Age- and disease-dependent HERV-W envelope allelic variation in brain: Association with neuroimmune gene expression

PLoS ONE

Volumn 6, Issue 4, 2011, Pages

  Bhat, Rakesh K ^a   Ellestad, Kristofor K ^a   Wheatley, B Matt ^a   Warren, Rene ^b   Holt, Robert A ^b   Power, Christopher ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

^b BRITISH COLUMBIA CANCER AGENCY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

GLYCOPROTEIN; SYNCYTIN 1; TRANSCRIPTOME; UNCLASSIFIED DRUG; VIRUS ENVELOPE PROTEIN; PLACENTA PROTEIN; SYNCYTIN;

ADULT; ARTICLE; ASTROCYTE; BRAIN NERVE CELL; CHROMOSOME; CHROMOSOME 7Q; CONTROLLED STUDY; ENCEPHALITIS; ENDOGENOUS RETROVIRUS; ENVELOPE GENE; FEMALE; FETUS; GENE EXPRESSION; GENE LOCUS; GENE SEQUENCE; GENETIC VARIABILITY; HOST; HUMAN; HUMAN CELL; HUMAN TISSUE; MALE; MICROGLIA; MOLECULAR CLONING; NEUROLOGIC DISEASE; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN EXPRESSION; RNA SEQUENCE; ADOLESCENT; AGE; AGED; ALLELE; BIOSYNTHESIS; BRAIN; GENE EXPRESSION REGULATION; GENETICS; HUMAN GENOME; IMMUNE SYSTEM; INFLAMMATION; MIDDLE AGED; NERVE CELL; PATHOLOGY; PRENATAL DEVELOPMENT; SEQUENCE ANALYSIS; VIROLOGY;

HUMAN ENDOGENOUS RETROVIRUS W;

ADOLESCENT; ADULT; AGE FACTORS; AGED; ALLELES; BRAIN; ENDOGENOUS RETROVIRUSES; FEMALE; GENE EXPRESSION REGULATION; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENE PRODUCTS, ENV; GENES, ENV; GENETIC VARIATION; GENOME, HUMAN; HUMANS; IMMUNE SYSTEM; INFLAMMATION; MALE; MIDDLE AGED; NEURONS; PREGNANCY PROTEINS; SEQUENCE ANALYSIS, RNA;

EID: 79955712708     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0019176     Document Type: Article

References (41)

