Administration of a murine diet supplemented with conjugated linoleic acid increases the expression and activity of hepatic uncoupling proteins

Journal of Bioenergetics and Biomembranes

Volumn 44, Issue 5, 2012, Pages 587-596

  Pereira, Amanda F ^a   Sá, Larissa L ^a   Reis, Felippe H Z ^a   Cardoso, Fernanda C ^a   Alberici, Rosana M ^b   Prado, Ieda M R ^a   Eberlin, Marcos N ^b   Uyemura, Sergio A ^a   Curti, Carlos ^a   Alberici, Luciane C ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b UNIVERSITY OF CAMPINAS   (Brazil)

Author keywords

CLA; Energy metabolism; Liver; Mitochondria; Obesity; UCP

Indexed keywords

CONJUGATED LINOLEIC ACID; GUANOSINE DIPHOSPHATE; MESSENGER RNA; NICOTINAMIDE ADENINE DINUCLEOTIDE; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; TRIACYLGLYCEROL; UNCOUPLING PROTEIN 2;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CITRIC ACID CYCLE; CONTROLLED STUDY; DIET SUPPLEMENTATION; ENERGY METABOLISM; FAT INTAKE; LIPID COMPOSITION; LIPID STORAGE; LIVER METABOLISM; LIVER MITOCHONDRION; MALE; MITOCHONDRIAL RESPIRATION; MOUSE; NONHUMAN; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; PROTEIN EXPRESSION; TRIACYLGLYCEROL BLOOD LEVEL;

ANIMALS; DIETARY SUPPLEMENTS; ENDOPEPTIDASES; GENE EXPRESSION REGULATION; LINOLEIC ACIDS, CONJUGATED; LIVER; MALE; MICE; MITOCHONDRIA, LIVER; NAD; REACTIVE OXYGEN SPECIES;

MURINAE; MUS;

EID: 84866732687     PISSN: 0145479X     EISSN: 15736881     Source Type: Journal    
DOI: 10.1007/s10863-012-9463-y     Document Type: Article

References (57)

