Bilberries potentially alleviate stress-related retinal gene expression induced by a high-fat diet in mice

Molecular Vision

Volumn 18, Issue , 2012, Pages 2338-2351

  Mykkänen, Otto T ^a   Kalesnykas, Giedrius ^a   Adriaens, Michiel ^b   Evelo, Chris T ^b   Törrönen, Riitta ^a   Kaarniranta, Kai ^a,c  

^a UNIVERSITY OF EASTERN FINLAND   (Finland)

^b MAASTRICHT UNIVERSITY   (Netherlands)

^c KUOPIO UNIVERSITY HOSPITAL   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

ANTHOCYANIN; BIOLOGICAL MARKER; CARBOHYDRATE; CRYSTALLIN; FAT; FATTY ACID; GLUCOSE; GLUTATHIONE; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BILBERRY; BLOOD PRESSURE MEASUREMENT; BLUEBERRY; CONTROLLED STUDY; CRYAA GENE; CRYAB GENE; CRYBA1 GENE; CRYBA2 GENE; CRYBA4 GENE; CRYBB1 GENE; CRYBB2 GENE; CRYBB3 GENE; CRYGB GENE; CRYGC GENE; CRYGD GENE; CRYGS GENE; DIETARY INTAKE; FATTY ACID BLOOD LEVEL; GENE; GENE ACTIVITY; GENE EXPRESSION PROFILING; GENE FUNCTION; GENE SEQUENCE; GENETIC REGULATION; GENETIC TRANSCRIPTION; GENETIC VARIABILITY; GLUCOSE BLOOD LEVEL; GLUTATHIONE METABOLISM; LIPID DIET; MALE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; NUTRITIONAL ASSESSMENT; OBESITY; OXIDATIVE STRESS; PHENOTYPE; PRIORITY JOURNAL; RETINA; RNA EXTRACTION; RNA HYBRIDIZATION; RNA PROBE; SYSTEMIC LUPUS ERYTHEMATOSUS; SYSTOLIC BLOOD PRESSURE; WEIGHT GAIN;

ANIMALS; ANTHOCYANINS; ANTIOXIDANTS; BLOOD PRESSURE; BODY WEIGHT; CRYSTALLINS; DIET, HIGH-FAT; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; MALE; MICE; MICE, INBRED C57BL; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; OBESITY; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; OXIDATIVE STRESS; RETINA; RNA, MESSENGER; SIGNAL TRANSDUCTION; VACCINIUM MYRTILLUS; WEIGHT GAIN;

EID: 84866707491     PISSN: None     EISSN: 10900535     Source Type: Journal    
DOI: None     Document Type: Article

References (64)

