The conflict between in vitro release studies in human biorelevant media and the in vivo exposure in rats of the lipophilic compound fenofibrate

International Journal of Pharmaceutics

Volumn 414, Issue 1-2, 2011, Pages 118-124

  Do, Thao Thi ^a   Van Speybroeck, Michiel ^a   Mols, Raf ^a   Annaert, Pieter ^a   Martens, Johan ^a   Van Humbeeck, Jan ^a   Vermant, Jan ^a   Augustijns, Patrick ^a   Van Den Mooter, Guy ^a  

^a UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

Fenofibrate; In vitro study; In vivo study; Lipid based formulation

Indexed keywords

CAPROL 3GO; CAPTEX 200P; FENOFIBRATE; OCTANOIN; POLYGLYCEROL 3 OLEATE; POLYSORBATE 80; PROPYLENE GLYCOL DICAPRATE; PROPYLENE GLYCOL DICAPRYLATE; PROPYLENE GLYCOL MONOCAPRATE; PROPYLENE GLYCOL MONOCAPRYLATE; SOYBEAN OIL; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; BILIARY EXCRETION; DRUG EXPOSURE; DRUG RELEASE; DRUG SOLUBILITY; GASTROINTESTINAL TRACT; IN VITRO STUDY; IN VIVO STUDY; INTESTINE FLUID; LIPOPHILICITY; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SIMULATION; STOMACH JUICE;

ANIMALS; DRUG COMPOUNDING; DRUG DELIVERY SYSTEMS; EXCIPIENTS; FENOFIBRATE; GASTROINTESTINAL CONTENTS; GASTROINTESTINAL TRACT; GLYCERIDES; HUMANS; HYPOLIPIDEMIC AGENTS; MALE; MODELS, ANIMAL; OCTANOIC ACIDS; POLYSORBATES; RATS; RATS, WISTAR; SOLUBILITY; SOYBEAN OIL; SURFACE-ACTIVE AGENTS;

EID: 79959720189     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2011.05.009     Document Type: Article

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