetuximab-based immunotherapy and radioimmunotherapy of head and neck quamous cell carcinoma. Clinical Cancer Research 2010; 16: 2095-2105. http://dx.doi.org/10.1158/1078-0432.CCR-09-2495
    • (2010) Clinical Cancer Research , vol.16 , pp. 2095-2105
    • Niu, G.1    Sun, X.2    Cao, Q.3    Courter, D.4    Koong, A.5
  • 14
    • 33646228635 scopus 로고    scopus 로고
    • K-RAS mutation status is predictive of response to cetuximab therapy in colorectal cancer
    • LIEVRE A, BACHET JB, LE CORRE D, BOIGE V, LANDI B et al. K-RAS mutation status is predictive of response to cetuximab therapy in colorectal cancer. Cancer Research 2006; 66: 3992-3995. http://dx.doi.org/10.1158/0008-5472.CAN-06-0191
    • (2006) Cancer Research , vol.66 , pp. 3992-3995
    • Lievre, A.1    Bachet, J.B.2    Le Corre, D.3    Boige, V.4    Landi, B.5
  • 15
    • 34247278727 scopus 로고    scopus 로고
    • Clinical relevance of KRAS mutation detection in metastatic colorectal cancer treated by Cetuximab plus chemotherapy
    • DI FIORE F, BLANCHARD F, CHARBONNIER F, LE PESSOT F, LAMY A et al. Clinical relevance of KRAS mutation detection in metastatic colorectal cancer treated by Cetuximab plus chemotherapy. British Journal of Cancer 2007; 96: 1166-1169. http://dx.doi.org/10.1038/sj.bjc.6603685
    • (2007) British Journal of Cancer , vol.96 , pp. 1166-1169
    • Di Fiore, F.1    Blanchard, F.2    Charbonnier, F.3    Le Pessot, F.4    Lamy, A.5
  • 16
    • 4544258999 scopus 로고    scopus 로고
    • EGFR and EGFRvIII expression in primary breast cancer and cell lines
    • RAE JM, SCHEYS JO, CLARK KM, CHADWICK RB, KIEFER MC et al. EGFR and EGFRvIII expression in primary breast cancer and cell lines. Breast Cancer Res Treat 2004; 87: 87-95. http://dx.doi.org/10.1023/B:BREA.0000041585.26734.f9
    • (2004) Breast Cancer Res Treat , vol.87 , pp. 87-95
    • Rae, J.M.1    Scheys, J.O.2    Clark, K.M.3    Chadwick, R.B.4    Kiefer, M.C.5
  • 17
    • 0037444275 scopus 로고    scopus 로고
    • Distinct amplification of an untranslated regulatory sequence in the egfr gene contributes to early steps in breast cancer development
    • TIDOW N, BOECKER A, SCHMIDT H, AGELOPOULOS K, BOECKER W et all. Distinct amplification of an untranslated regulatory sequence in the egfr gene contributes to early steps in breast cancer development. Cancer Res 2003; 63: 1172-1178.
    • (2003) Cancer Res , vol.63 , pp. 1172-1178
    • Tidow, N.1    Boecker, A.2    Schmidt, H.3    Agelopoulos, K.4    Boecker, W.5
  • 18
    • 79960352442 scopus 로고    scopus 로고
    • Diverse effects of combined radiotherapy and EGFR inhibition with antibodies or TK inhibitors on local tumour control and correlation with EGFR gene expression
    • GURTNER K, DEUSE Y, BUTOF R, SCHAAL K, EICHELER W et al. Diverse effects of combined radiotherapy and EGFR inhibition with antibodies or TK inhibitors on local tumour control and correlation with EGFR gene expression. Radiotherapy and Oncology 2011; 99: 323-330. http://dx.doi.org/10.1016/j.radonc.2011.05.035
    • (2011) Radiotherapy and Oncology , vol.99 , pp. 323-330
    • Gurtner, K.1    Deuse, Y.2    Butof, R.3    Schaal, K.4    Eicheler, W.5
  • 19
    • 33749237751 scopus 로고    scopus 로고
    • High gene copy number of epidermal growth factor receptor by fluorescence in situ hybridization is frequent in head and neck squamous cell carcinomas and associates with worse recurrence-free survival
    • CHUNG CHH, ELY K, CARTER J, MCGAVRAN L, VARELLA-GARCIA M et al. High gene copy number of epidermal growth factor receptor by fluorescence in situ hybridization is frequent in head and neck squamous cell carcinomas and associates with worse recurrence-free survival. J Clin Oncol 2006; 24 (Suppl 18): 5502.
