Human endogenous retrovirus type W envelope expression in blood and brain cells provides new insights into multiple sclerosis disease

Multiple Sclerosis Journal

Volumn 18, Issue 12, 2012, Pages 1721-1736

  Perron, Hervé ^a,b   Germi, Raphaëlle ^c   Bernard, Corinne ^a   Garcia Montojo, Marta ^a   Deluen, Cécile ^d   Farinelli, Laurent ^d   Faucard, Raphaël ^a   Veas, Francisco ^e,f   Stefas, Ilias ^e   Fabriek, Babs O ^g   Van Horssen, Jack ^h   Van Der Valk, Paul ^h   Gerdil, Claire ⁱ   Mancuso, Roberta ^j   Saresella, Marina ^j   Clerici, Mario ^j,k   Marcel, Sébastien ^c,t   Creange, Alain ^l   Cavaretta, Rosella ^j   Caputo, Domenico ^j   Arru, Giannina ^m   Morand, Patrice ^c   Lang, Alois B ^a   Sotgiu, Stefano ^m   Ruprecht, Klemens ^n,u   Rieckmann, Peter ^n,v   Villoslada, Pablo ^o,w   Chofflon, Michel ^p   Boucraut, Jose ^q   Pelletier, Jean ^r   Hartung, Hans Peter ^s   more..

^a GENEURO SA   (Switzerland)

^b UNIVERSITÉ DE LYON   (France)

^c GRENOBLE UNIVERSITY HOSPITAL   (France)

^d University Hospital ^*

^e IRD   (France)

^f UNIV MONTPELLIER   (France)

^g TNO   (Netherlands)

^h VU UNIVERSITY MEDICAL CENTER   (Netherlands)

ⁱ ETABLISSEMENT FRANÇAIS DU SANG   (France)

^j IRCCS FONDAZIONE DON CARLO GNOCCHI   (Italy)

^k UNIVERSITY OF MILAN   (Italy)

^l UNIVERSITÉ PARIS EST   (France)

^m UNIVERSITY OF SASSARI   (Italy)

ⁿ Centre for Applied Medical Research   (Germany)

^o UNIVERSITY OF NAVARRA   (Spain)

^p UNIVERSITY HOSPITAL   (Switzerland)

^q Faculty of Medicine   (France)

^r University Hospital   (France)

^s HEINRICH HEINE UNIVERSITY   (Germany)

^t CENTRE HOSPITALIER DE CHAMBÉRY   (France)

^u CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^v UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^w HOSPITAL CLÍNIC   (Spain)

more..

Author keywords

biomarker; endogenous retrovirus; HERV W; MSRV; multiple sclerosis; syncytin; TLR4

Indexed keywords

AZATHIOPRINE; BETA INTERFERON; CYCLOPHOSPHAMIDE; DNA; ENVELOPE PROTEIN; GLATIRAMER; METHOTREXATE; MITOXANTRONE; PROTEIN HERV W; RNA; UNCLASSIFIED DRUG;

ADULT; AGED; ANTIGEN DETECTION; ARTICLE; AUTOIMMUNITY; CHRONIC INFLAMMATORY DEMYELINATING POLYNEUROPATHY; CONTROLLED STUDY; COPY NUMBER VARIATION; ENDOGENOUS RETROVIRUS; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOASSAY; IMMUNOHISTOCHEMISTRY; INFECTION; MAJOR CLINICAL STUDY; MALE; MULTIPLE SCLEROSIS; NEUROLOGIC DISEASE; PERIPHERAL BLOOD MONONUCLEAR CELL; PREVALENCE; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; SEQUENCE ANALYSIS; SYSTEMIC LUPUS ERYTHEMATOSUS;

EID: 84866741091     PISSN: 13524585     EISSN: 14770970     Source Type: Journal    
DOI: 10.1177/1352458512441381     Document Type: Article

References (56)

