Copper-64-diacetyl-bis(N(4)-methylthiosemicarbazone) pharmacokinetics in FaDu xenograft tumors and correlation with microscopic markers of hypoxia

International Journal of Radiation Oncology Biology Physics

Volumn 84, Issue 3, 2012, Pages

  McCall, Keisha C ^a   Humm, John L ^a   Bartlett, Rachel ^a   Reese, Megan ^a   Carlin, Sean ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BLOOD FLOW; DISTRIBUTION VOLUME; DYNAMIC PET; EX-VIVO; HEAD-AND-NECK SQUAMOUS CELL CARCINOMA; IMMUNOHISTOCHEMICAL STAINING; IN-VIVO; KINETIC ANALYSIS; MICROENVIRONMENTS; MICROSCOPIC DISTRIBUTION; OXYGEN PARTIAL PRESSURE; PET IMAGES; PET IMAGING; POSTINJECTION; SPATIAL CHANGES; TEMPORAL CHANGE; TUMOR TARGETING;

COPPER; MUSCLE; POSITRON EMISSION TOMOGRAPHY; RADIOACTIVE TRACERS; RADIOGRAPHY;

TUMORS;

BIOLOGICAL MARKER; DIACETYL BIS[N(4) METHYLTHIOSEMICARBAZONE] CU 64; PIMONIDAZOLE; RADIOPHARMACEUTICAL AGENT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTORADIOGRAPHY; BLOOD FLOW; BLOOD OXYGEN TENSION; CONTROLLED STUDY; CORRELATION ANALYSIS; DRUG ACCUMULATION; DRUG DISTRIBUTION; DRUG UPTAKE; EX VIVO STUDY; HEAD AND NECK SQUAMOUS CELL CARCINOMA; HISTOPATHOLOGY; HYPOXIA; IMAGE RECONSTRUCTION; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; MICROSCOPY; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; RAT; THIN LAYER CHROMATOGRAPHY; TUMOR MICROENVIRONMENT; TUMOR XENOGRAFT;

ANIMALS; AUTORADIOGRAPHY; BIOLOGICAL MARKERS; CARCINOMA, SQUAMOUS CELL; CELL HYPOXIA; HEAD AND NECK NEOPLASMS; HUMANS; IMMUNOHISTOCHEMISTRY; MUSCLES; NITROIMIDAZOLES; ORGANOMETALLIC COMPOUNDS; PARTIAL PRESSURE; RATS; RATS, NUDE; THIOSEMICARBAZONES; TISSUE DISTRIBUTION; TRANSPLANTATION, HETEROLOGOUS; TUMOR MICROENVIRONMENT; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84866739954     PISSN: 03603016     EISSN: 1879355X     Source Type: Journal    
DOI: 10.1016/j.ijrobp.2012.05.005     Document Type: Article

References (20)

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