Issues of concern regarding the use of hypertonic/hyperoncotic fluid resuscitation of hemorrhagic hypotension

Shock

Volumn 25, Issue 4, 2006, Pages 321-328

  Dubick, Michael A ^a   Bruttig, Stephen P ^b   Wade, Charles E ^a  

^a US ARMY INSTITUTE OF SURGICAL RESEARCH   (United States)

^b Novel Technologies Inc   (United States)

Author keywords

Anaphylactoid reactions; Dehydration; Hemorrhage; Hypertonic saline; Hypertonic saline dextran (HSD)

Indexed keywords

DEXTRAN; HYPERTONIC SOLUTION; SODIUM CHLORIDE;

ANAPHYLAXIS; BLEEDING; BLOOD CLOTTING DISORDER; DEHYDRATION; DRUG MECHANISM; DRUG SAFETY; FLUID RESUSCITATION; HEAD INJURY; HEMORRHAGIC HYPOTENSION; HYPERNATREMIA; KIDNEY DISEASE; KIDNEY FAILURE; MILITARY MEDICINE; NONHUMAN; REVIEW;

EID: 33646783342     PISSN: 10732322     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (108)

1. Bickell WH, Bruttig SP, Wade CE: Hemodynamic response to abdominal aortotomy in anesthetized swine. Circ Shock 28:321-328, 1989.
2. Bickell WH, Wall MJ, Pepe PE, Martin RR, Ginger VF, Allen MK, Mattox KL: Immediate vs. delayed fluid resuscitation for hypotensive patients with penetrating torso injuries. N Engl J Med 331:1105-1109, 1994.
3. Matsuoka T, Hildreth J, Wisner DH: Liver injury as a model of uncontrolled hemorrhagic shock: resuscitation with different hypertonic regimens. J Trauma 39:674-680, 1995.
4. Bruttig SP, Calcagni DE: Hemorrhage and its treatment. Curr Opin Anesthesiol 10:124-129, 1997.
5. Heath KJ: Hypertonic saline: A review of the literature and evaluation of its role in resuscitation of traumatic hypovolaemic shock. J R Army Med Corps 140:37-41, 1994.
6. Dubick MA, Wade CE: A review of the efficacy and safety of 7.5% NaCl/6% Dextran 70 in experimental animals and in humans. J Trauma 36:323-330, 1994.
7. Kreimeier U, Frey L, Messmer K: Small volume resuscitation. Curr Opin Anesthesiol 6:400-408, 1993.
8. Moore EE: Hypertonic saline dextran for post-injury resuscitation: experimental background and clinical experience. Aust NZ Surg 61:732-736, 1991.
9. Dubick MA, Bruttig SP: Hypertonic saline dextran: a development update. Army Med Depart J PB-8:16-20, 1996.
10. Wade CE, Kramer GC, Grady JJ, Fabian TC, Younes RN: Efficacy of hypertonic 7.5% saline and 6% dextran-70 in treating trauma: a meta-analysis of controlled clinical studies. Surgery 122:609-616, 1997.
11. Maningas PA, DeGuzman LR, Tillman FJ, Hinson CS, Priegnitz KJ, Volk KA, Bellamy RF: Small-volume infusion of 7.5% NaCl in 6% dextran 70 for the treatment of severe hemorrhagic shock in swine. Ann Emerg Med 15:1131-1137, 1986.
12. Wade CE, Dubick MA, Grady JJ: Optimal dose of hypertonic saline/dextran in hemorrhaged swine. J Trauma 55(3):413-416, 2003.
13. Rocha-e-Silva M, Poli de Figueiredo LF: Small volume hypertonic resuscitation of circulatory shock. Clinics 60(2):159-172, 2005.
14. Wade CE, Hannon JP, Bossone CA, Hunt MM, Loveday JA, Coppes R, Gildengorin VL: Resuscitation of conscious pigs following hemorrhage. Comparative efficacy of small volume resuscitation. Circ Shock 29:193-204, 1989.
15. Hannon JP, Wade CE, Bossone CA, Hunt MM, Loveday JA: Oxygen delivery and demand in conscious pigs subjected to fixed-volume hemorrhage and resuscitated with 7.5% NaCl in 6% dextran. Circ Shock 29:205-217, 1989.
16. Hannon JP, Wade CE, Bossone CA, Hunt MM, Coppes RI, Loveday JA: Blood gas and acid base status of conscious pigs subjected to fixed-volume hemorrhage and resuscitated with hypertonic saline dextran. Circ Shock 32:19-29, 1990.