    • (2006) J Clin Oncol , vol.24 , Issue.SUPPL. 18 , pp. 5502
    • Chung, C.H.H.1    Ely, K.2    Carter, J.3    McGavran, L.4    Varella-Garcia, M.5
  • 20
    • 33749035470 scopus 로고    scopus 로고
    • Mutant epidermal growth factor receptor (EGFRvIII) contributes to head and neck cancer growth and resistance to EGFR targeting
    • SOK JC, COPPELLI FM, THOMAS SM, LANGO MN, XI S et al. Mutant epidermal growth factor receptor (EGFRvIII) contributes to head and neck cancer growth and resistance to EGFR targeting. Clinical Cancer Research 2006; 12: 5064-5073. http://dx.doi.org/10.1158/1078-0432.CCR-06-0913
    • (2006) Clinical Cancer Research , vol.12 , pp. 5064-5073
    • Sok, J.C.1    Coppelli, F.M.2    Thomas, S.M.3    Lango, M.N.4    Xi, S.5
  • 21
    • 21244499405 scopus 로고    scopus 로고
    • GAPDH as a housekeeping gene: Analysis of GAPDH mRNA expression in a panel of 72 human tissues
    • BARBER RD, HARMER DW, COLEMAN RA, CLARK BJL. GAPDH as a housekeeping gene: analysis of GAPDH mRNA expression in a panel of 72 human tissues. Physiol Genomics 2005; 21: 389-395. http://dx.doi.org/10.1152/physiolgenomics.00025.2005
    • (2005) Physiol Genomics , vol.21 , pp. 389-395
    • Barber, R.D.1    Harmer, D.W.2    Coleman, R.A.3    Clark, B.J.L.4
  • 22
    • 0142188691 scopus 로고    scopus 로고
    • Prognostic value of epidermal growth factor receptor in patients with glioblastoma multiforme
    • SHINOJIMA N, TADA K, SHIRAISHI S, KAMIRYO T, KOCHI M et al. Prognostic value of epidermal growth factor receptor in patients with glioblastoma multiforme. Cancer Res 2003; 63: 6962-6970.
    • (2003) Cancer Res , vol.63 , pp. 6962-6970
    • Shinojima, N.1    Tada, K.2    Shiraishi, S.3    Kamiryo, T.4    Kochi, M.5
  • 24
    • 33745058415 scopus 로고    scopus 로고
    • Pitfalls in immunohistochemical assessment of EGFR expression in soft tissue sarcomas
    • KERSTING C, PACKEISEN J, LEIDINGER B et al. Pitfalls in immunohistochemical assessment of EGFR expression in soft tissue sarcomas. J Clin Pathol 2006; 59: 585-590. http://dx.doi.org/10.1136/jcp.2005.028373
    • (2006) J Clin Pathol , vol.59 , pp. 585-590
    • Kersting, C.1    Packeisen, J.2    Leidinger, B.3
  • 25
    • 17844362179 scopus 로고    scopus 로고
    • Gene copy number for epidermal growth factor receptor (EGFR) and clinical response to antiEGFR treatment in colorectal cancar: A cohort study
    • MORONI M, VERONESE S, BENVENUTI S, MARRAPESE G, SARTORE-BIANCHI A et al. Gene copy number for epidermal growth factor receptor (EGFR) and clinical response to antiEGFR treatment in colorectal cancar: a cohort study. Lancet Oncol 2005; 6: 279-286. http://dx.doi.org/10.1016/S1470-2045(05)70102-9
    • (2005) Lancet Oncol , vol.6 , pp. 279-286
    • Moroni, M.1    Veronese, S.2    Benvenuti, S.3    Marrapese, G.4    Sartore-Bianchi, A.5
  • 26
    • 77951961432 scopus 로고    scopus 로고
    • Epidermal Growth Factor Receptor and K-RAS status in two cohorts of squamous cell carcinomas
    • VAN DAMME N, DERON P, VAN ROY N, DEMETTER P, BOLS A et al. Epidermal Growth Factor Receptor and K-RAS status in two cohorts of squamous cell carcinomas. BMC Cancer 2010; 10: 189-198. http://dx.doi.org/10.1186/1471-2407-10-189
