IVIVC for fenofibrate immediate release tablets using solubility and permeability as in vitro predictors for pharmacokinetics

Journal of Pharmaceutical Sciences

Volumn 99, Issue 10, 2010, Pages 4427-4436

  Buch, Philipp ^a   Holm, Per ^a,d   Thomassen, Jesper Qvist ^b   Scherer, Dieter ^c   Branscheid, Robert ^a   Kolb, Ute ^a   Langguth, Peter ^a  

^a JOHANNES GUTENBERG UNIVERSITY   (Germany)

^b LifeCycle Pharma   (Denmark)

^c ApisPharma   (Switzerland)

^d H LUNDBECK A S   (Denmark)

Author keywords

Bioavailability; In vitro in vivo correlations (IVIVC); Oral absorption; Solubility; Surfactants

Indexed keywords

CASTOR OIL; CROSPOVIDONE; DOCUSATE SODIUM; DODECYL SULFATE SODIUM; FENOFIBRATE; HYDROXYPROPYLMETHYLCELLULOSE; LACTOSE; MAGNESIUM STEARATE; MICROCRYSTALLINE CELLULOSE; PHOSPHATIDYLCHOLINE; POLOXAMER; POLYVINYL ALCOHOL; SUCROSE; TALC; TITANIUM DIOXIDE; XANTHAN;

ARTICLE; CONTROLLED RELEASE FORMULATION; CRYOELECTRON MICROSCOPY; DRUG PENETRATION; DRUG SOLUBILITY; IN VITRO STUDY; JEJUNUM; LIGHT SCATTERING; SIMULATION; SOLUBILIZATION; STOMACH JUICE; SURFACE TENSION; TABLET; TECHNIQUE;

EID: 77957377051     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.22148     Document Type: Article

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