17. Krausz MM, Horn Y, Gross D: The combined effect of small volume hypertonic saline solution in uncontrolled hemorrhagic shock. Surg Gyn Obstet 174:363-368, 1992.
18. Gross D, Landau EH, Klin B, Krausz MM: Treatment of uncontrolled hemorrhagic shock with hypertonic saline solution. Surg Gyn Obstet 170:106-112, 1990.
19. Matsuoka T, Wisner DH: Resuscitation of uncontrolled hemorrhage: effects on bleeding, oxygen delivery, and oxygen consumption. J Trauma 41:439-445, 1996.
20. Cannon WB, Fraser J, Cowell EM: The preventive treatment of wound shock. JAMA 70:618-621, 1918.
21. Bickell WH, Bruttig SP, Millnamow GA, O'Benar J, Wade CE: Use of hypertonic saline/dextran vs. lactated Ringer's solution as a resuscitation fluid following uncontrolled aortic hemorrhage in anesthetized swine. Ann Emerg Med 21:1077-1085, 1992.
22. Leppaniemi A, Soltero R, Burris D, Pikoulis E, Waasdorp C, Ratigan J, Hufnagel H, Malcolm D: Fluid resuscitation in a model of uncontrolled hemorrhage: Too much too early, or too little too late? J Surg Res 63:413-418, 1996.
23. Krausz MM, Kablan M, Rabinovici R, Klin B, Sherman Y, Gross D: Effect of injured vessel size on bleeding following hypertonic saline infusion in "uncontrolled" hemorrhagic shock in anesthetized rats. Circ Shock 35:9-13, 1991.
24. Bilynskyj MCV, Errington ML, Velasco IT, Rocha e Silva M: Effect of hypertonic sodium chloride (7.5%) on uncontrolled hemorrhage in rats and its interaction with different anesthetic procedures. Circ Shock 36:68-73, 1992.
25. Doucy DM, Sindlinger JF, Greene SP, Barber A, Illner H, Shires TG: Effects of anesthesia on a model of uncontrolled hemorrhage in rats. Crit Care Med 23:1528-1532, 1995.
26. Matsuoka T, Hildreth J, Wisner DH: Uncontrolled hemorrhage from parenchymal injury: is resuscitation helpful? J Trauma 40:915-921, 1996.
27. Leppaniemi A, Soltero R, Burris D, Pikoulis E, Ratigan J, Waasdorp C, Hufnagel H, Malcomb D: Early resuscitation with low-volume PolyDCLHb is effective in the treatment of shock induced by penetrating vascular injury. J Trauma 40:242-248, 1996.
28. Bruttig S, Discher T, Doherty P, Borgstrom P, Arfors K: Hypertonic Saline Dextran (HSD) improves peripheral microvascular performance following massive uncontrolled hemorrhage. Circ Shock 34:36, 1991.
29. Bruttig SP, O'Benar JD, Bickell WH, Wade CE: Effects of immediate versus delayed fluid resuscitation on hemorrhage volume and mortality in anesthetized pigs. Circ Shock 31:70-71, 1990.
30. O'Benar JD, Bruttig SP: Delayed resuscitation from uncontrolled aortotomy hemorrhage using bolus versus slow infusion of hypertonic saline/dextran. Circ Shock 31:68, 1990.
31. Elgjo GI, Knardahl S: Low-dose hypertonic saline (NaCl 8.0%) treatment of uncontrolled abdominal hemorrhage: Effects on arterial versus venous injury. Shock 5:52-58, 1996.
32. Bruttig SP, O'Benar J, Wade CE, Dubick MA: Benefit of slow infusion of hypertonic saline/dextran in swine with uncontrolled aortotomy hemorrhage. Shock 24(1):92-96, 2005.
33. Mattox KL, Maningas PA, Moore EE, Mateer JR, Marx JA, Aprahamian C, Burch JM, Pepe PE: Prehospital hypertonic saline/dextran infusion for post-traumatic hypotension. The USA multicenter study. Ann Surg 213:482-491, 1991.