1. Rossmeisl M, Rim JS, Koza RA, Kozak LP. Variation in type 2 diabetes-related traits in mouse strains susceptible to dietinduced obesity. Diabetes 2003; 52:1958-66. [PMID: 12882911]
2. Collins S, Martin TL, Surwit RS, Robidoux J. Genetic vulnerability to diet-induced obesity in the C57BL/6J mouse: Physiological and molecular characteristics. Physiol Behav 2004; 81:243-8. [PMID: 15159170]
3. Buettner R, Scholmerich J, Bollheimer LC. High-fat diets: Modeling the metabolic disorders of human obesity in rodents. Obesity (Silver Spring) 2007; 15:798-808. [PMID: 17426312]
4. Mills E, Kuhn CM, Feinglos MN, Surwit R. Hypertension in CB57BL/6J mouse model of non-insulin-dependent diabetes mellitus. Am J Physiol 1993; 264:R73-8. [PMID: 8430889]
5. Clee SM, Attie AD. The genetic landscape of type 2 diabetes in mice. Endocr Rev 2007; 28:48-83. [PMID: 17018838]
6. Cheung N, Wong TY. Obesity and eye diseases. Surv Ophthalmol 2007; 52:180-95. [PMID: 17355856]
7. Miceli MV, Newsome DA, Tate DJ Jr, Sarphie TG. Pathologic changes in the retinal pigment epithelium and bruch's membrane of fat-fed atherogenic mice. Curr Eye Res 2000; 20:8-16. [PMID: 10611710]
8. Edwards AO, Malek G. Molecular genetics of AMD and current animal models. Angiogenesis 2007; 10:119-32. [PMID: 17372852]
9. Brucklacher RM, Patel KM, VanGuilder HD, Bixler GV, Barber AJ, Antonetti DA, Lin CM, LaNoue KF, Gardner TW, Bronson SK, Freeman WM. Whole genome assessment of the retinal response to diabetes reveals a progressive neurovascular inflammatory response. BMC Med Genomics 2008; 1:26. [PMID: 18554398]
10. Klaassen I, Hughes JM, Vogels IM, Schalkwijk CG, Van Noorden CJ, Schlingemann RO. Altered expression of genes related to blood-retina barrier disruption in streptozotocin-induced diabetes. Exp Eye Res 2009; 89:4-15. [PMID: 19284967]
11. Van Kirk CA, VanGuilder HD, Young M, Farley JA, Sonntag WE, Freeman WM. Age-related alterations in retinal neurovascular and inflammatory transcripts. Mol Vis 2011; 17:1261-74. [PMID: 21633715]
12. Freeman WM, Bixler GV, Brucklacher RM, Walsh E, Kimball SR, Jefferson LS, Bronson SK. Transcriptomic comparison of the retina in two mouse models of diabetes. J. Ocul. Biol. Dis. Infor 2009; 2:202-13. [PMID: 20157355]
13. Losiewicz MK, Fort PE. Diabetes impairs the neuroprotective properties of retinal alpha-crystallins. Invest Ophthalmol Vis Sci 2011; 52:5034-42. [PMID: 21467180]
14. Määttä-Riihinen KR, Kamal-Eldin A, Mattila PH, Gonzalez-Paramas AM, Torronen AR. Distribution and contents of phenolic compounds in eighteen scandinavian berry species. J Agric Food Chem 2004; 52:4477-86. [PMID: 15237955]
15. Koponen JM, Happonen AM, Mattila PH, Torronen AR. Contents of anthocyanins and ellagitannins in selected foods consumed in finland. J Agric Food Chem 2007; 55:1612-9. [PMID: 17261015]
16. Mazza G, Kay CD, Cottrell T, Holub BJ. Absorption of anthocyanins from blueberries and serum antioxidant status in human subjects. J Agric Food Chem 2002; 50:7731-7. [PMID: 12475297]
17. Kalt W, Blumberg JB, McDonald JE, Vinqvist-Tymchuk MR, Fillmore SA, Graf BA, O'Leary JM, Milbury PE. Identification of anthocyanins in the liver, eye, and brain of blueberry-fed pigs. J Agric Food Chem 2008; 56:705-12. [PMID: 18211026]
18. Barros D, Amaral OB, Izquierdo I, Geracitano L, do Carmo Bassols Raseira M, Henriques AT, Ramirez MR. Behavioral and genoprotective effects of vaccinium berries intake in mice. Pharmacol Biochem Behav 2006; 84:229-34. [PMID: 16797063]
19. Wallace TC. Anthocyanins in cardiovascular disease. Adv Nutr 2011; 2:1-7. [PMID: 22211184]
20. Tsuda T, Horio F, Uchida K, Aoki H, Osawa T. Dietary cyanidin 3-O-beta-D-glucoside-rich purple corn color prevents obesity and ameliorates hyperglycemia in mice. J Nutr 2003; 133:2125-30. [PMID: 12840166]
21. Jayaprakasam B, Olson LK, Schutzki RE, Tai MH, Nair MG. Amelioration of obesity and glucose intolerance in high-fatfed C57BL/6 mice by anthocyanins and ursolic acid in cornelian cherry (cornus mas). J Agric Food Chem 2006; 54:243-8. [PMID: 16390206]
22. Guo H, Ling W, Wang Q, Liu C, Hu Y, Xia M, Feng X, Xia X. Effect of anthocyanin-rich extract from black rice (oryza sativa L. indica) on hyperlipidemia and insulin resistance in fructose-fed rats. Plant Foods Hum Nutr 2007; 62:1-6. [PMID: 17187297]
