메뉴 건너뛰기




Volumn 47, Issue 9, 2012, Pages 913-926

Isolation of a Δ5 desaturase gene from Euglena gracilis and functional dissection of its HPGG and HDASH motifs

Author keywords

5 desaturase; Double mutant; Fatty acid biosynthesis; HDASH motif; HPGG motif; Yarrowia lipolytica

Indexed keywords

ACYL COENZYME A DESATURASE 1; AMINO ACID; ARACHIDONIC ACID; ARGININE; COMPLEMENTARY DNA; DIHOMO GAMMA LINOLENIC ACID; NUCLEOTIDE; OLIGONUCLEOTIDE; POLYPEPTIDE; SERINE;

EID: 84866732382     PISSN: 00244201     EISSN: 15589307     Source Type: Journal    
DOI: 10.1007/s11745-012-3690-1     Document Type: Article
Times cited : (13)

References (59)
  • 1
    • 62749169989 scopus 로고    scopus 로고
    • A systemic review of the roles of n-3 fatty acids in health and disease
    • Riediger ND, Othman RA, Suh M, Moghadasian MH (2009) A systemic review of the roles of n-3 fatty acids in health and disease. J Am Diet Assoc 109:668-679
    • (2009) J Am Diet Assoc , vol.109 , pp. 668-679
    • Riediger, N.D.1    Othman, R.A.2    Suh, M.3    Moghadasian, M.H.4
  • 2
    • 77956426497 scopus 로고    scopus 로고
    • Beneficial effects of omega-3 fatty acids in cardiovascular disease
    • Freeman LM (2010) Beneficial effects of omega-3 fatty acids in cardiovascular disease. J Small Anim Pract 51:462-470
    • (2010) J Small Anim Pract , vol.51 , pp. 462-470
    • Freeman, L.M.1
  • 3
    • 79961131500 scopus 로고    scopus 로고
    • Developmentally dependent and different roles of fatty acids OMEGA-6 and OMEGA-3
    • Mourek J, Mourek J Jr (2011) Developmentally dependent and different roles of fatty acids OMEGA-6 and OMEGA-3. Prague Med Rep 112:81-92
    • (2011) Prague Med Rep , vol.112 , pp. 81-92
    • Mourek, J.1    Mourek Jr., J.2
  • 4
    • 79952039402 scopus 로고    scopus 로고
    • Docosahexaenoic acid: Brain accretion and roles in neuroprotection after brain hypoxia and ischemia
    • Mayurasakorn K, Williams JJ, Ten VS, Deckelbaum RJ (2011) Docosahexaenoic acid: brain accretion and roles in neuroprotection after brain hypoxia and ischemia. Curr Opin Clin Nutr Metab Care 14:158-167
    • (2011) Curr Opin Clin Nutr Metab Care , vol.14 , pp. 158-167
    • Mayurasakorn, K.1    Williams, J.J.2    Ten, V.S.3    Deckelbaum, R.J.4
  • 5
    • 78650688069 scopus 로고    scopus 로고
    • Resolvins: Natural agonists for resolution of pulmonary inflammation
    • Uddin M, Levy BD (2011) Resolvins: natural agonists for resolution of pulmonary inflammation. Prog Lipid Res 50:75-88
    • (2011) Prog Lipid Res , vol.50 , pp. 75-88
    • Uddin, M.1    Levy, B.D.2
  • 6
    • 34247847681 scopus 로고    scopus 로고
    • Resolution phase of inflammation: Novel endogenous anti-inflammatory and proresolving lipid mediators and pathways
    • Serhan CN (2007) Resolution phase of inflammation: novel endogenous anti-inflammatory and proresolving lipid mediators and pathways. Annu Rev Immunol 25:101-137
    • (2007) Annu Rev Immunol , vol.25 , pp. 101-137
    • Serhan, C.N.1
  • 7
    • 79955038914 scopus 로고    scopus 로고
    • Pharmacology in health foods: Effects of arachidonic acid and docosahexaenoic acid on the age-related decline in brain and cardiovascular system function
    • Kiso Y (2011) Pharmacology in health foods: effects of arachidonic acid and docosahexaenoic acid on the age-related decline in brain and cardiovascular system function. J Pharmacol Sci 115:471-475
    • (2011) J Pharmacol Sci , vol.115 , pp. 471-475
    • Kiso, Y.1
  • 10
    • 43549095504 scopus 로고    scopus 로고