34. Wade CE, Grady JJ, Kramer GC: Efficacy of hypertonic saline dextran fluid resuscitation for patients with hypotension from penetrating trauma. J Trauma 54(5 Suppl):S144-S148, 2003.
35. Vassar MJ, Perry CA, Gannaway WL, Holcroft JW: 7.5% sodium chloride/dextran for resuscitation of trauma patients undergoing helicopter transport. Arch Surg 126:1065-1072, 1991.
36. Vassar MJ, Fischer RP, O'Brien PE, Bachulis BL, Chambers JA, Hoyt DB, Holcroft JW: A multicenter trial for resuscitation of injured patients with 7.5% NaCl: The effect of added dextran. Arch Surg 128:1003-1013, 1993.
37. Saxe JM, Dombi GW, Lucas WF, Ledgerwood AM, Lucas CE: Hemodynamic, plasma volume, and pre-nodal skin lymph responses to varied resuscitation regimens. J Trauma 41:283-289, 1996.
38. Ryan BA, Summary JJ, Dubick MA, Bowman PD, Wilson L, Wade CE: The hemostatic and hematologic effects of hypertonic saline (7.5%) dextran-70 (HSD) in swine and rabbits. FASEB J 3:A1210, 1989.
39. Moon PF, Hollyfield-Gilbert MA, Myers TL, Uchida T, Kramer GC: Fluid compartments in hemorrhaged rats after hyperosmotic crystalloid and hyperoncotic colloid resuscitation. Am J Physiol 270:F1-F8, 1996.
40. Moore GL, Summary JJ, Dubick MA, Ledford ME, Ryan BA, Gonzales A, Wade CE: Effects of hypertonic saline (7.5%)/dextran 70 on human red cell typing, lysis, and metabolism in vitro. Vox Sang 59:227-231, 1990.
41. Dubick MA, Wade CE: Evaluation of the local irritation potential of hypertonic saline-dextran (HSD) in mice and rabbits. J Appl Toxicol 24(6):409-413, 2004.
42. Wade CE, Tillman FJ, Loveday JA, Blackmon A, Potanko E, Hunt MM, Hannon JP: Effect of dehydration on cardiovascular responses and electrolytes after hypertonic saline/dextran treatment for moderate hemorrhage. Ann Emerg Med 21:113-119, 1992.
43. Alemayehu A, McKirnan MD, Mozingo RD, Gray CG: Hypertonic saline/dextran treatment for severe pressure-driven hemorrhage in dehydrated conscious swine. Shock 6:298-306, 1996.
44. Krausz MM, Ravid A, Izhar U, Feigin E, Horowitz M, Gross D: The effect of heat load and dehydration on hypertonic saline solution treatment of controlled hemorrhagic shock. Surg Gyn Obstet 177:583-591, 1993.
45. Sondeen JL, Gunther RA, Dubick MA: Comparison of 7.5% NaCl/6% dextran-70 resuscitation of hemorrhage between euhydrated and dehydrated sheep. Shock 3:63-68, 1995.
46. McKirnan MD, Williams RL, Limjoco U, Ragland J, Gray CG: Hypertonic saline/dextran versus lactated Ringer's treatment for hemorrhage in dehydrated swine. Circ Shock 44:238-246, 1994.
47. Ho HS, Sondeen JL, Dubick MA, Wade CE, Gunther RA: The renal effects of 7.5% NaCl-6% dextran-70 versus lactated Ringer's resuscitation of hemorrhage in dehydrated sheep. Shock 5:289-297, 1996.
48. Matthew CB: Treatment of hyperthermia and dehydration with hypertonic saline in dextran. Shock 2:216-221, 1994.
49. Matthew CB, Durkot MJ, Patterson DR: Fluid shifts induced by the administration of 7.5% sodium chloride in 6% dextran 70 (HSD) in dehydrated swine. Circ Shock 41:150-155, 1993.
50. Dubick MA, Davis JM, Myers T, Wade CE, Kramer GC: Dose response effects of hypertonic saline and dextran on cardiovascular responses and plasma volume expansion in sheep. Shock 3:137-144, 1995.
51. Kramer G, Perron P, Lindsey D, Ho H, Gunther R, Boyle W: Small volume resuscitation with saline dextran solution. Surgery 100:239-246, 1986.
52. Dubick MA, Zaucha GM, Korte DW, Wade CE: Acute and subacute toxicity of 7.5% hypertonic saline-6% dextran-70 (HSD) in dogs 2. Biochemical and behavioral responses. J Appl Toxicol 13:49-55, 1993.