1. Haahr S, Sommerlund M, Moller-Larsen A, et al. Just another dubious virus in cells from a patient with multiple sclerosis?. Lancet. 1991 ; 337: 863-864
2. Perron H, Geny C, Laurent A, et al. Leptomeningeal cell line from multiple sclerosis with reverse transcriptase activity and viral particles. Res Virol. 1989 ; 140: 551-561
3. Perron H, Lalande B, Gratacap B, et al. Isolation of retrovirus from patients with multiple sclerosis. Lancet. 1991 ; 337: 862-863
4. Koprowski H, DeFreitas EC, Harper ME, et al. Multiple sclerosis and human T-cell lymphotropic retroviruses. Nature. 1985 ; 318: 154-160
5. Munch M, Moller-Larsen A, Christensen T, et al. B-lymphoblastoid cell lines from multiple sclerosis patients and a healthy control producing a putative new human retrovirus and Epstein-Barr virus. Mult Scler. 1995 ; 1: 78-81
6. Perron H, Firouzi R, Tuke P, et al. Cell cultures and associated retroviruses in multiple sclerosis. Collaborative Research Group on MS. Acta Neurol Scand Suppl. 1997 ; 169: 22-31
7. Perron H, Garson JA, Bedin F, et al. Molecular identification of a novel retrovirus repeatedly isolated from patients with multiple sclerosis. The Collaborative Research Group on Multiple Sclerosis. Proc Natl Acad Sci USA. 1997 ; 94: 7583-7588
8. Komurian-Pradel F, Paranhos-Baccala G, Bedin F, et al. Molecular cloning and characterization of MSRV-related sequences associated with retrovirus-like particles. Virology. 1999 ; 260: 1-9
9. Blond JL, Beseme F, Duret L, et al. Molecular characterization and placental expression of HERV-W, a new human endogenous retrovirus family. J Virol. 1999 ; 73: 1175-1185
10. Perron H, Perin JP, Rieger F, et al. Particle-associated retroviral RNA and tandem RGH/HERV-W copies on human chromosome 7q: possible components of a 'chain-reaction' triggered by infectious agents in multiple sclerosis?. J Neurovirol. 2000 ; 6: S67-75
11. Weiss RA. The discovery of endogenous retroviruses. Retrovirology. 2006 ; 3: 67 1-67.11
12. Griffiths DJ. Endogenous retroviruses in the human genome sequence. Genome Biol. 2001 ; 2: 1017.1-1017.5
13. Engel ME, Hiebert SW. The enemy within: dormant retroviruses awaken. Nat Med. 2010 ; 16: 517-518
14. Balada E, Ordi-Ros J, Vilardell-Tarres M. Molecular mechanisms mediated by human endogenous retroviruses (HERVs) in autoimmunity. Rev Med Virol. 2009 ; 19: 273-286
15. Perron H, Lang A. The human endogenous retrovirus link between genes and environment in multiple sclerosis and in multifactorial diseases associating neuroinflammation. Clin Rev Allergy Immunol. 2010 ; 39: 51-61
16. Christensen T, Tonjes RR, zur Megede J, et al. Reverse transcriptase activity and particle production in B lymphoblastoid cell lines established from lymphocytes of patients with multiple sclerosis. AIDS Res Hum Retroviruses. 1999 ; 15: 285-291
17. Garson JA, Tuke PW, Giraud P, et al. Detection of virion-associated MSRV-RNA in serum of patients with multiple sclerosis. Lancet. 1998 ; 351: 33
18. Dolei A, Serra C, Mameli G, et al. Multiple sclerosis-associated retrovirus (MSRV) in Sardinian MS patients. Neurology. 2002 ; 58: 471-473
19. Mameli G, Astone V, Arru G, et al. Brains and peripheral blood mononuclear cells of multiple sclerosis (MS) patients hyperexpress MS-associated retrovirus/HERV-W endogenous retrovirus, but not Human herpesvirus 6. J Gen Virol. 2007 ; 88: 264-274
20. Sotgiu S, Serra C, Mameli G, et al. Multiple sclerosis-associated retrovirus and MS prognosis: an observational study. Neurology. 2002 ; 59: 1071-1073