    • Plasma eicosa-pentaenoic acid is inversely associated with severity of depressive symptomatology in the elderly: Data from the bordeaux sample of the three-city study
    • Féart C, Peuchant E, Letenneur L, Samieri C, Montagnier D, Fourrier-Reglat A, Barberger-Gateau P (2008) Plasma eicosa-pentaenoic acid is inversely associated with severity of depressive symptomatology in the elderly: data from the Bordeaux sample of the three-city study. Am J Clin Nutr 87:1156-1162
    • (2008) Am J Clin Nutr , vol.87 , pp. 1156-1162
    • Féart, C.1    Peuchant, E.2    Letenneur, L.3    Samieri, C.4    Montagnier, D.5    Fourrier-Reglat, A.6    Barberger-Gateau, P.7
  • 11
    • 35248884029 scopus 로고    scopus 로고
    • Contaminants in fish: Risk-benefit considerations
    • Costa LG (2007) Contaminants in fish: risk-benefit considerations. Arh Hig Rada Toksikol 58:567-574
    • (2007) Arh Hig Rada Toksikol , vol.58 , pp. 567-574
    • Costa, L.G.1
  • 12
    • 84944400142 scopus 로고    scopus 로고
    • Arachidonic acid: Fermentative production by mortierella fungi
    • Cohen Z, Ratledge C (eds) 2nd edn. AOCS Press, Urbana
    • Streekstra H (2010) Arachidonic acid: fermentative production by Mortierella fungi. In: Cohen Z, Ratledge C (eds) Single cell oils, 2nd edn. AOCS Press, Urbana
    • (2010) Single Cell Oils
    • Streekstra, H.1
  • 13
    • 84944407052 scopus 로고    scopus 로고
    • Development of a docosahexaenoic acid production technology using schizochytrium: Historical perspective and update
    • Cohen Z, Ratledge C (eds) 2nd edn. AOCS Press, Urbana
    • Barclay W, Weaver C, Metz J, Hansen J (2010) Development of a docosahexaenoic acid production technology using Schizochytrium: historical perspective and update. In: Cohen Z, Ratledge C (eds) Single cell oils, 2nd edn. AOCS Press, Urbana
    • (2010) Single Cell Oils
    • Barclay, W.1    Weaver, C.2    Metz, J.3    Hansen, J.4
  • 16
    • 0033561806 scopus 로고    scopus 로고
    • The Δ8-desaturase of euglena gracilis: An alternate pathway for synthesis of 20-carbon polyunsaturated fatty acids
    • Wallis JG, Browse J (1999) The Δ8-desaturase of Euglena gracilis: an alternate pathway for synthesis of 20-carbon polyunsaturated fatty acids. Arch Biochem Biophys 365:307-316
    • (1999) Arch Biochem Biophys , vol.365 , pp. 307-316
    • Wallis, J.G.1    Browse, J.2
  • 17
    • 0037321867 scopus 로고    scopus 로고
    • Recent advances in the study of fatty acid desaturases from animals and lower eukaryotes
    • Pereira SL, Leonard AE, Mukerji P (2003) Recent advances in the study of fatty acid desaturases from animals and lower eukaryotes. Prostaglandins Leukot Essent Fatty Acids 68:97-106
    • (2003) Prostaglandins Leukot Essent Fatty Acids , vol.68 , pp. 97-106
    • Pereira, S.L.1    Leonard, A.E.2    Mukerji, P.3
  • 18
    • 0035943661 scopus 로고    scopus 로고
    • Identification of a delta 4 fatty acid desaturase from thraustochytrium sp. involved in the biosynthesis of docosahexanoic acid by heterologous expression in saccharomyces cerevisiae and brassica juncea
    • Qiu X, Hong H, MacKenzie SL (2001) Identification of a delta 4 fatty acid desaturase from Thraustochytrium sp. involved in the biosynthesis of docosahexanoic acid by heterologous expression in Saccharomyces cerevisiae and Brassica juncea. J Biol Chem 276:31561-31566
    • (2001) J Biol Chem , vol.276 , pp. 31561-31566
    • Qiu, X.1    Hong, H.2    MacKenzie, S.L.3
  • 20