53. Vassar JJ, Perry CA, Holcroft JW: Analysis of potential risks associated with 7.5% sodium chloride resuscitation of traumatic shock. Arch Surg 125:1309-1315, 1990.
54. Wade CE, Dubick MA, Vassar MJ, Perry CA, Holcroft JW: Plasma dextran concentrations in trauma patients administered hypertonic saline-dextran-70. Clin Chem 42:779-780, 1996.
55. Schertel ER, Allen DA, Muir W: Hansen BD. Evaluation of a hypertonic sodium chloride/dextran solution for treatment of traumatic shock in dogs. JAVMA 208:366-370, 1996.
56. Kramer GC, Poli de Figuriredo LF: Hypertonic 7.5% saline: evaluations of efficacy and safety from human trials. In: Okada K, Ogata H eds. Shock. From Molecular and Cellular Level to Whole Body. Amsterdam: Elsevier, 1996:363-368.
57. Svensen C: Hypertonic solutions: An update. Trauma Care 12:6-12, 2002.
58. Shackford SR, Schmoker JD, Zhuang J: The effect of hypertonic resuscitation on pial arteriolar tone after brain injury and shock. J Trauma 37:899-908, 1994.
59. Wade CE, Grady JJ, Kramer GC, Younes RN, Gehlsen K, Holcroft JW: Individual patient cohort analysis of the efficacy of hypertonic saline/dextran in patients with traumatic brain injury and hypotension. J Trauma 42:S61-S65, 1997.
60. Battistella FD, Wisner DH: Combined hemorrhagic shock and head injury: effects of hypertonic saline (7.5%) resuscitation. J Trauma 31:182-188, 1991.
61. Wisner DH, Schuster L, Quinn C: Hypertonic saline resuscitation of head injury: effects on cerebral water content. J Trauma 30:75-78, 1990.
62. Freshman SP, Battistella FD, Matteucci M, Wisner DH: Hypertonic saline (7.5%) versus mannitol: a comparison for treatment of acute head injuries. J Trauma 35:344-348, 1993.
63. Hartl R, Schurer L, Goetz C, Berger S, Rohrich F, Baethmann A: The effect of hypertonic fluid resuscitation on brain edema in rabbits subjected to brain injury and hemorrhagic shock. Shock 3:274-279, 1995.
64. Kempski O, Obert C, Mainka T, Heimann A, Strecker U: Small volume resuscitation as treatment of cerebral blood flow disturbances and increased ICP in trauma and ischemia. Acta Neurochir 66(Suppl):114-117, 1996.
65. Goulin GD, Duthie SE, Zornow MH, Scheller MS, Peterson BM: Global cerebral ischemia: Effects of pentastarch after reperfusion. Anesth Analg 79:1036-1042, 1994.
66. Sheikh AA, Matsuoka T, Wisner DH: Cerebral effects of resuscitation with hypertonic saline and a new low-sodium hypertonic fluid in hemorrhagic shock and head injury. Crit Care Med 24:1226-1232, 1996.
67. Berger S, Schurer L, Hartl R, Messmer K, Baethmann A: Reduction of post-traumatic intracranial hypertension by hypertonic/hyperoncotic saline/dextran and hypertonic mannitol. Neurosurgery 37:98-107, 1995.
68. Shackford SR: Effect of small-volume resuscitation on intracranial pressure and related cerebral variables. J Trauma 42(Suppl):S48-S53, 1997.
69. Taylor G, Myers S, Kurth CD, Duhaime AC, Yu M, McKernan M, Gallagher P, O'Neill J Jr, Templeton J Jr: Hypertonic saline improves brain resuscitation in a pediatric model of head injury and hemorrhagic shock. J Pediatr Surg 31:65-70, 1996.
70. Waschke KF, Albrecht DM, van Ackern K, Kuschinsky W: Coupling between local cerebral blood flow and metabolism after hypertonic/hyper-oncotic fluid resuscitation from hemorrhage in conscious rats. Anesth Analg 82:52-60, 1996.