21. Sotgiu S, Arru G, Mameli G, et al. Multiple sclerosis-associated retrovirus in early multiple sclerosis: a six-year follow-up of a Sardinian cohort. Mult Scler. 2006 ; 12: 698-703
22. Sotgiu S, Mameli G, Serra C, et al. Multiple sclerosis-associated retrovirus and progressive disability of multiple sclerosis. Mult Scler. 2010 ; 16: 1248-1251
23. Arru G, Mameli G, Astone V, et al. Multiple sclerosis and HERV-W/MSRV: A multicentric study. International journal of Biomedical science. 2007 ; 3: 292-297
24. Perron H, Jouvin-Marche E, Michel M, et al. Multiple sclerosis retrovirus particles and recombinant envelope trigger an abnormal immune response in vitro, by inducing polyclonal Vbeta16 T-lymphocyte activation. Virology. 2001 ; 287: 321-332
25. Rolland A, Jouvin-Marche E, Saresella M, et al. Correlation between disease severity and in vitro cytokine production mediated by MSRV (multiple sclerosis associated retroviral element) envelope protein in patients with multiple sclerosis. J Neuroimmunol. 2005 ; 160: 195-203
26. Rolland A, Jouvin-Marche E, Viret C, et al. The envelope protein of a human endogenous retrovirus-W family activates innate immunity through CD14/TLR4 and promotes Th1-like responses. J Immunol. 2006 ; 176: 7636-7644
27. Perron H, Lazarini F, Ruprecht K, et al. Human endogenous retrovirus (HERV)-W ENV and GAG proteins: physiological expression in human brain and pathophysiological modulation in multiple sclerosis lesions. J Neurovirol. 2005 ; 11: 23-33
28. Antony JM, van Marle G, Opii W, et al. Human endogenous retrovirus glycoprotein-mediated induction of redox reactants causes oligodendrocyte death and demyelination. Nat Neurosci. 2004 ; 7: 1088-1095
29. Bsibsi M, Ravid R, Gveric D, et al. Broad expression of Toll-like receptors in the human central nervous system. J Neuropathol Exp Neurol. 2002 ; 61: 1013-1021
30. Brettschneider J, Ecker D, Bitsch A, et al. The macrophage activity marker sCD14 is increased in patients with multiple sclerosis and upregulated by interferon beta-1b. J Neuroimmunol. 2002 ; 133: 193-197
31. Trinchieri G, Sher A. Cooperation of Toll-like receptor signals in innate immune defence. Nat Rev Immunol. 2007 ; 7: 179-190
32. Okun E, Griffioen KJ, Lathia JD, et al. Toll-like receptors in neurodegeneration. Brain Res Rev. 2009 ; 59: 278-292
33. Lehnardt S, Lachance C, Patrizi S, et al. The toll-like receptor TLR4 is necessary for lipopolysaccharide-induced oligodendrocyte injury in the CNS. J Neurosci. 2002 ; 22: 2478-2486
34. Perron H, Mekaoui L, Bernard C, et al. Endogenous retrovirus type W GAG and envelope protein antigenemia in serum of schizophrenic patients. Biol Psychiatry. 2008 ; 64: 1019-1023
35. Mameli G, Poddighe L, Astone V, et al. Novel reliable real-time PCR for differential detection of MSRVenv and syncytin-1 in RNA and DNA from patients with multiple sclerosis. J Virol Methods. 2009 ; 161: 98-106
36. Leboyer M, Tamouza R, Charron D, et al. Human endogenous retrovirus type W (HERV-W) in schizophrenia: A new avenue of research at the gene-environment interface. World J Biol Psychiatry. 2011 ;:
37. McDonald WI, Compston A, Edan G, et al. Recommended diagnostic criteria for multiple sclerosis: guidelines from the International Panel on the diagnosis of multiple sclerosis. Ann Neurol. 2001 ; 50: 121-127
38. van Horssen J, Schreibelt G, Drexhage J, et al. Severe oxidative damage in multiple sclerosis lesions coincides with enhanced antioxidant enzyme expression. Free Radic Biol Med. 2008 ; 45: 1729-1737