    • 4043052885 scopus 로고    scopus 로고
    • Isolation and characterization of delta(6)-desaturase, an ELO-like enzyme and delta(5)-desaturase from the liverwort marchantia polymorpha and production of arachidonic and eicosapentaenoic acids in the methylotrophic yeast pichia pastoris
    • Kajikawa M, Yamato KT, Kohzu Y, Nojiri M, Sakuradani E, Shimizu S, Sakai Y, Fukuzawa H, Ohyama K (2004) Isolation and characterization of delta(6)-desaturase, an ELO-like enzyme and delta(5)-desaturase from the liverwort Marchantia polymorpha and production of arachidonic and eicosapentaenoic acids in the methylotrophic yeast Pichia pastoris. Plant Mol Biol 54:335-352
    • (2004) Plant Mol Biol , vol.54 , pp. 335-352
    • Kajikawa, M.1    Yamato, K.T.2    Kohzu, Y.3    Nojiri, M.4    Sakuradani, E.5    Shimizu, S.6    Sakai, Y.7    Fukuzawa, H.8    Ohyama, K.9
  • 21
    • 36949016208 scopus 로고    scopus 로고
    • Engineering oilseeds to produce nutritional fatty acids
    • Damude HG, Kinney AJ (2008) Engineering oilseeds to produce nutritional fatty acids. Physiol Plant 132:1-10
    • (2008) Physiol Plant , vol.132 , pp. 1-10
    • Damude, H.G.1    Kinney, A.J.2
  • 22
    • 76549107629 scopus 로고    scopus 로고
    • An alternative to fish oils: Metabolic engineering of oil-seed crops to produce omega-3 long chain polyunsaturated fatty acids
    • Venegas-Calerón M, Sayanova O, Napier JA (2010) An alternative to fish oils: metabolic engineering of oil-seed crops to produce omega-3 long chain polyunsaturated fatty acids. Prog Lipid Res 49:108-119
    • (2010) Prog Lipid Res , vol.49 , pp. 108-119
    • Venegas-Calerón, M.1    Sayanova, O.2    Napier, J.A.3
  • 23
    • 79953171537 scopus 로고    scopus 로고
    • Metabolic engineering of saccharomyces cerevisiae for production of eicosapentaenoic acid, using a novel {delta}5-desaturase from paramecium tetraurelia
    • Tavares S, Grotkjær T, Obsen T, Haslam RP, Napier JA, Gunnarsson N (2011) Metabolic engineering of Saccharomyces cerevisiae for production of eicosapentaenoic acid, using a novel {delta}5-desaturase from Paramecium tetraurelia. Appl Environ Microbiol 77:1854-1861
    • (2011) Appl Environ Microbiol , vol.77 , pp. 1854-1861
    • Tavares, S.1    Grotkjær, T.2    Obsen, T.3    Haslam, R.P.4    Napier, J.A.5    Gunnarsson, N.6
  • 26
    • 84862268506 scopus 로고    scopus 로고
    • The front-end desaturase: Structure, function, evolution and biotechnological use
    • Meesapyodsuk D, Qiu X (2012) The front-end desaturase: structure, function, evolution and biotechnological use. Lipids 47:227-237
    • (2012) Lipids , vol.47 , pp. 227-237
    • Meesapyodsuk, D.1    Qiu, X.2
  • 27
    • 0035530093 scopus 로고    scopus 로고
    • Desaturases fused to their electron donor
    • Sperling P, Heinz E (2001) Desaturases fused to their electron donor. Eur J Lipid Sci Technol 103:158-180
    • (2001) Eur J Lipid Sci Technol , vol.103 , pp. 158-180
    • Sperling, P.1    Heinz, E.2
  • 30
    • 0025242338 scopus 로고
    • The OLE1 gene of saccharomyces cerevisiae encodes the delta 9 fatty acid desaturase and can be functionally replaced by the rat stearoyl-coa desaturase gene
    • Stukey JE, McDonough VM, Martin CE (1990) The OLE1 gene of Saccharomyces cerevisiae encodes the delta 9 fatty acid desaturase and can be functionally replaced by the rat stearoyl-CoA desaturase gene. J Biol Chem 265:20144-20149
    • (1990) J Biol Chem , vol.265 , pp. 20144-20149
    • Stukey, J.E.1    McDonough, V.M.2    Martin, C.E.3
  • 31