71. Walsh JC, Zhuang J, Shackford SR: A comparison of hypertonic to isotonic fluid in the resuscitation of brain injury and hemorrhagic shock. J Surg Res 50:284-292, 1991.
72. Hartl R, Ghajar J, Hochleuthner H, Mauritz W: Treatment of refractory intracranial hypertension in severe traumatic brain injury with repetitive hypertonic/hyperoncotic infusions. Zentralbl Chir 122:181-185, 1997.
73. Hartl R, Medary MB, Ruge M, Arfors KE, Ghahremani F, Ghajar J: Hypertonic/ hyperoncotic saline attenuates microcirculatory disturbances after traumatic brain injury. J Trauma 42:S41-S47, 1997.
74. Hamaguchi S, Ogata H: Does hypertonic saline have preventive effects against delayed neuronal death in gerbil hippocampus? Shock 3:280-283, 1995.
75. Tuma RF, Vasthare US, Arfors KE, Young WF: Hypertonic saline administration attenuates spinal cord injury. J Trauma 42:S54-S60, 1997.
76. DeWitt DS, Prough DS, Deal DD, Vines SM, Hoen H: Hypertonic saline does not improve cerebral oxygen delivery after head injury and mild hemorrhage in cats. Crit Care Med 24:1933-1936, 1996.
77. Kurnik BRC, Singer F, Groh W: Case report: dextran-induced acute anuric failure. Am J Med Sci 302:28-30, 1991.
78. Fleming JW, Cargill WH, Bloom WL: Effects of intravenous administration of dextran on renal function. Proc Soc Exp Biol Med 79:604-606, 1952.
79. Ingraham RC, Juster R, Froeb HF, Pirani CL: Renal function following dextran therapy of hemorrhagic shock. J Appl Physiol 9:123-128, 1956.
80. Malcolm DS, Friedland M, Moore T, Beauregard J, Hufnagel H, Wiesmann WP: Hypertonic saline resuscitation detrimentally affects renal function and survival in dehydrated rats. Circ Shock 40:69-74, 1993.
81. Younes RN, Aun F, Ching CT, Goldenberg DC, Franco MH, Miura FK, Santos SS, Sequeiros IMM, Rocha e Silva M, Fujimura I, Birolini D: Prognostic factors to predict outcome following the administration of hypertonic/hyperoncotic solution in hypovolemic patients. Shock 7:79-83, 1997.
82. Berg EM, Fasting S, Sellevold OF: Serious complications with dextran-70 despite hapten prophylaxis. Is it best avoided prior to delivery? Anaesthesia 46(12):1033-1035, 1991.
83. Bailey G, Strub RL, Klein RC, Salvaggio J: Dextran-induced anaphylaxis. JAMA 200(10):889-891, 1967.
84. Hedin H, Ljungstrom KG: Prevention of dextran anaphylaxis. Ten years experience with hapten dextran. Int Arch Allergy Immunol 113(1-3):358-359, 1997.
85. Kabat EA, Bezer AE: The effect of variation in molecular weight on the antigenicity of dextran in man. Arch Biochem Biophys 78(2):306-318, 1958.
86. Brisman R, Parks LC, Haller JA Jr: Anaphylactoid reactions associated with the clinical use of dextran 70. JAMA 204(9):824-825, 1968.
87. Ljungstrom KG, Renck H, Strandberg K, Hedin H, Richter W, Widerlov E: Adverse reactions to dextran in Sweden 1970-1979. Acta Chir Scand 149(3):253-262, 1983.
88. Barron ME, Wilkes MM, Navickis RJ: A systematic review of the comparative safety of colloids. Arch Surg 139(5):552-563, 2004.
89. Richter W: Hapten inhibition of passive antidextran dextran anaphylaxis in guinea pigs. Role of molecular size in anaphylactogenicity and precipitability of dextran fractions. Int Arch Allergy Appl Immunol 41(6):826-844, 1971.
90. Hedin H, Richter W, Ring J: Dextran-induced anaphylactoid reactions in man: role of dextran reactive antibodies. Int Arch Allergy Appl Immunol 52(1-4):145-159, 1976.
