α,β-DCP-LA selectively activates PKC-ε and stimulates neurotransmitter release with the highest potency among 4 diastereomers

Cellular Physiology and Biochemistry

Volumn 27, Issue 2, 2011, Pages 149-158

  Shimizu, Tadashi ^a   Kanno, Takeshi ^a   Tanaka, Akito ^a   Nishizaki, Tomoyuki ^a  

^a HYOGO COLLEGE OF MEDICINE   (Japan)

Author keywords

DCP LA; Diastereomer; PKC ; Selective optical resolution; Transmitter release

Indexed keywords

ALPHA,ALPHA 8 [2 (2 PENTYL CYCLOPROPYLMETHYL) CYCLOPROPYL]OCTANOIC ACID; ALPHA,BETA 8 [2 (2 PENTYL CYCLOPROPYLMETHYL) CYCLOPROPYL]OCTANOIC ACID; BETA,ALPHA 8 [2 (2 PENTYL CYCLOPROPYLMETHYL) CYCLOPROPYL]OCTANOIC ACID; BETA,BETA 8 [2 (2 PENTYL CYCLOPROPYLMETHYL) CYCLOPROPYL]OCTANOIC ACID; DOPAMINE; GLUTAMIC ACID; NICOTINIC RECEPTOR; NICOTINIC RECEPTOR ALPHA 7; OCTANOIC ACID DERIVATIVE; PROTEIN KINASE C EPSILON; SEROTONIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BRAIN REGION; DIASTEREOISOMER; DOPAMINE RELEASE; ENZYME ACTIVATION; ENZYME ACTIVITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; NEUROTRANSMITTER RELEASE; NONHUMAN; OPTICAL RESOLUTION; PRIORITY JOURNAL; RAT; SEROTONIN RELEASE; STIMULATION;

RATTUS;

EID: 79951633282     PISSN: 10158987     EISSN: None     Source Type: Journal    
DOI: 10.1159/000325217     Document Type: Article

References (16)

1. Tanaka A, Nishizaki T: The newly synthesized linoleic acid derivative FR236924 induces a long-lasting facilitation of hippocampal neurotransmission by targeting nicotinic acetylcholine receptors. Bioorg Med Chem Lett 2003;13:1037-1040. (Pubitemid 36331794)
2. Yamamoto S, Kanno T, Nagata T, Yaguchi T, Tanaka A, Nishizaki T: The linoleic acid derivative FR236924 facilitates hippocampal synaptic transmission by enhancing activity of presynaptic a 7 acetylcholine receptors on the glutamatergic terminals. Neuroscience 2005;130:207-213. (Pubitemid 39550426)
3. Kanno T, Yaguchi T, Yamamoto S, Yamamoto H, Fujikawa H, Nagata T, Tanaka A, Nishizaki T: 8-[2-(2-pentyl-cyclopropylmethyl)-cyclopropyl]-octa-noic acid stimulates GABA release from interneurons projecting to CA1 pyramidal neurons in the rat hippocampus via pre-synaptic a7 acetylcholine receptors. J Neurochem 2005;95:695-702. (Pubitemid 41567162)
4. Kanno T, Yaguchi T, Nagata T, Tanaka A, Nishizaki T: DCP-LA stimulates AMPA receptor exocytosis through CaMKII activation due to PP-1 inhibition. J Cell Physiol 2009;221:183-188.
5. Nagata T, Yamamoto S, Yaguchi T, Iso H, Tanaka A, Nishizaki T: The newly synthesized linoleic acid derivative DCP-LA ameliorates memory deficits in animal models treated with amyloid-p peptide and scopolamine. Psychogeriatrics 2005;5:122-126.
6. Yaguchi T, Nagata T, Mukasa T, Fujikawa H, Yamamoto H, Yamamoto S, Iso H, Tanaka A, Nishizaki T: Linoleic acid derivative DCP-LA improves learning impairment in SAMP8. Neuroreport 2006;17:105-108. (Pubitemid 43005750)
7. Nagata T, Tominaga T, Mori H, Yaguchi T, Nishizaki T: DCP-LA neutralizes mutant amyloid p peptide-induced impairment of long-term potentiation and spatial learning. Behav Brain Res 2009;206:151-154.
8. Yaguchi T, Fujikawa H, Nishizaki T: Linoleic acid derivative DCP-LA protects neurons from oxidative stress-induced apoptosis by inhibiting caspase-3/-9 activation. Neurochem Res 2010;35:712-717.
9. Law A, Gauthier S, Quirion R: Say NO to Alzheimer's disease: the putative links between nitric oxide and dementia of the Alzheimer's type. Brain Res Rev 2001;35:73-96. (Pubitemid 32201877)
10. Loh KP, Huang SH, De Silva R, Tan BK, Zhu YZ: Oxidative stress: apoptosis in neuronal injury. Curr Alzheimer Res 2006;3:327-337. (Pubitemid 44351476)
11. Nunomura A, Moreira PI, Lee HG, Zhu X, Castellani RJ, Smith MA, Perry G: Neuronal death and survival under oxidative stress in Alzheimer and Parkinson diseases. CNS Neurol Disord Drug Targets 2007;6:411-423. (Pubitemid 351486255)
12. Isakov N: Activation of murine lymphocytes by exogenous phosphatidy-lethanolamine- and phosphatidylcholine-specific phospholipase C. Cell Immunol 1993;152:72-81. (Pubitemid 23354807)
13. Nishizuka Y: Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C. Science 1992;258:607-614.
14. Nishizuka Y: Protein kinase C and lipid signaling for sustained cellular responses. FASEB J 1995;9:484-496.
15. Kanno T, Yamamoto H, Yaguchi T, Hi R, Mukasa T, Fujikawa H, Nagata T, Yamamoto S, Tanaka A, Nishizaki T: The linoleic acid derivative DCP-LA selectively activates PKC-e, possibly binding to the phosphatidylserine binding site. J Lipid Res 2006;47:1146-1156. (Pubitemid 43830706)
16. Blaschke G, Kraft HP, Fickentscher K, Köhler F; Chromatographische Race-mattrennung von Thalidomid und teratogene Wirkung der Enantiomere. Arzneimittelforschung 1979;29:1640-1642.