An enthalpic basis of additivity in biphenyl hydroxamic acid ligands for stromelysin-1

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 20, 2012, Pages 6521-6524

  Wilfong, Erin M ^a   Du, Yu ^a   Toone, Eric J ^a  

^a DUKE UNIVERSITY   (United States)

Author keywords

Additivity; Fragment based drug design; Matrix metalloproteinase 3; Stromelysin 1

Indexed keywords

BIPHENYLHYDROXAMIC ACID DERIVATIVE; HYDROXAMIC ACID DERIVATIVE; STROMELYSIN; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; BINDING KINETICS; BINDING SITE; CHEMICAL ANALYSIS; CONSTANT PRESSURE HEAT CAPACITY; DRUG DESIGN; ENERGY TRANSFER; ENTHALPY; ENTROPY; LIGAND BINDING; PARAMETERS; PROTON TRANSPORT; THERMODYNAMIC ADDITIVITY ANALYSIS; THERMODYNAMICS;

BINDING SITES; BIPHENYL COMPOUNDS; DRUG DESIGN; HUMANS; HYDROXAMIC ACIDS; LIGANDS; MATRIX METALLOPROTEINASE 3; MATRIX METALLOPROTEINASE INHIBITORS; THERMODYNAMICS;

EID: 84866740954     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.05.032     Document Type: Article

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