    • 67650517831 scopus 로고    scopus 로고
    • Desaturases: Emerging models for understanding functional diversification of diiron-containing enzymes
    • Shanklin J, Guy JE, Mishra G, Lindqvist Y (2009) Desaturases: emerging models for understanding functional diversification of diiron-containing enzymes. J Biol Chem 284:18559-18563
    • (2009) J Biol Chem , vol.284 , pp. 18559-18563
    • Shanklin, J.1    Guy, J.E.2    Mishra, G.3    Lindqvist, Y.4
  • 33
    • 0028089687 scopus 로고
    • Eight histidine residues are catalytically essential in a membrane-associated iron enzyme, stearoyl-coa desaturase, and are conserved in alkane hydroxylase and xylene monooxygenase
    • Shanklin J, Whittle E, Fox BG (1994) Eight histidine residues are catalytically essential in a membrane-associated iron enzyme, stearoyl-CoA desaturase, and are conserved in alkane hydroxylase and xylene monooxygenase. Biochemistry 33:12787-12794
    • (1994) Biochemistry , vol.33 , pp. 12787-12794
    • Shanklin, J.1    Whittle, E.2    Fox, B.G.3
  • 42
    • 84856618444 scopus 로고    scopus 로고
    • Engineering yarrowia lipolytica to express secretory invertase with strong FBA1IN promoter
    • Hong S-Y, Seip J, Walters-Pollak D, Rupert R, Jackson R, Xue Z, Zhu Q (2011) Engineering Yarrowia lipolytica to express secretory invertase with strong FBA1IN promoter. Yeast 29:59-72
    • (2011) Yeast , vol.29 , pp. 59-72
    • Hong, S.-Y.1    Seip, J.2    Walters-Pollak, D.3    Rupert, R.4    Jackson, R.5    Xue, Z.6    Zhu, Q.7
  • 43
  • 44
    • 0035951770 scopus 로고    scopus 로고
    • 12-oleic acid desaturase-related enzymes: Biosynthetic origin of calendic acid
    • 12- oleic acid desaturase-related enzymes: biosynthetic origin of calendic acid. J Biol Chem 276:2637-2643
    • (2001) J Biol Chem , vol.276 , pp. 2637-2643
    • Cahoon, E.B.1    Ripp, K.G.2    Hall, S.E.3    Kinney, A.L.4
  • 45
    • 0042026506 scopus 로고    scopus 로고
    • Biosynthesis of docosahexaenoic acid in euglena gracilis: Biochemical and molecular evidence for the involvement of a delta4-fatty acyl group desaturase
    • Meyer A, Cirpus P, Ott C, Schlecker R, Zahringer U, Heinz E (2003) Biosynthesis of docosahexaenoic acid in Euglena gracilis: biochemical and molecular evidence for the involvement of a delta4-fatty acyl group desaturase. J Biochem 42:9779-9788
    • (2003) J Biochem , vol.42 , pp. 9779-9788
    • Meyer, A.1    Cirpus, P.2    Ott, C.3    Schlecker, R.4    Zahringer, U.5    Heinz, E.6
  • 46
    • 0036757267 scopus 로고    scopus 로고
    • Isolation and characterization of a Δ5 FA desaturase from pythium irregulare by heterologous expression in saccharomyces cerevisiae and oilseed crops
    • Hong H, Datla N, MacKenzie SL, Qiu X (2002) Isolation and characterization of a Δ5 FA desaturase from Pythium irregulare by heterologous expression in Saccharomyces cerevisiae and oilseed crops. Lipids 37:863-868
    • (2002) Lipids , vol.37 , pp. 863-868
    • Hong, H.1    Datla, N.2    MacKenzie, S.L.3    Qiu, X.4
  • 47
    • 0036040288 scopus 로고    scopus 로고
    • Cloning and functional characterization of phaeodactylum tricornutum frontend desaturases involved in eicosapentaenoic acid biosynthesis
    • Domergue F, Lerchl J, Zahringer U, Heinz E (2002) Cloning and functional characterization of Phaeodactylum tricornutum frontend desaturases involved in eicosapentaenoic acid biosynthesis. Eur J Biochem 269:4105-4113
    • (2002) Eur J Biochem , vol.269 , pp. 4105-4113
