Free fatty acid derivative HUHS2002 potentiates α7 ACh receptor responses through indirect activation of CaMKII

Lipids

Volumn 47, Issue 9, 2012, Pages 865-871

  Kanno, Takeshi ^a   Shimizu, Tadashi ^a   Tanaka, Akito ^a   Nishimoto, Takaaki ^a   Nishizaki, Tomoyuki ^a  

^a HYOGO COLLEGE OF MEDICINE   (Japan)

Author keywords

7 ACh receptor; CaMKII; Derivative; Free fatty acid; PP1

Indexed keywords

2 [1 (3 DIMETHYLAMINOPROPYL) 3 INDOLYL] 3 (3 INDOLYL)MALEIMIDE; 4 [4 HEPT 1 ENYL PHENOXY]BUTYRIC ACID; BUNGAROTOXIN RECEPTOR; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE II; CYCLIC AMP DEPENDENT PROTEIN KINASE INHIBITOR; FATTY ACID; FREE FATTY ACID DERIVATIVE; N [2 (4 BROMOCINNAMYLAMINO)ETHYL] 5 ISOQUINOLINESULFONAMIDE; N [2 [[N [3 (4 CHLOROPHENYL) 2 PROPENYL] N METHYLAMINO]METHYL]PHENYL] N (2 HYDROXYETHYL) 4 METHOXYBENZENESULFONAMIDE; PHOSPHOPROTEIN PHOSPHATASE 1; PROTEIN KINASE C INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; EMBRYO; ENZYME ACTIVATION; ENZYME ASSAY; ENZYME INHIBITION; HIPPOCAMPUS; MEMBRANE CURRENT; NERVE CELL CULTURE; NONHUMAN; OOCYTE; PROTEIN EXPRESSION; RAT; WHOLE CELL; XENOPUS;

ANIMALS; BRAIN; BUTYRATES; CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASE TYPE 2; CELLS, CULTURED; ENZYME ACTIVATION; OOCYTES; PROTEIN PHOSPHATASE 1; RATS; RATS, WISTAR; RECEPTORS, NICOTINIC; XENOPUS;

RATTUS;

EID: 84866736070     PISSN: 00244201     EISSN: 15589307     Source Type: Journal    
DOI: 10.1007/s11745-012-3701-2     Document Type: Article

References (26)

