Ligustrazine derivatives. Part 5: Design, synthesis and biological evaluation of novel ligustrazinyloxy-cinnamic acid derivatives as potent cardiovascular agents

European Journal of Medicinal Chemistry

Volumn 46, Issue 11, 2011, Pages 5609-5615

  Chen, Hongfei ^a   Li, Guoning ^a   Zhan, Peng ^a   Liu, Xinyong ^a  

^a SHANDONG UNIVERSITY   (China)

Author keywords

Cardiovascular disease; Cinnamic acid; Ligustrazine; Oxidative damage; Platelet aggregation; Synthesis

Indexed keywords

3 [2 [(3,5,6 TRIMETHYLPYRAZIN 2 YL)METHOXY]PHENYL]ACRYLIC ACID; 3 [3 [(3,5,6 TRIMETHYLPYRAZIN 2 YL)METHOXY]PHENYL]ACRYLIC ACID; 3 [3 HYDROXY 4 [(3,5,6 TRIMETHYLPYRAZIN 2 YL)METHOXY]PHENYL]ACRYLIC ACID; 3 [3 METHOXY 2 [(3,5,6 TRIMETHYLPYRAZIN 2 YL)METHOXY]PHENYL]ACRYLATE; 3 [3 METHOXY 2 [(3,5,6 TRIMETHYLPYRAZIN 2 YL)METHOXY]PHENYL]ACRYLIC ACID; 3 [3 METHOXY 4 [(3,5,6 TRIMETHYLPYRAZIN 2 YL)METHOXY]PHENYL]ACRYLIC ACID; 3 [3,5 DIBROMO 2 [(3,5,6 TRIMETHYLPYRAZIN 2 YL)METHOXY]PHENYL]ACRYLIC ACID; 3 [3,5 DIBROMO 4 [(3,5,6 TRIMETHYLPYRAZIN 2 YL)METHOXY]PHENYL]ACRYLIC ACID; 3 [3,5 DIMETHOXY 4 [(3,5,6 TRIMETHYLPYRAZIN 2 YL)METHOXY]PHENYL]ACRYLIC ACID; 3 [4 [(3,5,6 TRIMETHYLPYRAZIN 2 YL)METHOXY]PHENYL]ACRYLIC ACID; 3 [5 CHLORO 2 [(3,5,6 TRIMETHYLPYRAZIN 2 YL)METHOXY]PHENYL]ACRYLIC ACID; ADENOSINE DIPHOSPHATE; ANTITHROMBOCYTIC AGENT; ETHYL 3 [2 [(3,5,6 TRIMETHYLPYRAZIN 2 YL)METHOXY]PHENYL]ACRYLATE; ETHYL 3 [3 [(3,5,6 TRIMETHYLPYRAZIN 2 YL)METHOXY]PHENYL]ACRYLATE; ETHYL 3 [3 HYDROXY 4 [(3,5,6 TRIMETHYLPYRAZIN 2 YL)METHOXY]PHENYL]ACRYLATE; ETHYL 3 [3 METHOXY 4 [(3,5,6 TRIMETHYLPYRAZIN 2 YL)METHOXY]PHENYL]ACRYLATE; ETHYL 3 [3,5 DIBROMO 2 [(3,5,6 TRIMETHYLPYRAZIN 2 YL)METHOXY]PHENYL]ACRYLATE; ETHYL 3 [3,5 DIBROMO 4 [(3,5,6 TRIMETHYLPYRAZIN 2 YL)METHOXY]PHENYL]ACRYLATE; ETHYL 3 [3,5 DIMETHOXY 4 [(3,5,6 TRIMETHYLPYRAZIN 2 YL)METHOXY]PHENYL]ACRYLATE; ETHYL 3 [4 [(3,5,6 TRIMETHYLPYRAZIN 2 YL)METHOXY]PHENYL]ACRYLATE; ETHYL 3 [5 CHLORO 2 [(3,5,6 TRIMETHYLPYRAZIN 2 YL)METHOXY]PHENYL]ACRYLATE; HYDROGEN PEROXIDE; LIGUSTRAZINYLOXY CINNAMIC ACID DERIVATIVE; TETRAMETHYLPYRAZINE; UNCLASSIFIED DRUG;

ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; DRUG DESIGN; DRUG DETERMINATION; DRUG SCREENING; DRUG SYNTHESIS; IN VITRO STUDY; NONHUMAN; OXIDATIVE STRESS; STRUCTURE ACTIVITY RELATION; THROMBOCYTE AGGREGATION INHIBITION;

ANIMALS; CARDIOVASCULAR AGENTS; CELL LINE; CHEMISTRY TECHNIQUES, SYNTHETIC; CINNAMATES; CYTOPROTECTION; DRUG DESIGN; ENDOTHELIAL CELLS; PLATELET AGGREGATION; PYRAZINES; RABBITS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 80054930628     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2011.09.030     Document Type: Article

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