1. Ryan FP, (2004) Human endogenous retroviruses in health and disease: a symbiotic perspective. J R Soc Med 97: 560-565.
2. Goodman M, Porter CA, Czelusniak J, Page SL, Schneider H, et al. (1998) Toward a phylogenetic classification of Primates based on DNA evidence complemented by fossil evidence. Mol Phylogenet Evol 9: 585-598.
3. Noorali S, Rotar IC, Lewis C, Pestaner JP, Pace DG, et al. (2009) Role of HERV-W syncytin-1 in placentation and maintenance of human pregnancy. Appl Immunohistochem Mol Morphol 17: 319-328.
4. Clausen J, (2003) Endogenous retroviruses and MS: using ERVs as disease markers. Int MS J 10: 22-28.
5. Bonnaud B, Bouton O, Oriol G, Cheynet V, Duret L, et al. (2004) Evidence of selection on the domesticated ERVWE1 env retroviral element involved in placentation. Mol Biol Evol 21: 1895-1901.
6. Costas J, (2002) Characterization of the intragenomic spread of the human endogenous retrovirus family HERV-W. Mol Biol Evol 19: 526-533.
7. Pavlicek A, Paces J, Elleder D, Hejnar J, (2002) Processed pseudogenes of human endogenous retroviruses generated by LINEs: their integration, stability, and distribution. Genome Res 12: 391-399.
8. Kim HS, Lee WH, (2001) Human endogenous retrovirus HERV-W family: Chromosomal localization, identification, and phylogeny. AIDS Research and Human Retroviruses 17: 643-648.
9. Voisset C, Bouton O, Bedin F, Duret L, Mandrand B, et al. (2000) Chromosomal distribution and coding capacity of the human endogenous retrovirus HERV-W family. AIDS Res Hum Retroviruses 16: 731-740.
10. Dewannieux M, Harper F, Richaud A, Letzelter C, Ribet D, et al. (2006) Identification of an infectious progenitor for the multiple-copy HERV-K human endogenous retroelements. Genome Res 16: 1548-1556.
11. Bannert N, Kurth R, (2006) The evolutionary dynamics of human endogenous retroviral families. Annu Rev Genomics Hum Genet 7: 149-173.
12. Mangeney M, Renard M, Schlecht-Louf G, Bouallaga I, Heidmann O, et al. (2007) Placental syncytins: Genetic disjunction between the fusogenic and immunosuppressive activity of retroviral envelope proteins. Proc Natl Acad Sci U S A 104: 20534-20539.
13. de Parseval N, Lazar V, Casella JF, Benit L, Heidmann T, (2003) Survey of human genes of retroviral origin: identification and transcriptome of the genes with coding capacity for complete envelope proteins. J Virol 77: 10414-10422.
14. Venables PJ, Brookes SM, Griffiths D, Weiss RA, Boyd MT, (1995) Abundance of an endogenous retroviral envelope protein in placental trophoblasts suggests a biological function. Virology 211: 589-592.
15. Frendo JL, Olivier D, Cheynet V, Blond JL, Bouton O, et al. (2003) Direct involvement of HERV-W Env glycoprotein in human trophoblast cell fusion and differentiation. Mol Cell Biol 23: 3566-3574.
16. Alliel PM, Perin JP, Pierig R, Nussbaum JL, Menard A, et al. (1998) Endogenous retroviruses and multiple sclerosis. II. HERV-7q. C R Acad Sci III 321: 857-863.
17. Blond JL, Beseme F, Duret L, Bouton O, Bedin F, et al. (1999) Molecular characterization and placental expression of HERV-W, a new human endogenous retrovirus family. J Virol 73: 1175-1185.
18. Antony JM, van Marle G, Opii W, Butterfield DA, Mallet F, et al. (2004) Human endogenous retrovirus glycoprotein-mediated induction of redox reactants causes oligodendrocyte death and demyelination. Nat Neurosci 7: 1088-1095.
19. Antony JM, Ellestad KK, Hammond R, Imaizumi K, Mallet F, et al. (2007) The Human Endogenous Retrovirus Envelope Glycoprotein, Syncytin-1, Regulates Neuroinflammation and Its Receptor Expression in Multiple Sclerosis: A Role for Endoplasmic Reticulum Chaperones in Astrocytes. J Immunol 179: 1210-1224.
20. Kim HS, Kim DS, Huh JW, Ahn K, Yi JM, et al. (2008) Molecular characterization of the HERV-W env gene in humans and primates: expression, FISH, phylogeny, and evolution. Mol Cells 26: 53-60.