23. DeFuria J, Bennett G, Strissel KJ, Perfield JW 2nd, Milbury PE, Greenberg AS, Obin MS. Dietary blueberry attenuates whole-body insulin resistance in high fat-fed mice by reducing adipocyte death and its inflammatory sequelae. J Nutr 2009; 139:1510-6. [PMID: 19515743]
24. Prior RL, Wu X, Gu L, Hager TJ, Hager A, Howard LR. Whole berries versus berry anthocyanins: Interactions with dietary fat levels in the C57BL/6J mouse model of obesity. J Agric Food Chem 2008; 56:647-53. [PMID: 18211017]
25. Prior RL, Wu X, Gu L, Hager T, Hager A, Wilkes S, Howard L. Purified berry anthocyanins but not whole berries normalize lipid parameters in mice fed an obesogenic high fat diet. Mol Nutr Food Res 2009; 53:1406-18. [PMID: 19743407]
26. Prior RL, Wilkes SE, Rogers TR, Khanal RC, Wu X, Howard LR. Purified blueberry anthocyanins and blueberry juice alter development of obesity in mice fed an obesogenic high-fat diet. J Agric Food Chem 2010; 58:3970-6. [PMID: 20148514]
27. Prior RL, Wu X. Anthocyanins: Structural characteristics that result in unique metabolic patterns and biological activities. Free Radic Res 2006; 40:1014-28. [PMID: 17015246]
28. He J, Giusti MM. Anthocyanins: Natural colorants with health-promoting properties. Annu. Rev. Food Sci. Technol. 2010; 1:163-87. [PMID: 22129334]
29. Ghosh D, Konishi T. Anthocyanins and anthocyanin-rich extracts: Role in diabetes and eye function. Asia Pac J Clin Nutr 2007; 16:200-8. [PMID: 17468073]
30. Miyake S, Takahashi N, Sasaki M, Kobayashi S, Tsubota K, Ozawa Y. Vision preservation during retinal inflammation by anthocyanin-rich bilberry extract: cellular and molecular mechanism. Lab Invest 2012; 92:102-9. [PMID: 21894150]
31. Yao N, Lan F, He RR, Kurihara H. Protective effects of bilberry (vaccinium myrtillus L.) extract against endotoxininduced uveitis in mice. J Agric Food Chem 2010; 58:4731-6. [PMID: 20222750]
32. Spencer JP. The impact of fruit flavonoids on memory and cognition. Br J Nutr 2010; 104:S40-7. [PMID: 20955649]
33. Rhone M, Basu A. Phytochemicals and age-related eye diseases. Nutr Rev 2008; 66:465-72. [PMID: 18667008]
34. Koponen JM, Happonen AM, Mattila PH, Torronen AR. Contents of anthocyanins and ellagitannins in selected foods consumed in finland. J Agric Food Chem 2007; 55:1612-9. [PMID: 17261015]
35. Johns C, Gavras I, Handy DE, Salomao A, Gavras H. Models of experimental hypertension in mice. Hypertension 1996; 28:1064-9. [PMID: 8952597]
36. Dunning MJ, Smith ML, Ritchie ME, Tavare S. Beadarray: R classes and methods for illumina bead-based data. Bioinformatics 2007; 23:2183-4. [PMID: 17586828]
37. Smyth GK. Linear models and empirical bayes methods for assessing differential expression in microarray experiments. Stat Appl Genet Mol Biol 2004; 3:e3. [PMID: 16646809]
38. Gentleman RC, Carey VJ, Bates DM, Bolstad B, Dettling M, Dudoit S, Ellis B, Gautier L, Ge Y, Gentry J, Hornik K, Hothorn T, Huber W, Iacus S, Irizarry R, Leisch F, Li C, Maechler M, Rossini AJ, Sawitzki G, Smith C, Smyth G, Tierney L, Yang JY, Zhang J. Bioconductor: Open software development for computational biology and bioinformatics. Genome Biol 2004; 5:R80. [PMID: 15461798]
39. Huang W, Sherman BT, Lempicki RA. vSystematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat Protoc 2009; 4:44-57. [PMID: 19131956]
40. van Iersel MP, Kelder T, Pico AR, Hanspers K, Coort S, Conklin BR, Evelo C. Presenting and exploring biological pathways with PathVisio. BMC Bioinformatics 2008; 9:399. [PMID: 18817533]
41. Kelder T, van Iersel MP, Hanspers K, Kutmon M, Conklin BR, Evelo CT, Pico AR. WikiPathways: building research communities on biological pathways. Nucleic Acids Res 2012; 40:D1301-7. [PMID: 22096230]
42. Shaughnessy KS, Boswall IA, Scanlan AP, Gottschall-Pass KT, Sweeney MI. Diets containing blueberry extract lower blood pressure in spontaneously hypertensive stroke-prone rats. Nutr Res 2009; 29:130-8. [PMID: 19285604]
43. Takikawa M, Inoue S, Horio F, Tsuda T. Dietary anthocyanin-rich bilberry extract ameliorates hyperglycemia and insulin sensitivity via activation of AMP-activated protein kinase in diabetic mice. J Nutr 2010; 140:527-33. [PMID: 20089785]
44. DeFuria J, Bennett G, Strissel KJ, Perfield JW 2nd, Milbury PE, Greenberg AS, Obin MS. Dietary blueberry attenuates whole-body insulin resistance in high fat-fed mice by reducing adipocyte death and its inflammatory sequelae. J Nutr 2009; 139:1510-6. [PMID: 19515743]