91. Renck H, Ljungstrom KG, Rosberg B, Dhuner KG, Dalil S: Prevention of dextran-induced anaphylactic reactions by hapten inhibition. II. A comparison of the effects of 20 ml dextran 1, 15%, administered either admixed to or before dextran 70 or dextran 40. Acta Chir Scand 149(4):349-353, 1983.
92. Renck H, Ljungstrom KG, Hedin H, Richter W: Prevention of dextran-induced anaphylactic reactions by hapten inhibition. III. A Scandinavian multicenter study on the effects of 20 ml dextran 1, 15%, administered before dextran 70 or dextran 40. Acta Chir Scand 149(4):355-360, 1983.
93. Ljungstrom KG, Willman B, Hedin H: Hapten inhibition of dextran anaphylaxis. Nine years of post-marketing surveillance of dextran 1. Ann Fr Anesth Reanim 12(2):219-222, 1993.
94. Ljungstrom KG, Renck H, Hedin H, Richter W, Rosberg B: Prevention of dextran-induced anaphylactic reactions by hapten inhibition. I. A Scandinavian multicenter study on the effects of 10 ml dextran 1, 15% administered before dextran 70 or dextran 40. Acta Chir Scand 149(4):341-348, 1983.
95. Laubenthal H, Peter K, Messmer K: Dextran for traumatic shock patients in spite of possible anaphylactic reactions? Circ Shock 21:372, 1987.
96. Maningas PA, Mattox KL, Pepe PE, Jones RL, Feliciano DV, Burch JM: Hypertonic saline-dextran solutions for the prehospital management of traumatic hypotension. Am J Surg 157(5):528-533, 1989. discussion 33-4.
97. Schimetta W, Schochl H, Kroll W, Polz W, Polz G, Mauritz W: Safety of hypertonic hyperoncotic solutions - a survey from Austria. Wien Klin Wochenschr 114(3):89-95, 2002.
98. Nilsson IM, Eiken O: Further studies on the effects of dextran of various molecular weight on the coagulation mechanism. Thromb Diath Hemorrhag 11:38-50, 1964.
99. Howard JM, Teng CT, Lowffler RK: Studies of dextrans of various molecular weights. Ann Surg 143:369-372, 1956.
100. Bergqvist D: Dextran and haemostasis. Acta Chir Scand 148:633-640, 1982.
101. Dubick MA, Kilani AF, Summary JJ, Greene JY, Wade CE: Further Evaluation of the effects of 7.5% sodium chloride/6% dextran -70 (HSD) administration on coagulation and platelet aggregation in hemorrhaged and euvolemic swine. Circ Shock 40:200-205, 1993.
102. Hess JR, Dubick MA, Summary JJ, Bangal NR, Wade CE: The effects of 7.5% NaCl/6% Dextran 70 on coagulation and platelet aggregation in humans. J Trauma 32:40-44, 1992.
103. Wilder DM, Reid TJ, Bakaltcheva IB: Hypertonic resuscitation and blood coagulation: in vitro comparison of several hypertonic solutions for their action on platelets and plasma coagulation. Thromb Res 107(5):255-261, 2002.
104. Coats TJ, Heron M: The effect of hypertonic saline dextran on whole blood coagulation. Resuscitation 60(1):101-104, 2004.
105. Reed LR, Johnston TD, Chen Y, Fischer RP: Hypertonic saline alters plasma clotting times and platelet aggregation. J Trauma 31:8-14, 1991.
106. O'Benar JD, Bruttig SP, Wade CE, Dubick MA: Hemodynamic and metabolic responses to repeated hemorrhage and resuscitation with hypertonic saline dextran in conscious swine. Shock 10(3):223-228, 1998.
107. Prist R, Roche e Silva M, Velasco IT, Loureiro MI: Pressure driven hemorrhage: A new experimental design for the study of crystalloid and small volume hypertonic resuscitation in anesthetized dogs. Circ Shock 36:13-20, 1992.
108. Zaucha GM, Dubick MA, Wade CE, Korte DW Jr: Studies on the acute and subacute toxicity of 7.5% NaCl/6% Dextran-70 in rabbits and dogs. Eur Surg Res 22:299-300, 1990.