1. Alberici LC, Oliveira HC, Patrício PR, Kowaltowski AJ, Vercesi AE (2006) Hyperlipidemic mice present enhanced catabolism and higher mitochondrial ATP-sensitive K+channel activity. Gastroenterology 131:1228-1234
2. Alberici RM, Simas RC, Sanvido GB, Romão W, Lalli PM, Benassi M et al (2010) Ambient mass spectrometry: bringing MS into the real world. Anal Bioanal Chem 398:265-294
3. Alberici LC, Oliveira HC, Catharino RR, Vercesi AE, Eberlin MN, Alberici RM (2011) Distinct hepatic lipid profile of hypertriglyceridemic mice determined by easy ambient sonic-spray ionization mass spectrometry. Anal Bioanal Chem 401:1651-1659
4. Azain MJ, Hausman DB, Sisk MB, Flatt WP, Jewell DE (2000) Dietary conjugated linoleic acid reduces rat adipose tissue cell size rather than cell number. J Nutr 130:1548-1554
5. Banni S, Carta G, Angioni E, Murru E, Scanu P, Melis MP et al (2001) Distribution of conjugated linoleic acid and metabolites in different lipid fractions in the rat liver. J Lipid Res 42:1056-1061
6. Bligh EG, Dyer WJ (1959) A rapid method of total lipid extraction and purification. Can J Biochem Physiol 37:911-917
7. Buege JA, Aust SD (1978) Microsomal lipid peroxidation. Methods Enzymol 52:302-310
8. Cherian G, Holsonbake TB, Goeger MP, Bildfell R (2002) Dietary CLA alters yolk and tissue FA composition and hepatic histopathology of laying hens. Lipids 37:751-757
9. Choi JS, Koh IU, Jung MH, Song J (2007) Effects of three different conjugated linoleic acid preparations on insulin signalling, fat oxidation and mitochondrial function in rats fed a high-fat diet. Br J Nutr 98:264-275
10. DeLany JP, West DB (2000) Changes in body composition with conjugated linoleic acid. J Am Coll Nutr 19:487S-493S
11. Ealey KN, El-Sohemy A, Archer MC (2002) Effects of dietary conjugated linoleic acid on the expression of uncoupling proteins in mice and rats. Lipids 37:853-861
12. Echtay KS, Murphy MP, Smith RA, Talbot DA, Brand MD (2002a) Superoxide activates mitochondrial uncoupling protein 2 from the matrix side. Studies using targeted antioxidants. J Biol Chem 277:47129-47135
13. Echtay KS, Roussel D, St-Pierre J, Jekabsons MB, Cadenas S, Stuart JA, Harper JA, Roebuck SJ, Morrison A, Pickering S, Clapham JC, Brand MD (2002b) Superoxide activates mitochondrial uncoupling proteins. Nature 415:96-99
14. Fruchart JC, Duriez P, Staels B (1999) Peroxisome proliferatoractivated receptor-alpha activators regulate genes governing lipoprotein metabolism, vascular inflammation and atherosclerosis. Curr Opin Lipidol 10:245-257
15. Garcia-Ruiz C, Colell A, Mari M, Morales A, Fernandez-Checa JC (1997) Direct effect of ceramide on the mitochondrial electron transport chain leads to generation of reactive oxygen species. Role of mitochondrial glutathione. J Biol Chem 272:11369-11377
16. Garlid KD, Jabůrek M, Jezek P, Varecha M (2000) How do uncoupling proteins uncouple? Biochim Biophys Acta 1459:383-389
17. Gavino VC, Gavino G, Leblanc MJ, Tuchweber B (2000) An isomeric mixture of conjugated linoleic acids but not pure cis-9, trans-11-octadecadienoic acid affects body weight gain and plasma lipids in hamsters. J Nutr 130:27-29
18. Gholam PM, Flancbaum L, Machan JT, Charney DA, Kotler DP (2007) Nonalcoholic fatty liver disease in severely obese subjects. Am J Gastroenterol 102:399-408
19. Griinari JM, Corl BA, Lacy SH, Chouinard PY, Nurmela KV, Bauman DE (2000) Conjugated linoleic acid is synthesized endogenously in lactating dairy cows by Delta (9)-desaturase. J Nutr 130:2285-2291
20. Haddad R, Sparrapan R, Eberlin MN (2006) Desorption sonic spray ionization for (high) voltage-free ambient mass spectrometry. Rapid Commun Mass Spectrom 20:2901-2905
21. Haddad R, Sparrapan R, Kotiaho T, Eberlin MN (2008) Easy ambient sonic-spray ionization-membrane interface mass spectrometry for direct analysis of solution constituents. Anal Chem 80:898-903
22. Halade GV, Rahman MM, Fernandes G (2009) Effect of CLA isomers and their mixture on aging C57Bl/6J mice. Eur J Nutr 48:409-418
23. Hissin PJ, Hilf R (1976) A fluorometric method for determination of oxidized and reduced glutathione in tissues. Anal Biochem 74:214-226
24. Jaudszus A, Moeckel P, Hamelmann E, Jahreis G (2010) Trans-10, cis-12-CLA-caused lipodystrophy is associated with profound changes of fatty acid profiles of liver, white adipose tissue and erythrocytes in mice: possible link to tissue-specific alterations of fatty acid desaturation. Ann Nutr Metab 57:103-111
25. Jezek P, Garlid KD (1998) Mammalian mitochondrial uncoupling proteins. Int J Biochem Cell Biol 30:1163-1168
26. Kennedy A, Martinez K, Schmidt S, Mandrup S, LaPoint K, McIntosh M (2010) Antiobesity mechanisms of action of conjugated linoleic acid. J Nutr Biochem 21:171-179
27. Konig B, Spielmann J, Haase K, Brandsch C, Kluge H, Stangl GI et al (2008) Effects offish oil and conjugated linoleic acids on expression of target genes of PPAR alpha and sterol regulatory elementbinding proteins in the liver of laying hens. Br J Nutr 100:355-363
28. Kritchevsky D, Tepper SA, Wright S, Tso P, Czarnecki SK (2000) Influence of conjugated linoleic acid (CLA) on establishment and progression of atherosclerosis in rabbits. J Am Coll Nutr 19:472S-477S
29. Lin H, Boylston TD, Chang MJ, Luedecke LO, Shultz TD (1995) Survey of the conjugated linoleic acid contents of dairy products. J Dairy Sci 78:2358-2365
30. Moya-Camarena SY, Vanden Heuvel JP, Blanchard SG, Leesnitzer LA, Belury MA (1999) Conjugated linoleic acid is a potent naturally occurring ligand and activator of PPARalpha. J Lipid Res 40:1426-1433