45. Van Kirk CA, VanGuilder HD, Young M, Farley JA, Sonntag WE, Freeman WM. Age-related alterations in retinal neurovascular and inflammatory transcripts. Mol Vis 2011; 17:1261-74. [PMID: 21633715]
46. Gustavsson C, Agardh CD, Zetterqvist AV, Nilsson J, Agardh E, Gomez MF. Vascular cellular adhesion molecule-1 (VCAM-1) expression in mice retinal vessels is affected by both hyperglycemia and hyperlipidemia. PLoS ONE 2010; 5:e12699. [PMID: 20856927]
47. Barber AJ, Antonetti DA, Kern TS, Reiter CE, Soans RS, Krady JK, Levison SW, Gardner TW, Bronson SK. The Ins2Akita mouse as a model of early retinal complications in diabetes. Invest Ophthalmol Vis Sci 2005; 46:2210-8. [PMID: 15914643]
48. Xi J, Farjo R, Yoshida S, Kern TS, Swaroop A, Andley UP. A comprehensive analysis of the expression of crystallins in mouse retina. Mol Vis 2003; 9:410-9. [PMID: 12949468]
49. Fort PE, Lampi KJ. New focus on alpha-crystallins in retinal neurodegenerative diseases. Exp Eye Res 2011; 92:98-103. [PMID: 21115004]
50. Fort PE, Freeman WM, Losiewicz MK, Singh RS, Gardner TW. The retinal proteome in experimental diabetic retinopathy: Up-regulation of crystallins and reversal by systemic and periocular insulin. Mol Cell Proteomics 2009; 8:767-79. [PMID: 19049959]
51. Sakaguchi H, Miyagi M, Darrow RM, Crabb JS, Hollyfield JG, Organisciak DT, Crabb JW. Intense light exposure changes the crystallin content in retina. Exp Eye Res 2003; 76:131-3. [PMID: 12589783]
52. Kumar PA, Haseeb A, Suryanarayana P, Ehtesham NZ, Reddy GB. Elevated expression of alphaA-and alphaBcrystallins in streptozotocin-induced diabetic rat. Arch Biochem Biophys 2005; 444:77-83. [PMID: 16309625]
53. Wang YD, Wu JD, Jiang ZL, Wang YB, Wang XH, Liu C, Tong MQ. Comparative proteome analysis of neural retinas from type 2 diabetic rats by two-dimensional electrophoresis. Curr Eye Res 2007; 32:891-901. [PMID: 17963109]
54. Kase S, Ishida S, Rao NA. Increased expression of alphaAcrystallin in human diabetic eye. Int J Mol Med 2011; 28:505-11. [PMID: 21617844]
55. Söhl G, Maxeiner S, Willecke K. Expression and functions of neuronal gap junctions. Nat Rev Neurosci 2005; 6:191-200. [PMID: 15738956]
56. Huang H, Gandhi JK, Zhong X, Wei Y, Gong J, Duh EJ, Vinores SA. TNFalpha is required for late BRB breakdown in diabetic retinopathy, and its inhibition prevents leukostasis and protects vessels and neurons from apoptosis. Invest Ophthalmol Vis Sci 2011; 52:1336-44. [PMID: 21212173]
57. Buschini E, Piras A, Nuzzi R, Vercelli A. Age related macular degeneration and drusen: Neuroinflammation in the retina. Prog Neurobiol 2011; 95:14-25. [PMID: 21740956]
58. Antonetti DA, Barber AJ, Bronson SK, Freeman WM, Gardner TW, Jefferson LS, Kester M, Kimball SR, Krady JK, LaNoue KF, Norbury CC, Quinn PG, Sandirasegarane L, Simpson IA, JDRF Diabetic Retinopathy Center Group. Diabetic retinopathy: Seeing beyond glucose-induced microvascular disease. Diabetes 2006; 55:2401-11. [PMID: 16936187]
59. Liu J, Shi B, He S, Yao X, Willcox MD, Zhao Z. Changes to tear cytokines of type 2 diabetic patients with or without retinopathy. Mol Vis 2010; 16:2931-8. [PMID: 21203348]
60. Gregor MF, Hotamisligil GS. Inflammatory mechanisms in obesity. Annu Rev Immunol 2011; 29:415-45. [PMID: 21219177]
61. Matsunaga N, Imai S, Inokuchi Y, Shimazawa M, Yokota S, Araki Y, Hara H. Bilberry and its main constituents have neuroprotective effects against retinal neuronal damage in vitro and in vivo. Mol Nutr Food Res 2009; 53:869-77. [PMID: 19415665]
62. Dutot M, Rambaux L, Warnet JM, Rat P. Oxidative stress modulation using polyphenol-rich blueberries: Application on a human retinal cell model. J Fr Ophtalmol 2008; 31:975-80. [PMID: 19107073]
63. Liu Y, Song X, Han Y, Zhou F, Zhang D, Ji B, Hu J, Lv Y, Cai S, Wei Y, Gao F, Jia X. Identification of anthocyanin components of wild chinese blueberries and amelioration of light-induced retinal damage in pigmented rabbit using whole berries. J Agric Food Chem 2011; 59:356-63. [PMID: 21142104]
64. Milbury PE, Graf B, Curran-Celentano JM, Blumberg JB. Bilberry (vaccinium myrtillus) anthocyanins modulate heme oxygenase-1 and glutathione S-transferase-pi expression in ARPE-19 cells. Invest Ophthalmol Vis Sci 2007; 48:2343-9. [PMID: 17460300]