Expression and cellular localization of p8 protein in thyroid neoplasms

Cancer Letters

Volumn 201, Issue 2, 2003, Pages 237-244

  Ito, Yasuhiro ^a   Yoshida, Hiroshi ^a   Motoo, Yoshiharu ^b   Miyoshi, Eiji ^c   Iovanna, Juan Lucio ^d   Tomoda, Chisato ^a   Uruno, Takashi ^a   Takamura, Yuuki ^a   Miya, Akihiro ^a   Kobayashi, Kaoru ^a   Matsuzuka, Fumio ^a   Matsuura, Nariaki ^c   Kuma, Kanji ^a   Miyauchi, Akira ^a  

^a KUMA HOSPITAL   (Japan)

^b KANAZAWA UNIVERSITY   (Japan)

^c OSAKA UNIVERSITY MEDICAL SCHOOL   (Japan)

^d INSERM   (France)

Author keywords

Immunohistochemistry; p8; Thyroid tumor

Indexed keywords

PROTEIN; PROTEIN P8; UNCLASSIFIED DRUG;

ANAPLASTIC CARCINOMA; ARTICLE; CANCER INCIDENCE; CELL NUCLEUS; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOPLASM; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LYMPH NODE METASTASIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; THYROID ADENOMA; THYROID FOLLICLE CELL; THYROID FOLLICULAR CARCINOMA; THYROID PAPILLARY CARCINOMA; THYROID TUMOR; TUMOR VOLUME;

EID: 0242352520     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.canlet.2003.07.002     Document Type: Article

References (12)

1. Aldinger K.A., Samaan N.A., Ibanez M., Hill C.S. Jr. Anaplastic carcinoma of the thyroid: a review of 84 cases of spindle and giant-cell carcinoma of the thyroid. Cancer. 141:1978;2267-2275.
2. Ito T., Seyama T., Mizuno T., Tsuyama N., Hayashi T., Hayashi Y., Nakamura N., Akiyama M. Unique association of p53 mutations with undifferentiated but not with differentiated carcinomas of the thyroid gland. Cancer Res. 52:1992;1369-1371.
3. Sakamoto A., Kasai N., Sugano H. Poorly differentiated carcinoma of the thyroid. A clinicopathological entity for a high-risk group of papillary and follicular carcinomas. Cancer. 52:1983;1849-1855.
4. Fagin J.A. Molecular genetics of tumors of thyroid follicular cells. Braverman L.E., Utger R.D. The Thyroid. 8th Edition:2000;886-898 Lippincott, Philadelphia, PA.
5. Mallo G.V., Fiedler F., Calvo E.L., Ortiz E.M., Vasseur S., Keim V., Morisset J., Iovanna J.L. Cloning and expression of the rat p8 cDNA, a new gene activated in pancreas during the acute phase of pancreatitis, pancreatic development, and regeneration, and which promotes cellular growth. J. Biol. Chem. 272:1997;32360-32369.
6. Vasseur S., Mallo G.V., Fiedler F., Bodeker H., Canepa E., Moreno S., Iovanna J.L. Cloning and expression of the human p8, a nuclear protein with mitogenic activity. Eur. J. Biochem. 259:1999;670-675.
7. Courjal F., Theillet C. Comparative genomic hybridization analysis of breast tumor with predetermined profiles of DNA amplification. Cancer Res. 57:1997;4368-4377.
8. Su S.B., Motoo Y., Iovanna J.L., Xie M.J., Mouri H., Ohtsubo K., Yamaguchi Y., Watanabe H., Okai T., Matsubara F., Sawabu N. Expression of p8 in human pancreatic cancer. Clin. Cancer Res. 7:2001;309-313.
9. Su S.B., Motoo Y., Iovanna J.L., Berthezene P., Xie M.J., Mouri H., Ohtsubo K., Matsubara F., Sawabu N. Overexpression of p8 is inversely correlated with apoptosis in pancreatic cancer. Clin. Cancer Res. 7:2001;1320-1324.
10. Hedinger C., Williams E.D., Sobin L.H. Histological Typing of Thyroid Tumours. 2nd Edition:1988;Springer, New York. pp. 9-11, World Health Organization.
11. Vesseur S., Hoffmeister A., Garcia S., Bagnis C., Dagorn J.C., Iovanna J.L. P8 is critical for tumour development induced by rasV12 mutated protein and E1A oncogene. EMBO Rep. 3:2002;165-170.
12. Basolo F., Pollina L., Fontanini G., Fiore L., Pacini F., Baldanzi A. Apoptotisis and proliferation in thyroid carcinoma: correlation with bcl-2 and p53 protein expression. Br. J. Cancer. 75:1997;537-541.