Preparation and pharmacokinetics in beagle dogs of once-a-day tetramethylpyrazine phosphate sustained-release pellets

Drug Development and Industrial Pharmacy

Volumn 38, Issue 3, 2012, Pages 301-306

  Xiao, Yanyu ^a   Ping, Qineng ^a   Su, Zhigui ^a   Li, Hongying ^a   Niu, Jiangxiu ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Beagle dogs; Extrusion spheronization; Fluidized bed; Once a day sustained release pellets; Pharmacokinetics; Tetramethylpyrazine phosphate

Indexed keywords

CALCIUM CHANNEL BLOCKING AGENT; POLYMER; SURLEASE; TETRAMETHYLPYRAZINE PHOSPHATE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; BEAGLE DOG; BIOEQUIVALENCE; CHEMICAL COMPOSITION; CONTROLLED STUDY; DOG; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG CAPSULE; DRUG COATING; DRUG FORMULATION; DRUG SOLUBILITY; FLUIDIZED BED; MACHINE; MALE; MAXIMUM PLASMA CONCENTRATION; MOLECULAR WEIGHT; NONHUMAN; PELLET EXTRUSION; PHARMACOLOGICAL PARAMETERS; SPHERONIZATION; SUSTAINED RELEASE PREPARATION; TABLET; TIME TO MAXIMUM PLASMA CONCENTRATION;

ADMINISTRATION, ORAL; ANIMALS; BIOLOGICAL AVAILABILITY; CALCIUM CHANNEL BLOCKERS; DELAYED-ACTION PREPARATIONS; DOGS; MALE; MODELS, ANIMAL; PHOSPHATES; PLATELET AGGREGATION INHIBITORS; PYRAZINES; RANDOM ALLOCATION; TABLETS; VASODILATOR AGENTS;

EID: 84863073830     PISSN: 03639045     EISSN: 15205762     Source Type: Journal    
DOI: 10.3109/03639045.2011.602408     Document Type: Article

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