    • Domergue, F.1    Lerchl, J.2    Zahringer, U.3    Heinz, E.4
  • 50
    • 0028173111 scopus 로고
    • The cytochrome b4-fold: An adaptable module
    • Lederer F (1994) The cytochrome b4-fold: an adaptable module. Biochimie 76:674-692
    • (1994) Biochimie , vol.76 , pp. 674-692
    • Lederer, F.1
  • 51
    • 0033213187 scopus 로고    scopus 로고
    • 5 domain of the borage delta6 fatty acid desaturase is essential for enzyme activity
    • 5 domain of the borage delta6 fatty acid desaturase is essential for enzyme activity. Plant Physiol 121:641-646
    • (1999) Plant Physiol , vol.121 , pp. 641-646
    • Sayanova, O.1    Shewry, P.R.2    Napier, J.A.3
  • 54
    • 77649239383 scopus 로고    scopus 로고
    • The evolution of fatty acid desaturases and cytochrome b5 in eukaryotes
    • Gostincar C, Turk M, Gunde-Cimerman N (2010) The evolution of fatty acid desaturases and cytochrome b5 in eukaryotes. J Membr Biol 233:63-72
    • (2010) J Membr Biol , vol.233 , pp. 63-72
    • Gostincar, C.1    Turk, M.2    Gunde-Cimerman, N.3
  • 55
    • 84944409057 scopus 로고    scopus 로고
    • Single cell oils for the 21st century
    • Cohen Z, Ratledge C (eds) 2nd edn. AOCS Press, Urbana
    • Ratledge C (2010) Single cell oils for the 21st century. In: Cohen Z, Ratledge C (eds) Single cell oils, 2nd edn. AOCS Press, Urbana
    • (2010) Single Cell Oils
    • Ratledge, C.1
  • 56
    • 79955560245 scopus 로고    scopus 로고
    • An overview of lipid metabolism in yeasts and its impact on biotechnological processes
    • Beopoulos A, Nicaud JM, Gaillardin C (2011) An overview of lipid metabolism in yeasts and its impact on biotechnological processes. Appl Microbiol Biotechnol 90:1193-1206
    • (2011) Appl Microbiol Biotechnol , vol.90 , pp. 1193-1206
    • Beopoulos, A.1    Nicaud, J.M.2    Gaillardin, C.3
  • 57
    • 78349234191 scopus 로고    scopus 로고
    • The 'LipoYeasts' project: Using the oleaginous yeast yarrowia lipolytica in combination with specific bacterial genes for the bioconversion of lipids, fats and oils into high-value products
    • Sabirova JS, Haddouche R, Van Bogaert IN, Mulaa F, Verstraete W, Timmis KN, Schmidt-Dannert C, Nicaud JM, Soetaert W (2011) The 'LipoYeasts' project: using the oleaginous yeast Yarrowia lipolytica in combination with specific bacterial genes for the bioconversion of lipids, fats and oils into high-value products. Microb Biotechnol 4:47-54
    • (2011) Microb Biotechnol , vol.4 , pp. 47-54
    • Sabirova, J.S.1    Haddouche, R.2    Van Bogaert, I.N.3    Mulaa, F.4    Verstraete, W.5    Timmis, K.N.6    Schmidt-Dannert, C.7    Nicaud, J.M.8    Soetaert, W.9
  • 58
    • 64849114915 scopus 로고    scopus 로고
    • Coding sequence determinants of gene expression in escherichia coli
    • Kudla G, Murray AW, Tollervey D, Plotkin JB (2009) Coding sequence determinants of gene expression in Escherichia coli. Science 324:255-258
    • (2009) Science , vol.324 , pp. 255-258
    • Kudla, G.1    Murray, A.W.2    Tollervey, D.3    Plotkin, J.B.4
  • 59
    • 79957642995 scopus 로고    scopus 로고
    • Selective constraints in yeast genes with differential expressivity: Codon pair usage and mRNA stability perspectives
    • Kahali B, Ahmad S, Ghosh TC (2011) Selective constraints in yeast genes with differential expressivity: codon pair usage and mRNA stability perspectives. Gene 481:76-82
    • (2011) Gene , vol.481 , pp. 76-82
    • Kahali, B.1    Ahmad, S.2    Ghosh, T.C.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.