SCOPUS 정보 검색 플랫폼

Volumn 7, Issue 10, 2012, Pages 1815-1824

Synthesis and Biological Evaluation of ortho-Aryl N-Hydroxycinnamides as Potent Histone Deacetylase (HDAC) 8 Isoform-Selective Inhibitors

(11) Huang, Wei Jan a Wang, Yi Ching b Chao, Shi Wei a Yang, Chen Yui c Chen, Liang Chieh a Lin, Mei Hsiang a Hou, Wen Chi a Chen, Mei Yu b Lee, Tai Lin a Yang, Ping a Chang, Chung I c,d

a TAIPEI MEDICAL UNIVERSITY (Taiwan)

b NATIONAL CHENG KUNG UNIVERSITY (Taiwan)

c INSTITUTE OF BIOLOGICAL CHEMISTRY (Taiwan)

d NATIONAL TAIWAN UNIVERSITY (Taiwan)

Author keywords

Cinnamides; Epigenetics; Histone deacetylases; Isoform selective inhibitors; Molecular modeling

Indexed keywords

2 ARYL N HYDROXYCINNAMIDE DERIVATIVE; ANTINEOPLASTIC AGENT; HISTONE DEACETYLASE 8; HISTONE DEACETYLASE 8 INHIBITOR; HISTONE DEACETYLASE INHIBITOR; N HYDROXY 2 (4 BROMOBENZYLOXY) 4 METHOXYCINNAMIDE; N HYDROXY 2 (4 CHLOROBENZYLOXY) 4 METHOXYCINNAMIDE; N HYDROXY 2 (4 METHOXYBENZYLOXY) 4 METHOXYCINNAMIDE; N HYDROXY 2 [(NAPHTHALEN 4 YL)METHOXY] 4 METHOXYCINNAMIDE; N HYDROXY 2 [2 (4 METHOXYPHENOXYOXY)BUTOXY] 4 METHOXYCINNAMIDE; N HYDROXY 2 [2 (4 METHOXYPHENOXYOXY)ETHOXY] 4 METHOXYCINNAMIDE; N HYDROXY 2 [2 (4 METHOXYPHENOXYOXY)PENTYLOXY] 4 METHOXYCINNAMIDE; N HYDROXY 2 [2 (4 METHOXYPHENOXYOXY)PROPOXY] 4 METHOXYCINNAMIDE; N HYDROXY 2 BENZYLOXY 4 METHOXYCINNAMIDE; N HYDROXY 4 (4 BROMOBENZYLOXY) 2 METHOXYCINNAMIDE; N HYDROXY 4 (4 CHLOROBENZYLOXY) 2 METHOXYCINNAMIDE; N HYDROXY 4 (4 METHOXYBENZYLOXY) 2 METHOXYCINNAMIDE; N HYDROXY 4 (TRIFLUOROMETHOXY) 2 METHOXYCINNAMIDE; N HYDROXY 4 [(NAPHTHALEN 4 YL)METHOXY] 2 METHOXYCINNAMIDE; N HYDROXY 4 BENZYLOXY 2 METHOXYCINNAMIDE; N HYDROXY 4 METHOXY 2 (4 BENZOYLPHENYL)CINNAMIDE; N HYDROXY 4 METHOXY 2 (4 BROMOPHENYL)CINNAMIDE; N HYDROXY 4 METHOXY 2 (4 PHENOXYPHENYL)CINNAMIDE; N HYDROXY 4 METHOXY 2 (BIPHENYL 4 YL)CINNAMIDE; N HYDROXY 4 METHOXY 2 (DIBENZOFURAN 4 YL)CINNAMIDE; N HYDROXY 4 METHOXY 2 (NAPHTHALEN 1 YL)CINNAMIDE; N HYDROXY 4 METHOXY 2 PHENYLCINNAMIDE; PCI 34051; UNCLASSIFIED DRUG; UNINDEXED DRUG; VORINOSTAT;

ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; CANCER CELL CULTURE; DRUG DESIGN; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; IC 50; LUNG CANCER; PRIORITY JOURNAL;

AMIDES; BINDING SITES; CELL LINE, TUMOR; CELL SURVIVAL; CINNAMATES; DRUG DESIGN; HALF-LIFE; HELA CELLS; HISTONE DEACETYLASE INHIBITORS; HISTONE DEACETYLASES; HUMANS; MOLECULAR DOCKING SIMULATION; REPRESSOR PROTEINS;

EID: 84866756851 PISSN: 18607179 EISSN: 18607187 Source Type: Journal
DOI: 10.1002/cmdc.201200300 Document Type: Article

Times cited : (65)

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