P(HPMA)-block-P(LA) copolymers in paclitaxel formulations: Polylactide stereochemistry controls micellization, cellular uptake kinetics, intracellular localization and drug efficiency

Journal of Controlled Release

Volumn 163, Issue 1, 2012, Pages 63-74

  Barz, Matthias ^a,b   Armiñán, Ana ^a   Canal, Fabiana ^a   Wolf, Florian ^b   Koynov, Kaloian ^c   Frey, Holger ^b   Zentel, Rudolf ^b   Vicent, María J ^a  

^a CENTRO DE INVESTIGACIÓN PRÍNCIPE FELIPE   (Spain)

^b JOHANNES GUTENBERG UNIVERSITY   (Germany)

^c MAX PLANCK INSTITUTE FOR POLYMER RESEARCH   (Germany)

Author keywords

HPMA block copolymers; Poly(N (2 hydroxypropyl) methacrylamide; Polylactide block copolymers; RAFT polymerization; Structure activity relationship; Tacticity

Indexed keywords

METHACRYLAMIDES; POLY LACTIDE; RAFT POLYMERIZATION; STRUCTURE ACTIVITY RELATIONSHIPS; TACTICITIES;

BLOCK COPOLYMERS; DRUG DELIVERY; FLUORESCENCE SPECTROSCOPY; LIVING POLYMERIZATION; LOADING; MICELLIZATION; MICROSTRUCTURE; STEREOCHEMISTRY; STEREOSELECTIVITY;

POLYMERS;

COPOLYMER; FLUORESCENT DYE; PACLITAXEL; POLYLACTIDE;

CELL TRANSPORT; CELLULAR DISTRIBUTION; CONFERENCE PAPER; CONTROLLED STUDY; DRUG EFFICACY; DRUG FORMULATION; FEMALE; FLUORESCENCE CORRELATION SPECTROSCOPY; HUMAN; HUMAN CELL; IC 50; MICELLIZATION; MOLECULAR WEIGHT; PH; PRIORITY JOURNAL; STEREOCHEMISTRY; SYNTHESIS;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; BIOLOGICAL TRANSPORT; CELL SURVIVAL; HELA CELLS; HUMANS; KINETICS; METHACRYLATES; MICELLES; MOLECULAR CONFORMATION; PACLITAXEL; POLYESTERS;

EID: 84866736510     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2012.05.024     Document Type: Conference Paper

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