21. Bonnaud B, Beliaeff J, Bouton O, Oriol G, Duret L, et al. (2005) Natural history of the ERVWE1 endogenous retroviral locus. Retrovirology 2: 57.
22. Altschul SF, Madden TL, Schaffer AA, Zhang J, Zhang Z, et al. (1997) Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. Nucleic Acids Res 25: 3389-3402.
23. Mayer J, Meese EU, (2002) The human endogenous retrovirus family HERV-K(HML-3). Genomics 80: 331-343.
24. Hahn BH, Shaw GM, De KM, Cock, Sharp PM, (2000) AIDS as a Zoonosis: Scientific and Public Health Implications. Science 287: 607-614.
25. Maquat LE, (2004) Nonsense-mediated mRNA decay: splicing, translation and mRNP dynamics. Nat Rev Mol Cell Biol 5: 89-99.
26. Chang YF, Imam JS, Wilkinson MF, (2007) The nonsense-mediated decay RNA surveillance pathway. Annu Rev Biochem 76: 51-74.
27. Mendell JT, Sharifi NA, Meyers JL, Martinez-Murillo F, Dietz HC, (2004) Nonsense surveillance regulates expression of diverse classes of mammalian transcripts and mutes genomic noise. Nat Genet 36: 1073-1078.
28. Poliseno L, Salmena L, Zhang J, Carver B, Haveman WJ, et al. (2010) A coding-independent function of gene and pseudogene mRNAs regulates tumour biology. Nature 465: 1033-1038.
29. Noorbakhsh F, Vergnolle N, McArthur JC, Silva C, Vodjgani M, et al. (2005) Proteinase-activated receptor-2 induction by neuroinflammation prevents neuronal death during HIV infection. J Immunol 174: 7320-7329.
30. Zhu Y, Vergote D, Pardo C, Noorbakhsh F, McArthur JC, et al. (2009) CXCR3 activation by lentivirus infection suppresses neuronal autophagy: neuroprotective effects of antiretroviral therapy. FASEB J 23: 2928-2941.
31. Antony JM, Izad M, Bar-Or A, Warren KG, Vodjgani M, et al. (2006) Quantitative Analysis of Human Endogenous Retrovirus-W env in Neuroinflammatory Diseases. AIDS Research and Human Retroviruses 22: 1253.
32. Antony JM, Zhu Y, Izad M, Warren KG, Vodjgani M, et al. (2007) Comparative Expression of Human Endogenous Retrovirus-W Genes in Multiple Sclerosis. AIDS Research and Human Retroviruses 23: 1251.
33. Maingat F, Viappiani S, Zhu Y, Vivithanaporn P, Ellestad KK, et al. (2010) Regulation of lentivirus neurovirulence by lipopolysaccharide conditioning: suppression of CXCL10 in the brain by IL-10. J Immunol 184: 1566-1574.
34. Noorbakhsh F, Ramachandran R, Barsby N, Ellestad KK, LeBlanc A, et al. (2010) MicroRNA profiling reveals new aspects of HIV neurodegeneration: caspase-6 regulates astrocyte survival. FASEB J 24: 1799-1812.
35. Ellestad KK, Tsutsui S, Noorbakhsh F, Warren KG, Yong VW, et al. (2009) Early life exposure to lipopolysaccharide suppresses experimental autoimmune encephalomyelitis by promoting tolerogenic dendritic cells and regulatory T cells. J Immunol 183: 298-309.
36. Ogawa T, Berosik S, Joe L, Swei A, Bourey J, et al. (2005) Increased Productivity For Core Labs Using One Polymer and One Array Length for Multiple Applications. ABRF ′05: Biomolecular Technologies: Discovery to Hypotheses: Poster P108-T.
37. Chandrasekar A, Kumar S, Sreenath J, Sarkar BN, Urade BP, et al. (2009) Updating phylogeny of mitochondrial DNA macrohaplogroup m in India: dispersal of modern human in South Asian corridor. PLoS One 4: e7447.
38. Tamura K, Dudley J, Nei M, Kumar S, (2007) MEGA4: Molecular Evolutionary Genetics Analysis (MEGA) software version 4.0. Mol Biol Evol 24: 1596-1599.
39. Li WH, Tanimura M, Sharp PM, (1988) Rates and dates of divergence between AIDS virus nucleotide sequences. Mol Biol Evol 5: 313-330.
40. Khatkar MS, Hobbs M, Neuditschko M, Solkner J, Nicholas FW, et al. (2010) Assignment of chromosomal locations for unassigned SNPs/scaffolds based on pair-wise linkage disequilibrium estimates. BMC Bioinformatics 11: 171.
41. Zhang Z, Li J, Zhao XQ, Wang J, Wong GK, et al. (2006) KaKs_Calculator: calculating Ka and Ks through model selection and model averaging. Genomics Proteomics Bioinformatics 4: 259-263.