Optimal Integration of Directly Combined Hydrophobic Interaction and Ion Exchange Chromatography Purification Processes

Chemical Engineering and Technology

Volumn 35, Issue 10, 2012, Pages 1786-1796

  Helling, C ^a   Borrmann, C ^a   Strube, J ^a  

^a CLAUSTHAL UNIVERSITY OF TECHNOLOGY   (Germany)

Author keywords

Biotechnology; Downstream processing; Hydrophobic interaction chromatography; Ion exchange chromatography; Modeling

Indexed keywords

ALTERNATIVE APPROACH; BIOPHARMACEUTICALS; CULTURE SUPERNATANT; DIRECT INTEGRATION; DOWNSTREAM-PROCESSING; EXPERIMENTAL MODELS; HYDROPHOBIC INTERACTION CHROMATOGRAPHY; HYDROPHOBIC INTERACTIONS; ION EXCHANGE CHROMATOGRAPHY; MAMMALIAN CELL CULTURE; MODEL PARAMETERS; MODEL-BASED OPC; OPTIMAL INTEGRATION; PROCESS MODELING; PURIFICATION PROCESS; SINGLE-STEP; SMALL SCALE; STATISTICAL DESIGN OF EXPERIMENTS; YIELD IMPROVEMENT;

BIOTECHNOLOGY; CELL CULTURE; CHROMATOGRAPHIC ANALYSIS; DESIGN OF EXPERIMENTS; HYDROPHOBIC CHROMATOGRAPHY; HYDROPHOBICITY; LIQUID CHROMATOGRAPHY; MODELS; PURIFICATION; SEPARATION;

OPTIMIZATION;

MAMMALIA;

EID: 84866754636     PISSN: 09307516     EISSN: 15214125     Source Type: Journal    
DOI: 10.1002/ceat.201200043     Document Type: Article

References (30)

1. S. Sommerfeld, J. Strube, Chem. Eng. Proc. 2005, 44, 1123.
2. L. Deiberle, R. Dohrn, Miniplant-Technik, Wiley-VCH, Weinheim 2006.
3. R.L. Baldwin, Biophys. J. 1996, 71 (4), 2056.
4. A. Vailay, C. Horvath, Biochemistry 1996, 62, 81.
5. H.P. Jennissen, A. Demiroglu, J. Chromatogr. A 2006, 1109, 197.
6. E. Ruckenstein, I.L. Shulgina, Adv. Colloid Interface Sci. 2006, 97, 123.
7. C. Borrmann, C. Helling, M. Lohrmann, S. Sommerfeld, J. Strube, Sep. Sci. Technol. 2011, 46 (8), 1289.
8. A. Wiesel, H. Schmidt-Traub, J. Lenz, J. Strube, J. Chromatogr. A 2003, 1006, 101.
9. S. Cramer, C.A. Brooks, AIChE J. 1992, 38, 1969.
10. A. Mahn, G. Zapata-Torres, J.A. Asenjo, J. Chromatogr. A 2005, 1066, 81.
11. J.C. Salgado, I. Rapaport, J.A. Asenjo, J. Chromatogr. A 2006, 110, 110.
12. E. Haimer, A. Tscheliessnig, R. Hahn, A. Jungbauer, J. Chromatogr. A 2007, 1139, 84.
13. T. McCue, P. Engel, A. Ng, R. Macniven, J. Thommas, Bioprocess Biosyst. Eng. 2008, 31, 261.
14. J.M. Mollerup, T.B. Hansen, S. Kidal, A. Staby, J. Chromatogr. A 2008, 1177, 200.
15. K. Westerberg, E. Broberg Hansen, M. Degerman, T. Budde Hansen, B. Nilsson, Chem. Eng. Technol. 2012, 35 (1), 183.
16. N. Jakobsson, M. Degerman, B. Nilsson, J. Chromatogr. A 2005, 1099 (1-2), 157.
17. G. Carta, A. Jungbauer Protein Chromatography, Wiley, Hoboken, NJ 2010.
18. S. Sohn, D. Kim, Chemosphere 2005, 58, 115.
19. J.C. Bosma, J.A. Wesselingh, AIChE J. 2004, 50, 848.
20. N. Forrer, A. Butté, M. Morbidelli, J. Chromatogr. A 2008, 1214, 71.
21. S. Dimartino, C. Boi, G.C. Sarti, J. Chromatogr. A 2011, 1218, 1677.
22. nd ed., Academic Press Elsevier, Maryland Heights, MO 2007.
23. F. Grote, Methode zur Integration von Recyclingstrategien in die Aufarbeitung von pharmazeutischen Biotechnologieprozessen, Shaker Verlag GmbH, Aachen, 2012.
24. N. Jakobsson, M. Degerman, E. Stenborg, B. Nilsson, J. Chromatogr. A 2007, 1138, 109.
25. G. Carta, R.K. Lewus, Sep. Sci. Technol. 1999, 34 (14), 2685.
26. A.I. Liapis, B.A. Grimes, J. Sep. Sci. 2005, 28, 1909.
27. F. Grote, H. Fröhlich, J. Strube, Chem. Eng. Technol. 2011, 34 (5), 673.
28. F. Oliveira de Medeiros, C.A. Veiga Burkert, S. Juliano Kalil, Chem. Eng. Technol. 2012, 35 (5), 911.
29. Guidance for Industry PAT - A Framework for Innovative Pharmaceutical Manufacturing and Quality Assurance, U.S. Food and Drug Administration, US Department of Health and Human Services, Rockville, MD 2004.
30. J. Strube, F. Grote, R. Ditz, in Biopharmaceutical Production Technology (Ed: G. Subramanian), Wiley-VCH, Weinheim 2012.