39. Perron H, Bernard C, Bertrand JB, et al. Endogenous retroviral genes, herpesviruses and gender in multiple sclerosis. J Neurol Sci. 2009 ; 286: 65-72
40. Gaudin P, Ijaz S, Tuke PW, et al. Infrequency of detection of particle-associated MSRV/HERV-W RNA in the synovial fluid of patients with rheumatoid arthritis. Rheumatology (Oxford). 2000 ; 39: 950-954
41. Stoll G, Bendszus M. Imaging of inflammation in the peripheral and central nervous system by magnetic resonance imaging. Neuroscience. 2009 ; 158: 1151-1160
42. Ifergan I, et al. The blood-brain barrier induces differentiation of migrating monocytes into Th17-polarizing dendritic cells. Brain. 2008 ; 131: 785-799
43. Menard A, Amouri R, Michel M, et al. Gliotoxicity, reverse transcriptase activity and retroviral RNA in monocyte/ macrophage culture supernatants from patients with multiple sclerosis. FEBS Lett. 1997 ; 413: 477-485
44. Mameli G, Serra C, Astone V, et al. Inhibition of multiple-sclerosis- associated retrovirus as biomarker of interferon therapy. J Neurovirol. 2008 ; 14: 73-77
45. Sotgiu S, Arru G, Soderstrom M, et al. Multiple sclerosis-associated retrovirus and optic neuritis. Mult Scler. 2006 ; 12: 357-359
46. Hummell DS, Dooley JS, Khan AS, et al. Coordinate transcriptional control of murine endogenous retrovirus and Ig genes during B cell differentiation. J Immunol. 1993 ; 151: 3131-3139
47. Perron H. Microbial agents triggering endogenous retroviruses within genetic susceptibility loci, resulting in expression of superantigen and gliotoxic molecules: a plausible 'immunovirogenetic' cascade causing multiple sclerosis ?. Modern Aspects of Immunobiology. 2001 ; 1: 198-203
48. Perron H, Suh M, Lalande B, et al. Herpes simplex virus ICP0 and ICP4 immediate early proteins strongly enhance expression of a retrovirus harboured by a leptomeningeal cell line from a patient with multiple sclerosis. J Gen Virol. 1993 ; 74 (Pt 1). 65-72
49. Lecellier CH, Dunoyer P, Arar K, et al. A cellular microRNA mediates antiviral defense in human cells. Science. 2005 ; 308: 557-560
50. Pelisson A, Sarot E, Payen-Groschene G, et al. A novel repeat-associated small interfering RNA-mediated silencing pathway downregulates complementary sense gypsy transcripts in somatic cells of the Drosophila ovary. J Virol. 2007 ; 81: 1951-1960
51. Bhat RK, Ellestad KK, Wheatley BM, et al. Age- and disease-dependent HERV-W envelope allelic variation in brain: association with neuroimmune gene expression. PLoS One. 2011 ; 6 :
52. Roebke C, Wahl S, Laufer G, et al. An N-terminally truncated envelope protein encoded by a human endogenous retrovirus W locus on chromosome Xq22.3. Retrovirology. 2010 ; 7: 69
53. Perron H, Garson JA, Bedin F, et al. Molecular identification of a novel retrovirus repeatedly isolated from patients with multiple sclerosis. The Collaborative Research Group on Multiple Sclerosis. Proc Natl Acad Sci USA. 1997 ; 94: 7583-758
54. Saresella M, Rolland A, Marventano I, et al. Multiple sclerosis-associated retroviral agent (MSRV)-stimulated cytokine production in patients with relapsing-remitting multiple sclerosis. Mult Scler. 2009 ; 15: 443-447
55. Perron H, Perin JP, Rieger F, et al. Particle-associated retroviral RNA and tandem RGH/HERV-W copies on human chromosome 7q: possible components of a 'chain-reaction' triggered by infectious agents in multiple sclerosis?. J Neurovirol. 2000 ; 6 (Suppl 2). S67-75
56. Douville R, Liu J, Rothstein J, et al. Identification of active loci of a human endogenous retrovirus in neurons of patients with amyotrophic lateral sclerosis. Ann Neurol. 2011 ; 69: 141-151