    • (2010) BMC Cancer , vol.10 , pp. 189-198
    • Van Damme, N.1    Deron, P.2    Van Roy, N.3    Demetter, P.4    Bols, A.5
  • 27
    • 33748653109 scopus 로고    scopus 로고
    • Increased Epidermal Growth Factor Receptor Gene Copy Number Is Associated With Poor Prognosis in Head and Neck Squamous Cell Carcinomas
    • CHUNG CHH, ELY K, MCGAVRAN L, VARELLA-GARCIA M, PARKER J et al. Increased Epidermal Growth Factor Receptor Gene Copy Number Is Associated With Poor Prognosis in Head and Neck Squamous Cell Carcinomas. Journal of Clinical Oncology 2006; 24: 4170-4176. http://dx.doi.org/10.1200/JCO.2006.07.2587
    • (2006) Journal of Clinical Oncology , vol.24 , pp. 4170-4176
    • Chung, C.H.H.1    Ely, K.2    McGavran, L.3    Varella-Garcia, M.4    Parker, J.5
  • 28
    • 0142119289 scopus 로고    scopus 로고
    • Epidermal growth factor receptor in non-small-cell lung carcinomas: Correlation between gene copy number and protein expression and impact on prognosis
    • HIRSCH FR, VARELLA-GARCIA M, BUNN PA JR, DI MARIA MV, VEVE R et al. Epidermal growth factor receptor in non-small-cell lung carcinomas: Correlation between gene copy number and protein expression and impact on prognosis. J Clin Oncol 2003; 21: 3798-3807. http://dx.doi.org/10.1200/JCO.2003.11.069
    • (2003) J Clin Oncol , vol.21 , pp. 3798-3807
    • Hirsch, F.R.1    Varella-Garcia, M.2    Bunn Jr., P.A.3    Di Maria, M.V.4    Veve, R.5
  • 29
    • 2342624080 scopus 로고    scopus 로고
    • EGFR mutations in lung cancer: Correlation with clinical response to gefitinib therapy
    • PAEZ JG, JANNE PA, LEE JC, TRACY S, GREULICH H et al. EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy. Science 2004; 304: 1497-1500. http://dx.doi.org/10.1126/science.1099314
    • (2004) Science , vol.304 , pp. 1497-1500
    • Paez, J.G.1    Janne, P.A.2    Lee, J.C.3    Tracy, S.4    Greulich, H.5
  • 30
    • 2342471392 scopus 로고    scopus 로고
    • Activating mutations in the epidermal growth factor receptor underlying responsiveness of nonsmall-cell lung cancer to gefitinib
    • LYNCH TJ, BELL DW, SORDELLA R, GURUBHAGVATULA S, OKIMOTO RA. Activating mutations in the epidermal growth factor receptor underlying responsiveness of nonsmall-cell lung cancer to gefitinib. N Engl J Med 2004; 350: 2129-2139. http://dx.doi.org/10.1056/NEJMoa040938
    • (2004) N Engl J Med , vol.350 , pp. 2129-2139
    • Lynch, T.J.1    Bell, D.W.2    Sordella, R.3    Gurubhagvatula, S.4    Okimoto, R.A.5
  • 31
    • 70350661090 scopus 로고    scopus 로고
    • Prevalence of K-RAS codon 12 mutations in locally advanced head and neck squamous cell carcinoma and influence with regards to response to chemoradiation therapy
    • Abstr 17008
    • BISSADA E, ABOU-CHACRA Z, WENG X, GUERTIN P, NGUYEN-TAN M et al. Prevalence of K-RAS codon 12 mutations in locally advanced head and neck squamous cell carcinoma and influence with regards to response to chemoradiation therapy. J Clin Oncol, Meeting Proceedings 2008; 26: Abstr 17008.
