Development of ligustrazine-loaded lipid emulsion: Formulation optimization, characterization and biodistribution

International Journal of Pharmaceutics

Volumn 437, Issue 1-2, 2012, Pages 203-212

  Wei, Lijun ^a   Marasini, Nirmal ^b   Li, Gao ^a   Yong, Chul Soon ^b   Kim, Jong Oh ^b   Quan, Qizhe ^c  

^a YANBIAN UNIVERSITY   (China)

^b Yeungnam University   (South Korea)

^c BEIJING UNION UNIVERSITY   (China)

Author keywords

Characterization; Ligustrazine; Lipid emulsion; Pharmacokinetics; Tissue distribution

Indexed keywords

GLYCEROL; LIPID EMULSION; OLEIC ACID; PHOSPHATIDYLCHOLINE; POLOXAMER; SOYBEAN OIL; TETRAMETHYLPYRAZINE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG DELIVERY SYSTEM; DRUG DISTRIBUTION; DRUG FORMULATION; DRUG RELEASE; DRUG SAFETY; HEMOLYSIS; IN VITRO STUDY; IN VIVO STUDY; MALE; NONHUMAN; PARTICLE SIZE; PH; PLASMA CONCENTRATION-TIME CURVE; PRIORITY JOURNAL; RAT; ROOM TEMPERATURE; SUSTAINED DRUG RELEASE; TISSUE DISTRIBUTION; ZETA POTENTIAL;

ANIMALS; CELLS, CULTURED; CHEMISTRY, PHARMACEUTICAL; DRUG DELIVERY SYSTEMS; DRUG STABILITY; EMULSIONS; ERYTHROCYTES; GLYCEROL; HEMOLYSIS; LECITHINS; MALE; OLEIC ACID; POLOXAMER; PYRAZINES; RABBITS; RATS; RATS, SPRAGUE-DAWLEY; SOYBEAN OIL; TISSUE DISTRIBUTION;

EID: 84866740137     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2012.08.027     Document Type: Article

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