31. Nicholls DG (1976) The bioenergetics of brown adipose tissue mitochondria. FEBS Lett 61:103-110
32. Ohnuki K, Haramizu S, Ishihara K, Fushiki T (2001a) Increased energy metabolism and suppressed body fat accumulation in mice by a low concentration of conjugated linoleic acid. Biosci Biotechnol Biochem 65:2200-2204
33. Ohnuki K, Haramizu S, Oki K, Ishihara K, Fushiki T (2001b) A single oral administration of conjugated linoleic acid enhanced energy metabolism in mice. Lipids 36:583-587
34. Ostrowska E, Muralitharan M, Cross RF, Bauman DE, Dunshea FR (1999) Dietary conjugated linoleic acids increase lean tissue and decrease fat deposition in growing pigs. J Nutr 129:2037-2042
35. Park Y, Albright KJ, Liu W, Storkson JM, Cook ME, Pariza MW (1997) Effect of conjugated linoleic acid on body composition in mice. Lipids 32:853-858
36. Peters JM, Park Y, Gonzalez FJ, Pariza MW (2001) Influence of conjugated linoleic acid on body composition and target gene expression in peroxisome proliferator-activated receptor alphanull mice. Biochim Biophys Acta 1533:233-242
37. Rahman MM, Bhattacharya A, Banu J, Fernandes G (2007) Conjugated linoleic acid protects against age-associated bone loss in C57BL/6 female mice. J Nutr Biochem 18:467-474
38. Rakhshandehroo M, Hooiveld G, Müller M, Kersten S (2009) Comparative analysis of gene regulation by the transcription factor PPARalpha between mouse and human. PLoS One 4:e6796
39. Reznick AZ, Packer L (1994) Oxidative damage to proteins: spectrophotometric method for the carbonyl assay. Methods Enzymol 233:357-363
40. Ribot J, Portillo MP, Picó C, Macarulla MT, Palou A (2007) Effects of trans-10, cis-12 conjugated linoleic acid on the expression of uncoupling proteins in hamsters fed an atherogenic diet. Br J Nutr 97:1074-1082
41. Roche HM, Noone E, Sewter C, Mc BS, Savage D, Gibney MJ, O'Rahilly S, Vidal-Puig AJ (2002) Isomer-dependent metabolic effects of conjugated linoleic acid: insights from molecular markers sterol regulatory element-binding protein-1c and LXRalpha. Diabetes 51:2037-2044
42. Ryder JW, Portocarrero CP, Song XM, Cui L, Yu M, Combatsiaris T, Galuska D, Bauman DE, Barbano DM, Charron MJ, Zierath JR, Houseknecht KL (2001) Isomer-specific antidiabetic properties of conjugated linoleic acid. Improved glucose tolerance, skeletal muscle insulin action, and UCP-2 gene expression. Diabetes 50:1149-1157
43. Samec S, Seydoux J, Dulloo AG (1998) Role of UCP homologues in skeletal muscles and brown adipose tissue: mediators of thermogenesis or regulators of lipids as fuel substrate? FASEB J 12:715-724
44. Schild L, Reinheckel T, Wiswedel I, Augustin W (1997) Short-term impairment of energy production in isolated rat liver mitochondria by hypoxia/reoxygenation: involvement of oxidative protein modification. Biochem J 15:205-210
45. Schönfeld P, Wojtczak L (2008) Fatty acids as modulators of the cellular production of reactive oxygen species. Free Radic Biol Med 45:231-241
46. Schoonjans K, Staels B, Auwerx J (1996) Role of the peroxisome proliferator-activated receptor (PPAR) in mediating the effects of fibrates and fatty acids on gene expression. J Lipid Res 37:907-925
47. Semighini CP, Marins M, Goldman M H S, Goldman GH (2002) Quantitative analysis of the relative transcript levels of ABC transporter Atr genes in Aspergillus nidulans by real-time reverse transcripition-PCR assay. Appl Environ Microbiol 68:1351-1357
48. Simas RC, Catharino RR, Cunha I B S, Cabral EC, Barrera-Arellano D, Eberlin MN et al (2010) Instantaneous characterization of vegetable oils via TAG and FFA profiles by easy ambient sonicspray ionization mass spectrometry. Analyst 135:735-744
49. Takahashi Y, Kushiro M, Shinohara K, Ide T (2002) Dietary conjugated linoleic acid reduces body fat mass and affects gene expression of proteins regulating energy metabolism in mice. Comp Biochem Physiol B Biochem Mol Biol 133:395-404
50. Terpstra AH (2004) Effect of conjugated linoleic acid on body composition and plasma lipids in humans: an overview of the literature. Am J Clin Nutr 79:352-361
51. Tsuboyama-Kasaoka N, Takahashi M, Tanemura K, Kim HJ, Tange T, Okuyama H et al (2000) Conjugated linoleic acid supplementation reduces adipose tissue by apoptosis and develops lipodystrophy in mice. Diabetes 49:1534-1542
52. Tsuboyama-Kasaoka N, Miyazaki H, Kasaoka S, Ezaki O (2003) Increasing the amount of fat in a conjugated linoleic acid-supplemented diet reduces lipodystrophy in mice. J Nutr 133:1793-1799
53. Wang YW, Jones PJ (2004) Conjugated linoleic acid and obesity control: efficacy and mechanisms. Int J Obes Relat Metab Disord 28:941-955
54. West DB, Delany JP, Camet PM, Blohm F, Truett AA, Scimeca J (1998) Effects of conjugated linoleic acid on body fat and energy metabolism in the mouse. Am J Physiol 275:R667-R672
55. West DB, Blohm FY, Truett AA, DeLany JP (2000) Conjugated linoleic acid persistently increases total energy expenditure in AKR/J mice without increasing uncoupling protein gene expression. J Nutr 130:2471-2477
56. World Health Organization, Programmes and Projects, Nutrition topics, Controlling the global obesity epidemic. Available from: http://www.who.int/ nutrition/topics/obesity/en. Accessed April 5, 2012
57. Zhou M, Diwu Z, Panchuk-Voloshina N, Haugland RP (1997) A stable nonfluorescent derivative of resorufin for the fluorometric determination of trace hydrogen peroxide: applications in detecting the activity of phagocyte NADPH oxidase and other oxidases. Anal Biochem 15:162-168