    • (2008) J Clin Oncol, Meeting Proceedings , vol.26
    • Bissada, E.1    Abou-Chacra, Z.2    Weng, X.3    Guertin, P.4    Nguyen-Tan, M.5
  • 32
    • 49749113623 scopus 로고    scopus 로고
    • Expression and mutation analysis of epidermal growth factor receptor in head and neck squamous cell carcinoma
    • SHEIKH ALI MAL, GUNDUZ M, NAGATSUKA H, GUNDUZ E, CENGIZ B et al. Expression and mutation analysis of epidermal growth factor receptor in head and neck squamous cell carcinoma. Cancer Sci 2008; 99: 1589-1594. http://dx.doi.org/10.1111/j.1349-7006.2008.00861.x
    • (2008) Cancer Sci , vol.99 , pp. 1589-1594
    • Sheikh Ali, M.A.L.1    Gunduz, M.2    Nagatsuka, H.3    Gunduz, E.4    Cengiz, B.5
  • 33
    • 0037115610 scopus 로고    scopus 로고
    • Amplification of Wild-Type K-ras Promotes Growth of Head and Neck Squamous Cell Carcinoma
    • HOA M, DAVIS SL, AMES SJ, SPANJAARD RA. Amplification of Wild-Type K-ras Promotes Growth of Head and Neck Squamous Cell Carcinoma. Cancer Res 2002; 62: 7154-7156.
    • (2002) Cancer Res , vol.62 , pp. 7154-7156
    • Hoa, M.1    Davis, S.L.2    Ames, S.J.3    Spanjaard, R.A.4
  • 34
    • 33646716077 scopus 로고    scopus 로고
    • Epidermal growth factor receptor variant III mutations in lung tumorigenesis and sensitivity to tyrosine kinase inhibitors
    • JI H, ZHAO X, YUZA Y, et al. Epidermal growth factor receptor variant III mutations in lung tumorigenesis and sensitivity to tyrosine kinase inhibitors. Proc Natl Acad Sci USA 2006;103: 7817-7822. http://dx.doi.org/10.1073/pnas.0510284103
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 7817-7822
    • Ji, H.1    Zhao, X.2    Yuza, Y.3
  • 35
    • 79951952444 scopus 로고    scopus 로고
    • The association between EGFR variant III, HPV, p16, c-MET, EGFR gene copy number and response to EGFR inhibitors in patients with recurrent or metastatic squamous cell carcinoma of the head and neck
    • CHAU NG, PEREZ-ORDONEZ B, ZHANG K, PHAM N, JAMES HO J et al. The association between EGFR variant III, HPV, p16, c-MET, EGFR gene copy number and response to EGFR inhibitors in patients with recurrent or metastatic squamous cell carcinoma of the head and neck. Head & Neck Oncology 2011; 3: 1-11.
    • (2011) Head & Neck Oncology , vol.3 , pp. 1-11
    • Chau, N.G.1    Perez-Ordonez, B.2    Zhang, K.3    Pham, N.4    James Ho, J.5
  • 36
    • 10944269712 scopus 로고    scopus 로고
    • Gefitinib (lressa) in oncogen-adddictive cancers and therapy for common cancers
    • BLAGOSKLONNY, M V. Gefitinib (lressa) in oncogen-adddictive cancers and therapy for common cancers. Cancer Biol Ther 2004; 3: 436-440. http://dx.doi.org/10.4161/cbt.3.5.984
    • (2004) Cancer Biol Ther , vol.3 , pp. 436-440
    • Blagosklonny, M.V.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.