1. Nishizaki T, Nomura T, Matsuyama S, Kondoh T, Fujimoto E, Yoshii M (2001) Critical role of presynaptic nicotinic ACh receptor in the formation of long-term potentiation: implication of development of anti-dementia drug. Psychogeriatrics 1:209-217
2. Nishizaki T, Nomura T, Matsuoka T, Enikolopov G, Sumikawa K (1999) Arachidonic acid induces a long-lasting facilitation of hippocampal synaptic transmission by modulating PKC activity and nicotinic ACh receptors. Mol Brain Res 69:263-272
3. Nishizaki T, Nomura T, Matuoka T, Kondoh T, Enikolopo G, Sumikawa K, Watabe S, Shiotani T, Yoshii M (2000) The antidementia drug nefiracetam facilitates hippocampal synaptic transmission by functionally targeting presynaptic nicotinic ACh receptors. Mol Brain Res 80:53-62
4. Tanaka A, Nishizaki T (2003) The newly synthesized linoleic acid derivative FR236924 induces a long-lasting facilitation of hippocampal neurotransmission by targeting nicotinic acetylcholine receptors. Bioorg Med Chem Lett 13:1037-1040
5. Yamamoto S, Kanno T, Nagata T, Yaguchi T, Tanaka A, Nishizaki T (2005) The linoleic acid derivative FR236924 facilitates hippocampal synaptic transmission by enhancing activity of presynaptic α7 acetylcholine receptors on the glutamatergic terminals. Neuroscience 130:207-213
6. Kanno T, Yaguchi T, Yamamoto S, Nagata T, Yamamoto H, Fujikawa H, Nishizaki T (2005) Bidirectional regulations for glutamate and GABA release in the hippocampus by α7 and non-α7 ACh receptors. Biochem Biophys Res Commun 338:742-747
7. Kanno T, Yaguchi T, Yamamoto S, Yamamoto H, Fujikawa H, Nagata T, Tanaka A, Nishizaki T (2005) 8-[2-(2-pentyl-cyclopropylmethyl)-cyclopropyl]-octanoic acid stimulates GABA release from interneurons projecting to CA1 pyramidal neurons in the rat hippocampus via pre-synaptic α7 acetylcholine receptors. J Neurochem 95:695-702
8. Shimizu T, Kanno T, Tanaka A, Nishizaki T (2011) α,β-DCP-LA selectively activates PKC-ε and stimulates neurotransmitter release with the highest potency among 4 diastereomers. Cell Physiol Biochem 27:149-158
9. Aubert I, Araujo DM, Cécyre D, Robitaille Y, Gauthier S, Quirion R (1992) Comparative alterations of nicotinic and muscarinic binding sites in Alzheimer's and Parkinson's diseases. J Neurochem 58:529-541
10. Perry EK, Perry RH, Smith CJ, Dick DJ, Candy JM, Edwardson JA, Fairbairn A, Blessed G (1987) Nicotinic receptor abnormalities in Alzheimer's and Parkinson's diseases. J Neurol Neurosurg Psychiatry 50:806-809
11. 3H]nicotinic acetylcholine binding in Alzheimer's disease and Parkinson's disease: an autoradiographic study. Neurology 38:720-723
12. Parri HR, Hernandez CM, Dineley KT (2011) Research update: α7 nicotinic acetylcholine receptor mechanisms in Alzheimer's disease. Biochem Pharmacol 82:931-942
13. Nordberg A (1994) Human nicotinic receptors-their role in aging and dementia. Neurochem Int 25:93-97
14. Hernandez CM, Dineley KT (2012) α7 nicotinic acetylcholine receptors in Alzheimer's disease: neuroprotective, neurotrophic or both? Curr Drug Targets 13:613-622
15. Ikeuchi Y, Nishizaki T, Matsuoka T, Sumikawa K (1996) Arachidonic acid potentiates ACh receptor currents by protein kinase C activation but not by receptor phosphorylation. Biochem Biophys Res Commun 221:716-721
16. Nishizaki T, Ikeuchi Y, Matsuoka T, Sumikawa K (1997) Short-term depression and long-term enhancement of ACh-gated channel currents induced by linoleic and linolenic acid. Brain Res 751:253-258
17. Nishizaki T, Matsuoka T, Nomura T, Sumikawa K (1998) Modulation of ACh receptor currents by arachidonic acid. Mol Brain Res 57:173-179
18. Yaguchi T, Yamamoto S, Nagata T, Kanno T, Tanaka A, Nishizaki T (2005) Effects of cis-unsaturated free fatty acids on PKC-ε activation and nicotinic ACh receptor responses. Mol Brain Res 133:320-324
19. Nishizuka Y (1995) Protein kinase C and lipid signaling for sustained cellular responses. FASEB J 9:484-496
20. Steinberg SF (2008) Structural basis of protein kinase C isoform function. Physiol Rev 88:1341-1378
21. Kanno T, Yamamoto H, Yaguchi T, Hi R, Mukasa T, Fujikawa H, Nagata T, Yamamoto S, Tanaka A, Nishizaki T (2006) The linoleic acid derivative DCP-LA selectively activates PKC-ε, possibly binding to the phosphatidylserine binding site. J Lipid Res 47:1146-1156
22. 2+/calmodulin-dependent protein kinase II. NeuroReport 8:597-601
23. 2+-permeable AMPA receptors by interacting with a CaMKII pathway. Mol Brain Res 67:184-189
24. Kanno T, Yaguchi T, Nagata T, Tanaka A, Nishizaki T (2009) DCP-LA stimulates AMPA receptor exocytosis through CaMKII activation due to PP1 inhibition. J Cell Physiol 221:183-188
25. Moss SJ, McDonald BJ, Rudhard Y, Schoepfer R (1996) Phosphorylation of the predicted major intracellular domains of the rat and chick neuronal nicotinic acetylcholine receptor α7 subunit by cAMP-dependent protein kinase. Neuropharmacol 35:1023-1028
26. Gómez-Varela D, Schmidt M, Schoellerman J, Peters EC, Berg DK (2012) PMCA2 via PSD-95 controls calcium signaling by α7-containing nicotinic acetylcholine receptors on aspiny interneurons. J Neurosci 32:6894-6905